TDR Targets

Basic information

Technical information

TDR Targets ID: 130832
Name: 5-acetyl-4-[4-(2-methoxyphenyl)piperazin-1-yl ]-2-methyl-6-phenylpyridazin-3-one
MW: 418.488 | Formula: C24H26N4O3
H donors: 0 H acceptors: 2 LogP: 3.23 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1N1CCN(CC1)c1c(C(=O)C)c(nn(c1=O)C)c1ccccc1
InChi: 1S/C24H26N4O3/c1-17(29)21-22(18-9-5-4-6-10-18)25-26(2)24(30)23(21)28-15-13-27(14-16-28)19-11-7-8-12-20(19)31-3/h4-12H,13-16H2,1-3H3
InChiKey: JALWBCWMBMTPNJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-acetyl-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-methyl-6-phenyl-pyridazin-3-one
5-acetyl-4-[4-(2-methoxyphenyl)-1-piperazinyl]-2-methyl-6-phenyl-3-pyridazinone
5-ethanoyl-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-methyl-6-phenyl-pyridazin-3-one
5-acetyl-4-[4-(2-methoxyphenyl)piperazino]-2-methyl-6-phenyl-pyridazin-3-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	adrenoceptor alpha 1D	Starlite/ChEMBL	References
Homo sapiens	adrenoceptor alpha 1A	Starlite/ChEMBL	References
Homo sapiens	adrenoceptor alpha 1B	Starlite/ChEMBL	References
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	serotonin receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma japonicum	Octopamine receptor, putative	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Get druggable targets OG5_128924	All targets in OG5_128924
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma japonicum	ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative	Get druggable targets OG5_133249	All targets in OG5_133249
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma mansoni	biogenic amine (5HT) receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma japonicum	Alpha-1D adrenergic receptor, putative	Get druggable targets OG5_128924	All targets in OG5_128924
Echinococcus multilocularis	serotonin receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma mansoni	amine GPCR	Get druggable targets OG5_128924	All targets in OG5_128924
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133249	All targets in OG5_133249
Echinococcus granulosus	biogenic amine 5HT receptor	Get druggable targets OG5_133249	All targets in OG5_133249

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0004
Loa Loa (eye worm)	glutathione reductase	0.005	0.0064	0.0064
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0143	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0011	0.0003	0.0003
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.008	0.0111	1
Echinococcus granulosus	g protein coupled receptor	0.0011	0.0003	0.0003
Trypanosoma cruzi	polo-like protein kinase, putative	0.01	0.0143	0.0131
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0015	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0004
Trichomonas vaginalis	inositol monophosphatase, putative	0.008	0.0111	0.7678
Schistosoma mansoni	fructose-16-bisphosphatase-related	0.6342	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0004
Echinococcus multilocularis	allatostatin A receptor	0.0011	0.0003	0.0003
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0012	0.0004	0.0001
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0038	0.0038
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0115	0.0165	0.8837
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0143	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Echinococcus multilocularis	Chromo domain	0.0012	0.0004	0.0004
Schistosoma mansoni	chromobox protein	0.0074	0.0101	0.0099
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0003	0.0003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0003	0.0003
Echinococcus multilocularis	neuropeptide receptor	0.0011	0.0003	0.0003
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0011	0.0003	0.0003
Mycobacterium tuberculosis	Probable oxidoreductase	0.0127	0.0186	1
Plasmodium falciparum	thioredoxin reductase	0.005	0.0064	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.008	0.0111	0.7678
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0143	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0011	0.0003	0.0003
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0015	0.0811
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0011	0.0003	0.0003
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0011	0.0003	0.0003
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0014	0.0007	0.0007
Echinococcus multilocularis	chromobox protein 1	0.0074	0.0101	0.0101
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0127	0.0186	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.009	0.0088
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0011	0.0003	0.0003
Echinococcus multilocularis	fmrfamide receptor	0.0011	0.0003	0.0003
Echinococcus granulosus	G protein coupled receptor 139	0.0011	0.0003	0.0003
Toxoplasma gondii	fructose-bisphospatase II	0.6342	1	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0127	0.0186	1
Echinococcus multilocularis	serotonin receptor	0.0159	0.0235	0.0235
Plasmodium vivax	glutathione reductase, putative	0.005	0.0064	1
