Detailed information for compound 1310311

Basic information

Technical information
  • TDR Targets ID: 1310311
  • Name: 2-[(1,3-dimethyl-2,4-dioxoquinazolin-6-yl)sul fonylamino]-N-(4-ethylphenyl)-3-phenylpropana mide
  • MW: 520.6 | Formula: C27H28N4O5S
  • H donors: 2 H acceptors: 5 LogP: 3.47 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCc1ccc(cc1)NC(=O)C(NS(=O)(=O)c1ccc2c(c1)c(=O)n(c(=O)n2C)C)Cc1ccccc1
  • InChi: 1S/C27H28N4O5S/c1-4-18-10-12-20(13-11-18)28-25(32)23(16-19-8-6-5-7-9-19)29-37(35,36)21-14-15-24-22(17-21)26(33)31(3)27(34)30(24)2/h5-15,17,23,29H,4,16H2,1-3H3,(H,28,32)
  • InChiKey: QAIKVFIZFCWUBK-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-[(1,3-dimethyl-2,4-dioxo-quinazolin-6-yl)sulfonylamino]-N-(4-ethylphenyl)-3-phenyl-propanamide
  • 2-[(1,3-dimethyl-2,4-dioxo-6-quinazolinyl)sulfonylamino]-N-(4-ethylphenyl)-3-phenylpropanamide
  • 2-[(2,4-diketo-1,3-dimethyl-quinazolin-6-yl)sulfonylamino]-N-(4-ethylphenyl)-3-phenyl-propionamide
  • C597-0273
  • NCGC00110711-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0084 0.029 0.0408
Brugia malayi Peptidase family M1 containing protein 0.0954 0.3853 0.5417
Brugia malayi Uncoordinated protein 44 0.0016 0.0009 0.0012
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0485 0.193 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0333 0.1307 0.677
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0152 0.0758
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0051 0.0152 0.0152
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0011
Plasmodium falciparum M1-family alanyl aminopeptidase 0.2257 0.9189 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0039 0.0039
Echinococcus granulosus lamin dm0 0.0029 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0029 0.0063 0.0063
Schistosoma mansoni intermediate filament proteins 0.0029 0.0063 0.0063
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0063 0.0089
Onchocerca volvulus Cell death protein 3 homolog 0.0064 0.0208 0.0539
Mycobacterium tuberculosis Probable oxidoreductase 0.037 0.1459 0.7557
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0009 0.0009
Onchocerca volvulus 0.0034 0.0083 0.0215
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0075 0.0375
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0022
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0118 0.0426 0.2209
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0357 0.1405 0.7008
Echinococcus multilocularis flap endonuclease 1 0.0028 0.006 0.006
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0076 0.0255 0.0359
Echinococcus granulosus bloom syndrome protein 0.0023 0.0038 0.0038
Echinococcus multilocularis expressed conserved protein 0.0045 0.0131 0.0131
Brugia malayi Peptidase family M1 containing protein 0.0357 0.1405 0.1976
Brugia malayi Protein kinase domain containing protein 0.0056 0.0173 0.0243
Toxoplasma gondii hypothetical protein 0.0015 0.0008 0.0009
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0075 0.0389
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0235 0.0906 0.0906
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0007 0.0008
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0027 0.0137
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0503 0.2005 0.2005
Onchocerca volvulus 0.0015 0.0008 0.0021
Echinococcus granulosus Ankyrin 0.0016 0.0009 0.0009
Echinococcus granulosus caspase 2 0.0064 0.0208 0.0208
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.2257 0.9189 1
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0426 0.0426
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0083 0.0083
Brugia malayi Protein kinase domain containing protein 0.0016 0.0009 0.0012
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.006 0.006
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0076 0.0255 0.0359
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0357 0.1405 0.1405
Brugia malayi Cell death protein 3 precursor 0.0064 0.0208 0.0292
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0511 0.2037 0.2037
Schistosoma mansoni thyroid hormone receptor 0.0159 0.0595 0.0595
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.006 0.3974
Toxoplasma gondii kringle domain-containing protein 0.0056 0.0173 0.0188
Echinococcus multilocularis leukotriene A 4 hydrolase 0.2455 1 1
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0023 0.0039 0.0203
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0078 0.0078
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0075 0.0375
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0503 0.2005 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0027 0.0137
Loa Loa (eye worm) hypothetical protein 0.0034 0.0083 0.0083
Toxoplasma gondii hypothetical protein 0.0015 0.0008 0.0009
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0002 0.0002
Brugia malayi 6-phosphofructokinase 0.0118 0.0426 0.0599
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0083 0.009
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0019 0.0019
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0069 0.0226 0.0226
Loa Loa (eye worm) peptidase family M1 containing protein 0.0808 0.3253 0.3253
Brugia malayi Flap endonuclease-1 0.0028 0.006 0.0085
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Treponema pallidum NADH oxidase 0.0051 0.0152 0.3564
Brugia malayi hypothetical protein 0.0064 0.0208 0.0292
