Detailed information for compound 1308947

Basic information

Technical information
  • TDR Targets ID: 1308947
  • Name: Oprea1_204835
  • MW: 351.379 | Formula: C18H13N3O3S
  • H donors: 0 H acceptors: 3 LogP: 2.17 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccccc1n1c(=O)c2c(c1=O)n1c(s2)nc2c(c1=O)CCC2
  • InChi: 1S/C18H13N3O3S/c1-9-5-2-3-8-12(9)20-16(23)13-14(17(20)24)25-18-19-11-7-4-6-10(11)15(22)21(13)18/h2-3,5,8H,4,6-7H2,1H3
  • InChiKey: GYSBZJAKQUEIOW-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • ST5189990
  • Oprea1_076107
  • ZINC00946905
  • MLS000111518
  • SMR000107440

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Leishmania mexicana pyruvate kinase, putative Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, putative 498 aa 515 aa 27.6 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus tar DNA binding protein 0.0076 0.1651 0.2306
Trypanosoma brucei Aminopeptidase M1, putative 0.0054 0.0889 0.307
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0311 0.0427
Onchocerca volvulus 0.0036 0.0311 0.0362
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0947 0.1322
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0947 0.1272
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0947 0.1316
Trypanosoma cruzi aminopeptidase, putative 0.0054 0.0889 0.307
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0054 0.0889 0.0889
Giardia lamblia Pyruvate kinase 0.004 0.0451 0.0595
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0296 0.1024
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0243 0.716 0.716
Schistosoma mansoni pyruvate kinase 0.004 0.0451 0.0451
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.2897 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.6887 0.8837
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0296 0.0345
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0296 0.1024
Echinococcus multilocularis aminopeptidase N 0.0153 0.4177 0.5831
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.2897 0.2897
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2897 0.337
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0296 0.1175
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1111 0.1492
Echinococcus multilocularis pyruvate kinase 0.0032 0.017 0.023
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0451 0.0525
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0054 0.0889 0.307
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0296 0.0296
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.7754 1
Leishmania major trypanothione reductase 0.0103 0.2523 0.8708
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0451 0.1557
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0054 0.0889 0.0889
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0988 0.1149
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0451 0.0207
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0296 0.1024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0296 0.1024
Loa Loa (eye worm) hypothetical protein 0.006 0.1111 0.1492
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0054 0.0889 0.1242
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0947 0.0947
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1111 0.1492
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0054 0.0889 0.1035
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0451 0.1557
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0451 0.0606
Treponema pallidum NADH oxidase 0.0036 0.0296 0.5
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.2897 0.4046
Trypanosoma brucei Aminopeptidase M1, putative 0.0054 0.0889 0.307
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0296 0.1024
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.2897 0.389
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0296 0.1024
Schistosoma mansoni kinase 0.0058 0.1037 0.1037
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2897 0.337
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.048 0.0645
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0296 0.1175
Toxoplasma gondii thioredoxin reductase 0.0103 0.2523 1
Loa Loa (eye worm) pyruvate kinase 0.004 0.0451 0.0606
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.6887 0.8837
Loa Loa (eye worm) hypothetical protein 0.0099 0.2404 0.3229
Loa Loa (eye worm) glutathione reductase 0.0103 0.2523 0.3388
Giardia lamblia Kinase, PLK 0.0114 0.2897 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0311 0.0427
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0296 0.1024
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0054 0.0889 0.1242
Plasmodium falciparum pyruvate kinase 0.004 0.0451 0.1788
Trypanosoma brucei trypanothione reductase 0.0103 0.2523 0.8708
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1651 0.1651
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2897 0.337
Plasmodium vivax pyruvate kinase, putative 0.004 0.0451 0.1788
Echinococcus granulosus pyruvate kinase 0.004 0.0451 0.063
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0296 0.1175
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0054 0.0889 0.307
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0296 0.1024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0296 0.1024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0947 0.1316
Plasmodium falciparum glutathione reductase 0.0103 0.2523 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.2897 0.389
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.6887 0.8813
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0311 0.0311
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0296 0.1024
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1651 0.2218
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0296 0.1024
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0243 0.716 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2897 0.337
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0311 0.1232
Brugia malayi Peptidase family M1 containing protein 0.0153 0.4177 0.561
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0296 0.5
Trypanosoma brucei polo-like protein kinase 0.0114 0.2897 1
Echinococcus multilocularis pyruvate kinase 0.004 0.0451 0.0623
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0054 0.0889 0.1236
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0243 0.716 0.9616
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0451 0.0606
Echinococcus multilocularis pyruvate kinase 0.004 0.0451 0.0623
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1651 0.1651
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0054 0.0889 0.1236
Brugia malayi Thioredoxin reductase 0.0103 0.2523 0.3388
Loa Loa (eye worm) hypothetical protein 0.0041 0.048 0.0645
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2897 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0296 0.1024
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.2897 1
Schistosoma mansoni hypothetical protein 0.0041 0.048 0.048
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0027 0.0005 0.0019
Echinococcus granulosus aminopeptidase N 0.0153 0.4177 0.5834
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2897 1
Plasmodium falciparum glutathione reductase 0.0036 0.0296 0.1175
Onchocerca volvulus 0.0153 0.4177 0.4859
