Detailed information for compound 130813

Basic information

Technical information
  • TDR Targets ID: 130813
  • Name: 6,7-dichloro-3,4-dihydro-2H-thiochromene-4-ca rboxylic acid
  • MW: 263.14 | Formula: C10H8Cl2O2S
  • H donors: 1 H acceptors: 2 LogP: 3.32 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C1CCSc2c1cc(Cl)c(c2)Cl
  • InChi: 1S/C10H8Cl2O2S/c11-7-3-6-5(10(13)14)1-2-15-9(6)4-8(7)12/h3-5H,1-2H2,(H,13,14)
  • InChiKey: UPLSQALLBFGVAY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6,7-dichlorothiochromane-4-carboxylic acid
  • 6,7-dichloro-4-thiochromanecarboxylic acid
  • 6,7-dichlorothiochroman-4-carboxylic acid
  • 6,7-dichloro-4-thiochromancarboxylic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Aldose reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae Conserved hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Toxoplasma gondii aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum IPR001395,Aldo/keto reductase,domain-containing Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae PROBABLE OXIDOREDUCTASE Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldehyde reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K00011 aldehyde reductase [EC1.1.1.21], putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense prostaglandin f synthase. putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Neospora caninum Oxidoreductase, aldo/keto reductase family, related Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium ulcerans oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei prostaglandin f synthase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni pol-related Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Multiple coagulation factor deficiency protein 2 homolog Aldose reductase   315 aa 323 aa 40.2 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   315 aa 310 aa 20.0 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 18.2 %
Toxoplasma gondii aldo/keto reductase family oxidoreductase Aldose reductase   315 aa 294 aa 24.8 %
Onchocerca volvulus Aldose reductase   315 aa 316 aa 36.7 %
Trypanosoma cruzi aldo/keto reductase, putative Aldose reductase   315 aa 304 aa 29.3 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 19.7 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   315 aa 326 aa 20.9 %
Mycobacterium ulcerans hypothetical protein Aldose reductase   315 aa 322 aa 24.8 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 19.7 %
Onchocerca volvulus Aldose reductase   315 aa 324 aa 39.8 %
Leishmania mexicana aldo/keto reductase, putative,aldo/keto reductase family-like protein Aldose reductase   315 aa 349 aa 25.2 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   315 aa 279 aa 29.7 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   315 aa 294 aa 35.4 %
Candida albicans similar to putative aryl alcohol dehydrogenase family Aldose reductase   315 aa 314 aa 18.2 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   315 aa 294 aa 35.4 %
Mycobacterium tuberculosis Conserved protein Aldose reductase   315 aa 323 aa 25.4 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   315 aa 279 aa 29.7 %
Neospora caninum aldo/keto reductase family oxidoreductase, putative Aldose reductase   315 aa 291 aa 21.3 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 18.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0374 0.0573
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.108 0.2093
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0374 0.0564
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.1196 0.2184
Onchocerca volvulus 0.0038 0.1196 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0038 0.1196 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0374 0.0564
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0374 0.0564
Onchocerca volvulus 0.0036 0.108 0.8584
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0182 0.026
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.1196 0.2184
Loa Loa (eye worm) oxidoreductase 0.0038 0.1196 0.2318
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0664 0.1287
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0664 0.1287
Echinococcus granulosus hypothetical protein 0.0038 0.1196 0.2261
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1196 0.2261
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0374 0.0564
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0374 0.0322
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1196 0.1911
Echinococcus multilocularis aldo keto reductase 0.0038 0.1196 0.1911
Loa Loa (eye worm) hypothetical protein 0.0021 0.0374 0.0726
Loa Loa (eye worm) hypothetical protein 0.0038 0.1196 0.2318
Onchocerca volvulus 0.0036 0.108 0.8584
Giardia lamblia Aldose reductase 0.0038 0.1196 0.5
Schistosoma mansoni intermediate filament proteins 0.0027 0.0664 0.0806
Loa Loa (eye worm) hypothetical protein 0.0016 0.0182 0.0353
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1196 0.2261
Toxoplasma gondii aldose reductase, putative 0.0038 0.1196 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.1196 0.2184
Entamoeba histolytica aldose reductase, putative 0.0038 0.1196 0.5
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.5212 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.1819 0.3526
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0182 0.0307
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0044
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1196 0.1911
Entamoeba histolytica aldose reductase, putative 0.0038 0.1196 0.5
Onchocerca volvulus 0.0038 0.1196 1
Loa Loa (eye worm) oxidoreductase 0.0038 0.1196 0.2318
Leishmania major aldo-keto reductase-like protein 0.0038 0.1196 1
Onchocerca volvulus 0.0038 0.1196 1
Echinococcus granulosus aldo keto reductase 0.0038 0.1196 0.2261
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0038 0.1196 1