Toxoplasma gondii microneme protein MIC17C 0.0015 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0027 0.0027
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0008 0.0008
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0011
Schistosoma mansoni leucine aminopeptidase 0.0076 0.0255 0.0255
Trypanosoma brucei Aminopeptidase M1, putative 0.0503 0.2005 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0075 0.0375
Plasmodium falciparum cysteine repeat modular protein 1 0.0056 0.0173 0.0188
Brugia malayi intermediate filament protein 0.0029 0.0063 0.0089
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Onchocerca volvulus 0.0015 0.0008 0.0021
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0503 0.2005 1
Echinococcus multilocularis leucyl aminopeptidase 0.0076 0.0255 0.0255
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0156 0.0156
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0037 0.0097 0.0136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0152 0.0758
Onchocerca volvulus 0.0015 0.0008 0.0021
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0426 0.2126
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0146 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.0146 0.0545 0.0545
Echinococcus multilocularis lamin 0.0029 0.0063 0.0063
Brugia malayi hypothetical protein 0.0018 0.0017 0.0024
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0027 0.0137
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0333 0.1307 0.677
Onchocerca volvulus 0.0503 0.2005 0.5205
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0051 0.0152 0.0758
Schistosoma mansoni caspase-7 (C14 family) 0.0064 0.0208 0.0208
Mycobacterium tuberculosis Probable reductase 0.0333 0.1307 0.677
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0083 0.0083
Onchocerca volvulus 0.0015 0.0008 0.0021
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0045 0.0128 0.0128
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0503 0.2005 0.2005
Brugia malayi cytosol aminopeptidase 0.0076 0.0255 0.0359
Onchocerca volvulus 0.0019 0.0022 0.0058
Leishmania major ATP-dependent phosphofructokinase 0.0118 0.0426 0.2126
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0146 0.0545 0.2718
Toxoplasma gondii aminopeptidase N, putative 0.2257 0.9189 1
Entamoeba histolytica hypothetical protein 0.0042 0.0117 0.0583
Echinococcus granulosus nuclear factor of activated T cells 5 0.008 0.0271 0.0271
Schistosoma mansoni hypothetical protein 0.0042 0.0117 0.0117
Trichomonas vaginalis mercuric reductase, putative 0.0051 0.0152 0.0758
Trypanosoma brucei aminopeptidase, putative 0.0357 0.1405 0.7008
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0051 0.0152 0.0165
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0357 0.1405 0.7008
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0051 0.0152 0.0758
Echinococcus multilocularis Ankyrin 0.0016 0.0009 0.0009
Schistosoma mansoni netrin receptor unc5 0.0016 0.0009 0.0009
Onchocerca volvulus 0.0084 0.029 0.0752
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0117 0.0117
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0051 0.0152 0.0165
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0051 0.0152 0.0758
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0485 0.193 0.2101
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0051 0.0152 0.0787
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.037 0.1459 0.7557
Plasmodium falciparum thioredoxin reductase 0.0146 0.0542 0.059
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0011
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0076 0.0255 0.1274
Trypanosoma brucei Aminopeptidase M1, putative 0.0503 0.2005 1
Trypanosoma brucei trypanothione reductase 0.0146 0.0542 0.2703
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0076 0.0255 0.1274
Loa Loa (eye worm) thioredoxin reductase 0.0146 0.0542 0.0542
Schistosoma mansoni hypothetical protein 0.0056 0.0173 0.0173
Toxoplasma gondii microneme protein, putative 0.0015 0.0008 0.0009
Trichomonas vaginalis glutathione reductase, putative 0.0051 0.0152 0.0758
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0002
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0503 0.2005 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0117 0.0117
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0051 0.0152 0.0758
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0027 0.0027
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0357 0.1405 0.7008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Leishmania major pyroglutamyl-peptidase I (C15 family) 0.0465 0.1847 0.9213
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0503 0.2005 1
Toxoplasma gondii leucyl aminopeptidase LAP 0.0485 0.193 0.2101
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0076 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0027 0.0057 0.0057
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0038 0.0192
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0027 0.003
Toxoplasma gondii microneme protein MIC17A 0.0015 0.0008 0.0009
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0027 0.0137
Leishmania major hypothetical protein, conserved 0.0056 0.0173 0.0861
Entamoeba histolytica hypothetical protein 0.0042 0.0117 0.0583
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0051 0.0152 0.0758
