Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9228 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3818 | 0.4014 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.9039 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.3514 | 0.3678 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.724 | 0.801 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.405 | 0.3419 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1992 | 0.1993 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0191 | 0.0211 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.7886 | 0.8724 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.405 | 0.3419 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0535 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3391 | 0.3541 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.3514 | 0.7399 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.3514 | 0.2714 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.405 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0535 | 0.0592 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.9039 | 0.8936 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0535 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4163 | 0.4395 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.9039 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.724 | 0.801 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.9039 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.9039 | 0.979 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.3514 | 0.2714 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3378 | 0.2673 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.9039 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0047 | 0.3514 | 0.2824 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2951 | 0.3265 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2951 | 0.3265 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (binding) | 63.0957 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.