Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Cathepsin B precursor | 0.0116 | 0.2232 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0106 | 0.1828 | 0.1323 |
Brugia malayi | cathepsin L-like precursor | 0.0074 | 0.0582 | 0.0582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0106 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | cathepsin B | 0.0116 | 0.2232 | 0.1752 |
Echinococcus granulosus | cathepsin l1 | 0.0074 | 0.0582 | 0.0582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0074 | 0.0582 | 0.0582 |
Loa Loa (eye worm) | cysteine protease | 0.0106 | 0.1828 | 0.1323 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0106 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0116 | 0.2232 | 1 |
Onchocerca volvulus | 0.0106 | 0.1828 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0106 | 0.1828 | 0.1828 |
Echinococcus granulosus | cathepsin b | 0.0315 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0106 | 0.1828 | 1 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0116 | 0.2232 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0106 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0074 | 0.0582 | 0.0582 |
Giardia lamblia | Cathepsin B precursor | 0.0116 | 0.2232 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0116 | 0.2232 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0106 | 0.1828 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0074 | 0.0582 | 0.0582 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0106 | 0.1828 | 0.1828 |
Brugia malayi | Cathepsin L-like precursor | 0.0106 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0106 | 0.1828 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0106 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0315 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0106 | 0.1828 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0106 | 0.1828 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0116 | 0.2232 | 0.2232 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0315 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0106 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0315 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin b | 0.0315 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.1828 | 0.8189 |
Plasmodium vivax | vivapain-2 | 0.0106 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cysteine protease | 0.0106 | 0.1828 | 0.1828 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0074 | 0.0582 | 0.0582 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0116 | 0.2232 | 1 |
Echinococcus granulosus | cathepsin b | 0.0315 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0106 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0106 | 0.1828 | 0.1828 |
Toxoplasma gondii | cathepsin B | 0.0116 | 0.2232 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0106 | 0.1828 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0106 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0106 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin L homolog | 0.0106 | 0.1828 | 1 |
Onchocerca volvulus | 0.0106 | 0.1828 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0106 | 0.1828 | 0.1828 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0106 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0074 | 0.0582 | 0.3182 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0106 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0074 | 0.0582 | 0.2606 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0106 | 0.1828 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Plasmodium vivax | vivapain-2 | 0.0106 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0106 | 0.1828 | 0.1828 |
Loa Loa (eye worm) | fibroinase | 0.0106 | 0.1828 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l1 | 0.0106 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0106 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0074 | 0.0582 | 0.0582 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0106 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0116 | 0.2232 | 0.2232 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0315 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0106 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0106 | 0.1828 | 1 | |
Onchocerca volvulus | Cathepsin F homolog | 0.0106 | 0.1828 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0106 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0106 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1828 | 0.1323 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0106 | 0.1828 | 0.1323 |
Onchocerca volvulus | 0.0106 | 0.1828 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.0106 | 0.1828 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0106 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0074 | 0.0582 | 0.2606 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0315 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0106 | 0.1828 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0106 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0315 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0106 | 0.1828 | 0.8189 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 23.3228 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.