Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1571 | 0.142 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1571 | 0.142 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0176 | 0.0176 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0176 | 0.0176 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3217 | 0.3217 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0176 | 0.0305 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2355 | 0.4066 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3217 | 0.5485 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0176 | 0.0305 |
Brugia malayi | hypothetical protein | 0.0036 | 0.1058 | 0.1696 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1058 | 0.5 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0892 | 0.0892 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2355 | 0.3971 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1571 | 0.142 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0176 | 0.0149 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0892 | 0.0728 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0892 | 0.0892 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3217 | 0.3096 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0092 | 0.0158 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1058 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2355 | 0.3971 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0892 | 0.0892 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3217 | 0.3096 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.5791 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3217 | 0.5556 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3217 | 0.3096 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.5791 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1346 | 0.2325 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3217 | 0.5556 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1571 | 0.2596 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.1058 | 0.0898 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0892 | 0.154 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2355 | 0.4066 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0892 | 0.154 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1571 | 0.1571 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0176 | 0.0176 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0176 | 0.0176 |
Onchocerca volvulus | 0.0033 | 0.0892 | 0.5 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3217 | 0.5485 |
Onchocerca volvulus | 0.0033 | 0.0892 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1346 | 0.1191 |
Echinococcus granulosus | lamin | 0.0033 | 0.0892 | 0.0892 |
Schistosoma mansoni | lamin | 0.0033 | 0.0892 | 0.0728 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1571 | 0.1571 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1571 | 0.1571 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.1058 | 0.1058 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0892 | 0.0892 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0176 | 0.0176 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3217 | 0.5556 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3217 | 0.3096 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1571 | 0.1571 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3217 | 0.3217 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3217 | 0.5485 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0176 | 0.0149 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1346 | 0.2202 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.1058 | 0.1058 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0892 | 0.154 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1058 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1571 | 0.2713 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3217 | 0.3096 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1058 | 0.0898 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0892 | 0.1404 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.5791 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0176 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.086 | 0.1486 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0892 | 0.0892 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0892 | 0.1404 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.0892 | 0.0728 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1058 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0126 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.1032 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.5119 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 8.1995 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.