Schistosoma mansoni coup transcription factor 0.0021 0.0374 0.0322
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0374 0.0678
Schistosoma mansoni lamin 0.0027 0.0664 0.0806
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1196 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0374 0.0564
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.108 0.1501
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0374 0.0564
Brugia malayi MH2 domain containing protein 0.0124 0.5159 1
Schistosoma mansoni pol-related 0.0038 0.1196 0.1695
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.1196 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0374 0.0678
Echinococcus multilocularis aldo keto reductase 0.0038 0.1196 0.1911
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0182 0.0184
Loa Loa (eye worm) hypothetical protein 0.0021 0.0374 0.0726
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0374 0.0726
Giardia lamblia Aldose reductase 0.0038 0.1196 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.108 0.2093
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0374 0.0678
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0374 0.0564
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1196 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1196 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0374 0.0726
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1196 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1196 0.1911
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1196 0.2261
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.5159 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1196 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0374 0.0322
Mycobacterium leprae conserved hypothetical protein 0.0036 0.108 0.7733
Onchocerca volvulus 0.0036 0.108 0.8584
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1196 0.1911
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1622 0.3081
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0374 0.0564
Echinococcus granulosus lamin 0.0027 0.0664 0.1236
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.1819 0.3413
Loa Loa (eye worm) hypothetical protein 0.0021 0.0374 0.0726
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0374 0.0726
Schistosoma mansoni thyroid hormone receptor 0.0145 0.6162 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1196 0.1911
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0182 0.026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0374 0.0573
Loa Loa (eye worm) hypothetical protein 0.0026 0.0642 0.1243
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0374 0.0564
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1196 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.1196 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1196 0.1911
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.5159 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1622 0.3081
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0374 0.0564
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1622 0.2407
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0374 0.0564
Loa Loa (eye worm) oxidoreductase 0.0038 0.1196 0.2318
Trypanosoma brucei aldo-keto reductase, putative 0.0038 0.1196 1
Echinococcus granulosus aldehyde reductase 0.0027 0.0683 0.1272
Loa Loa (eye worm) hypothetical protein 0.0021 0.0374 0.0726
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0374 0.0678
Echinococcus multilocularis musashi 0.0027 0.0664 0.1045
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1196 0.1911
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1196 1
Onchocerca volvulus 0.0027 0.0664 0.3527
Loa Loa (eye worm) hypothetical protein 0.0021 0.0374 0.0726
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.1622 0.3143
Schistosoma mansoni aldo-keto reductase 0.0038 0.1196 0.1695
Echinococcus granulosus GPCR family 2 0.0016 0.0182 0.0307
Loa Loa (eye worm) hypothetical protein 0.0021 0.0374 0.0726
Onchocerca volvulus 0.0038 0.1196 1
Echinococcus granulosus lamin dm0 0.0027 0.0664 0.1236
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0374 0.0564
Entamoeba histolytica aldose reductase, putative 0.0038 0.1196 0.5
Mycobacterium leprae Probable lipase LipE 0.0036 0.108 0.7733
Loa Loa (eye worm) hypothetical protein 0.0036 0.108 0.2093
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.1622 0.3023
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0374 0.0726
Loa Loa (eye worm) hypothetical protein 0.0036 0.108 0.2093
Echinococcus multilocularis thyroid hormone receptor alpha 0.0145 0.6162 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0374 0.0726
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.108 0.2037
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1196 0.2261
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1622 0.2604
Plasmodium vivax hypothetical protein, conserved 0.0036 0.108 0.5
Echinococcus multilocularis aldehyde reductase 0.0027 0.0683 0.1075
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0374 0.0322
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1196 0.2261
Loa Loa (eye worm) hypothetical protein 0.0036 0.108 0.2093
Loa Loa (eye worm) hypothetical protein 0.0036 0.108 0.2093
Echinococcus granulosus intermediate filament protein 0.0027 0.0664 0.1236
Brugia malayi beta-lactamase family protein 0.0036 0.108 0.1955
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0374 0.0322
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1196 0.2261
Schistosoma mansoni aldo-keto reductase 0.0038 0.1196 0.1695
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.1196 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0182 0.0184
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.1196 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0374 0.0678