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0296 0.1024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0947 0.0947
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0054 0.0889 0.307
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0296 0.3333
Loa Loa (eye worm) hypothetical protein 0.0036 0.0311 0.0417
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.6887 0.8837
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.2543 0.3546
Brugia malayi hypothetical protein 0.0105 0.2593 0.3482
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0267 0.0373
Plasmodium falciparum thioredoxin reductase 0.0036 0.0296 0.1175
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0451 0.0525
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0988 0.1149
Mycobacterium tuberculosis Probable reductase 0.0234 0.6887 0.8837
Onchocerca volvulus 0.0054 0.0889 0.1035
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.7754 1
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0296 0.1024
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0451 0.1788
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0451 0.1557
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0451 0.0525
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.2523 0.2985
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0296 0.3333
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0054 0.0889 0.1242
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0311 0.0434
Trypanosoma brucei pyruvate kinase 1 0.004 0.0451 0.1557
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0296 0.1175
Brugia malayi Peptidase family M1 containing protein 0.0054 0.0889 0.1194
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.7754 1
Mycobacterium ulcerans aminopeptidase N PepN 0.0054 0.0889 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.2897 0.4041
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1651 0.2301
Brugia malayi RNA binding protein 0.0076 0.1651 0.2218
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1651 0.1651
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0296 0.0345
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0296 0.1175
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2897 0.337
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0947 0.1322
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.2523 0.8708
Loa Loa (eye worm) peptidase family M1 containing protein 0.0126 0.3288 0.4416
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0311 0.0311
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0296 0.0398
Loa Loa (eye worm) hypothetical protein 0.004 0.0451 0.0606
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0947 0.0947
Plasmodium vivax glutathione reductase, putative 0.0103 0.2523 1
Mycobacterium ulcerans pyruvate kinase 0.004 0.0451 0.5073
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0451 0.0525
Trypanosoma cruzi Aminopeptidase M1, putative 0.0054 0.0889 0.307
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1651 0.2218
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2897 0.337
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0054 0.0889 0.1035
Brugia malayi Pre-SET motif family protein 0.0036 0.0311 0.0417
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0054 0.0889 0.1242
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.2897 0.337
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0296 0.5
Chlamydia trachomatis pyruvate kinase 0.004 0.0451 1
Plasmodium vivax SET domain protein, putative 0.0036 0.0311 0.1232
Brugia malayi TAR-binding protein 0.0076 0.1651 0.2218
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0047 0.0063
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0027 0.0005 0.0005
Brugia malayi Pre-SET motif family protein 0.0251 0.7446 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0947 0.1272
Loa Loa (eye worm) pyruvate kinase 0.004 0.0451 0.0606
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0054 0.0889 0.1236
Leishmania major pyruvate kinase 0.004 0.0451 0.1557
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0063
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.7446 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.6887 0.8837
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0296 0.0407
Leishmania major pyruvate kinase 0.004 0.0451 0.1557
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2897 0.337
Loa Loa (eye worm) aminopeptidase N 0.0054 0.0889 0.1194
Loa Loa (eye worm) pyruvate kinase 0.004 0.0451 0.0606
Onchocerca volvulus 0.0286 0.8597 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1111 0.1492
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0311 0.0311
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.6887 0.8837
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0296 0.3333
Brugia malayi hypothetical protein 0.0054 0.0889 0.1194
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0054 0.0889 0.1236
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0054 0.0889 0.1236
Trichomonas vaginalis set domain proteins, putative 0.0286 0.8597 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0296 0.1024
Entamoeba histolytica aminopeptidase, putative 0.0054 0.0889 0.2956
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.2523 0.3388
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0296 0.1024
Echinococcus granulosus leukotriene A 4 hydrolase 0.0243 0.716 1
Brugia malayi glutathione reductase 0.0103 0.2523 0.3388
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.2523 1
Echinococcus granulosus pyruvate kinase 0.004 0.0451 0.063
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0296 0.0414
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.7754 1
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0451 0.0525
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1651 0.1651
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1651 0.1651
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0311 0.0311
Schistosoma mansoni pyruvate kinase 0.004 0.0451 0.0451
Loa Loa (eye worm) RNA binding protein 0.0076 0.1651 0.2218
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.2543 0.3551
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0054 0.0889 0.307
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0296 0.1175
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0296 0.1024
Plasmodium falciparum thioredoxin reductase 0.0103 0.2523 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0054 0.0889 0.1236
Loa Loa (eye worm) hypothetical protein 0.0126 0.3293 0.4423
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1651 0.2218

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 54.874 uM PUBCHEM_BIOASSAY: High Throughput Fluorescence Polarization Screen for Bcl-B Phenotype Converters. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1007, AID1008, AID1009, AID1240, AID1243, AID1244, AID1245, AID1320, AID1322, AID1327, AID1328, AID1329, AID1330, AID1693, AID2075, AID2077, AID2080, AID2081, AID2084, AID2086, AID432, AID504598, AID950, AID951, AID952] ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.4368 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation in Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Texas Red Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Fluorescein Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Beta-Lactamase Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.