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0012	0.0004	0.0001
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0017	0.0012	0.0009
Echinococcus granulosus	neuropeptide Y receptor	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Echinococcus multilocularis	neuropeptides capa receptor	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0011	0.0003	0.0003
Onchocerca volvulus		0.0012	0.0004	0.007
Echinococcus multilocularis	orexin receptor type 2	0.0011	0.0003	0.0003
Echinococcus granulosus	fructose 16 bisphosphatase 1	0.6342	1	1
Schistosoma mansoni	cpg binding protein	0.0032	0.0034	0.0032
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0012	0.0004	0.0004
Mycobacterium tuberculosis	Probable dehydrogenase	0.0115	0.0165	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0017	0.0012	0.0012
Loa Loa (eye worm)	heterochromatin protein 1	0.0074	0.0101	0.0101
Echinococcus multilocularis	fmrfamide receptor	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0235	0.0235
Trypanosoma brucei	sedoheptulose-1,7-bisphosphatase	0.2358	0.3709	0.3701
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0143	1
Schistosoma mansoni	hypothetical protein	0.0074	0.0101	0.0098
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0115	0.0165	0.8837
Echinococcus granulosus	somatostatin receptor	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.6342	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0011	0.0003	0.0003
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.009	0.0087
Trichomonas vaginalis	chromobox protein, putative	0.0074	0.0101	0.7015
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.008	0.0111	0.0099
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.008	0.0111	0.0099
Echinococcus granulosus	neuropeptide Y receptor	0.0011	0.0003	0.0003
Echinococcus multilocularis	G protein coupled receptor 139	0.0011	0.0003	0.0003
Trichomonas vaginalis	CAMK family protein kinase	0.005	0.0063	0.4257
Onchocerca volvulus		0.0032	0.0034	0.2262
Treponema pallidum	NADH oxidase	0.0017	0.0012	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0011	0.0003	0.0003
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0071	0.0097	0.4918
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0038	0.0038
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0003	0.0003
Toxoplasma gondii	fructose-bisphospatase I	0.2358	0.3709	0.3707
Onchocerca volvulus		0.0013	0.0005	0.0148
Trypanosoma brucei	trypanothione reductase	0.005	0.0064	0.0052
Trichomonas vaginalis	glutathione reductase, putative	0.0017	0.0012	0.06
Toxoplasma gondii	thioredoxin reductase	0.005	0.0064	0.006
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0003	0.0003
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0011	0.0003	0.0003
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	0.6342	1	1
Schistosoma mansoni	inositol monophosphatase	0.008	0.0111	0.0108
Echinococcus granulosus	neuropeptide FF receptor 2	0.0011	0.0003	0.0003
Echinococcus granulosus	cpg binding protein	0.0033	0.0037	0.0037
Echinococcus granulosus	GPCR family 2	0.0034	0.0038	0.0038
Echinococcus multilocularis	somatostatin receptor	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0003	0.0003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0003	0.0003
Echinococcus granulosus	allatostatin A receptor	0.0011	0.0003	0.0003
Echinococcus granulosus	biogenic amine 5HT receptor	0.0159	0.0235	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0038	0.0038
Echinococcus granulosus	neuropeptide s receptor	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0004
Echinococcus granulosus	inositol monophosphatase 1	0.008	0.0111	0.0111
Trichomonas vaginalis	CAMK family protein kinase	0.005	0.0063	0.4257
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0003	0.0003
Schistosoma mansoni	chromobox protein	0.0012	0.0004	0.0001
Echinococcus granulosus	chromobox protein 2	0.0012	0.0004	0.0004
Schistosoma mansoni	hypothetical protein	0.045	0.0695	0.0692
Echinococcus granulosus	orexin receptor type 2	0.0011	0.0003	0.0003
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0115	0.0165	0.7712
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Echinococcus multilocularis	neuropeptide s receptor	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0235	0.0235
Loa Loa (eye worm)	inositol-1	0.008	0.0111	0.0111
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0067	0.009	0.449
Loa Loa (eye worm)	helicase	0.0012	0.0004	0.0004
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.2358	0.3709	0.3701
Plasmodium vivax	thioredoxin reductase, putative	0.005	0.0064	1
Brugia malayi	SET domain containing protein	0.0013	0.0005	0.0002
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0012	0.0004	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0017	0.0012	0.1389
Schistosoma mansoni	cpg binding protein	0.0033	0.0037	0.0035
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.005	0.0064	0.2985
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Brugia malayi	glutathione reductase	0.005	0.0064	0.0061
