TDR Targets

Basic information

Technical information

TDR Targets ID: 1313081
Name: MLS000078803
MW: 194.23 | Formula: C10H14N2O2
H donors: 2 H acceptors: 2 LogP: 0.54 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: [O-][N+]12CCN(CC1)c1c2cccc1.O
InChi: 1S/C10H12N2O.H2O/c13-12-7-5-11(6-8-12)9-3-1-2-4-10(9)12;/h1-4H,5-8H2;1H2
InChiKey: MBPMTECXEYODST-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

SMR000057986

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	patched 1	0.0042	0.0349	0.0858
Schistosoma mansoni	voltage-gated potassium channel	0.0175	0.2012	0.4951
Loa Loa (eye worm)	hypothetical protein	0.002	0.0075	0.0266
Brugia malayi	CHE-14 protein	0.0042	0.0349	0.1241
Brugia malayi	Steroid receptor seven-up type 2	0.002	0.0075	0.0266
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0617	0.152
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0054	0.0496	0.0499
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.023	0.0819
Schistosoma mansoni	hypothetical protein	0.0072	0.0722	0.1778
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0428	0.1522
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0016	0.0025	0.0026
Echinococcus multilocularis	Niemann Pick C1 protein	0.0098	0.1049	0.1056
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0194	0.0478
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0396	0.0399
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0054	0.0496	0.5
Echinococcus multilocularis	ecdysone induced protein 78C	0.002	0.0075	0.0075
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0054	0.0496	0.122
Echinococcus granulosus	intermediate filament protein	0.0033	0.023	0.0566
Echinococcus multilocularis	protein patched	0.0042	0.0349	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0175	0.2012	0.7159
Brugia malayi	hypothetical protein	0.0237	0.2792	0.9936
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0617	0.2197
Echinococcus granulosus	lamin	0.0033	0.023	0.0566
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.002	0.0075	0.0075
Brugia malayi	nuclear receptor NHR-88	0.002	0.0075	0.0266
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.002	0.0075	0.0266
Schistosoma mansoni	Smad4	0.0016	0.0025	0.0063
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0099	0.1068	0.263
Loa Loa (eye worm)	hypothetical protein	0.002	0.0075	0.0266
Brugia malayi	Isocitrate dehydrogenase	0.0054	0.0496	0.1764
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.002	0.0075	0.0266
Onchocerca volvulus	Huntingtin homolog	0.0122	0.1349	0.472
Toxoplasma gondii	isocitrate dehydrogenase	0.0054	0.0496	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0223	0.0792
Echinococcus granulosus	potassium voltage gated channel protein	0.0175	0.2012	0.4951
Schistosoma mansoni	hypothetical protein	0.0338	0.4063	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.002	0.0075	0.0075
Toxoplasma gondii	isocitrate dehydrogenase	0.0054	0.0496	1
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0054	0.0496	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.002	0.0075	0.0184
Echinococcus multilocularis	X box binding protein 1	0.0287	0.3414	0.3437
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.002	0.0075	0.0184
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.002	0.0075	0.0266
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.002	0.0075	0.0184
Brugia malayi	MH2 domain containing protein	0.0016	0.0025	0.009
Brugia malayi	photoreceptor-specific nuclear receptor	0.002	0.0075	0.0266
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.0722	0.1778
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0054	0.0496	0.0499
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.002	0.0075	0.0266
Schistosoma mansoni	retinoic acid receptor RXR	0.002	0.0075	0.0184
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.0722	0.1778
Brugia malayi	Nuclear hormone receptor-like 1	0.002	0.0075	0.0266
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0194	0.0478
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0349	0.0858
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.002	0.0075	0.0184
Loa Loa (eye worm)	hypothetical protein	0.002	0.0075	0.0266
Loa Loa (eye worm)	transcription factor SMAD2	0.0238	0.281	1
Onchocerca volvulus	Huntingtin homolog	0.0122	0.1349	0.472
Loa Loa (eye worm)	hypothetical protein	0.002	0.0075	0.0266
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0016	0.0019	0.0046
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0054	0.0496	0.0499
Brugia malayi	RNA binding protein	0.0063	0.0617	0.2197
Loa Loa (eye worm)	hypothetical protein	0.002	0.0075	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0237	0.2792	0.9936
Echinococcus multilocularis	lamin dm0	0.0033	0.023	0.0232
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.002	0.0075	0.0266
Brugia malayi	steroid hormone receptor	0.002	0.0075	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1349	0.4802
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0349	0.1241
Trichomonas vaginalis	set domain proteins, putative	0.0236	0.2775	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0075	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0467	0.1663
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.002	0.0075	0.0075
