Detailed information for compound 1309282

Basic information

Technical information
  • TDR Targets ID: 1309282
  • Name: N-(6-methyl-1-propylpyrazolo[5,4-b]quinolin-3 -yl)pyridine-2-carboxamide
  • MW: 345.398 | Formula: C20H19N5O
  • H donors: 1 H acceptors: 4 LogP: 3.57 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1nc(c2c1nc1ccc(cc1c2)C)NC(=O)c1ccccn1
  • InChi: 1S/C20H19N5O/c1-3-10-25-19-15(12-14-11-13(2)7-8-16(14)22-19)18(24-25)23-20(26)17-6-4-5-9-21-17/h4-9,11-12H,3,10H2,1-2H3,(H,23,24,26)
  • InChiKey: CETGYOCALXFRPE-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(6-methyl-1-propyl-pyrazolo[5,4-b]quinolin-3-yl)pyridine-2-carboxamide
  • N-(6-methyl-1-propyl-3-pyrazolo[5,4-b]quinolinyl)-2-pyridinecarboxamide
  • N-(6-methyl-1-propyl-pyrazolo[5,4-b]quinolin-3-yl)picolinamide
  • SMR000148777
  • ZINC02453321
  • MLS000558061
  • STOCK4S-91708
  • Pyridine-2-carboxylic acid (6-methyl-1-propyl-1H-pyrazolo[3,4-b]quinolin-3-yl)-amide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens core-binding factor, beta subunit No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2033 1
Brugia malayi Bromodomain containing protein 0.0079 0.0381 0.0724
Trypanosoma brucei cytochrome P450, putative 0.0064 0.0291 0.6747
Leishmania major GTP-binding protein, putative 0.0043 0.0164 0.4275
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0017 0.0026
Echinococcus granulosus zinc finger protein 0.0021 0.0027 0.0045
Echinococcus multilocularis para nitrobenzyl esterase 0.0127 0.0667 0.0665
Onchocerca volvulus 0.0036 0.012 0.0147
Loa Loa (eye worm) inositol-1 0.0039 0.0138 0.0244
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0043 0.0164 0.3761
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2033 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0117 0.0206
Brugia malayi beta-lactamase 0.0036 0.0117 0.0219
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0017 0.0331
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.1002 0.1
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0017 0.0014
Loa Loa (eye worm) glutaminase 2 0.0273 0.1551 0.2791
Brugia malayi Inositol-1 0.0039 0.0138 0.0259
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0036 0.0117 0.0206
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0052
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0164 0.4275
Leishmania major cytochrome p450-like protein 0.0019 0.0014 0.0373
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0097 0.049 0.1358
Mycobacterium tuberculosis Carboxylesterase LipT 0.0127 0.0667 0.5187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0365 0.8445
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0034 0.0057
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0274 0.7139
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0117 0.0211
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0279 0.1586 0.3033
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0331 0.0592
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0071 0.0332 0.1621
Echinococcus multilocularis acetylcholinesterase 0.075 0.4429 0.4427
Loa Loa (eye worm) hypothetical protein 0.075 0.4429 0.7975
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0073 0.1688
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0117 0.0668
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0508 0.0506
Leishmania major hypothetical protein, conserved 0.0027 0.0063 0.1647
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2033 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0113 0.0787
Toxoplasma gondii HEAT repeat-containing protein 0.0088 0.0432 1
Echinococcus multilocularis acetylcholinesterase 0.075 0.4429 0.4427
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0075 0.0656
Echinococcus multilocularis neuroligin 0.0127 0.0667 0.0665
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0026
Schistosoma mansoni hypothetical protein 0.0279 0.1586 0.2856
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0274 0.1336
Schistosoma mansoni sex comb on midleg homolog 0.0097 0.049 0.0883
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0138 0.0667
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0274 0.0489
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0164 0.4275
Loa Loa (eye worm) hypothetical protein 0.0036 0.0117 0.0206
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0075 0.0396
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.1002 0.1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0274 0.0489
Schistosoma mansoni hypothetical protein 0.0058 0.0254 0.0457
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0206 0.152
Leishmania major cytochrome p450-like protein 0.0019 0.0014 0.0373
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0117 0.0219
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0127 0.0667 0.0665
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0071 0.0332 0.1621
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0127 0.0667 0.1198
