TDR Targets

Basic information

Technical information

TDR Targets ID: 1309240
Name: 4-[3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl]bu tanamide
MW: 265.696 | Formula: C12H12ClN3O2
H donors: 1 H acceptors: 3 LogP: 1.93 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: NC(=O)CCCc1onc(n1)c1ccccc1Cl
InChi: 1S/C12H12ClN3O2/c13-9-5-2-1-4-8(9)12-15-11(18-16-12)7-3-6-10(14)17/h1-2,4-5H,3,6-7H2,(H2,14,17)
InChiKey: UGVTUYUPCUBTJS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl]butyramide
ZINC02436930
4-[3-(2-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-butyramide
MLS000558990
SMR000149306

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	ATM serine/threonine kinase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	similar to putative phosphatidylinositol kinase involved in telomere length regulation	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania major	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania donovani	phosphatidylinositol 3-kinase-like protein	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania infantum	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Neospora caninum	phosphatidylinositol 3- and 4-kinase domain- containing protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	ko:K04728 ataxia telangectasia mutated family protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Toxoplasma gondii	FATC domain-containing protein	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus granulosus	serine protein kinase ATM	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus multilocularis	serine protein kinase ATM	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	similar to putative phosphatidylinositol kinase involved in telomere length regulation	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania braziliensis	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania mexicana	phosphatidylinositol 3-kinase-like protein	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma brucei gambiense	phosphatidylinositol kinase domain protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Cytochrome P450 family protein	0.0019	0.1912	0.1804
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0014	0.0546	0.0546
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.3008	0.2915
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.003	0.5178	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.3008	0.2915
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.3008	0.2915
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.3008	0.2915
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.3008	0.2915
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0035	0.6617	0.5
Brugia malayi	ecdysteroid receptor	0.0022	0.3008	0.2915
Loa Loa (eye worm)	hypothetical protein	0.0022	0.3008	0.2915
Entamoeba histolytica	hypothetical protein	0.0035	0.6537	0.649
Echinococcus granulosus	serine protein kinase ATM	0.003	0.5178	0.7879
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0.285	0.2754
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0546	0.042
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.3008	0.2915
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.3008	0.4491
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.003	0.5178	0.5114
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.3008	0.4491
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.3008	0.4491
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	1	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.3008	0.4491
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.3008	0.2915
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0026	0.3979	0.7623
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0014	0.0546	0.0821
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.3008	0.4491
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.3008	0.4491
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.3008	0.2915
Brugia malayi	nuclear receptor NHR-88	0.0022	0.3008	0.2915
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	1	1
Leishmania major	cytochrome p450-like protein	0.0019	0.1912	0.1445
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.6617	0.6617
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.3008	0.4491
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.1912	0.1804
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.6071	0.6071
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.003	0.5178	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.285	0.4987
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.3008	0.4491
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.285	0.5386
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0014	0.0546	0.042
Trypanosoma brucei	cytochrome P450, putative	0.0019	0.1912	0.2969
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.3008	0.2915
Loa Loa (eye worm)	hypothetical protein	0.0047	1	1
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0022	0.285	0.2437
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0022	0.285	0.4244
Schistosoma mansoni	hypothetical protein	0.0035	0.6537	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Brugia malayi	steroid hormone receptor	0.0022	0.3008	0.2915
Brugia malayi	AMP-binding enzyme family protein	0.0047	1	1
Entamoeba histolytica	hypothetical protein	0.0035	0.6537	0.649
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0022	0.285	0.4244
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0.285	0.2754
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.3008	0.2915
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.6617	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.3008	0.2915
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.5178	1
Schistosoma mansoni	acetyl-CoA synthetase	0.0014	0.0546	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0035	0.6617	0.6571
Brugia malayi	hypothetical protein	0.0035	0.6537	0.649
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.3008	0.4491
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0014	0.0546	0.0546
Onchocerca volvulus	Bile acid receptor homolog	0.0022	0.3008	0.2604
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.3008	0.2915
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Loa Loa (eye worm)	hypothetical protein	0.0035	0.6617	0.6571
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.285	0.4987
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.3008	0.2915
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Toxoplasma gondii	FATC domain-containing protein	0.003	0.5178	1
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.3008	0.4491
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.3008	0.2915
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0546	0.042
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.3008	0.2915
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.3008	0.2915
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.3008	0.4491
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.6617	0.6421
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.1912	0.3528
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.3008	0.2915
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0022	0.285	0.4244
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.2862	0.541
Loa Loa (eye worm)	hypothetical protein	0.0035	0.6617	0.6571
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0014	0.0546	0.042
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.3008	0.4491
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0546	0.0546
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0014	0.0546	0.0546
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.3008	0.4491
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.6071	0.6071
Entamoeba histolytica	hypothetical protein	0.0035	0.6537	0.649
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.3008	0.4491
