Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8867 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4393 | 0.4331 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.3781 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3781 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4393 | 0.5381 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3781 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.3781 | 0.4445 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0014 | 0.1361 | 0.108 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.3781 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.4393 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0525 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3781 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4678 | 0.6015 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3781 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0634 | 0.0531 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.1361 | 0.1265 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0014 | 0.1361 | 0.108 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.7357 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.7357 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.7357 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7357 | 0.7328 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.7357 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.7357 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7357 | 0.7328 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.3781 | 0.4428 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.2226 | 0.2029 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7357 | 0.7328 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.7357 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0939 | 0.0453 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4678 | 0.4619 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0939 | 0.0453 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4393 | 0.5396 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.3781 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4678 | 0.4619 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4678 | 0.6015 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1413 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.3115 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.