Detailed information for compound 1311007

Basic information

Technical information
  • TDR Targets ID: 1311007
  • Name: 3-pyrrolidin-1-ylpropyl 2-cyclohexyl-2-hydrox y-2-phenylacetate hydrochloride
  • MW: 381.937 | Formula: C21H32ClNO3
  • H donors: 1 H acceptors: 2 LogP: 5.03 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(c1ccccc1)(C1CCCCC1)O)OCCCN1CCCC1.Cl
  • InChi: 1S/C21H31NO3.ClH/c23-20(25-17-9-16-22-14-7-8-15-22)21(24,18-10-3-1-4-11-18)19-12-5-2-6-13-19;/h1,3-4,10-11,19,24H,2,5-9,12-17H2;1H
  • InChiKey: XMXVVZSPVANELK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-pyrrolidin-1-ylpropyl 2-cyclohexyl-2-hydroxy-2-phenyl-acetate hydrochloride
  • 2-cyclohexyl-2-hydroxy-2-phenylacetic acid 3-1-pyrrolidinylpropyl ester hydrochloride
  • 2-cyclohexyl-2-hydroxy-2-phenyl-acetic acid 3-pyrrolidin-1-ylpropyl ester hydrochloride
  • 3-pyrrolidin-1-ylpropyl 2-cyclohexyl-2-hydroxy-2-phenyl-ethanoate hydrochloride
  • Cyclohexyl-hydroxy-phenyl-acetic acid 3-pyrrolidin-1-yl-propyl ester
  • MLS001047432
  • SMR000425437