Mycobacterium ulcerans aminopeptidase N PepN 0.0503 0.2005 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0051 0.0152 0.0758
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0084 0.029 0.029
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0503 0.2005 0.2005
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0076 0.0255 0.0255
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0173 0.0861
Chlamydia trachomatis cytosol aminopeptidase 0.0485 0.193 1
Echinococcus granulosus leucyl aminopeptidase 0.0076 0.0255 0.0255
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0075 0.0082
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0485 0.193 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0156 0.0156
Echinococcus multilocularis nuclear factor of activated T cells 5 0.008 0.0271 0.0271
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0009 0.0023
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0333 0.1307 0.677
Brugia malayi Matrixin family protein 0.0046 0.0132 0.0185
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.006 0.0066
Trypanosoma cruzi aminopeptidase, putative 0.0503 0.2005 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Echinococcus granulosus aminopeptidase N 0.0954 0.3853 0.3853
Schistosoma mansoni ap endonuclease 0.002 0.0027 0.0027
Onchocerca volvulus Deterin homolog 0.0084 0.029 0.0752
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0357 0.1405 0.1405
Loa Loa (eye worm) hypothetical protein 0.0064 0.0208 0.0208
Brugia malayi hypothetical protein 0.0042 0.0117 0.0164
Trypanosoma cruzi Aminopeptidase M1, putative 0.0503 0.2005 1
Echinococcus multilocularis caspase 2 0.0064 0.0208 0.0208
Echinococcus multilocularis leucyl aminopeptidase 0.0076 0.0255 0.0255
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.038 0.1503 0.7494
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0426 0.2126
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0503 0.2005 0.2005
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0008 0.0008
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0076 0.0255 0.0255
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0075 0.0375
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0008 0.0009
Loa Loa (eye worm) RecQ helicase 0.0023 0.0038 0.0038
Brugia malayi Kringle domain containing protein 0.0056 0.0173 0.0243
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0156 0.0156
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0076 0.0255 0.0255
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0011
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0357 0.1405 0.1529
Onchocerca volvulus 0.0064 0.0208 0.0539
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0426 0.0426
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0008 0.0008
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0057 0.0062
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0357 0.1405 0.7008
Plasmodium vivax thioredoxin reductase, putative 0.0146 0.0542 0.059
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0075 0.0082
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0075 0.0375
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0037 0.0097 0.0136
Toxoplasma gondii aminopeptidase N protein 0.2257 0.9189 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0357 0.1405 0.7008
Loa Loa (eye worm) hypothetical protein 0.0056 0.0173 0.0173
Echinococcus granulosus apoptotic protease activating factor 1 0.0064 0.0208 0.0208
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0002 0.0002
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0051 0.0152 0.0787
Schistosoma mansoni lamin 0.0029 0.0063 0.0063
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0147 0.0546 0.0546
Onchocerca volvulus 0.0267 0.104 0.2699
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0019 0.0022 0.0022
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0357 0.1405 0.1405
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0076 0.0255 0.1274
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0146 0.0542 0.2808
Onchocerca volvulus 0.0027 0.0055 0.0142
Leishmania major hypothetical protein, conserved 0.0027 0.0057 0.0283
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0075 0.4942
Echinococcus granulosus 6 phosphofructokinase 0.0118 0.0426 0.0426
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0027 0.0137
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0057 0.0283
Brugia malayi TATA binding protein associated factor 0.0357 0.1405 0.1976
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Toxoplasma gondii PAN/Apple domain-containing protein 0.0015 0.0008 0.0009
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0075 0.0082
Onchocerca volvulus 0.0357 0.1405 0.3648
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0156 0.0156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0156 0.0156
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0152 0.0758
Echinococcus multilocularis leucyl aminopeptidase 0.0076 0.0255 0.0255
Schistosoma mansoni hypothetical protein 0.0027 0.0055 0.0055
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0075 0.0082
Echinococcus multilocularis inhibitor of apoptosis protein 0.0084 0.029 0.029
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0051 0.0152 0.0214
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0083 0.0083
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0011
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0051 0.0152 0.0758
