Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.4033 | 0.4033 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.4033 | 0.4033 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0183 | 0.4033 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.3317 | 0.3317 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0183 | 0.4033 | 0.4033 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0163 | 0.3317 | 0.3317 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0183 | 0.4033 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.3317 | 0.3317 |
Brugia malayi | hypothetical protein | 0.0163 | 0.3317 | 0.3317 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.3317 | 0.3317 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.4033 | 0.4033 |
Brugia malayi | nuclear receptor RXR | 0.0183 | 0.4033 | 0.4033 |
Brugia malayi | nuclear hormone receptor | 0.0163 | 0.3317 | 0.3317 |
Brugia malayi | tailless protein | 0.0163 | 0.3317 | 0.3317 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0163 | 0.3317 | 0.3317 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0183 | 0.4033 | 0.4033 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0163 | 0.3317 | 0.3317 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.3317 | 0.3317 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.3317 | 0.3317 |
Brugia malayi | nuclear receptor NHR-88 | 0.0163 | 0.3317 | 0.3317 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0183 | 0.4033 | 0.4033 |
Brugia malayi | conserved hypotetical protein | 0.0163 | 0.3317 | 0.3317 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.3317 | 0.3317 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.3317 | 0.3317 |
Brugia malayi | ecdysone receptor | 0.0163 | 0.3317 | 0.3317 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0163 | 0.3317 | 0.3317 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.4033 | 0.4033 |
Brugia malayi | nuclear receptor NHR-67 | 0.0163 | 0.3317 | 0.3317 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.3317 | 0.3317 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0163 | 0.3317 | 0.3317 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0163 | 0.3317 | 0.3317 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.3317 | 0.3317 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0183 | 0.4033 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0183 | 0.4033 | 0.4033 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.3317 | 0.3317 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0163 | 0.3317 | 0.3317 |
Loa Loa (eye worm) | DR-78 | 0.0163 | 0.3317 | 0.3317 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0163 | 0.3317 | 0.3317 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.4033 | 0.4033 |
Brugia malayi | hypothetical protein | 0.0163 | 0.3317 | 0.3317 |
Brugia malayi | nuclear receptor RXR | 0.0163 | 0.3317 | 0.3317 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0183 | 0.4033 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.3317 | 0.3317 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.3317 | 0.3317 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0163 | 0.3317 | 0.3317 |
Brugia malayi | hypothetical protein | 0.0183 | 0.4033 | 0.4033 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.3317 | 0.3317 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.