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.009	0.7906
Echinococcus multilocularis	thioredoxin glutathione reductase	0.005	0.0064	0.0064
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0011	0.0003	0.0003
Leishmania major	trypanothione reductase	0.005	0.0064	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Echinococcus granulosus	neuropeptide receptor	0.0011	0.0003	0.0003
Brugia malayi	CHD4 protein	0.0014	0.0007	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Brugia malayi	hypothetical protein	0.0012	0.0004	0.0001
Echinococcus granulosus	biogenic amine 5HT receptor	0.0011	0.0003	0.0003
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0067	0.009	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.005	0.3329
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0012	0.0009
Echinococcus multilocularis	serotonin receptor	0.0159	0.0235	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.0143	0.014
Echinococcus multilocularis	inositol monophosphatase 1	0.008	0.0111	0.0111
Brugia malayi	chromobox protein homolog 3	0.0041	0.005	0.0047
Loa Loa (eye worm)	thioredoxin reductase	0.005	0.0064	0.0064
Loa Loa (eye worm)	G-protein coupled receptor	0.0011	0.0003	0.0003
Echinococcus granulosus	Chromobox protein 3	0.0012	0.0004	0.0004
Leishmania major		0.6342	1	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0143	1
Echinococcus granulosus	dnaJ subfamily B	0.045	0.0695	0.0695
Toxoplasma gondii	sedoheptulose-1,7-bisphosphatase	0.2358	0.3709	0.3707
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0038	0.0036
Echinococcus granulosus	chromobox protein 1	0.0074	0.0101	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.008	0.0111	0.0107
Loa Loa (eye worm)	neuropeptide F receptor	0.0011	0.0003	0.0003
Echinococcus granulosus	neuropeptide receptor	0.0011	0.0003	0.0003
Loa Loa (eye worm)	neuropeptide F receptor	0.0011	0.0003	0.0003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0003	0.0003
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.008	0.0111	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0017	0.0012	0.0012
Echinococcus granulosus	sex peptide receptor	0.0011	0.0003	0.0003
Trichomonas vaginalis	mercuric reductase, putative	0.0017	0.0012	0.06
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0015	0.0811
Brugia malayi	Protein cec-1.	0.0012	0.0004	0.0001
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.008	0.0111	0.7678
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.001	0.0435
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0108	0.0155	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Echinococcus granulosus	7TM GPCR rhodopsin	0.0011	0.0003	0.0003
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Echinococcus granulosus	7tm_1 domain containing protein	0.0011	0.0003	0.0003
Echinococcus granulosus	g-protein coupled receptor	0.0011	0.0003	0.0003
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0004
Brugia malayi	Heterochromatin protein 1	0.0074	0.0101	0.0099
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0159	0.0235	0.0232
Echinococcus granulosus	serotonin receptor	0.0011	0.0003	0.0003
Echinococcus granulosus	chromobox protein 1	0.0074	0.0101	0.0101
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0011	0.0003	0.0003
Schistosoma mansoni	inositol monophosphatase	0.008	0.0111	0.0108
Echinococcus granulosus	tm gpcr rhodopsin	0.0011	0.0003	0.0003
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	0.6342	1	1
Mycobacterium tuberculosis	Probable reductase	0.0115	0.0165	0.8837
Echinococcus multilocularis	neuropeptide Y receptor	0.0011	0.0003	0.0003
Loa Loa (eye worm)	melatonin receptor type 1A	0.0011	0.0003	0.0003
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0014	0.0007	0.0007
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0003	0.0003
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0012	0.0004	0.0004
Trypanosoma brucei	polo-like protein kinase	0.01	0.0143	0.0131
Echinococcus multilocularis	g-protein coupled receptor	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0015	0.0811
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0067	0.009	0.009
Trichomonas vaginalis	chromobox protein, putative	0.0074	0.0101	0.7015
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0003	0.0003
Echinococcus granulosus	neuropeptide receptor A26	0.0011	0.0003	0.0003
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0013	0.0005	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Echinococcus granulosus	tm gpcr rhodopsin	0.0011	0.0003	0.0003
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.2358	0.3709	0.3701
Echinococcus granulosus	thioredoxin glutathione reductase	0.005	0.0064	0.0064
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0011	0.0003	0.0003
Trichomonas vaginalis	chromobox protein, putative	0.0045	0.0055	0.3686
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0015	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0034	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0041	0.005	0.005