Brugia malayi Cytochrome P450 family protein 0.0064 0.0291 0.0553
Onchocerca volvulus 0.0127 0.0667 0.1937
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.1002 0.18
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0172 0.0043
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0073 0.1639
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0073 0.0381
Brugia malayi jmjC domain containing protein 0.0019 0.0017 0.0027
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0172 0.0305
Brugia malayi Pre-SET motif family protein 0.0251 0.1419 0.2714
Loa Loa (eye worm) hypothetical protein 0.0127 0.0667 0.1198
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0017 0.0331
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0384 0.073
Onchocerca volvulus 0.0286 0.1629 0.5085
Mycobacterium leprae Probable lipase LipE 0.0036 0.0117 0.1105
Loa Loa (eye worm) latrophilin receptor protein 2 0.0279 0.1586 0.2853
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0117 0.0564
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0075 0.0484
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.4933 0.4931
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0062 0.1381
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0343 0.0614
Plasmodium vivax choline kinase, putative 0.0044 0.017 0.3903
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0073 0.0631
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0365 0.8445
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0172 0.4483
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.0014 0.0331
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0117 0.2709
Brugia malayi Pre-SET motif family protein 0.0036 0.012 0.0225
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0112 0.0197
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0015 0.0023
Trypanosoma cruzi cytochrome P450, putative 0.0064 0.0291 0.7594
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0075 0.0396
Loa Loa (eye worm) hypothetical protein 0.0043 0.0162 0.0288
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.0014 0.0274
Trichomonas vaginalis spcc417.12 protein, putative 0.0127 0.0667 0.3274
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.075 0.4429 0.7976
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.0343 0.0614
Brugia malayi Latrophilin receptor protein 2 0.0279 0.1586 0.3033
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0075 0.0396
Schistosoma mansoni ran 0.0043 0.0164 0.0295
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.012 0.0118
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0011 0.0016
Brugia malayi jmjC domain containing protein 0.0019 0.0017 0.0027
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0046 0.0079
Mycobacterium ulcerans hypothetical protein 0.0036 0.0117 0.0668
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0073 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0075 0.0139
Echinococcus granulosus snurportin 1 0.0936 0.5553 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0081
Leishmania major importin beta-1 subunit, putative 0.0071 0.0332 0.8645
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0943 1
Onchocerca volvulus 0.0036 0.0117 0.0137
Echinococcus multilocularis GPCR, family 2 0.0279 0.1586 0.1584
Echinococcus multilocularis geminin 0.0334 0.192 0.1918
Mycobacterium tuberculosis Conserved protein 0.0036 0.0117 0.0816
Brugia malayi Carboxylesterase family protein 0.075 0.4429 0.8477
Brugia malayi RNA, U transporter 1 0.0249 0.1408 0.2691
Leishmania major hypothetical protein, conserved 0.0036 0.0117 0.3049
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0073 0.0381
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0032 0.0676
Loa Loa (eye worm) hypothetical protein 0.0535 0.3131 0.5636
Schistosoma mansoni gliotactin 0.0127 0.0667 0.1202
Brugia malayi Carboxylesterase family protein 0.0127 0.0667 0.1273
Plasmodium falciparum choline kinase 0.0044 0.017 0.3903
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0274 0.7139
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0138 0.0135
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0172 0.4483
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0365 0.0363
Entamoeba histolytica hypothetical protein 0.0043 0.0165 0.0799
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0274 0.6321
Toxoplasma gondii phosphotransferase enzyme family protein 0.0044 0.017 0.3903
Echinococcus granulosus histone acetyltransferase MYST2 0.0111 0.0572 0.1025
Mycobacterium ulcerans hypothetical protein 0.0029 0.0075 0.0396
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0127 0.0667 0.5187
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0343 0.0618
Echinococcus multilocularis snurportin 1 0.0936 0.5553 0.5552
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0274 0.1336
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0138 0.0244
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0165 0.0292
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0274 0.7139
