Detailed information for compound 130783

Basic information

Technical information
  • TDR Targets ID: 130783
  • Name: 6-[(E)-N-(methanesulfonamido)-C-(5,5,8,8-tetr amethyl-6,7-dihydronaphthalen-2-yl)carbonimid oyl]naphthalene-2-carboxylic acid
  • MW: 478.603 | Formula: C27H30N2O4S
  • H donors: 2 H acceptors: 4 LogP: 6.75 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1ccc2c(c1)ccc(c2)/C(=N\NS(=O)(=O)C)/c1ccc2c(c1)C(C)(C)CCC2(C)C
  • InChi: 1S/C27H30N2O4S/c1-26(2)12-13-27(3,4)23-16-20(10-11-22(23)26)24(28-29-34(5,32)33)19-8-6-18-15-21(25(30)31)9-7-17(18)14-19/h6-11,14-16,29H,12-13H2,1-5H3,(H,30,31)/b28-24+
  • InChiKey: AFXUXZQUPCCJSH-ZZIIXHQDSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-[(E)-N-(methanesulfonamido)-C-(1,1,4,4-tetramethyltetralin-6-yl)carbonimidoyl]naphthalene-2-carboxylic acid
  • 6-[(E)-(methylsulfonylhydrazono)-(1,1,4,4-tetramethyl-6-tetralinyl)methyl]-2-naphthalenecarboxylic acid
  • 6-[(E)-N-(methylsulfonylamino)-C-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]naphthalene-2-carboxylic acid
  • 6-[(E)-N-(methanesulfonamido)-C-(1,1,4,4-tetramethyltetralin-6-yl)carbonimidoyl]-2-naphthoic acid
  • 6-[N-methanesulfonamido-C-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]naphthalene-2-carboxylic acid
  • 6-[N-methanesulfonamido-C-(1,1,4,4-tetramethyltetralin-6-yl)carbonimidoyl]naphthalene-2-carboxylic acid
  • 6-[N-methanesulfonamido-C-(1,1,4,4-tetramethyltetralin-6-yl)carbonimidoyl]-2-naphthoic acid
  • 6-[N-(methylsulfonylamino)-C-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]naphthalene-2-carboxylic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens retinoic acid receptor, alpha Starlite/ChEMBL References
Homo sapiens retinoic acid receptor, gamma Starlite/ChEMBL References
Homo sapiens retinoic acid receptor, beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog Get druggable targets OG5_131607 All targets in OG5_131607
Loa Loa (eye worm) nuclear receptor nhr-7B Get druggable targets OG5_131607 All targets in OG5_131607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131607 All targets in OG5_131607
Brugia malayi nuclear hormone receptor Get druggable targets OG5_131607 All targets in OG5_131607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0048 0.0285 0.033
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0048 0.0285 0.033
Entamoeba histolytica hypothetical protein 0.0078 0.0624 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0048 0.0285 0.0336
Schistosoma mansoni hypothetical protein 0.0368 0.3884 0.4584
Echinococcus multilocularis thyroid hormone receptor alpha 0.0048 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0048 0.0285 0.033
Brugia malayi Muscleblind-like protein 0.0168 0.1635 0.1892
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0048 0.0285 0.0336
Echinococcus multilocularis lamin dm0 0.0059 0.0405 0.0405
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0048 0.0285 0.0336
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0514 0.5
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0405 0.0469
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0624 0.0737
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0014 0.0016
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0048 0.0285 0.0336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0824 0.0973
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0048 0.0285 0.033
Schistosoma mansoni importin beta-1 0.0032 0.011 0.013
Brugia malayi hypothetical protein 0.0078 0.0624 0.0723
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0048 0.0285 0.033
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0514 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0048 0.0285 0.033
Echinococcus multilocularis muscleblind protein 1 0.0168 0.1635 0.1635
Loa Loa (eye worm) hypothetical protein 0.0031 0.0097 0.0113
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0048 0.0285 0.0336
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0514 1
Schistosoma mansoni hypothetical protein 0.0074 0.0578 0.0682
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0014 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0048 0.0285 0.033
Brugia malayi steroid hormone receptor 0.0048 0.0285 0.033
Schistosoma mansoni hypothetical protein 0.0034 0.0131 0.0155
Schistosoma mansoni survival motor neuron protein 0.0105 0.0924 0.109
Echinococcus granulosus FTZ F1 alpha 0.0048 0.0285 0.0336
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0097 0.1665
Echinococcus granulosus survival motor neuron protein 1 0.0514 0.5521 0.6516
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0064 0.0064
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0514 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0131 0.0152
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0824 0.0824
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0624 0.0624
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0099 0.0115
Brugia malayi hypothetical protein 0.0514 0.5521 0.639
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0099 0.0115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0048 0.0285 0.0336
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0048 0.0285 0.0336
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0097 0.0115
Echinococcus multilocularis microtubule associated protein 2 0.0777 0.8472 0.8472
Echinococcus granulosus lamin 0.0059 0.0405 0.0478
Brugia malayi intermediate filament protein 0.0059 0.0405 0.0469
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0131 0.0152
Onchocerca volvulus 0.0059 0.0405 0.0454
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0963 0.1115
Plasmodium vivax importin-beta 2, putative 0.0032 0.011 1
Brugia malayi Pre-SET motif family protein 0.0218 0.2197 0.2542
