Detailed information for compound 1308181

Basic information

Technical information
  • TDR Targets ID: 1308181
  • Name: 1-[(1-cyclopentyltetrazol-5-yl)-phenylmethyl] piperidine-4-carboxamide
  • MW: 354.449 | Formula: C19H26N6O
  • H donors: 1 H acceptors: 4 LogP: 1.67 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)C1CCN(CC1)C(c1nnnn1C1CCCC1)c1ccccc1
  • InChi: 1S/C19H26N6O/c20-18(26)15-10-12-24(13-11-15)17(14-6-2-1-3-7-14)19-21-22-23-25(19)16-8-4-5-9-16/h1-3,6-7,15-17H,4-5,8-13H2,(H2,20,26)
  • InChiKey: RNIASRUMZWVDCT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(1-cyclopentyltetrazol-5-yl)-phenyl-methyl]piperidine-4-carboxamide
  • 1-[(1-cyclopentyl-5-tetrazolyl)-phenylmethyl]-4-piperidinecarboxamide
  • 1-[(1-cyclopentyltetrazol-5-yl)-phenyl-methyl]isonipecotamide
  • 1-[(1-cyclopentyl-1,2,3,4-tetrazol-5-yl)-phenyl-methyl]piperidine-4-carboxamide
  • Oprea1_795417
  • 1-[(1-Cyclopentyl-1H-tetrazol-5-yl)-phenyl-methyl]-piperidine-4-carboxylic acid
  • ASN 05551573
  • 1-[(1-Cyclopentyl-1H-tetrazol-5-yl)-phenyl-methyl]-piperidine-4-carboxylic acid amide
  • MLS000122098
  • SMR000119493

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.305 0.2369
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.305 0.5
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.305 0.5
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.1532 0.5
Brugia malayi TAR-binding protein 0.0062 0.3217 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.1532 0.5
Echinococcus granulosus tar DNA binding protein 0.0062 0.3217 0.3217
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.305 0.305
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.1532 0.5
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.1532 0.0703
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.1532 0.1532
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.1532 0.0703
Echinococcus multilocularis musashi 0.0027 0.0892 0.0892
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0892 0.2561
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0092 0.0285
Echinococcus multilocularis tar DNA binding protein 0.0062 0.3217 0.3217
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.3217 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.1532 0.5
Echinococcus multilocularis lamin 0.0027 0.0892 0.0892
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.1532 0.1532
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.305 0.305
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.1532 0.1532
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0892 0.2772
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.305 0.5
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3217 0.2553
Schistosoma mansoni hypothetical protein 0.0167 1 1
Echinococcus granulosus lamin dm0 0.0027 0.0892 0.0892
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.1532 0.1532
Schistosoma mansoni hypothetical protein 0.0167 1 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.1532 0.1532
Echinococcus granulosus intermediate filament protein 0.0027 0.0892 0.0892
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3217 0.2553
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.305 0.5
Loa Loa (eye worm) RNA binding protein 0.0062 0.3217 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.1532 0.4762
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.1532 0.5
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.1532 0.5
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.305 1
Echinococcus granulosus lamin 0.0027 0.0892 0.0892
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.305 0.2369
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.1532 0.5
Onchocerca volvulus 0.0027 0.0892 0.5
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3217 0.2553
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.3217 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0892 0.2772
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3217 0.2553
Onchocerca volvulus 0.0027 0.0892 0.5
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0892 0.2772
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.1532 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.086 0.2674
Echinococcus multilocularis geminin 0.0167 1 1
Brugia malayi RNA binding protein 0.0062 0.3217 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.3217 1
Brugia malayi intermediate filament protein 0.0027 0.0892 0.2561
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3217 0.2553
Echinococcus multilocularis lamin dm0 0.0027 0.0892 0.0892
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.1532 0.1532
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.1532 0.4608
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.305 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 79.4328 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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