Detailed information for compound 1308017

Basic information

Technical information
  • TDR Targets ID: 1308017
  • Name: 3-methyl-1-propyl-6,7-dihydropyrrolo[4,5-e]py rimidine-2,4,5-trione
  • MW: 223.229 | Formula: C10H13N3O3
  • H donors: 1 H acceptors: 3 LogP: 0.27 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c2NCC(=O)c2c(=O)n(c1=O)C
  • InChi: 1S/C10H13N3O3/c1-3-4-13-8-7(6(14)5-11-8)9(15)12(2)10(13)16/h11H,3-5H2,1-2H3
  • InChiKey: HQMFMPQQIZVRKN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ZINC03887014
  • MLS000771900
  • SMR000376489

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0192 0.0191
Schistosoma mansoni smad1 5 8 and 0.0016 0.007 0.0003
Loa Loa (eye worm) TATA binding protein associated factor 0.0039 0.033 0.0329
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0516 0.0453
Trypanosoma cruzi aminopeptidase, putative 0.0039 0.033 0.0265
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0212 0.0211
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0422 0.0421
Schistosoma mansoni hypothetical protein 0.0047 0.0422 0.0358
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0067 0.0065
Mycobacterium ulcerans Sir2-like regulatory protein 0.0131 0.1381 1
Giardia lamblia Hypothetical protein 0.089 1 1
Echinococcus multilocularis smad 0.0016 0.007 0.0068
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.033 0.0329
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.0213
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0214 0.0214
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.089 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.254 0.2539
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.2547 0.2546
Schistosoma mansoni chromatin regulatory protein sir2 0.0131 0.1381 0.1323
Loa Loa (eye worm) hypothetical protein 0.003 0.0232 0.023
Loa Loa (eye worm) transcriptional regulator 0.0131 0.1381 0.138
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0131 0.1381 0.138
Onchocerca volvulus 0.003 0.0232 0.0167
Onchocerca volvulus Peroxidase homolog 0.0029 0.0214 0.0093
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0131 0.1381 0.138
Onchocerca volvulus 0.0039 0.033 0.0583
Loa Loa (eye worm) hypothetical protein 0.0148 0.1574 0.1572
Brugia malayi NAD-dependent deacetylase SIRT1 0.0131 0.1381 0.1381
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0192 0.0192
Onchocerca volvulus 0.0058 0.0543 0.1483
Onchocerca volvulus Chorion peroxidase homolog 0.0029 0.0214 0.0093
Loa Loa (eye worm) hypothetical protein 0.0101 0.1041 0.1039
Loa Loa (eye worm) sirtuin 4 0.0131 0.1381 0.138
Brugia malayi CXXC zinc finger family protein 0.0028 0.0212 0.0212
Echinococcus granulosus aminopeptidase N 0.0039 0.033 0.0329
Brugia malayi hypothetical protein 0.0121 0.1266 0.1266
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0634 0.0571
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.007 0.0068
Onchocerca volvulus Huntingtin homolog 0.0121 0.1266 0.4538
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0039 0.033 0.0265
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0516 0.0515
Trypanosoma brucei Silent information regulator 2 related protein 1 0.089 1 1
Onchocerca volvulus 0.0029 0.0214 0.0093
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0131 0.1381 0.1086
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.007 0.0068
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0039 0.033 0.0265
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0039 0.033 0.0265
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0516 0.0516
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.2466 0.2465
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0131 0.1381 1
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0131 0.1381 0.1323
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.089 1 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0039 0.033 0.0329
Mycobacterium ulcerans NAD-dependent deacetylase 0.0131 0.1381 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0039 0.033 0.0265
Trypanosoma brucei SIR2-like protein 4, putative 0.0131 0.1381 0.1323
Brugia malayi isocitrate dehydrogenase 0.0016 0.0067 0.0067
Trichomonas vaginalis set domain proteins, putative 0.0235 0.2558 0.2304
Brugia malayi MH2 domain containing protein 0.0016 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0187 0.0185
Trypanosoma brucei hypothetical protein, conserved 0.0115 0.1193 0.1134
Schistosoma mansoni microtubule-associated protein tau 0.0683 0.7645 0.7629
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0634 0.0634
Schistosoma mansoni lamin 0.0027 0.0192 0.0126
Leishmania major silent information regulator 2, putative 0.089 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.033 0.0329
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0543 0.048
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0214 0.0214
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0422 0.0421
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.0213
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0051 0.0051
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0232 0.023
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.007 0.0003
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.033 0.0329
Echinococcus multilocularis microtubule associated protein 2 0.0683 0.7645 0.7644
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0232 0.0166
Brugia malayi mbt repeat family protein 0.0058 0.0543 0.0543
