Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2896 | 0.3051 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1159 | 0.1159 |
Loa Loa (eye worm) | tubulin alpha-3 chain | 0.0026 | 0.0675 | 0.0675 |
Echinococcus multilocularis | beta tubulin | 0.0121 | 0.7954 | 1 |
Echinococcus multilocularis | lamin | 0.0033 | 0.1159 | 0.0664 |
Brugia malayi | Tubulin gamma chain | 0.0026 | 0.0675 | 0.0675 |
Leishmania major | beta tubulin | 0.0121 | 0.7954 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.0121 | 0.7954 | 0.7954 |
Entamoeba histolytica | tubulin family protein | 0.0121 | 0.7954 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0121 | 0.7954 | 1 |
Leishmania major | beta tubulin | 0.0121 | 0.7954 | 1 |
Toxoplasma gondii | beta tubulin | 0.0121 | 0.7954 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2896 | 0.3051 |
Schistosoma mansoni | lamin | 0.0033 | 0.1159 | 0.0664 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.1159 | 0.0664 |
Brugia malayi | Tubulin alpha chain | 0.0026 | 0.0675 | 0.0675 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0121 | 0.7954 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0121 | 0.7954 | 0.7954 |
Brugia malayi | Tubulin beta chain | 0.0026 | 0.0675 | 0.0675 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0121 | 0.7954 | 1 |
Brugia malayi | Cell division protein ftsZ | 0.0026 | 0.0675 | 0.0675 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1159 | 0.1159 |
Leishmania major | beta tubulin | 0.0121 | 0.7954 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0121 | 0.7954 | 1 |
Giardia lamblia | Beta tubulin | 0.0121 | 0.7954 | 1 |
Loa Loa (eye worm) | alpha-tubulin | 0.0026 | 0.0675 | 0.0675 |
Echinococcus granulosus | beta tubulin | 0.0121 | 0.7954 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0121 | 0.7954 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0121 | 0.7954 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0121 | 0.7954 | 1 |
Trypanosoma brucei | beta tubulin | 0.0121 | 0.7954 | 1 |
Mycobacterium leprae | cell division protein FtsZ | 0.0026 | 0.0675 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.1159 | 0.0664 |
Treponema pallidum | cell division protein FtsZ | 0.0026 | 0.0675 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1159 | 0.1159 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.1159 | 0.0664 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0026 | 0.0675 | 0.0675 |
Brugia malayi | Tubulin alpha-2 chain | 0.0026 | 0.0675 | 0.0675 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2896 | 0.3051 |
Mycobacterium tuberculosis | Cell division protein FtsZ | 0.0026 | 0.0675 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1159 | 0.1159 |
Mycobacterium ulcerans | cell division protein FtsZ | 0.0026 | 0.0675 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0121 | 0.7954 | 1 |
Leishmania major | beta tubulin | 0.0121 | 0.7954 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.0121 | 0.7954 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0121 | 0.7954 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0121 | 0.7954 | 1 |
Leishmania major | beta tubulin | 0.0121 | 0.7954 | 1 |
Echinococcus multilocularis | tubulin subunit beta | 0.0121 | 0.7954 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0121 | 0.7954 | 0.7954 |
Echinococcus granulosus | tubulin subunit beta | 0.0121 | 0.7954 | 1 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsZ | 0.0026 | 0.0675 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0121 | 0.7954 | 1 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0026 | 0.0675 | 0.0675 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 1 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0121 | 0.7954 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2896 | 0.3051 |
Brugia malayi | tubulin alpha-2 chain | 0.0026 | 0.0675 | 0.0675 |
Trypanosoma brucei | beta tubulin | 0.0121 | 0.7954 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0675 | 0.0675 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0121 | 0.7954 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0121 | 0.7954 | 1 |
Giardia lamblia | Beta tubulin | 0.0121 | 0.7954 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0121 | 0.7954 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0121 | 0.7954 | 0.7954 |
Brugia malayi | Tubulin alpha chain | 0.0026 | 0.0675 | 0.0675 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2896 | 0.2896 |
Leishmania major | beta tubulin | 0.0121 | 0.7954 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0121 | 0.7954 | 0.7954 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1113 | 0.1113 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0121 | 0.7954 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2896 | 0.3051 |
Loa Loa (eye worm) | tubulin beta chain | 0.0121 | 0.7954 | 0.7954 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2896 | 0.3051 |
Echinococcus multilocularis | beta tubulin | 0.0121 | 0.7954 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0121 | 0.7954 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.1159 | 0.0664 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0121 | 0.7954 | 1 |
Brugia malayi | Tubulin alpha-2 chain | 0.0026 | 0.0675 | 0.0675 |
Leishmania major | beta tubulin | 0.0121 | 0.7954 | 1 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0026 | 0.0675 | 0.0675 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2896 | 0.3051 |
Leishmania major | beta tubulin | 0.0121 | 0.7954 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0121 | 0.7954 | 1 |
Brugia malayi | alpha-tubulin | 0.0026 | 0.0675 | 0.0675 |
Loa Loa (eye worm) | alpha-tubulin | 0.0026 | 0.0675 | 0.0675 |
Leishmania major | beta tubulin | 0.0121 | 0.7954 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0121 | 0.7954 | 0.7954 |
Leishmania major | beta tubulin | 0.0121 | 0.7954 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.1159 | 0.0664 |
Leishmania major | beta tubulin | 0.0121 | 0.7954 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0121 | 0.7954 | 0.7954 |
Giardia lamblia | Beta tubulin | 0.0121 | 0.7954 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0121 | 0.7954 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0121 | 0.7954 | 1 |
Leishmania major | beta tubulin | 0.0121 | 0.7954 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1159 | 0.1159 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0121 | 0.7954 | 0.7954 |
Leishmania major | beta tubulin | 0.0121 | 0.7954 | 1 |
Leishmania major | beta tubulin | 0.0121 | 0.7954 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0121 | 0.7954 | 1 |
Brugia malayi | tubulin alpha chain - mouse | 0.0026 | 0.0675 | 0.0675 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0121 | 0.7954 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.1159 | 0.0664 |
Loa Loa (eye worm) | tubulin beta chain | 0.0026 | 0.0675 | 0.0675 |
Trypanosoma brucei | beta tubulin | 0.0121 | 0.7954 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2896 | 0.2896 |
Schistosoma mansoni | tubulin subunit beta | 0.0121 | 0.7954 | 1 |
Trypanosoma brucei | beta tubulin | 0.0121 | 0.7954 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0121 | 0.7954 | 1 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0026 | 0.0675 | 0.0675 |
Echinococcus granulosus | beta tubulin | 0.0121 | 0.7954 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0121 | 0.7954 | 1 |
Leishmania major | beta tubulin | 0.0121 | 0.7954 | 1 |
Leishmania major | beta tubulin | 0.0121 | 0.7954 | 1 |
Leishmania major | beta tubulin | 0.0121 | 0.7954 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0121 | 0.7954 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0121 | 0.7954 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0121 | 0.7954 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0121 | 0.7954 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.1159 | 0.0664 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0675 | 0.0675 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0121 | 0.7954 | 1 |
Leishmania major | beta tubulin | 0.0121 | 0.7954 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0415 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 0.1995 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (binding) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.