Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0323 | 0 | 0.5 | |
Onchocerca volvulus | 0.0323 | 0 | 0.5 | |
Onchocerca volvulus | 0.0323 | 0 | 0.5 | |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.4135 | 0.4135 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.191 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.191 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.191 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0323 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.191 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0323 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0323 | 0 | 0.5 |
Onchocerca volvulus | 0.0323 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.191 | 1 | 1 |
Onchocerca volvulus | 0.0323 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0323 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.191 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.191 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.191 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0323 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.191 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.191 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.191 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.191 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0323 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 4.609 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.