Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0519 | 0.1334 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0519 | 0.0519 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3637 | 0.3637 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0063 | 0.3886 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0519 | 0.1334 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.2194 | 0.2194 |
Brugia malayi | cytochrome P450 | 0.0063 | 0.3886 | 0.3886 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0519 | 0.1334 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0112 | 0.7599 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0063 | 0.3886 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0519 | 0.1334 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0063 | 0.3886 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0063 | 0.3886 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0112 | 0.7599 | 0.7599 |
Schistosoma mansoni | cytochrome P450 | 0.0063 | 0.3886 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0112 | 0.7599 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0112 | 0.7599 | 0.7599 |
Brugia malayi | Cytochrome P450 family protein | 0.0086 | 0.5573 | 0.5573 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0063 | 0.3886 | 0.5 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0063 | 0.3886 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0519 | 0.1334 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0063 | 0.3886 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0063 | 0.3886 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0063 | 0.3886 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0519 | 0.1334 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3637 | 0.3637 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0063 | 0.3886 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0519 | 0.1334 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0063 | 0.3886 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0063 | 0.3886 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0063 | 0.3886 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2194 | 0.2194 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0519 | 0.0519 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2787 | 0.2787 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0063 | 0.3886 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0063 | 0.3886 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0086 | 0.5573 | 0.5573 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0063 | 0.3886 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.2194 | 0.5644 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0063 | 0.3886 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0519 | 0.0519 |
Trypanosoma brucei | cytochrome P450, putative | 0.0112 | 0.7599 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0112 | 0.7599 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0112 | 0.7599 | 0.7599 |
Brugia malayi | Cytochrome P450 family protein | 0.0112 | 0.7599 | 0.7599 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0112 | 0.7599 | 0.7599 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.3886 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0063 | 0.3886 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3637 | 0.3637 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0112 | 0.7599 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0519 | 0.1334 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0519 | 0.1334 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0063 | 0.3886 | 0.5 |
Echinococcus multilocularis | 0.0063 | 0.3886 | 1 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3637 | 0.3637 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0063 | 0.3886 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0063 | 0.3886 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0063 | 0.3886 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0519 | 0.1334 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0519 | 0.0519 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0063 | 0.3886 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0063 | 0.3886 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0063 | 0.3886 | 0.3886 |
Loa Loa (eye worm) | cytochrome P450 | 0.0063 | 0.3886 | 0.3886 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 33.8078 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.