Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0062 | 0.0704 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0108 | 0.2706 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0062 | 0.0704 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0062 | 0.0704 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0108 | 0.2706 | 1 |
Treponema pallidum | NADH oxidase | 0.0062 | 0.0704 | 0.5 |
Leishmania major | trypanothione reductase | 0.0108 | 0.2706 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0108 | 0.2706 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0108 | 0.2706 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0108 | 0.2706 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0108 | 0.2706 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0062 | 0.0704 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0108 | 0.2706 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0062 | 0.0704 | 0.2603 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0062 | 0.0704 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0062 | 0.0704 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0062 | 0.0704 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0108 | 0.2706 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0062 | 0.0704 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0108 | 0.2706 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0108 | 0.2706 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0062 | 0.0704 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0108 | 0.2706 | 0.2153 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0062 | 0.0704 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0108 | 0.2706 | 1 |
Brugia malayi | glutathione reductase | 0.0108 | 0.2706 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0108 | 0.2706 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.