Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Neospora caninum | Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0105 | 1 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.6097 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.3021 | 0.2968 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0361 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0361 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.3217 | 0.2907 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0361 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0361 | 1 |
Brugia malayi | Transient-receptor-potential like protein | 0.0039 | 0.3457 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0361 | 1 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0039 | 0.3457 | 0.3158 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0361 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.3217 | 0.2907 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 0.201 | 0.1458 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.3457 | 0.3005 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.3021 | 0.2539 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0361 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.3217 | 0.3165 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0361 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0361 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0361 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0361 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.3109 | 0.2633 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0069 | 0.6473 | 0.6312 |
Brugia malayi | Cytochrome P450 family protein | 0.0024 | 0.201 | 0.4877 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0646 | 0.0219 |
Schistosoma mansoni | transient receptor potential channel | 0.0069 | 0.6473 | 0.6446 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0361 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0105 | 1 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.6876 | 0.6852 |
Schistosoma mansoni | transient receptor potential channel | 0.0069 | 0.6473 | 0.6446 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0102 | 0.9653 | 0.9637 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0361 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 1 | 1 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0102 | 0.9653 | 0.9637 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0361 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0361 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.3217 | 0.3165 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0105 | 1 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.3021 | 0.8457 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0069 | 0.6473 | 0.6312 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0436 | 0.0364 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0361 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0361 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0069 | 0.6473 | 0.6312 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0361 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0646 | 0.0219 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0039 | 0.3457 | 0.3158 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.6125 | 0.5858 |
Onchocerca volvulus | 0.0035 | 0.3021 | 0.5 | |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0069 | 0.6473 | 0.6312 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.