Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 | |
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0219 | 0.0254 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0174 | 0.5606 | 0.8168 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0174 | 0.5606 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.6815 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0174 | 0.5606 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0174 | 0.5606 | 0.8168 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0219 | 0.0078 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0174 | 0.5606 | 0.6487 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6815 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0.0219 | 0.0391 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0174 | 0.5606 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0174 | 0.5606 | 0.8168 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0174 | 0.5606 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0174 | 0.5606 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6815 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0174 | 0.5606 | 0.6487 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0174 | 0.5606 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0174 | 0.5606 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0174 | 0.5606 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0174 | 0.5606 | 0.8168 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0174 | 0.5606 | 0.8168 |
Brugia malayi | isocitrate dehydrogenase | 0.0174 | 0.5606 | 0.6487 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.8642 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0174 | 0.5606 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.0219 | 0.0254 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0174 | 0.5606 | 0.8182 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0174 | 0.5606 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0174 | 0.5606 | 0.8168 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.8642 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.6815 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0036 | 0.0219 | 0.0391 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0928 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 0.1889 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.