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0038	0.0038
Brugia malayi	Valyl-tRNA synthetase	0.0012	0.0004	0.0001
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0015	0.0811
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0011	0.0003	0.0003
Echinococcus multilocularis	neuropeptide Y receptor	0.0011	0.0003	0.0003
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0017	0.0012	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0011	0.0003	0.0003
Giardia lamblia	Kinase, PLK	0.01	0.0143	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.0079	0.0075
Echinococcus multilocularis	neuropeptides capa receptor	0.0011	0.0003	0.0003
Echinococcus multilocularis	neuropeptide receptor	0.0011	0.0003	0.0003
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0108	0.0155	0.0152
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0011	0.0003	0.0003
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0003	0.0003
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0017	0.0012	0.1389
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0038	0.0038
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0017	0.0012	0.1389
Echinococcus multilocularis	Chromobox protein 3	0.0012	0.0004	0.0004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0003	0.0003
Echinococcus multilocularis	chromobox protein 2	0.0012	0.0004	0.0004
Brugia malayi	Inositol-1	0.008	0.0111	0.0108
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0011	0.0003	0.0003
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0108	0.0155	0.0155
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.01	0.0143	0.0143
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0015	0.0009	0.0376
Schistosoma mansoni	hypothetical protein	0.0034	0.0038	0.0036
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0034	0.0034
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0011	0.0003	0.0003
Plasmodium falciparum	glutathione reductase	0.0017	0.0012	0.1389
Brugia malayi	Associated with TFs and helicases family protein	0.0012	0.0004	0.0001
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0016	0.001	0.0435
Echinococcus granulosus	g protein coupled receptor	0.0011	0.0003	0.0003
Schistosoma mansoni	kinase	0.0051	0.0065	0.0062
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.008	0.0111	0.0099
Echinococcus multilocularis	cpg binding protein	0.0033	0.0037	0.0037
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0011	0.0003	0.0003
Echinococcus multilocularis	dro:myosuppressin receptor	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Trypanosoma brucei	fructose-1,6-bisphosphatase	0.6342	1	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Plasmodium falciparum	thioredoxin reductase	0.0017	0.0012	0.1389
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.6342	1	1
Brugia malayi	Thioredoxin reductase	0.005	0.0064	0.0061
Onchocerca volvulus	Serine\/threonine kinase homolog	0.01	0.0143	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0011	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0034	0.0038	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0003	0.0003
Loa Loa (eye worm)	TYRA-2 protein	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Trypanosoma cruzi	polo-like protein kinase, putative	0.01	0.0143	0.0131
Echinococcus granulosus	g protein coupled receptor	0.0011	0.0003	0.0003
Brugia malayi	serine/threonine-protein kinase plk-2	0.01	0.0143	0.014
Echinococcus granulosus	neuropeptides capa receptor	0.0011	0.0003	0.0003
Brugia malayi	M-phase phosphoprotein, mpp8	0.0012	0.0004	0.0001
Schistosoma mansoni	chromobox protein	0.0074	0.0101	0.0099
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.01	0.0143	0.0143
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0115	0.0165	0.8837
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0011	0.0003	0.0003
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0011	0.0003	0.0003
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0003	0.0003
Echinococcus multilocularis	dnaJ subfamily B	0.045	0.0695	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Brugia malayi	latrophilin 2 splice variant baaae	0.0074	0.0101	0.0098
Echinococcus granulosus	tm gpcr rhodopsin	0.0011	0.0003	0.0003
Toxoplasma gondii	NADPH-glutathione reductase	0.0017	0.0012	0.0008
Schistosoma mansoni	chromobox protein	0.0012	0.0004	0.0001
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.009	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0036	0.0036
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.005	0.3376
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0067	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.009	0.7906
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0011	0.0003	0.0003
Echinococcus granulosus	hypothetical protein	0.0011	0.0003	0.0003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0003	0.0003
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.009	0.7906
Schistosoma mansoni	hypothetical protein	0.0034	0.0038	0.0036
Schistosoma mansoni	cpg binding protein	0.0033	0.0037	0.0035