Brugia malayi	isocitrate dehydrogenase	0.0054	0.0496	0.1764
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0617	0.152
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0075	0.0184
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0175	0.2012	0.7159
Schistosoma mansoni	hypothetical protein	0.0041	0.033	0.0811
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0054	0.0496	0.5
Echinococcus granulosus	Niemann Pick C1 protein	0.014	0.1576	0.3879
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0175	0.2012	0.4951
Loa Loa (eye worm)	Smad1	0.0016	0.0025	0.009
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.023	0.0819
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0054	0.0496	0.122
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.002	0.0075	0.0184
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0098	0.1049	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0194	0.0478
Schistosoma mansoni	hypothetical protein	0.0338	0.4063	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0396	0.0975
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0617	0.0622
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0075	0.0266
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0423	0.0426
Echinococcus multilocularis	Smad4	0.0016	0.0025	0.0026
Echinococcus multilocularis	geminin	0.0338	0.4063	0.409
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0075	0.0266
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0016	0.0025	0.0026
Echinococcus granulosus	mothers against decapentaplegic 5	0.0016	0.0025	0.0063
Loa Loa (eye worm)	hypothetical protein	0.002	0.0075	0.0266
Echinococcus granulosus	expressed conserved protein	0.0092	0.0975	0.24
Echinococcus granulosus	Niemann Pick C1 protein	0.0098	0.1049	0.2583
Schistosoma mansoni	thyroid hormone receptor	0.002	0.0075	0.0184
Echinococcus multilocularis	lamin	0.0033	0.023	0.0232
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0016	0.0025	0.0063
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0396	0.0975
Brugia malayi	MH1 domain containing protein	0.0016	0.0025	0.009
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0019	0.0067
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0396	0.0975
Loa Loa (eye worm)	hypothetical protein	0.002	0.0075	0.0266
Echinococcus multilocularis	expressed conserved protein	0.0092	0.0975	0.0982
Onchocerca volvulus		0.0033	0.023	0.0575
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0194	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0033	0.023	0.0819
Loa Loa (eye worm)	MH1 domain-containing protein	0.0016	0.0025	0.009
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0617	0.152
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0011	0.0041
Schistosoma mansoni	hypothetical protein	0.0048	0.0428	0.1052
Loa Loa (eye worm)	MH2 domain-containing protein	0.0238	0.281	1
Schistosoma mansoni	intermediate filament proteins	0.0033	0.023	0.0566
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.0722	0.0727
Brugia malayi	intermediate filament protein	0.0033	0.023	0.0819
Echinococcus multilocularis	smad	0.0016	0.0025	0.0026
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.002	0.0075	0.0184
Echinococcus granulosus	geminin	0.0338	0.4063	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.002	0.0075	0.0266
Schistosoma mansoni	lamin	0.0033	0.023	0.0566
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0041	0.0144
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0396	0.0975
Echinococcus multilocularis	Niemann Pick C1 protein	0.014	0.1576	0.1587
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.002	0.0075	0.0075
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.002	0.0075	0.0184
Loa Loa (eye worm)	steroid hormone receptor	0.002	0.0075	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0011	0.0041
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0075	0.0075
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.002	0.0075	0.0184
Brugia malayi	TAR-binding protein	0.0063	0.0617	0.2197
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1349	0.4802
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0054	0.0496	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.002	0.0075	0.0266
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.018	0.0444
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0054	0.0496	0.5
Echinococcus granulosus	lamin dm0	0.0033	0.023	0.0566
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0054	0.0496	0.5
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.023	0.0819
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0075	0.0266
Echinococcus granulosus	FTZ F1 alpha	0.002	0.0075	0.0184
Onchocerca volvulus		0.0236	0.2775	1
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0054	0.0496	0.5
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0617	0.2197
Onchocerca volvulus		0.003	0.0194	0.0442
Brugia malayi	nuclear hormone receptor	0.002	0.0075	0.0266
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.002	0.0075	0.0266
Echinococcus granulosus	X box binding protein 1	0.0287	0.3414	0.8403
Echinococcus granulosus	Smad4	0.0016	0.0025	0.0063
Loa Loa (eye worm)	MH2 domain-containing protein	0.0016	0.0025	0.009
