Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hexokinase 2 | 0.1315 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.1315 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.1315 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0874 | 0.6497 | 0.6497 |
Echinococcus granulosus | hexokinase | 0.1315 | 1 | 1 |
Onchocerca volvulus | 0.1315 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.1315 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.1315 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.1315 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.1315 | 1 | 0.5 |
Schistosoma mansoni | hexokinase | 0.1315 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.1315 | 1 | 0.5 |
Plasmodium falciparum | hexokinase | 0.1315 | 1 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0899 | 0.6699 | 0.6699 |
Echinococcus granulosus | hexokinase type 2 | 0.1315 | 1 | 1 |
Onchocerca volvulus | 0.1315 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase type II | 0.1315 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0927 | 0.6924 | 0.2093 |
Trypanosoma cruzi | hexokinase, putative | 0.1315 | 1 | 0.5 |
Toxoplasma gondii | hexokinase | 0.1315 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.1315 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.1315 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0897 | 0.6681 | 0.6681 |
Echinococcus multilocularis | hexokinase | 0.1315 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.1315 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0825 | 0.611 | 0.611 |
Entamoeba histolytica | hexokinase 1 | 0.1315 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0418 | 0.288 | 0.288 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0899 | 0.6699 | 0.6699 |
Trypanosoma cruzi | hexokinase, putative | 0.1315 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.1315 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.1315 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0418 | 0.288 | 0.288 |
Onchocerca volvulus | 0.1315 | 1 | 1 | |
Brugia malayi | hexokinase type II | 0.0418 | 0.288 | 0.288 |
Echinococcus multilocularis | hexokinase | 0.1315 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0825 | 0.611 | 0.611 |
Echinococcus granulosus | hexokinase | 0.1315 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0407 | 0.2791 | 0.2791 |
Leishmania major | hexokinase, putative | 0.1315 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0407 | 0.2791 | 0.2791 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.