Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | transient receptor potential cation channel | 0.0014 | 0.00000020822 | 0.00000075753 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.074 | 0.0851 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0014 | 0.0022 | 0.0081 |
Schistosoma mansoni | transient receptor potential channel | 0.0014 | 0.00000020822 | 0.00000075753 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.074 | 0.0851 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.074 | 0.2693 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2749 | 0.3161 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.00000020822 | 0.00000023948 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.074 | 0.2693 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2749 | 0.3161 |
Trichomonas vaginalis | set domain proteins, putative | 0.0242 | 0.9978 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0014 | 0.0022 | 0.0081 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.074 | 0.2693 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0014 | 0.0022 | 0.0081 |
Leishmania major | hypothetical protein, unknown function | 0.0014 | 0 | 0.5 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0014 | 0 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.074 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.074 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2749 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0022 | 0.0026 |
Leishmania major | hypothetical protein, conserved | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.074 | 0.2693 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2749 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0014 | 0.00000020822 | 0.00000075753 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2749 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.074 | 0.2693 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2749 | 0.3161 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.074 | 0.2693 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0213 | 0.8695 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0014 | 0.00000020822 | 0.00000075753 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2749 | 1 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0014 | 0 | 0.5 |
Brugia malayi | olfactory channel protein osm-9 | 0.0014 | 0.0022 | 0.0026 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0014 | 0.0022 | 0.0081 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0691 | 0.2515 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2749 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2749 | 0.3161 |
Onchocerca volvulus | 0.0031 | 0.074 | 0.074 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2749 | 0.3161 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2749 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.5704 | 0.656 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2749 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0014 | 0.0022 | 0.0081 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.5704 | 0.656 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2749 | 0.3161 |
Brugia malayi | Pre-SET motif family protein | 0.0213 | 0.8695 | 1 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0014 | 0.0022 | 0.0081 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.5704 | 0.656 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.074 | 0.2693 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.00000020822 | 0.00000023948 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0014 | 0.00000020822 | 0.00000075753 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0329 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.