Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.4849 | 0.573 |
Leishmania major | DNA polymerase eta, putative | 0.0137 | 0.2747 | 0.3152 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.2843 | 0.2688 |
Loa Loa (eye worm) | glutaminase | 0.0308 | 0.8302 | 1 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0104 | 0.1671 | 0.1489 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0546 | 0.0411 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 0.5754 | 0.685 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0059 | 0.0213 | 0.0258 |
Echinococcus multilocularis | geminin | 0.036 | 1 | 1 |
Onchocerca volvulus | 0.023 | 0.5754 | 0.5 | |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0069 | 0.0546 | 0.034 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0137 | 0.2747 | 0.3329 |
Brugia malayi | Melibiase family protein | 0.0069 | 0.0546 | 0.0411 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0104 | 0.1671 | 0.1489 |
Trichomonas vaginalis | glutaminase, putative | 0.0308 | 0.8302 | 1 |
Schistosoma mansoni | glutaminase | 0.0308 | 0.8302 | 0.8265 |
Leishmania major | DNA polymerase eta, putative | 0.0096 | 0.1423 | 0.1505 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0307 | 0.8251 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0059 | 0.0213 | 0.0258 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.014 | 0.2843 | 0.2688 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0104 | 0.1671 | 0.1489 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.2843 | 0.2688 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0307 | 0.8251 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.014 | 0.2843 | 0.2688 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.2843 | 0.2688 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0104 | 0.1671 | 0.1489 |
Brugia malayi | glutaminase DH11.1 | 0.0308 | 0.8302 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0145 | 0.3006 | 0.3643 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0059 | 0.0213 | 0.0258 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0059 | 0.0213 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.036 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0137 | 0.2747 | 0.2589 |
Mycobacterium ulcerans | glutaminase | 0.0308 | 0.8302 | 1 |
Schistosoma mansoni | hypothetical protein | 0.036 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0137 | 0.2747 | 0.3152 |
Giardia lamblia | DINP protein human, muc B family | 0.0059 | 0.0213 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0161 | 0.3538 | 1 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0069 | 0.0546 | 0.0411 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0104 | 0.1671 | 0.1489 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0096 | 0.1423 | 0.1725 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0104 | 0.1671 | 0.1489 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0145 | 0.3006 | 0.3475 |
Echinococcus granulosus | dna polymerase eta | 0.0137 | 0.2747 | 0.2589 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.4849 | 0.573 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0307 | 0.8251 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0069 | 0.0546 | 0.034 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0059 | 0.0213 | 0.0258 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0104 | 0.1671 | 0.1489 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.014 | 0.2843 | 0.3252 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0137 | 0.2747 | 0.3132 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.014 | 0.2843 | 0.3252 |
Echinococcus multilocularis | dna polymerase eta | 0.0137 | 0.2747 | 0.2589 |
Toxoplasma gondii | melibiase subfamily protein | 0.0104 | 0.1671 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0307 | 0.8251 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0161 | 0.3538 | 0.4111 |
Loa Loa (eye worm) | glutaminase 2 | 0.0308 | 0.8302 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.2747 | 0.3132 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0145 | 0.3006 | 0.3475 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.014 | 0.2843 | 0.2688 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.014 | 0.2843 | 0.2688 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (binding) | = 0.6 | Ratio of I50 of compound and I50 of theophylline for inhibition of cAMP phosphodiesterase isolated from rabbit lung | ChEMBL. | 6279841 |
Ratio (binding) | = 0.6 | Ratio of I50 of compound and I50 of theophylline for inhibition of cAMP phosphodiesterase isolated from rabbit kidney | ChEMBL. | 6279841 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.