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0543 0.0542
Onchocerca volvulus 0.0029 0.0214 0.0093
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0131 0.1381 0.138
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.033 0.0329
Echinococcus multilocularis cpg binding protein 0.003 0.023 0.0229
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.007 0.0068
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0634 0.0632
Onchocerca volvulus 0.0048 0.0431 0.101
Brugia malayi Peptidase family M1 containing protein 0.0039 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0029
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.007 0.0068
Echinococcus granulosus smad 0.0016 0.007 0.0068
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0131 0.1381 0.138
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0131 0.1381 0.1086
Brugia malayi intermediate filament protein 0.0027 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0121 0.1266 0.1265
Schistosoma mansoni cpg binding protein 0.003 0.023 0.0165
Schistosoma mansoni smad1 5 8 and 0.0016 0.007 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0586 0.0523
Schistosoma mansoni hypothetical protein 0.0332 0.3656 0.3614
Plasmodium vivax SET domain protein, putative 0.003 0.0232 0.1255
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0634 0.0632
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.2466 0.2465
Echinococcus granulosus cpg binding protein 0.003 0.023 0.0229
Schistosoma mansoni hypothetical protein 0.0101 0.1041 0.098
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0035 0.0034
Echinococcus multilocularis Smad4 0.0016 0.007 0.0068
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.0213
Echinococcus granulosus GPCR family 2 0.0047 0.0422 0.0421
Onchocerca volvulus 0.0235 0.2558 1
Onchocerca volvulus 0.0039 0.033 0.0583
Brugia malayi Pre-SET motif family protein 0.003 0.0232 0.0232
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0067 0.0065
Trypanosoma brucei aminopeptidase, putative 0.0039 0.033 0.0265
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0039 0.033 0.0265
Schistosoma mansoni hypothetical protein 0.035 0.3865 0.3824
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.0213
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0214 0.0213
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0214 0.0214
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0039 0.033 0.2005
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0048 0.0431 0.0367
Brugia malayi hypothetical protein 0.0039 0.033 0.033
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.1574 0.1572
Loa Loa (eye worm) hypothetical protein 0.0131 0.1381 0.138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.0213
Echinococcus granulosus neuropeptide receptor A26 0.0458 0.5086 0.5086
Loa Loa (eye worm) hypothetical protein 0.0039 0.033 0.0329
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0232 0.023
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0115 0.1193 0.1134
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.007 0.0068
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0115 0.1193 0.1134
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0131 0.1381 0.1323
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0131 0.1381 1
Schistosoma mansoni hypothetical protein 0.0047 0.0422 0.0358
Echinococcus multilocularis lamin dm0 0.0027 0.0192 0.0191
Onchocerca volvulus 0.0029 0.0214 0.0093
Brugia malayi hypothetical protein 0.0234 0.2547 0.2547
Schistosoma mansoni chromatin regulatory protein sir2 0.089 1 1
Echinococcus granulosus peroxidasin 0.0029 0.0214 0.0213
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0039 0.033 0.0329
Schistosoma mansoni cpg binding protein 0.0028 0.0212 0.0146
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.0213
Schistosoma mansoni chromatin regulatory protein sir2 0.0131 0.1381 0.1323
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0543 0.048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0516 0.0453
Toxoplasma gondii aminopeptidase N protein 0.0039 0.033 0.2005
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.089 1 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0731 0.8191 0.8191
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0422 0.0421
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.089 1 1
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.2547 0.2546
Brugia malayi Peptidase family M1 containing protein 0.0039 0.033 0.033
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0039 0.033 0.0265
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0067 0.0065
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.0213
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0543 0.0542
Schistosoma mansoni hypothetical protein 0.0405 0.4486 0.4449
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0067 0.0065
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2235 0.2234
Loa Loa (eye worm) Smad1 0.0016 0.007 0.0068
Echinococcus granulosus lamin 0.0027 0.0192 0.0191
Schistosoma mansoni cpg binding protein 0.003 0.023 0.0165
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0131 0.1381 0.1086
Schistosoma mansoni smad1 5 8 and 0.0016 0.007 0.0003
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0039 0.033 0.0329
Schistosoma mansoni chromatin regulatory protein sir2 0.089 1 1
Schistosoma mansoni peroxidasin 0.0029 0.0214 0.0148
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0131 0.1381 0.1086
