TDR Targets

Basic information

Technical information

TDR Targets ID: 1310748
Name: [3-(4-bromophenyl)-5-hydroxy-5-(trifluorometh yl)-4H-pyrazol-1-yl]-furan-2-ylmethanone
MW: 403.151 | Formula: C15H10BrF3N2O3
H donors: 1 H acceptors: 2 LogP: 3.88 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc(cc1)C1=NN(C(C1)(O)C(F)(F)F)C(=O)c1ccco1
InChi: 1S/C15H10BrF3N2O3/c16-10-5-3-9(4-6-10)11-8-14(23,15(17,18)19)21(20-11)13(22)12-2-1-7-24-12/h1-7,23H,8H2
InChiKey: DOVIZSXPDSIZAH-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

[3-(4-bromophenyl)-5-hydroxy-5-(trifluoromethyl)-4H-pyrazol-1-yl]-(2-furyl)methanone
[3-(4-bromophenyl)-5-hydroxy-5-(trifluoromethyl)-4H-pyrazol-1-yl]-furan-2-yl-methanone
3-(4-bromophenyl)-1-(2-furoyl)-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-ol
MLS000724238
SMR000305832

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0019	0.0687	0.2744
Schistosoma mansoni	coup transcription factor	0.0012	0.0177	0.0708
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0177	0.0177
Schistosoma mansoni	hypothetical protein	0.0019	0.0687	0.2744
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0177	0.0708
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0177	0.0708
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0687	0.0687
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0177	0.0177
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0177	0.0708
Entamoeba histolytica	hypothetical protein	0.0043	0.2503	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0177	0.0177
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0177	0.0177
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0177	0.0708
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0177	0.0177
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0177	0.0708
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.2503	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0687	0.0687
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.375	0.375
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0687	0.2744
Schistosoma mansoni	hypothetical protein	0.0019	0.0687	0.2744
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.2503	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0177	0.0708
Brugia malayi	ecdysteroid receptor	0.0012	0.0177	0.0177
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0177	0.0708
Schistosoma mansoni	hypothetical protein	0.0041	0.2332	0.9318
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0177	0.0708
Schistosoma mansoni	hypothetical protein	0.0043	0.2503	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0177	0.0177
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0177	0.0708
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0177	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0177	0.0177
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0177	0.0708
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0687	0.0687
Brugia malayi	hypothetical protein	0.0043	0.2503	0.2503
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0177	0.0177
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0177	0.0177
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0177	0.0177
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0177	0.0708
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0177	0.5
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0177	0.0177
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	1	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0177	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0177	0.0708
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0177	0.0708
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.375	0.375
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0177	0.0708
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0177	0.0708
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0177	0.0708
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0177	0.0177
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0177	0.0177
Schistosoma mansoni	hypothetical protein	0.0019	0.0687	0.2744
Brugia malayi	nuclear hormone receptor	0.0012	0.0177	0.0177
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0177	0.0708
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0177	0.0177
Entamoeba histolytica	hypothetical protein	0.0043	0.2503	0.5
Brugia malayi	steroid hormone receptor	0.0012	0.0177	0.0177
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0177	0.0177
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0177	0.0708
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0177	0.0708
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0177	0.0708
Loa Loa (eye worm)	hypothetical protein	0.0041	0.2332	0.2332
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0177	0.0177
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0177	0.0708
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0177	0.0708
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0177	0.0708
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0177	0.0177
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0687	0.0687
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0177	0.0708
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.375	0.375
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0177	0.0177
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0687	0.2744
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	1	1
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.2503	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.375	0.375
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0177	0.0177
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0687	0.2744
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0177	0.0708
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0177	0.0177
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0177	0.0708
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0177	0.0708
Onchocerca volvulus		0.0012	0.0177	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0177	0.0177
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0177	0.0177
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0177	0.0177
Echinococcus granulosus	GPCR family 2	0.0019	0.0687	0.2744
Entamoeba histolytica	hypothetical protein	0.0043	0.2503	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0177	0.0708
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0177	0.0177
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0177	0.0708
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0177	0.0177
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0177	0.0177
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0687	0.2744
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0177	0.0177
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.2332	0.2332
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0177	0.0708
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0687	0.2744
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0177	0.0177
Entamoeba histolytica	hypothetical protein	0.0043	0.2503	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)	= 27.11 uM	PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.2512 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.2387 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	= 7.0795 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.9433 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.5821 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.081 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1416026

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1310748