Schistosoma mansoni	RAR-like nuclear receptor	0.002	0.0075	0.0184
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0025	0.0063
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0054	0.0496	0.0499
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.2792	0.6872
Brugia malayi	hypothetical protein	0.0122	0.1349	0.4802
Onchocerca volvulus		0.0033	0.023	0.0575
Echinococcus multilocularis	isocitrate dehydrogenase	0.0054	0.0496	0.0499
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0396	0.0399
Brugia malayi	hypothetical protein	0.0072	0.0722	0.257
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0054	0.0496	0.1764
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.002	0.0075	0.0266
Schistosoma mansoni	thyroid hormone receptor	0.002	0.0075	0.0184
Brugia malayi	Pre-SET motif family protein	0.003	0.0194	0.0691
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.002	0.0075	0.0184
Schistosoma mansoni	hypothetical protein	0.0041	0.033	0.0811
Brugia malayi	MH2 domain containing protein	0.0238	0.281	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.002	0.0075	0.0184
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.002	0.0075	0.0184
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.002	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1049	0.3735
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0167	0.1916	0.1929
Schistosoma mansoni	voltage-gated potassium channel	0.0175	0.2012	0.4951
Loa Loa (eye worm)	hypothetical protein	0.002	0.0075	0.0266
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0617	0.2197
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0025	0.0063
Brugia malayi	ecdysteroid receptor	0.002	0.0075	0.0266
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0016	0.0025	0.0063
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0016	0.0019	0.0019
Echinococcus granulosus	ecdysone induced protein 78C	0.002	0.0075	0.0184
Brugia malayi	MH2 domain containing protein	0.0016	0.0025	0.009
Echinococcus multilocularis	FTZ F1 alpha	0.002	0.0075	0.0075
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0025	0.0063
Echinococcus granulosus	smad	0.0016	0.0025	0.0063
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0349	0.1241
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0194	0.0195
Schistosoma mansoni	smad	0.0016	0.0025	0.0063
Brugia malayi	Pre-SET motif family protein	0.0207	0.2417	0.8601
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0075	0.0266
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.002	0.0075	0.0184
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0349	0.0858
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0396	0.141
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0075	0.0266
Schistosoma mansoni	hypothetical protein	0.0041	0.033	0.0811
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.0812	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0617	0.152
Schistosoma mansoni	coup transcription factor	0.002	0.0075	0.0184
Echinococcus multilocularis	potassium voltage gated channel protein	0.0175	0.2012	0.2025
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0428	0.1052
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0075	0.0075
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.002	0.0075	0.0266
Brugia malayi	Smad1	0.0016	0.0025	0.009
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0194	0.0195
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.002	0.0075	0.0266
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0396	0.141
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0617	0.152
Echinococcus multilocularis	musashi	0.0033	0.023	0.0232
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0806	0.9933	1
Schistosoma mansoni	lamin	0.0033	0.023	0.0566
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0349	0.0351
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0075	0.0184
Mycobacterium ulcerans	proteasome PrcA	0.0812	1	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.002	0.0075	0.0266
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0617	0.2197
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0041	0.0144
Loa Loa (eye worm)	hypothetical protein	0.003	0.0194	0.0691
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.002	0.0075	0.0266
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0207	0.2417	0.8601
Schistosoma mansoni	hypothetical protein	0.0041	0.033	0.0811
Schistosoma mansoni	hypothetical protein	0.0287	0.3414	0.8403
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.2792	0.2811
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0396	0.0975
Brugia malayi	Niemann-Pick C1 protein precursor	0.0098	0.1049	0.3735
Onchocerca volvulus		0.0048	0.0428	0.1307
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0617	0.152
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0075	0.0266
Brugia malayi	MH1 domain containing protein	0.0016	0.0025	0.009
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.002	0.0075	0.0266
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0194	0.0478

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.3323 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	7.0795 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1464828

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1313081