Loa Loa (eye worm)	hypothetical protein	0.0022	0.3008	0.2915
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0546	0.0546
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.285	0.5386
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0014	0.0546	0.0821
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0014	0.0546	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0047	1	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0022	0.285	0.2437
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.3008	0.4491
Giardia lamblia	GTOR	0.0022	0.285	0.5
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.6537	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.3008	0.4491
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.3008	0.2915
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.3008	0.2915
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0.285	0.4987
Trichomonas vaginalis	antibiotic synthetase, putative	0.0014	0.0546	0.0821
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0014	0.0546	0.0027
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.6537	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0022	0.285	0.4987
Onchocerca volvulus		0.0022	0.3008	0.2604
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.3008	0.4491
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.3008	0.4491
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0014	0.0546	0.0027
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.3008	0.2915
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0014	0.0546	0.0647
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0546	0.042
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.3008	0.4491
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.3008	0.2915
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0534	0.0407
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.6071	0.6071
Loa Loa (eye worm)	hypothetical protein	0.0022	0.3008	0.2915
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0014	0.0546	0.0821
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0022	0.285	0.4244
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0014	0.0534	0.0796
Entamoeba histolytica	hypothetical protein	0.003	0.5178	0.5114
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	1	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.6071	0.6071
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.3008	0.4491
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0.285	0.4987
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0022	0.285	0.4244
Loa Loa (eye worm)	hypothetical protein	0.0035	0.6617	0.6571
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.3008	0.2915
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0022	0.3008	0.2604
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0546	0.0546
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.3008	0.4491
Brugia malayi	AMP-binding enzyme family protein	0.0047	1	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	1	1
Toxoplasma gondii	propionate-CoA ligase	0.0014	0.0546	0.0027
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0014	0.0546	0.0546
Brugia malayi	Cytochrome P450 family protein	0.0019	0.1912	0.1804
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0014	0.0546	0.042
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.3008	0.4491
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.3008	0.4491
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0022	0.285	0.2437
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.3008	0.2915
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.3008	0.2915
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.3008	0.4491
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.3008	0.2915
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.3008	0.4491
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.1912	0.3528
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.285	0.2754
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0022	0.285	0.4244
Loa Loa (eye worm)	oxidoreductase	0.0014	0.0546	0.042
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.3008	0.4491
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.3008	0.4491
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.285	0.2754
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0014	0.0546	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0022	0.3008	0.2915
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0546	0.0546
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0014	0.0546	0.0546
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0022	0.285	0.2437
Onchocerca volvulus		0.0047	1	1
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0014	0.0546	0.0027
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0546	0.042
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0014	0.0546	0.0546
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0.285	0.4987
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0014	0.0546	0.0546
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.003	0.5178	0.7879
Brugia malayi	nuclear hormone receptor	0.0022	0.3008	0.2915
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0014	0.0546	0.042
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.6617	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.6617	0.6571
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0014	0.0546	0.0027
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0534	0.0796
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.3008	0.4491
Entamoeba histolytica	hypothetical protein	0.0035	0.6537	0.649
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0022	0.285	0.5386
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.3008	0.4491
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Schistosoma mansoni	coup transcription factor	0.0022	0.3008	0.4491
Loa Loa (eye worm)	CYP4Cod1	0.0019	0.1912	0.1804
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0022	0.285	0.5386
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0014	0.0546	0.042
Mycobacterium ulcerans	hypothetical protein	0.0047	1	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.3008	0.2915
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.6537	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.285	0.5386
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.3008	0.2915
Loa Loa (eye worm)	hypothetical protein	0.0026	0.3979	0.3898
Trichomonas vaginalis	antibiotic synthetase, putative	0.0014	0.0546	0.0821
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0019	0.1912	0.1445
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.285	0.2754
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0022	0.2862	0.245
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	1	1
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0546	0.042
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.3008	0.2915
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.3008	0.4491
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.1912	0.1804
Onchocerca volvulus	Protein ultraspiracle homolog	0.0022	0.3008	0.2604
Echinococcus multilocularis	serine protein kinase ATM	0.003	0.5178	0.7879
Loa Loa (eye worm)	hypothetical protein	0.0047	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.285	0.2754
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0022	0.285	0.2437
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0546	0.042
Trypanosoma cruzi	target of rapamycin kinase 3	0.0022	0.285	0.5386

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0033 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 2.8184 um	PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 6.3096 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	23.9341 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1425167

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1309240