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0008 0.0009
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0118 0.0426 0.2209
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0009 0.0009
Echinococcus multilocularis thyroid hormone receptor alpha 0.0159 0.0595 0.0595
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0051 0.0152 0.0758
Echinococcus granulosus leucine aminopeptidase protein 0.0485 0.193 0.193
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0084 0.029 0.0408
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0083 0.0083
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0011
Echinococcus multilocularis leucine aminopeptidase protein 0.0485 0.193 0.193
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.006 0.0301
Schistosoma mansoni hypothetical protein 0.0147 0.0546 0.0546
Loa Loa (eye worm) leukotriene A4 hydrolase 0.2455 1 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0118 0.0426 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.037 0.1459 0.7557
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0426 0.0426
Loa Loa (eye worm) matrixin family protein 0.0046 0.0132 0.0132
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0076 0.0255 0.1274
Loa Loa (eye worm) matrixin family protein 0.0042 0.0116 0.0116
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0057 0.0283
Schistosoma mansoni lamin 0.0029 0.0063 0.0063
Onchocerca volvulus 0.0015 0.0008 0.0021
Leishmania major trypanothione reductase 0.0146 0.0542 0.2703
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.038 0.1503 0.7494
Loa Loa (eye worm) hypothetical protein 0.0084 0.029 0.029
Schistosoma mansoni hypothetical protein 0.0064 0.0208 0.0208
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0009 0.0009
Echinococcus multilocularis lamin dm0 0.0029 0.0063 0.0063
Onchocerca volvulus 0.0015 0.0008 0.0021
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0008 0.0008
Brugia malayi Matrixin family protein 0.0019 0.0022 0.0031
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0051 0.0152 0.0787
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0009 0.0012
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.006 0.0301
Echinococcus granulosus intermediate filament protein 0.0029 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0042 0.0117 0.0583
Brugia malayi POT family protein 0.0044 0.0126 0.0177
Trypanosoma cruzi Cysteine peptidase, Clan CF, family C15 0.0465 0.1847 0.9213
Entamoeba histolytica Flap nuclease, putative 0.0028 0.006 0.0301
Onchocerca volvulus 0.0015 0.0008 0.0021
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0357 0.1405 0.1529
Echinococcus granulosus expressed conserved protein 0.0045 0.0131 0.0131
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0051 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0064 0.0208 0.0208
Echinococcus granulosus thioredoxin glutathione reductase 0.0146 0.0544 0.0544
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0051 0.0152 0.0758
Toxoplasma gondii aminopeptidase n, putative 0.2257 0.9189 1
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0011
Loa Loa (eye worm) matrix metalloproteinase 0.0019 0.0022 0.0022
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0009
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0051 0.0152 0.0758
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.002
Echinococcus granulosus lamin 0.0029 0.0063 0.0063
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0075 0.0375
Brugia malayi hypothetical protein 0.0357 0.1405 0.1976
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0009 0.0009
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0027 0.0142
Schistosoma mansoni inhibitor of apoptosis protein 0.0084 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0146 0.0545 0.0545
Mycobacterium tuberculosis Probable dehydrogenase 0.0333 0.1307 0.677
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0426 0.2126
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0147 0.0546 0.0546
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0075 0.0375
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0051 0.0152 0.0787
Plasmodium falciparum glutathione reductase 0.0051 0.0152 0.0165
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0063 0.0063
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0051 0.0152 0.0165
Loa Loa (eye worm) hypothetical protein 0.0357 0.1405 0.1405
Onchocerca volvulus 0.0056 0.0173 0.0448
Mycobacterium ulcerans leucyl aminopeptidase 0.0485 0.193 0.9627
Loa Loa (eye worm) hypothetical protein 0.0451 0.1793 0.1793
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0117 0.0117
Toxoplasma gondii exonuclease III APE 0.002 0.0027 0.003
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0051 0.0152 0.0758
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0357 0.1405 0.7008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0022
Trypanosoma brucei aminopeptidase, putative 0.0076 0.0255 0.1274
Brugia malayi hypothetical protein 0.0132 0.0484 0.0681
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0023 0.0039 0.0055
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0051 0.0152 0.0165
Mycobacterium ulcerans aminopeptidase N PepN 0.0357 0.1405 0.7008
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0503 0.2005 1
Toxoplasma gondii microneme protein MIC17B 0.0015 0.0008 0.0009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0156 0.0156
