Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0146 | 0.3541 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0126 | 0.2874 | 0.4255 |
Brugia malayi | MH2 domain containing protein | 0.0239 | 0.6692 | 1 |
Onchocerca volvulus | 0.0256 | 0.7273 | 1 | |
Trichomonas vaginalis | set domain proteins, putative | 0.0256 | 0.7273 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0296 | 0.8615 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0239 | 0.6692 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0645 | 0.0964 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0126 | 0.2874 | 0.4255 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.2863 | 0.7205 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.6363 | 1 |
Plasmodium falciparum | glutathione reductase | 0.005 | 0.0289 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0645 | 0.0964 |
Brugia malayi | Thioredoxin reductase | 0.005 | 0.0289 | 0.0432 |
Entamoeba histolytica | hypothetical protein | 0.0146 | 0.3541 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.3614 | 0.54 |
Loa Loa (eye worm) | glutathione reductase | 0.005 | 0.0289 | 0.0432 |
Onchocerca volvulus | 0.0148 | 0.3614 | 0.4771 | |
Plasmodium vivax | thioredoxin reductase, putative | 0.005 | 0.0289 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0336 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0146 | 0.3541 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0126 | 0.2874 | 0.4255 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.2863 | 0.7205 |
Loa Loa (eye worm) | RNA binding protein | 0.0126 | 0.2863 | 0.4278 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.005 | 0.0289 | 0.0321 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.014 | 0.3343 | 0.3871 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.3541 | 0.8911 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0296 | 0.8615 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.005 | 0.0289 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0113 | 0.2445 | 0.355 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.2863 | 0.7205 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0126 | 0.2874 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0645 | 0.0964 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0296 | 0.8615 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0113 | 0.2445 | 0.355 |
Plasmodium falciparum | thioredoxin reductase | 0.005 | 0.0289 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.2863 | 0.7205 |
Loa Loa (eye worm) | thioredoxin reductase | 0.005 | 0.0289 | 0.0432 |
Brugia malayi | hypothetical protein | 0.0148 | 0.3614 | 0.54 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0225 | 0.6221 | 0.9297 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0146 | 0.3541 | 0.3349 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0156 | 0.3878 | 0.5909 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0239 | 0.6692 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.3343 | 0.3871 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0296 | 0.8615 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0126 | 0.2863 | 0.4278 |
Brugia malayi | RNA binding protein | 0.0126 | 0.2863 | 0.4278 |
Brugia malayi | glutathione reductase | 0.005 | 0.0289 | 0.0432 |
Echinococcus multilocularis | tar DNA binding protein | 0.0126 | 0.2863 | 0.265 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0322 | 0.0358 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.3343 | 0.3668 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0645 | 0.0964 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0113 | 0.2445 | 0.355 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0146 | 0.3541 | 0.3349 |
Loa Loa (eye worm) | TAR-binding protein | 0.0126 | 0.2863 | 0.4278 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0113 | 0.2445 | 0.355 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0274 | 0.069 |
Entamoeba histolytica | hypothetical protein | 0.0146 | 0.3541 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0274 | 0.041 |
Mycobacterium ulcerans | hypothetical protein | 0.0156 | 0.3878 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.005 | 0.0289 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.005 | 0.0289 | 0.0321 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.2863 | 0.7205 |
Brugia malayi | hypothetical protein | 0.0146 | 0.3541 | 0.5291 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0113 | 0.2445 | 0.355 |
Brugia malayi | TAR-binding protein | 0.0126 | 0.2863 | 0.4278 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0126 | 0.2863 | 0.4278 |
Brugia malayi | Pre-SET motif family protein | 0.0225 | 0.6221 | 0.9297 |
Echinococcus granulosus | tar DNA binding protein | 0.0126 | 0.2863 | 0.265 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0113 | 0.2445 | 0.355 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0146 | 0.3541 | 0.8911 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | = 21.91 uM | PubChem BioAssay. FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 35.4813 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.