Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Echinococcus granulosus | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0123 | 0 | 0.5 | |
Onchocerca volvulus | 0.0123 | 0 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0123 | 0 | 0.5 |
Onchocerca volvulus | 0.0123 | 0 | 0.5 | |
Onchocerca volvulus | 0.0123 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0123 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0726 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0123 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0726 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0726 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0726 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0726 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0726 | 1 | 1 |
Onchocerca volvulus | 0.0123 | 0 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0726 | 1 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.4729 | 0.4729 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0123 | 0 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.4729 | 0.4729 |
Loa Loa (eye worm) | carboxylesterase | 0.0726 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0123 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0123 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0726 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0726 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0891 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.