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0048 0.0285 0.033
Onchocerca volvulus 0.0105 0.0924 0.1035
Onchocerca volvulus 0.0059 0.0405 0.0454
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0097 0.0097
Entamoeba histolytica hypothetical protein 0.0078 0.0624 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0285 0.033
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0824 0.0954
Brugia malayi Nuclear hormone receptor-like 1 0.0048 0.0285 0.033
Loa Loa (eye worm) hypothetical protein 0.0769 0.8386 0.9706
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0963 0.1115
Loa Loa (eye worm) hypothetical protein 0.0059 0.0405 0.0469
Schistosoma mansoni steroid hormone receptor ad4bp 0.0048 0.0285 0.0336
Loa Loa (eye worm) hypothetical protein 0.0034 0.0131 0.0152
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.0035
Echinococcus granulosus muscleblind protein 0.0168 0.1635 0.193
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0514 0.5
Loa Loa (eye worm) hypothetical protein 0.0048 0.0285 0.033
Loa Loa (eye worm) hypothetical protein 0.0168 0.1635 0.1892
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.011 0.1927
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0405 0.0469
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0048 0.0285 0.033
Echinococcus granulosus importin subunit beta 1 0.0032 0.011 0.013
Entamoeba histolytica hypothetical protein 0.0078 0.0624 1
Schistosoma mansoni intermediate filament proteins 0.0059 0.0405 0.0478
Loa Loa (eye worm) hypothetical protein 0.0048 0.0285 0.033
Echinococcus granulosus snurportin 1 0.0347 0.3638 0.4294
Brugia malayi ecdysteroid receptor 0.0048 0.0285 0.033
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0347 0.3638 0.4211
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0131 0.0155
Schistosoma mansoni hypothetical protein 0.0105 0.0924 0.109
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0048 0.0285 0.0336
Plasmodium vivax SET domain protein, putative 0.0031 0.0097 0.8639
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0048 0.0285 0.033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0048 0.0285 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0048 0.0285 0.033
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0048 0.0285 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0048 0.0285 0.033
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0824 0.0954
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0041 0.0108
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0048 0.0285 0.0336
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0025 0.003 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.003 0.0035
Onchocerca volvulus 0.0031 0.0097 0.0109
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0131 0.0152
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0824 0.0973
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0048 0.0285 0.033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0824 0.0973
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0048 0.0285 0.033
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.0035
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.003 0.0036
Brugia malayi hypothetical protein 0.0025 0.003 0.0035
Echinococcus granulosus microtubule associated protein 2 0.0777 0.8472 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0131 0.0131
Onchocerca volvulus 0.0048 0.0285 0.0319
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0105 0.0924 0.1069
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0514 0.0606
Brugia malayi nuclear hormone receptor 0.0048 0.0285 0.033
Schistosoma mansoni hypothetical protein 0.0034 0.0131 0.0155
Echinococcus granulosus intermediate filament protein 0.0059 0.0405 0.0478
Schistosoma mansoni thyroid hormone receptor 0.0048 0.0285 0.0336
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0963 0.1115
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0048 0.0285 0.033
Echinococcus multilocularis FTZ F1 alpha 0.0048 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0032 0.011 0.0128
Echinococcus multilocularis ecdysone induced protein 78C 0.0048 0.0285 0.0285
Schistosoma mansoni hypothetical protein 0.0034 0.0131 0.0155
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0041 0.0108
Schistosoma mansoni microtubule-associated protein tau 0.0777 0.8472 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.011 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0824 0.0824
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0014 0.0017
Schistosoma mansoni nuclear hormone receptor 0.0048 0.0285 0.0336
Onchocerca volvulus Bile acid receptor homolog 0.0048 0.0285 0.0319
Schistosoma mansoni hypothetical protein 0.0368 0.3884 0.4584
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0624 0.0737
Echinococcus granulosus lamin dm0 0.0059 0.0405 0.0478
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0514 0.0606
Brugia malayi RNA, U transporter 1 0.0092 0.0783 0.0906
Schistosoma mansoni RAR-like nuclear receptor 0.0048 0.0285 0.0336
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0097 0.0115
Echinococcus granulosus GPCR family 2 0.0034 0.0131 0.0155
Loa Loa (eye worm) hypothetical protein 0.0108 0.0963 0.1115
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0048 0.0285 0.0336
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0514 0.5
Loa Loa (eye worm) hypothetical protein 0.0048 0.0285 0.033
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0025 0.003 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0097 0.0115
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0405 0.0469
Schistosoma mansoni hypothetical protein 0.0347 0.3638 0.4294
Echinococcus multilocularis survival motor neuron protein 1 0.0514 0.5521 0.5521
Brugia malayi nuclear receptor RXR 0.0025 0.003 0.0035