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0206 0.206
Trypanosoma cruzi cytochrome P450, putative 0.0064 0.0291 0.7594
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0229 0.0412
Loa Loa (eye worm) hypothetical protein 0.0603 0.354 0.6373
Onchocerca volvulus 0.0036 0.0117 0.0137
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0017 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0081
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0384 0.0687
Loa Loa (eye worm) hypothetical protein 0.0127 0.0667 0.1198
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0384 0.8885
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0384 0.2219 0.3993
Echinococcus multilocularis zinc finger protein 0.0021 0.0027 0.0025
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0127 0.0667 0.1202
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0063 0.1464
Loa Loa (eye worm) MBCTL1 0.0111 0.0572 0.1025
Schistosoma mansoni glutaminase 0.0273 0.1551 0.2794
Toxoplasma gondii ABC1 family protein 0.0036 0.0117 0.2666
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0117 0.0211
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0075 0.0358
Brugia malayi Cytochrome P450 family protein 0.0064 0.0291 0.0553
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0182 0.1002 0.1914
Loa Loa (eye worm) hypothetical protein 0.0279 0.1586 0.2853
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.1002 0.1804
Loa Loa (eye worm) hypothetical protein 0.0045 0.0172 0.0305
Schistosoma mansoni acetylcholinesterase 0.0127 0.0667 0.1202
Mycobacterium tuberculosis Conserved protein 0.0036 0.0117 0.0816
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0011 0.002
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0384 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0172 0.0325
Loa Loa (eye worm) carboxylesterase 0.0127 0.0667 0.1198
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0117 0.0816
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0384 0.0381
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0936 0.5553 1
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0017 0.003
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0138 0.3597
Schistosoma mansoni cytochrome P450 0.0019 0.0014 0.0026
Trypanosoma brucei importin beta-1 subunit, putative 0.0088 0.0432 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0026
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0014 0.0021
Onchocerca volvulus 0.0097 0.049 0.1358
Loa Loa (eye worm) acetylcholinesterase 1 0.075 0.4429 0.7975
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0014 0.0373
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.4933 0.8882
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0063 0.1413
Trichomonas vaginalis glutaminase, putative 0.0273 0.1551 0.7629
Plasmodium falciparum importin beta, putative 0.0088 0.0432 1
Brugia malayi Probable ClpP-like protease 0.0077 0.0365 0.0694
Echinococcus granulosus acetylcholinesterase 0.075 0.4429 0.7975
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1629 0.8011
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0365 0.8445
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0882 0.5224 0.9407
Brugia malayi glutaminase DH11.1 0.0273 0.1551 0.2967
Loa Loa (eye worm) carboxylesterase 0.0127 0.0667 0.1198
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0073 0.1639
Echinococcus multilocularis importin subunit beta 1 0.0088 0.0432 0.0429
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0063 0.1413
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1419 0.2553
Onchocerca volvulus 0.0036 0.0117 0.0137
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0172 0.0305
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0014 0.0373
Schistosoma mansoni hypothetical protein 0.0279 0.1586 0.2856
Brugia malayi Bromodomain containing protein 0.004 0.0147 0.0276
Loa Loa (eye worm) hypothetical protein 0.0029 0.0075 0.0131
Loa Loa (eye worm) cytochrome P450 family protein 0.0064 0.0291 0.052
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0017 0.0437
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0127 0.0667 0.1198
Echinococcus granulosus choline:ethanolamine kinase 0.0044 0.017 0.0302
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.1002 0.18
Brugia malayi mbt repeat family protein 0.0097 0.049 0.0934
Brugia malayi jmjC domain containing protein 0.0073 0.0343 0.0653
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0182 0.1002 0.18
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.0229 0.0226
Schistosoma mansoni hypothetical protein 0.0279 0.1586 0.2856
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.012 0.0216
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2033 1
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0206 0.0366
Onchocerca volvulus 0.0127 0.0667 0.1937
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0075 0.0396
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0075 0.0139