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.254 0.2539
Schistosoma mansoni chromatin regulatory protein sir2 0.0131 0.1381 0.1323
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0131 0.1381 0.1086
Schistosoma mansoni peroxidasin 0.0029 0.0214 0.0148
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0051 0.005
Loa Loa (eye worm) transcriptional regulator 0.0131 0.1381 0.138
Onchocerca volvulus Huntingtin homolog 0.0121 0.1266 0.4538
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0422 0.0422
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.033 0.0329
Brugia malayi Blistered cuticle protein 3 0.0029 0.0214 0.0214
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0513 0.3396
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.0213
Loa Loa (eye worm) hypothetical protein 0.0234 0.2547 0.2546
Echinococcus multilocularis geminin 0.0332 0.3656 0.3655
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0232 0.0166
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0131 0.1381 0.1086
Schistosoma mansoni lamin 0.0027 0.0192 0.0126
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0214 0.0214
Schistosoma mansoni hypothetical protein 0.0047 0.0422 0.0358
Onchocerca volvulus 0.0028 0.0212 0.0083
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.033 0.0329
Brugia malayi MH1 domain containing protein 0.0016 0.007 0.007
Schistosoma mansoni chromatin regulatory protein sir2 0.0131 0.1381 0.1323
Loa Loa (eye worm) peptidase family M1 containing protein 0.0039 0.033 0.0329
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0131 0.1381 0.1086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0516 0.0515
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0039 0.033 0.2005
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0039 0.033 0.2005
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0131 0.1381 0.138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.0213
Onchocerca volvulus Peroxidasin homolog 0.0029 0.0214 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0516 0.0453
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0516 0.0515
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0039 0.033 0.0265
Schistosoma mansoni chromatin regulatory protein sir2 0.089 1 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.1266 0.1265
Schistosoma mansoni aminopeptidase A (M01 family) 0.0039 0.033 0.0265
Loa Loa (eye worm) hypothetical protein 0.0013 0.0035 0.0034
Schistosoma mansoni hypothetical protein 0.0047 0.0422 0.0358
Echinococcus multilocularis musashi 0.0027 0.0192 0.0191
Brugia malayi Pre-SET motif family protein 0.0207 0.2235 0.2235
Schistosoma mansoni survival motor neuron protein 0.0048 0.0431 0.0367
Leishmania major sir2-family protein-like protein 0.0131 0.1381 0.1323
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0214 0.0214
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0731 0.8191 0.8179
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.089 1 1
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0039 0.033 0.0265
Toxoplasma gondii histone deacetylase SIR2-like 0.0131 0.1381 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0131 0.1381 0.1086
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.089 1 1
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0039 0.033 0.0265
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0029
Onchocerca volvulus Peroxidasin homolog 0.0029 0.0214 0.0093
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0131 0.1381 0.1086
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0422 0.0422
Toxoplasma gondii aminopeptidase n, putative 0.0039 0.033 0.2005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.1574 0.1574
Trypanosoma brucei Aminopeptidase M1, putative 0.0039 0.033 0.0265
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.0213
Brugia malayi MH2 domain containing protein 0.0234 0.254 0.254
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0634 0.0632
Trypanosoma brucei Aminopeptidase M1, putative 0.0039 0.033 0.0265
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0214 0.0213
Echinococcus granulosus neuropeptide s receptor 0.0458 0.5086 0.5086
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0543 0.0542
Plasmodium vivax hypothetical protein, conserved 0.0131 0.1381 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0192 0.0191
Toxoplasma gondii histone deacetylase SIR2 0.0131 0.1381 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0029 0.0214 0.0213
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0115 0.1193 0.1134
Brugia malayi hypothetical protein 0.0039 0.033 0.033
Echinococcus granulosus Smad4 0.0016 0.007 0.0068
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.1041 0.1041
Schistosoma mansoni hypothetical protein 0.0332 0.3656 0.3614
Trypanosoma cruzi aminopeptidase, putative 0.0039 0.033 0.0265
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0232 0.0166
Brugia malayi hypothetical protein 0.0029 0.0214 0.0214
Schistosoma mansoni smad 0.0016 0.007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.0213
Echinococcus multilocularis neuropeptide s receptor 0.0458 0.5086 0.5086
Brugia malayi TATA binding protein associated factor 0.0039 0.033 0.033
Loa Loa (eye worm) aminopeptidase N 0.0039 0.033 0.0329
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0067 0.0065
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.0213
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.089 1 1
