Detailed information for compound 1312355

Basic information

Technical information
  • TDR Targets ID: 1312355
  • Name: 2-(3-methylphenoxy)-N-[(4-sulfamoylphenyl)met hyl]propanamide
  • MW: 348.417 | Formula: C17H20N2O4S
  • H donors: 2 H acceptors: 3 LogP: 2.06 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(Oc1cccc(c1)C)C)NCc1ccc(cc1)S(=O)(=O)N
  • InChi: 1S/C17H20N2O4S/c1-12-4-3-5-15(10-12)23-13(2)17(20)19-11-14-6-8-16(9-7-14)24(18,21)22/h3-10,13H,11H2,1-2H3,(H,19,20)(H2,18,21,22)
  • InChiKey: JPTOHYXFYNIVOA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3-methylphenoxy)-N-(4-sulfamoylbenzyl)propionamide
  • MLS000705686
  • N-[4-(aminosulfonyl)benzyl]-2-(3-methylphenoxy)propanamide
  • SMR000231296
  • IVK/9172901

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0041 0.0166 0.3445
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1721 1 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0336 0.1895 0.1895
Loa Loa (eye worm) hypothetical protein 0.0291 0.163 0.163
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0069 0.1427
Leishmania major hypothetical protein, conserved 0.0041 0.0166 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0291 0.163 1
Trypanosoma cruzi amidase, putative 0.0041 0.0166 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0481 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0069 0.1427
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0291 0.163 0.163
Loa Loa (eye worm) hypothetical protein 0.0291 0.163 0.163
Loa Loa (eye worm) hypothetical protein 0.0291 0.163 0.163
Schistosoma mansoni amidase 0.0336 0.1895 0.1895
Loa Loa (eye worm) amidase 0.0041 0.0166 0.0166
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.0069 0.5
Loa Loa (eye worm) amidase 0.0041 0.0166 0.0166
Echinococcus multilocularis acetylcholinesterase 0.1721 1 1
Echinococcus multilocularis carboxylesterase 5A 0.1721 1 1
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0041 0.0166 0.0098
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0291 0.163 1
Trypanosoma cruzi amidase, putative 0.0041 0.0166 1
Loa Loa (eye worm) hypothetical protein 0.1721 1 1
Loa Loa (eye worm) hypothetical protein 0.0291 0.163 0.163
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0041 0.0166 0.3445
Mycobacterium tuberculosis Carboxylesterase LipT 0.0291 0.163 1
Schistosoma mansoni DNA helicase recq5 0.0024 0.0069 0.0069
Echinococcus multilocularis acetylcholinesterase 0.1721 1 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0481 0.2154
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0481 0.0416
Brugia malayi Amidase family protein 0.0041 0.0166 0.0098
Loa Loa (eye worm) hypothetical protein 0.0291 0.163 0.163
Brugia malayi Carboxylesterase family protein 0.1721 1 1
Echinococcus granulosus para nitrobenzyl esterase 0.0291 0.163 0.1572
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0291 0.163 1
Brugia malayi Amidase family protein 0.0041 0.0166 0.0098
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0119 0.122
Loa Loa (eye worm) hypothetical protein 0.0291 0.163 0.163
Trichomonas vaginalis spcc417.12 protein, putative 0.0291 0.163 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0119 0.2473
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0481 1
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0041 0.0166 0.1292
Brugia malayi Carboxylesterase family protein 0.0291 0.163 0.1572
Toxoplasma gondii hypothetical protein 0.0033 0.0119 0.2473
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0336 0.1895 0.1839
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0041 0.0166 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0291 0.0854
Brugia malayi Carboxylesterase family protein 0.0291 0.163 0.1572
Loa Loa (eye worm) hypothetical protein 0.1721 1 1
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0069 1
Loa Loa (eye worm) hypothetical protein 0.0291 0.163 0.163
Echinococcus granulosus fatty acid amide hydrolase 1 0.0336 0.1895 0.1839
Loa Loa (eye worm) carboxylesterase 0.0291 0.163 0.163
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0291 0.163 1
Echinococcus multilocularis neuroligin 0.0291 0.163 0.1572
Schistosoma mansoni fatty-acid amide hydrolase 0.0041 0.0166 0.0166
Onchocerca volvulus 0.0291 0.163 0.5
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0481 1
Echinococcus granulosus acetylcholinesterase 0.1721 1 1
Loa Loa (eye worm) RecQ helicase 0.0024 0.0069 0.0069
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0041 0.0166 0.0166
Onchocerca volvulus 0.0291 0.163 0.5
Brugia malayi hypothetical protein 0.0291 0.163 0.1572
Loa Loa (eye worm) hypothetical protein 0.0094 0.0481 0.0481
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0481 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0291 0.163 0.163
Loa Loa (eye worm) carboxylesterase 0.1721 1 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0291 0.163 0.1572
Brugia malayi Probable ClpP-like protease 0.0094 0.0481 0.0416
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0481 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0336 0.1895 0.1839
Onchocerca volvulus 0.0291 0.163 0.5
Loa Loa (eye worm) acetylcholinesterase 1 0.1721 1 1
Brugia malayi amidase 0.0336 0.1895 0.1839
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0481 1
Brugia malayi Carboxylesterase family protein 0.0291 0.163 0.1572
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0481 0.0416
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0481 0.2154
Echinococcus granulosus carboxylesterase 5A 0.1721 1 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0291 0.163 0.1572
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0291 0.4744
Schistosoma mansoni DNA helicase recq1 0.0024 0.0069 0.0069
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0481 0.0481
Onchocerca volvulus 0.0291 0.163 0.5
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0481 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0291 0.0854
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0291 0.163 0.1572
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0069 0.4142
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0291 0.163 0.163
Loa Loa (eye worm) hypothetical protein 0.0024 0.0069 0.0069
Schistosoma mansoni BC026374 protein (S09 family) 0.0291 0.163 0.163
Echinococcus multilocularis BC026374 protein (S09 family) 0.0291 0.163 0.1572
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0291 0.0224
Loa Loa (eye worm) hypothetical protein 0.0336 0.1895 0.1895
Onchocerca volvulus 0.0291 0.163 0.5
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0041 0.0166 0.1292
Brugia malayi Carboxylesterase family protein 0.0291 0.163 0.1572
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0041 0.0166 0.2354
Loa Loa (eye worm) carboxylesterase 0.0291 0.163 0.163
Echinococcus granulosus acetylcholinesterase 0.1721 1 1
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0041 0.0166 0.0098
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0069 0.0069
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0291 0.0224
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0481 1
Echinococcus granulosus BC026374 protein S09 family 0.0291 0.163 0.1572
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0119 0.2473
Brugia malayi putative amidase 0.0041 0.0166 0.0098
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0041 0.0166 0.0098
Schistosoma mansoni neuroligin 3 (S09 family) 0.0291 0.163 0.163
Echinococcus granulosus neuroligin 0.0291 0.163 0.1572
Echinococcus granulosus fatty acid amide hydrolase 1 0.0336 0.1895 0.1839
Echinococcus granulosus fatty acid amide hydrolase 1 0.0041 0.0166 0.0098
Loa Loa (eye worm) hypothetical protein 0.0012 0.000000000057761 0.000000000057761
Schistosoma mansoni acetylcholinesterase 0.0291 0.163 0.163
Schistosoma mansoni gliotactin 0.0291 0.163 0.163
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0481 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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