Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0766 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0129 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0129 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0129 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0129 | 0 | 0.5 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0766 | 1 | 1 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0766 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0766 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0766 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0766 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0766 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0766 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0129 | 0 | 0.5 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0766 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0129 | 0 | 0.5 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0766 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0766 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0766 | 1 | 1 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 75.6863 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Saccharomyces cerevisiae | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.