Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | Starlite/ChEMBL | No references |
Trypanosoma brucei gambiense | ATP-dependent phosphofructokinase,6-phospho-1-fructokinase | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0803 | 0.0803 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0035 | 0.1036 | 1 |
Onchocerca volvulus | 0.0054 | 0.2734 | 0.5 | |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0029 | 0.0405 | 0.0405 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0047 | 0.0047 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0131 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0054 | 0.2734 | 0.2734 |
Echinococcus multilocularis | lamin dm0 | 0.0054 | 0.2734 | 0.2632 |
Brugia malayi | 6-phosphofructokinase | 0.0131 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0054 | 0.2734 | 0.2632 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0139 | 0.0139 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2642 | 0.2642 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0131 | 1 | 1 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0131 | 1 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0131 | 1 | 1 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0131 | 1 | 0.5 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0035 | 0.1036 | 1 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0131 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.621 | 0.5879 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2734 | 0.2734 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0035 | 0.1036 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0054 | 0.2734 | 0.2734 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.2231 | 0.2231 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0131 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.621 | 0.6157 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0029 | 0.0405 | 0.0405 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.621 | 0.5879 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0131 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0054 | 0.2734 | 0.21 |
Schistosoma mansoni | lamin | 0.0054 | 0.2734 | 0.21 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0035 | 0.1036 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0054 | 0.2734 | 0.2632 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.2231 | 0.2231 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.2231 | 0.2231 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0131 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.621 | 0.6157 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0035 | 0.1036 | 1 |
Brugia malayi | intermediate filament protein | 0.0054 | 0.2734 | 0.2734 |
Echinococcus multilocularis | musashi | 0.0054 | 0.2734 | 0.2632 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0131 | 1 | 1 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0131 | 1 | 0.5 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0131 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0054 | 0.2734 | 0.2632 |
Onchocerca volvulus | 0.0054 | 0.2734 | 0.5 | |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0035 | 0.1036 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0131 | 1 | 1 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0131 | 1 | 1 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0035 | 0.1036 | 1 |
Loa Loa (eye worm) | phosphofructokinase | 0.0131 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0131 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0054 | 0.2734 | 0.2734 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2231 | 0.2231 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0131 | 1 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.621 | 0.6157 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0131 | 1 | 1 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0035 | 0.1036 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0091 | 0.621 | 0.621 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0803 | 0.0803 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0131 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.621 | 0.5879 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0035 | 0.1036 | 1 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0035 | 0.1036 | 0.5 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0131 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0091 | 0.621 | 0.621 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.621 | 0.6157 |
Echinococcus multilocularis | lamin | 0.0054 | 0.2734 | 0.2632 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0131 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0054 | 0.2734 | 0.21 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0131 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.4921 uM | PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.