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0148 0.0403
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0148 0.0132
Echinococcus granulosus cpg binding protein 0.0033 0.0648 0.0633
Brugia malayi hypothetical protein 0.0006 0.003 0.0043
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0148 0.0132
Brugia malayi hypothetical protein 0.0039 0.0787 0.2356
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0118 0.0102
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1028 0.1028
Schistosoma mansoni nuclear receptor 0.0005 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0043
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0562 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0148 0.0403
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0148 0.0403
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0148 0.0132
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0148 0.0148
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0148 0.0132
Echinococcus multilocularis dnaJ subfamily B 0.0441 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0148 0.0403
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0148 0.0132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1028 0.1028
Echinococcus multilocularis cpg binding protein 0.0033 0.0648 0.0633
Brugia malayi ecdysteroid receptor 0.0011 0.0148 0.0403
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0253 0.2922
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.003 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0148 0.0403
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0043
Schistosoma mansoni hypothetical protein 0.0039 0.0787 0.0787
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0148 0.0132
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.003 0.0014
Entamoeba histolytica hypothetical protein 0.0039 0.0787 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0148 0.0132
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0148 0.0403
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0059 0.0000000022456
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0148 0.0403
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0148 0.0132
Brugia malayi steroid hormone receptor 0.0011 0.0148 0.0403
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0148 0.0132
Schistosoma mansoni hypothetical protein 0.0019 0.0335 0.0335
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0253 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0335 0.0319
Schistosoma mansoni cpg binding protein 0.0031 0.0608 0.0608
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0148 0.0132
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0118 0.0102
Schistosoma mansoni nuclear receptor 0.0005 0.0016 0.0016
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1277 0.3856
Entamoeba histolytica hypothetical protein 0.0039 0.0787 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.3287 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1028 0.1014
Schistosoma mansoni cpg binding protein 0.0033 0.0648 0.0648
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0148 0.0403
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0172 0.0157
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0019 0.0335 0.0335
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0172 0.1116
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0172 0.0478
Schistosoma mansoni hypothetical protein 0.0019 0.0335 0.0335
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0787 0.0772
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0148 0.0132
Schistosoma mansoni coup transcription factor 0.0011 0.0148 0.0148
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0148 0.0403
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0148 0.0148
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.003 0.0043
Brugia malayi CXXC zinc finger family protein 0.0031 0.0608 0.1808
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0074 0.0059
Schistosoma mansoni blooms syndrome DNA helicase 0.0006 0.0038 0.0038
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0059 0.0000000022456
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.003 0.0014
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.1028 0.3094
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0335 0.0974
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0148 0.0403
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0148 0.0132
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0059 0.0000000022456
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.003 0.003
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0253 0.3855
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0148 0.0403
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0059 0.0000000022456
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0148 0.0132
Onchocerca volvulus Huntingtin homolog 0.0148 0.3287 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0253 0.5
Loa Loa (eye worm) histone methyltransferase 0.001 0.0118 0.0311
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.1028 0.3094
Schistosoma mansoni hypothetical protein 0.0041 0.0841 0.0841
Schistosoma mansoni zinc finger protein 0.0005 0.0016 0.0016
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0016 0.0016
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0172 0.0478
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0115 0.0302
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0148 0.0403
Loa Loa (eye worm) hypothetical protein 0.006 0.1277 0.3856
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0787 0.0787
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.1242 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0148 0.0132
Treponema pallidum ATP-dependent DNA helicase 0.0006 0.0038 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.0038 0.0067
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0148 0.0148
Brugia malayi hypothetical protein 0.0148 0.3287 1
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0148 0.0403
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.0172 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0335 0.0974
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0016 0.0016
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0011 0.0148 0.0403
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0148 0.0403
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0148 0.0403
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0059 0.0000000022456
Entamoeba histolytica recQ family DNA helicase 0.0006 0.0038 0.0071
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0074 0.0059
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0148 0.0148
Brugia malayi nuclear receptor RXR 0.0006 0.003 0.0043
Entamoeba histolytica hypothetical protein 0.0039 0.0787 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0148 0.0132
Brugia malayi hypothetical protein 0.0006 0.003 0.0043
Loa Loa (eye worm) hypothetical protein 0.0011 0.0148 0.0403
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0148 0.0148
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0148 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0148 0.0403
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0172 0.0157
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0074 0.0059
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0148 0.0403
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0335 0.0974
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0059 0.0000000022456
Onchocerca volvulus 0.0011 0.0148 0.0403
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0148 0.0148
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0608 0.1808
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0148 0.0148
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0172 0.0478
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0148 0.0403
Entamoeba histolytica hypothetical protein 0.0039 0.0787 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0148 0.0403
Loa Loa (eye worm) hypothetical protein 0.0011 0.0148 0.0403
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0172 0.0157
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0335 0.0319
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0016 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0059 0.0000000022456
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0342 0.2524
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0172 0.0157
Schistosoma mansoni DNA helicase recq5 0.0012 0.0172 0.0172
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0148 0.0403
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0335 0.0319
Loa Loa (eye worm) RecQ helicase 0.0029 0.0562 0.167
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0148 0.0403
Echinococcus granulosus GPCR family 2 0.0019 0.0335 0.0319
Onchocerca volvulus 0.0031 0.0608 0.1808
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0562 0.0547
Loa Loa (eye worm) hypothetical protein 0.0148 0.3287 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1277 0.3856
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0148 0.0403
Loa Loa (eye worm) hypothetical protein 0.0146 0.3241 0.9858
Loa Loa (eye worm) hypothetical protein 0.0011 0.0148 0.0403
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0787 0.0772
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0148 0.0403
Brugia malayi nuclear receptor NHR-88 0.0011 0.0148 0.0403
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0148 0.0132
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0482 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0043
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.003 0.003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0148 0.0148
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0074 0.0074
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0841 0.2522
Loa Loa (eye worm) hypothetical protein 0.0041 0.0841 0.2522
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0347 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0148 0.0132
Loa Loa (eye worm) hypothetical protein 0.0011 0.0148 0.0403
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0562 1
Brugia malayi nuclear hormone receptor 0.0011 0.0148 0.0403
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0172 0.1116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1028 0.1028
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0148 0.0403
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0148 0.0403
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0016 0.0016
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1277 0.3856
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0148 0.0403
Loa Loa (eye worm) hypothetical protein 0.0019 0.0335 0.0974
Schistosoma mansoni cpg binding protein 0.0033 0.0648 0.0648
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0253 0.5
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.003 0.0043
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.1403 0.1403
Schistosoma mansoni DNA helicase recq1 0.0012 0.0172 0.0172
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0335 0.0319
Onchocerca volvulus Huntingtin homolog 0.0148 0.3287 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1028 0.1014
Schistosoma mansoni hypothetical protein 0.0441 1 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0335 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0148 0.0403
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0562 0.167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0148 0.0403
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0074 0.0059
Schistosoma mansoni hypothetical protein 0.0019 0.0335 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0148 0.0403
Echinococcus granulosus bloom syndrome protein 0.0029 0.0562 0.0547
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0043
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1028 0.1014
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0043
Loa Loa (eye worm) hypothetical protein 0.0011 0.0148 0.0403
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0148 0.0148
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1028 0.1014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0059 0.0000000022456
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0148 0.0132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0172 0.0478

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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