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0374 0.0726
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1196 0.2261
Echinococcus multilocularis lamin dm0 0.0027 0.0664 0.1045
Onchocerca volvulus 0.0027 0.0664 0.3527
Loa Loa (eye worm) hypothetical protein 0.0027 0.0664 0.1287
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1196 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 0.1196 0.013
Onchocerca volvulus 0.0038 0.1196 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0374 0.0564
Brugia malayi beta-lactamase 0.0036 0.108 0.1955
Echinococcus multilocularis lamin 0.0027 0.0664 0.1045
Brugia malayi nuclear receptor NHR-88 0.0021 0.0374 0.0564
Loa Loa (eye worm) beta-lactamase 0.0036 0.108 0.2093
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0374 0.0564
Echinococcus multilocularis aldo keto reductase 0.0038 0.1196 0.1911
Onchocerca volvulus 0.0038 0.1196 1
Mycobacterium ulcerans oxidoreductase 0.0038 0.1196 1
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.1061 0.1919
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1196 0.1911
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0664 0.1135
Schistosoma mansoni hypothetical protein 0.0035 0.1061 0.147
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.108 0.1501
Loa Loa (eye worm) hypothetical protein 0.0035 0.1061 0.2057
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.1196 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0374 0.0678
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0182 0.0353
Brugia malayi beta-lactamase family protein 0.0036 0.108 0.1955
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.108 0.1722
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.1819 0.3526
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1196 0.2261
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0374 0.0573
Brugia malayi steroid hormone receptor 0.0021 0.0374 0.0564
Echinococcus granulosus aldo keto reductase 0.0038 0.1196 0.2261
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1622 0.2407
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1196 0.2261
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.5212 0.8452
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0182 0.0307
Loa Loa (eye worm) oxidoreductase 0.0038 0.1196 0.2318
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1196 0.1911
Trypanosoma brucei prostaglandin f synthase 0.0038 0.1196 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0038 0.1196 1
Schistosoma mansoni thyroid hormone receptor 0.0145 0.6162 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0374 0.0322
Brugia malayi intermediate filament protein 0.0027 0.0664 0.1135
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1196 1
Brugia malayi nuclear hormone receptor 0.0021 0.0374 0.0564
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0374 0.0564
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0374 0.0726
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1196 0.1911
Echinococcus granulosus aldo keto reductase 0.0038 0.1196 0.2261
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0374 0.0322
Loa Loa (eye worm) hypothetical protein 0.0021 0.0374 0.0726
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0374 0.0678
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1622 0.2604
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0374 0.0573
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0374 0.0678
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0374 0.0322
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1622 0.2407
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0374 0.0573
Echinococcus multilocularis aldo keto reductase 0.0038 0.1196 0.1911
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0374 0.0564
Echinococcus multilocularis GPCR, family 2 0.0016 0.0182 0.026
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1196 0.1911
Schistosoma mansoni lamin 0.0027 0.0664 0.0806
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0374 0.0322
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.1196 1
Trypanosoma cruzi aldo-keto reductase 0.0038 0.1196 1
Schistosoma mansoni hypothetical protein 0.0125 0.5212 0.8411
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0089 0.0172
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0374 0.0678
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1196 1
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0374 0.0573
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1196 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.1819 0.3413
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.1196 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0374 0.0726
Loa Loa (eye worm) oxidoreductase 0.0038 0.1196 0.2318
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0374 0.0573
Loa Loa (eye worm) hypothetical protein 0.0036 0.108 0.2093
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0374 0.0322
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0374 0.0322
Loa Loa (eye worm) hypothetical protein 0.0021 0.0374 0.0726
Brugia malayi ecdysteroid receptor 0.0021 0.0374 0.0564
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1196 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.1196 0.2184
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.108 0.1955
Leishmania major prostaglandin f synthase, putative 0.0038 0.1196 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0374 0.0573

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.00001 M In vitro inhibition of partially purified calf lens aldose reductase ChEMBL. 3121857
IC50 (binding) = 0.00001 M In vitro inhibition of partially purified calf lens aldose reductase ChEMBL. 3121857

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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