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0043 0.0164 0.3798
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.1002 0.1804
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0274 0.0271
Schistosoma mansoni bromodomain containing protein 0.0067 0.0306 0.0551
Schistosoma mansoni BC026374 protein (S09 family) 0.0127 0.0667 0.1202
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0138 0.3597
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0117 0.1105
Entamoeba histolytica hypothetical protein 0.0043 0.0165 0.0799
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0075 0.0484
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.0229 0.0408
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0073 0.0465
Leishmania major hypothetical protein, conserved 0.0019 0.0017 0.0437
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0138 0.0667
Brugia malayi latrophilin 2 splice variant baaae 0.0603 0.354 0.6775
Schistosoma mansoni lozenge 0.0067 0.0307 0.0554
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0029 0.0026
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0331 0.0329
Brugia malayi Carboxylesterase family protein 0.0127 0.0667 0.1273
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.2033 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0229 0.0408
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0138 0.0667
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.1002 0.1804
Echinococcus granulosus polycomb protein SCMH1 0.0097 0.049 0.0879
Trichomonas vaginalis importin beta-1, putative 0.0071 0.0332 0.1621
Loa Loa (eye worm) hypothetical protein 0.0036 0.0117 0.0206
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0014 0.0021
Mycobacterium ulcerans glutaminase 0.0273 0.1551 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0365 0.2281
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0172 0.0835
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0073 0.1239
Loa Loa (eye worm) hypothetical protein 0.0882 0.5224 0.9407
Trypanosoma cruzi importin beta-1 subunit, putative 0.0071 0.0332 0.8645
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0172 0.3983
Plasmodium vivax importin-beta 2, putative 0.0088 0.0432 1
Schistosoma mansoni sex comb on midleg homolog 0.0097 0.049 0.0883
Schistosoma mansoni hypothetical protein 0.0334 0.192 0.3457
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0026
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0117 0.0816
Echinococcus multilocularis histone acetyltransferase MYST2 0.0111 0.0572 0.0569
Brugia malayi Carboxylesterase family protein 0.075 0.4429 0.8477
Schistosoma mansoni hypothetical protein 0.0022 0.0034 0.0061
Loa Loa (eye worm) hypothetical protein 0.0127 0.0667 0.1198
Brugia malayi jmjC domain containing protein 0.0071 0.0331 0.0629
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0063 0.1647
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0172 0.0169
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0075 0.0396
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0943 0.6042
Brugia malayi mbt repeat family protein 0.0097 0.049 0.0934
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0043 0.0164 0.3761
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0181 0.0178
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0283 0.0506
Schistosoma mansoni hypothetical protein 0.0334 0.192 0.3457
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0127 0.0667 0.5187
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0075 0.0358
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0127 0.0667 0.1202
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0274 0.6343
Brugia malayi hypothetical protein 0.0043 0.0165 0.0311
Echinococcus multilocularis choline:ethanolamine kinase 0.0044 0.017 0.0168
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0274 0.0271
Brugia malayi Carboxylesterase family protein 0.0127 0.0667 0.1273
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0138 0.0667
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0274 0.7139
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0117 0.0816
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0117 0.0668
Echinococcus granulosus GTP binding nuclear protein Ran 0.0043 0.0164 0.0291
Schistosoma mansoni myelin transcription factor 1 myt1 0.0111 0.0572 0.1029
Entamoeba histolytica hypothetical protein 0.0028 0.0073 0.0346
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0111 0.0572 0.109
Brugia malayi Cytochrome P450 family protein 0.0019 0.0014 0.0023
Echinococcus multilocularis SAM and MBT domain containing protein 0.0097 0.049 0.0488
Loa Loa (eye worm) hypothetical protein 0.0075 0.0353 0.0632
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2033 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0882 0.5224 1
Loa Loa (eye worm) runx1 0.0067 0.0307 0.0549
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0117 0.0564
Schistosoma mansoni ran 0.0043 0.0164 0.0295
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0279 0.1586 0.1584