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0008 0.0009
Mycobacterium leprae PROBABLE HYDROLASE 0.0023 0.0039 0.0203
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0027 0.0142
Toxoplasma gondii subtilisin SUB12 0.0015 0.0008 0.0009
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0051 0.0152 0.0152
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.006 0.0066
Onchocerca volvulus 0.0015 0.0008 0.0021
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0076 0.0255 0.1274
Brugia malayi Matrixin family protein 0.0019 0.0022 0.0031
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0051 0.0152 0.0165
Trichomonas vaginalis set domain proteins, putative 0.0267 0.1039 0.5183
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0038 0.0192
Echinococcus granulosus flap endonuclease 1 0.0028 0.006 0.006
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0011
Echinococcus multilocularis 6 phosphofructokinase 0.0118 0.0426 0.0426
Trypanosoma cruzi pyroglutamyl-peptidase I, putative 0.0465 0.1847 0.9213
Loa Loa (eye worm) hypothetical protein 0.0084 0.029 0.029
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.2455 1 1
Mycobacterium ulcerans hydrolase 0.0023 0.0039 0.0195
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0426 0.2126
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0011
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0076 0.0255 0.1274
Loa Loa (eye worm) POT family protein 0.0044 0.0126 0.0126
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0038 0.0054
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0333 0.1307 0.677
Toxoplasma gondii microneme protein MIC4 0.0015 0.0008 0.0009
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0333 0.1307 0.677
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0426 0.0426
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0051 0.0152 0.0758
Echinococcus granulosus leucyl aminopeptidase 0.0076 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0009
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0503 0.2005 0.2005
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0357 0.1405 0.7008
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0009 0.0009
Onchocerca volvulus 0.0015 0.0008 0.0021
Brugia malayi hypothetical protein 0.175 0.7112 1
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0008 0.0009
Brugia malayi hypothetical protein 0.0027 0.0057 0.008
Trypanosoma cruzi trypanothione reductase, putative 0.0146 0.0542 0.2703
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0426 0.2126
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.006 0.0301
Entamoeba histolytica hypothetical protein 0.0042 0.0117 0.0583
Brugia malayi Pre-SET motif family protein 0.0235 0.0906 0.1274
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0083 0.0083
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0038 0.0038
Onchocerca volvulus 0.0029 0.0063 0.0164
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0056 0.0173 0.0188
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.006 0.0301
Loa Loa (eye worm) hypothetical protein 0.0343 0.135 0.135
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0009 0.0009
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0485 0.193 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0503 0.2005 0.2005
Echinococcus multilocularis musashi 0.0029 0.0063 0.0063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0156 0.0156
Onchocerca volvulus 0.0015 0.0008 0.0021
Onchocerca volvulus 0.0015 0.0008 0.0021
Trypanosoma cruzi aminopeptidase, putative 0.0357 0.1405 0.7008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0083 0.0083
Mycobacterium ulcerans 6-phosphofructokinase 0.0118 0.0426 0.2126
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0083 0.0083
Echinococcus multilocularis tissue type plasminogen activator 0.0056 0.0173 0.0173
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0503 0.2005 0.2005
Schistosoma mansoni hypothetical protein 0.0016 0.0009 0.0009
Echinococcus multilocularis thioredoxin glutathione reductase 0.0146 0.0544 0.0544
Echinococcus granulosus tissue type plasminogen activator 0.0056 0.0173 0.0173
Plasmodium falciparum thioredoxin reductase 0.0051 0.0152 0.0165
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0076 0.0255 0.0359
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0015 0.0008 0.0009
Echinococcus multilocularis apoptotic protease activating factor 1 0.0064 0.0208 0.0208
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0027 0.0027
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0075 0.0375
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0027 0.0137
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.0497 0.0497
Brugia malayi Peptidase family M1 containing protein 0.0503 0.2005 0.2819
Schistosoma mansoni aminopeptidase A (M01 family) 0.0357 0.1405 0.1405
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0027 0.0137
Loa Loa (eye worm) glutathione reductase 0.0146 0.0542 0.0542
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.037 0.1459 0.7557
Brugia malayi phosphofructokinase 0.0118 0.0426 0.0599
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0503 0.2005 0.2005
Brugia malayi 6-phosphofructokinase 0.0118 0.0426 0.0599
Loa Loa (eye worm) aminopeptidase N 0.0503 0.2005 0.2005
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.038 0.1503 0.7494
