Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.0292 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.2218 | 0.3289 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0292 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 0.6742 | 1 |
Schistosoma mansoni | hypothetical protein | 0.019 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0292 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 0.6742 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3096 | 0.3096 |
Brugia malayi | MH2 domain containing protein | 0.0134 | 0.6742 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3096 | 0.3096 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3096 | 0.3096 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.3096 | 0.4591 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.1191 | 0.1767 |
Brugia malayi | RNA binding protein | 0.0071 | 0.3096 | 0.4591 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.3096 | 0.3096 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0292 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0292 | 0.0292 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3096 | 0.3096 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0292 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0292 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0292 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3096 | 0.3096 |
Echinococcus multilocularis | geminin | 0.019 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0292 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.3096 | 0.4591 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1191 | 0.1767 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0292 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.2218 | 0.3289 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.3096 | 0.4591 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0292 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.3096 | 0.4591 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.2218 | 0.3289 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0292 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0292 | 0.0434 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0292 | 0.0292 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0292 | 0.0434 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.3096 | 0.3096 |
Schistosoma mansoni | hypothetical protein | 0.019 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.0292 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.0292 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0292 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1191 | 0.1191 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.3096 | 0.4591 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0292 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.2218 | 0.3289 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1889 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.