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0206 0.152
Loa Loa (eye worm) hypothetical protein 0.0127 0.0667 0.1198
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0017 0.003
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0172 0.0835
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0172 0.031
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0017 0.0006 0.0137
Loa Loa (eye worm) hypothetical protein 0.0286 0.1626 0.2925
Brugia malayi beta-lactamase family protein 0.0036 0.0117 0.0219
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0043 0.0164 0.0161
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0073 0.1639
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0365 0.8445
Schistosoma mansoni hypothetical protein 0.0603 0.354 0.6375
Mycobacterium ulcerans lipase LipD 0.0036 0.0117 0.0668
Echinococcus granulosus neuroligin 0.0127 0.0667 0.1198
Loa Loa (eye worm) mbt repeat family protein 0.0097 0.049 0.0879
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1626 0.1624
Echinococcus multilocularis Protein lozenge 0.0067 0.0307 0.0305
Leishmania major hypothetical protein, conserved 0.0017 0.0003 0.0066
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0117 0.3049
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0132 0.0129
Loa Loa (eye worm) hypothetical protein 0.0046 0.0179 0.0319
Schistosoma mansoni zinc finger protein 0.0021 0.0027 0.0049
Brugia malayi Importin beta-1 subunit 0.0088 0.0432 0.0822
Loa Loa (eye worm) hypothetical protein 0.0077 0.0365 0.0653
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0365 0.0657
Loa Loa (eye worm) hypothetical protein 0.0535 0.3131 0.5636
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0117 0.0816
Loa Loa (eye worm) hypothetical protein 0.0127 0.0667 0.1198
Loa Loa (eye worm) hypothetical protein 0.0041 0.0147 0.0261
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0111 0.0572 0.1025
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0075 0.0396
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0274 0.1336
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0117 0.3049
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0075 0.0139
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0081
Brugia malayi Cytochrome P450 family protein 0.0019 0.0014 0.0023
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0011 0.0009
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0075 0.1961
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0279 0.1586 0.2853
Loa Loa (eye worm) hypothetical protein 0.0036 0.0117 0.0206
Leishmania major cytochrome p450-like protein 0.0064 0.0291 0.7594
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2033 1
Loa Loa (eye worm) glutaminase 0.0273 0.1551 0.2791
Echinococcus granulosus para nitrobenzyl esterase 0.0127 0.0667 0.1198
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0283 0.0281
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0274 0.0493
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0172 0.0169
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0181 0.0321
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2033 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0138 0.3156
Echinococcus granulosus SAM and MBT domain containing protein 0.0097 0.049 0.0879
Echinococcus multilocularis polycomb protein SCMH1 0.0097 0.049 0.0488
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0017 0.0003 0.0059
Brugia malayi Calcitonin receptor-like protein seb-1 0.0882 0.5224 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.012 0.2737
Schistosoma mansoni neuroligin 3 (S09 family) 0.0127 0.0667 0.1202
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0029 0.0048
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0043 0.0164 0.0309
Brugia malayi jmjC domain containing protein 0.0019 0.0017 0.0027
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0075 0.0656
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0043 0.0164 0.3761
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0365 0.0653
Loa Loa (eye worm) hypothetical protein 0.01 0.0508 0.0911
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0117 0.0816
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0138 0.0805
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0017 0.0026
Echinococcus granulosus carboxylesterase 5A 0.075 0.4429 0.7975
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0274 0.7139
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0138 0.3196
Loa Loa (eye worm) hypothetical protein 0.0045 0.0174 0.031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0229 0.0412
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0097 0.049 0.0883
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0331 0.0596
Onchocerca volvulus 0.0127 0.0667 0.1937
Loa Loa (eye worm) choline/ethanolamine kinase 0.0044 0.017 0.0302
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0109
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0081
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0075 0.1961