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0084 0.029 0.029
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.038 0.1503 0.7494
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0069 0.0226 0.0226
Toxoplasma gondii NADPH-glutathione reductase 0.0051 0.0152 0.0165
Loa Loa (eye worm) TK/ROR protein kinase 0.0056 0.0173 0.0173
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0426 0.2126
Plasmodium falciparum M17 leucyl aminopeptidase 0.038 0.1503 0.1635
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0075 0.0082
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0008 0.0009
Onchocerca volvulus Matrilysin homolog 0.0019 0.0022 0.0058
Plasmodium vivax SET domain protein, putative 0.0034 0.0083 0.009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0156 0.022
Brugia malayi Matrixin family protein 0.0019 0.0022 0.0031
Brugia malayi glutathione reductase 0.0146 0.0542 0.0762
Brugia malayi Matrixin family protein 0.0019 0.0022 0.0031
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0426 0.2126
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0075 0.0082
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0503 0.2005 0.2005
Brugia malayi Hemopexin family protein 0.0027 0.0055 0.0077
Echinococcus multilocularis aminopeptidase N 0.0954 0.3853 0.3853
Schistosoma mansoni hypothetical protein 0.0084 0.029 0.029
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0152 0.0758
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0146 0.0545 0.0545
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0027 0.003
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0152 0.0758
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0008 0.0009
Schistosoma mansoni ap endonuclease 0.002 0.0027 0.0027
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0057 0.0283
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0057 0.0062
Onchocerca volvulus Matrilysin homolog 0.0042 0.0116 0.0302
Trypanosoma brucei pyroglutamyl-peptidase I, putative 0.0465 0.1847 0.9213
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0156 0.0156
Brugia malayi MH2 domain containing protein 0.0135 0.0497 0.0698
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0022
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0051 0.0152 0.0758
Brugia malayi Pre-SET motif family protein 0.0034 0.0083 0.0117
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0008 0.0008
Schistosoma mansoni thyroid hormone receptor 0.0159 0.0595 0.0595
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0027 0.0039
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0426 0.2126
Echinococcus granulosus inhibitor of apoptosis protein 0.0084 0.029 0.029
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0057 0.0062
Loa Loa (eye worm) hypothetical protein 0.0357 0.1405 0.1405
Onchocerca volvulus 0.0029 0.0063 0.0164
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0075 0.1762
Toxoplasma gondii thioredoxin reductase 0.0146 0.0542 0.059
Entamoeba histolytica aminopeptidase, putative 0.0503 0.2005 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0152 0.0758
Schistosoma mansoni hypothetical protein 0.0055 0.0171 0.0171
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0027 0.1803
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0084 0.029 0.029
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0027 0.0137
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0008 0.0012
Brugia malayi Thioredoxin reductase 0.0146 0.0542 0.0762
Schistosoma mansoni flap endonuclease-1 0.0025 0.0049 0.0049
Echinococcus granulosus death domain containing protein 0.0016 0.0009 0.0009
Giardia lamblia NADH oxidase lateral transfer candidate 0.0051 0.0152 1
Loa Loa (eye worm) TATA binding protein associated factor 0.0357 0.1405 0.1405
Brugia malayi Death domain containing protein 0.0016 0.0009 0.0012
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0027 0.0643
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0357 0.1405 0.1405
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0426 0.2126
Onchocerca volvulus 0.0954 0.3853 1
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0503 0.2005 1
Loa Loa (eye worm) hypothetical protein 0.0598 0.2393 0.2393
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0063 0.0063
Plasmodium falciparum glutathione reductase 0.0146 0.0542 0.059
Loa Loa (eye worm) phosphofructokinase 0.0118 0.0426 0.0426
Plasmodium falciparum flap endonuclease 1 0.0028 0.006 0.0066
Plasmodium vivax glutathione reductase, putative 0.0146 0.0542 0.059
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0076 0.0255 0.1274
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0075 0.0082
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0061
Brugia malayi hypothetical protein 0.0503 0.2005 0.2819
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0152 0.0758
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0057 0.0062
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0027 0.003
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0075 0.0389
Onchocerca volvulus Matrix metalloproteinase homolog 0.0042 0.0116 0.0302
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0503 0.2005 0.2005
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0503 0.2005 0.2005
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0008 0.0008

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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