Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0226 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0226 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0226 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0226 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0226 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0226 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0226 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0226 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0226 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0226 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0226 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0226 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0226 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0226 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0226 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0226 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0226 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0226 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0226 | 1 | 1 |
Onchocerca volvulus | 0.0226 | 1 | 0.5 | |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0226 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0226 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0226 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0226 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.8034 | 0.8034 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0226 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8034 | 0.8034 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.2351 | 0.2351 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0226 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8034 | 0.8034 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.2351 | 0.2351 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0226 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.2351 | 0.2351 |
Echinococcus granulosus | geminin | 0.0205 | 0.8034 | 0.8034 |
Brugia malayi | nuclear hormone receptor | 0.0226 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0226 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0226 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0226 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0226 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0226 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0226 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0226 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0226 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0226 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0226 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0226 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0226 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0226 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0226 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0226 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0226 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0226 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0226 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0226 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0226 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0226 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1458 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.8913 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.