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0111 0.0572 0.0569
Echinococcus multilocularis carboxylesterase 5A 0.075 0.4429 0.4427
Schistosoma mansoni inositol monophosphatase 0.0039 0.0138 0.0249
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2033 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0043 0.0164 0.0291
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0117 0.0564
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0052
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0279 0.1586 0.1584
Loa Loa (eye worm) cytochrome P450 family protein 0.0064 0.0291 0.052
Schistosoma mansoni hypothetical protein 0.0019 0.0014 0.0026
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0331 0.0329
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0508 0.0911
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0365 0.1538
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0075 0.0358
Trypanosoma brucei protein kinase, putative 0.0062 0.0274 0.6343
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0165 0.0297
Mycobacterium ulcerans carboxylesterase, LipT 0.0127 0.0667 0.4248
Plasmodium vivax JmjC domain containing protein 0.0019 0.0017 0.0331
Loa Loa (eye worm) carboxylesterase 0.075 0.4429 0.7975
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0365 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0117 0.0816
Brugia malayi hypothetical protein 0.0027 0.0063 0.0116
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0052
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0075 0.0396
Entamoeba histolytica hypothetical protein 0.0071 0.0332 0.1621
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0172 0.031
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0127 0.0667 0.1202
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0046 0.0044
Onchocerca volvulus 0.0127 0.0667 0.1937
Brugia malayi PHD-finger family protein 0.0026 0.0061 0.0113
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0017 0.003
Mycobacterium tuberculosis Conserved protein 0.0036 0.0117 0.0816
Brugia malayi MAP kinase sur-1 0.0062 0.0274 0.052
Echinococcus granulosus acetylcholinesterase 0.075 0.4429 0.7975
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0017 0.0437
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0165 0.0162
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0365 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0062 0.1381
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0063 0.1413
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0254 0.0482
Trichomonas vaginalis ran, putative 0.0043 0.0164 0.0795
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0384 0.0687
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0017 0.0014
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0063 0.1413
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0011 0.002
Brugia malayi jmjC domain containing protein 0.0019 0.0017 0.0027
Schistosoma mansoni hypothetical protein 0.0279 0.1586 0.2856
Brugia malayi Choline/ethanolamine kinase family protein 0.0044 0.017 0.0321
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0274 0.7139
Echinococcus granulosus BC026374 protein S09 family 0.0127 0.0667 0.1198
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0384 0.2219 0.2217
Onchocerca volvulus 0.0127 0.0667 0.1937
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2033 1
Mycobacterium ulcerans beta-lactamase 0.0036 0.0117 0.0668
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0172 0.0835
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.1273 1
Schistosoma mansoni inositol monophosphatase 0.0039 0.0138 0.0249
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0172 0.0169
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0127 0.0667 0.3274
Brugia malayi Carboxylesterase family protein 0.0127 0.0667 0.1273
Schistosoma mansoni hypothetical protein 0.0043 0.0165 0.0297
Onchocerca volvulus 0.0535 0.3131 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0132 0.0233
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0365 0.3776
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0384 0.1877
Trypanosoma brucei importin beta-1 subunit, putative 0.0088 0.0432 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0063 0.1647
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0046 0.0083
Brugia malayi hypothetical protein 0.0127 0.0667 0.1273
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.012 0.0216
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0384 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0279 0.1586 0.2853
Loa Loa (eye worm) beta-lactamase 0.0036 0.0117 0.0206
Loa Loa (eye worm) hypothetical protein 0.0029 0.0075 0.0131
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0064 0.0291 0.1802
Schistosoma mansoni hypothetical protein 0.0592 0.3476 0.626
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0365 1
Entamoeba histolytica Ran family GTPase 0.0043 0.0164 0.0795