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0025 0.003 0.003
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0084 0.01
Loa Loa (eye worm) hypothetical protein 0.0074 0.0578 0.0669
Echinococcus multilocularis musashi 0.0059 0.0405 0.0405
Echinococcus multilocularis GPCR, family 2 0.0034 0.0131 0.0131
Echinococcus multilocularis snurportin 1 0.0347 0.3638 0.3638
Brugia malayi Importin beta-1 subunit 0.0032 0.011 0.0128
Echinococcus granulosus ecdysone induced protein 78C 0.0048 0.0285 0.0336
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0048 0.0285 0.033
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0048 0.0285 0.0285
Schistosoma mansoni lamin 0.0059 0.0405 0.0478
Echinococcus multilocularis lamin 0.0059 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0048 0.0285 0.033
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.2197 0.2542
Echinococcus multilocularis importin subunit beta 1 0.0032 0.011 0.011
Schistosoma mansoni lamin 0.0059 0.0405 0.0478
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0048 0.0285 0.0336
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0514 0.0606
Brugia malayi nuclear hormone receptor 0.0792 0.864 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0097 0.0115
Onchocerca volvulus Protein ultraspiracle homolog 0.0048 0.0285 0.0319
Loa Loa (eye worm) steroid hormone receptor 0.0048 0.0285 0.033
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0131 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0048 0.0285 0.033
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.011 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0048 0.0285 0.033
Brugia malayi hypothetical protein 0.0025 0.003 0.0035
Schistosoma mansoni ran 0.0024 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0048 0.0285 0.033
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.003 0.0035
Brugia malayi photoreceptor-specific nuclear receptor 0.0048 0.0285 0.033
Trichomonas vaginalis set domain proteins, putative 0.0248 0.2535 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.0035
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0025 0.003 0.0036
Leishmania major importin beta-1 subunit, putative 0.0026 0.0041 0.0547
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.0035
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0131 0.0131
Entamoeba histolytica hypothetical protein 0.0078 0.0624 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0014 0.0016
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0048 0.0285 0.0336
Loa Loa (eye worm) hypothetical protein 0.0168 0.1635 0.1892
Echinococcus multilocularis muscleblind protein 0.0168 0.1635 0.1635
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0041 0.0108
Loa Loa (eye worm) hypothetical protein 0.0048 0.0285 0.033
Echinococcus multilocularis geminin 0.0368 0.3884 0.3884
Entamoeba histolytica hypothetical protein 0.0026 0.0041 0.0447
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0824 0.0973
Schistosoma mansoni coup transcription factor 0.0048 0.0285 0.0336
Brugia malayi Pre-SET motif family protein 0.0031 0.0097 0.0113
Schistosoma mansoni hypothetical protein 0.0034 0.0131 0.0155
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0514 0.0514
Loa Loa (eye worm) hypothetical protein 0.0058 0.0393 0.0455
Schistosoma mansoni ran 0.0024 0.0014 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0048 0.0285 0.033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0097 0.0115
Echinococcus granulosus geminin 0.0368 0.3884 0.4584
Loa Loa (eye worm) hypothetical protein 0.0514 0.5521 0.639
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0824 0.0973
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0048 0.0285 0.0285
Onchocerca volvulus 0.0248 0.2535 0.2841
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0048 0.0285 0.033
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0578 0.0669
Schistosoma mansoni retinoic acid receptor RXR 0.0048 0.0285 0.0336
Schistosoma mansoni thyroid hormone receptor 0.0048 0.0285 0.0336
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0064 0.0075
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0041 1
Plasmodium falciparum importin beta, putative 0.0032 0.011 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0817 0.8925 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0048 0.0285 0.033
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0048 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0048 0.0285 0.0285
Brugia malayi Steroid receptor seven-up type 2 0.0048 0.0285 0.033
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0792 0.864 1
Schistosoma mansoni hypothetical protein 0.0078 0.0624 0.0737
Brugia malayi nuclear receptor NHR-88 0.0048 0.0285 0.033
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0048 0.0285 0.0336
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0014 0.5

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) = 1275 nM Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assay ChEMBL. 8691435
Kd (binding) = 1275 nM Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assay ChEMBL. 8691435
Kd (binding) = 4375 nM Apparent binding constant against Retinoic acid receptor gamma in HeLa cell GAl-4 transactivation assay ChEMBL. 8691435
Kd (binding) = 4375 nM Apparent binding constant against Retinoic acid receptor gamma in HeLa cell GAl-4 transactivation assay ChEMBL. 8691435
Kd (binding) = 11000 nM Apparent binding constant against Retinoic acid receptor alpha in HeLa cell GAl-4 transactivation assay ChEMBL. 8691435
Kd (binding) = 11000 nM Apparent binding constant against Retinoic acid receptor alpha in HeLa cell GAl-4 transactivation assay ChEMBL. 8691435

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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