Trypanosoma cruzi Aminopeptidase M1, putative 0.0039 0.033 0.0265
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.0213
Loa Loa (eye worm) MBCTL1 0.0066 0.0634 0.0632
Onchocerca volvulus Dual oxidase homolog 0.0029 0.0214 0.0093
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0067 0.0065
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0731 0.8191 0.8191
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0543 0.0542
Echinococcus granulosus lamin dm0 0.0027 0.0192 0.0191
Brugia malayi MH1 domain containing protein 0.0016 0.007 0.007
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0115 0.1193 0.1134
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0039 0.033 0.0329
Loa Loa (eye worm) hypothetical protein 0.0027 0.0192 0.0191
Echinococcus multilocularis peroxidasin 0.0029 0.0214 0.0213
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0516 0.0515
Onchocerca volvulus Peroxidase homolog 0.0029 0.0214 0.0093
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0039 0.033 0.0265
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0212 0.0211
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0543 0.048
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.4486 0.4485
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0634 0.0632
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0115 0.1193 0.1134
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.033 0.0329
Echinococcus granulosus leukotriene A 4 hydrolase 0.0731 0.8191 0.8191
Schistosoma mansoni intermediate filament proteins 0.0027 0.0192 0.0126
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0431 0.0431
Echinococcus multilocularis GPCR, family 2 0.0047 0.0422 0.0421
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0214 0.0213
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.007 0.0068
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0131 0.1381 0.1323
Trypanosoma brucei hypothetical protein, conserved 0.0115 0.1193 0.1134
Brugia malayi transcriptional regulator, Sir2 family protein 0.0131 0.1381 0.1381
Echinococcus granulosus intermediate filament protein 0.0027 0.0192 0.0191
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0039 0.033 0.0265
Brugia malayi MH2 domain containing protein 0.0016 0.007 0.007
Brugia malayi Smad1 0.0016 0.007 0.007
Echinococcus granulosus chromatin regulatory protein sir2 0.089 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.1574 0.1574
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0039 0.033 0.2005
Plasmodium vivax NAD-dependent deacetylase, putative 0.0131 0.1381 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0232 0.0166
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.089 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0516 0.0515
Toxoplasma gondii aminopeptidase N, putative 0.0039 0.033 0.2005
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0232 0.023
Echinococcus granulosus microtubule associated protein 2 0.0683 0.7645 0.7644
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0422 0.0421
Echinococcus multilocularis neuropeptide receptor A26 0.0458 0.5086 0.5086
Loa Loa (eye worm) transcriptional regulator 0.089 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0422 0.0421
Brugia malayi transcriptional regulator, Sir2 family protein 0.0131 0.1381 0.1381
Onchocerca volvulus 0.0039 0.033 0.0583
Entamoeba histolytica hypothetical protein, conserved 0.0131 0.1381 0.1086
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0067 0.0065
Echinococcus multilocularis chromatin regulatory protein sir2 0.089 1 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0039 0.033 0.0329
Loa Loa (eye worm) hypothetical protein 0.0058 0.0543 0.0542
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0131 0.1381 1
Brugia malayi Peptidase family M1 containing protein 0.0039 0.033 0.033
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0039 0.033 0.0265
Echinococcus multilocularis aminopeptidase N 0.0039 0.033 0.0329
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0039 0.033 0.0265
Echinococcus multilocularis lamin 0.0027 0.0192 0.0191
Loa Loa (eye worm) hypothetical protein 0.0047 0.0422 0.0421
Loa Loa (eye worm) hypothetical protein 0.0039 0.033 0.0329
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0131 0.1381 0.1323
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0214 0.0213
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0131 0.1381 0.138
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0131 0.1381 0.1086
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0543 0.0542
Brugia malayi Peroxidasin 0.0029 0.0214 0.0214
Brugia malayi mbt repeat family protein 0.0058 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.0066 0.0634 0.0632
Schistosoma mansoni Smad4 0.0016 0.007 0.0003
Echinococcus granulosus dnaJ subfamily B 0.0405 0.4486 0.4485
Trypanosoma brucei Enriched in surface-labeled proteome protein 12 0.0115 0.1193 0.1134
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0039 0.033 0.0329
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0232 0.1255
Echinococcus granulosus geminin 0.0332 0.3656 0.3655
Brugia malayi hypothetical protein 0.0336 0.3706 0.3706
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0543 0.1483
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.0213
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0035 0.0034
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0131 0.1381 0.1086

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.