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0117 0.2666
Entamoeba histolytica hypothetical protein 0.0043 0.0165 0.0799
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0343 0.0618
Loa Loa (eye worm) hypothetical protein 0.0111 0.0572 0.1025
Loa Loa (eye worm) CYP4Cod1 0.0064 0.0291 0.052
Entamoeba histolytica hypothetical protein 0.0043 0.0165 0.0799
Loa Loa (eye worm) hypothetical protein 0.0127 0.0667 0.1198
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0943 0.7379
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0172 0.0305
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0073 0.19
Toxoplasma gondii hypothetical protein 0.0026 0.0062 0.1381
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0206 0.0203
Loa Loa (eye worm) hypothetical protein 0.0097 0.049 0.0879
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0384 1
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0017 0.0026
Onchocerca volvulus 0.01 0.0508 0.1418
Schistosoma mansoni survival motor neuron protein 0.0058 0.0254 0.0457
Schistosoma mansoni importin beta-1 0.0088 0.0432 0.0777
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0117 0.0564
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0032 0.0112
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0384 0.0691
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0052
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0062 0.0511
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0117 0.0206
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.2033 1
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0274 0.0588
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0508 0.0969
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2033 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0017 0.0331
Echinococcus multilocularis BC026374 protein (S09 family) 0.0127 0.0667 0.0665
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0138 0.2229
Loa Loa (eye worm) hypothetical protein 0.0029 0.0075 0.0131
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0017 0.0388
Onchocerca volvulus 0.0058 0.0254 0.0585
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0073 0.1639
Brugia malayi cytochrome P450 0.0019 0.0014 0.0023
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0117 0.0816
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.0014 0.0373
Schistosoma mansoni hypothetical protein 0.0936 0.5553 1
Brugia malayi hypothetical protein 0.0535 0.3131 0.5992
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0117 0.0564
Echinococcus granulosus geminin 0.0334 0.192 0.3454
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0032 0.0676
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0172 0.4483
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0017 0.0014
Echinococcus granulosus importin subunit beta 1 0.0088 0.0432 0.0773
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0017 0.0014
Loa Loa (eye worm) cytochrome P450 0.0019 0.0014 0.0021
Brugia malayi beta-lactamase family protein 0.0036 0.0117 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0172 0.0835
Loa Loa (eye worm) hypothetical protein 0.0036 0.0117 0.0206
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1626 0.2925
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0117 0.0206
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0274 0.1336
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0017 0.003
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0113 0.1066
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0075 0.1961
Echinococcus granulosus GPCR family 2 0.0279 0.1586 0.2853
Echinococcus granulosus microtubule associated protein 2 0.0833 0.4933 0.8882
Echinococcus multilocularis 0.0019 0.0014 0.0012
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0032 0.0137
Brugia malayi hypothetical protein 0.0286 0.1626 0.3109
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0017 0.0026
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0117 0.0114
Brugia malayi hypothetical protein 0.0017 0.0006 0.0007
Echinococcus granulosus phd:f box containing protein 0.0019 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.075 0.4429 0.7975
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0138 0.3597
Trichomonas vaginalis esterase, putative 0.0036 0.0117 0.0564
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0274 0.0489
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0508 0.0916
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0365 0.2281
Loa Loa (eye worm) hypothetical protein 0.0088 0.0432 0.0773
Plasmodium vivax SET domain protein, putative 0.0036 0.012 0.2737
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0014 0.0373
Schistosoma mansoni importin-beta 2 0.0017 0.0003 0.0005

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.2 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 10.691 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 95.2834 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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