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0011	0.0003	0.0003
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0013	0.0005	0.0002
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0038	0.0036
Toxoplasma gondii	aldehyde dehydrogenase	0.0067	0.009	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0004
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.01	0.0143	0.0131
Trichomonas vaginalis	chromobox protein, putative	0.0045	0.0055	0.3686
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0115	0.0165	0.8837
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0015	0.0811
Echinococcus multilocularis	chromobox protein 1	0.0074	0.0101	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Entamoeba histolytica	serine/threonine protein kinase, putative	0.01	0.0143	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0143	1
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0013	0.0005	0.0002
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.0003	0.0003
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0101	0.0101
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0031	0.1956
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0017	0.0012	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Echinococcus multilocularis	neuropeptide receptor A26	0.0011	0.0003	0.0003
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.0003	0.0003
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0038	0.0038
Echinococcus granulosus	neuropeptides capa receptor	0.0011	0.0003	0.0003
Onchocerca volvulus		0.0033	0.0036	0.2367
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0014	0.0007	0.0004
Onchocerca volvulus		0.0012	0.0004	0.007
Trypanosoma cruzi	trypanothione reductase, putative	0.005	0.0064	0.0052
Loa Loa (eye worm)	CHromoDomain protein family member	0.0014	0.0007	0.0007
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0143	1
Plasmodium falciparum	glutathione reductase	0.005	0.0064	1
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0031	0.1956
Echinococcus multilocularis	sex peptide receptor	0.0011	0.0003	0.0003
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0012	0.0004	0.0001
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.008	0.0111	0.7678
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0127	0.0186	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0012	0.0004	0.0001
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0011	0.0003	0.0003
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0045	0.0055	0.3731
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.008	0.0111	1
Schistosoma mansoni	amine GPCR	0.0411	0.0634	0.0632
Schistosoma mansoni	hypothetical protein	0.0034	0.0038	0.0036
Echinococcus granulosus	fmrfamide receptor	0.0011	0.0003	0.0003
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.01	0.0143	0.0143
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0015	0.0811
Echinococcus granulosus	dro:myosuppressin receptor	0.0011	0.0003	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.005	0.3329
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0017	0.0012	0.1389
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Echinococcus granulosus	Chromo domain	0.0012	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	> 10 nM	Binding affinity towards human cloned alpha1d-adrenoceptor using [3H]-prazosin as radioligand	ChEMBL.	11448222
Ki (binding)	> 10 nM	Binding affinity towards human cloned alpha1d-adrenoceptor using [3H]-prazosin as radioligand	ChEMBL.	11448222
Ki (binding)	= 162.8 nM	Binding affinity towards human cloned alpha1A-adrenoceptor using [3H]-prazosin as radioligand	ChEMBL.	11448222
Ki (binding)	= 162.8 nM	Binding affinity towards human cloned alpha1A-adrenoceptor using [3H]-prazosin as radioligand	ChEMBL.	11448222
Ki (binding)	= 258.92 nM	Binding affinity towards human cloned alpha1B-adrenoceptor using [3H]-prazosin as radioligand	ChEMBL.	11448222
Ki (binding)	= 258.92 nM	Binding affinity towards human cloned alpha1B-adrenoceptor using [3H]-prazosin as radioligand	ChEMBL.	11448222
Ki (binding)	> 1000 nM	Binding affinity towards human cloned 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand	ChEMBL.	11448222
Ki (binding)	> 1000 nM	Binding affinity towards human cloned 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand	ChEMBL.	11448222
pK1a (binding)	= 6.79	Experimental binding affinity for alpha1A-adrenergic receptor	ChEMBL.	11448222
pK1a (binding)	= 6.79	Experimental binding affinity for alpha1A-adrenergic receptor	ChEMBL.	11448222
pK1b (binding)	= 6.59	Experimental binding affinity for alpha1B-adrenergic receptor	ChEMBL.	11448222
pK1b (binding)	= 6.59	Experimental binding affinity for alpha1B-adrenergic receptor	ChEMBL.	11448222
pK1d (binding)	= 5	Experimental binding affinity for alpha1d-adrenergic receptor	ChEMBL.	11448222
pK1d (binding)	= 5	Experimental binding affinity for alpha1d-adrenergic receptor	ChEMBL.	11448222

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL78584
PubChem: 11732516

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 130832