Detailed information for compound 1313638

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 421.351 | Formula: C19H21BrN2O2S
  • H donors: 0 H acceptors: 2 LogP: 4.11 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc2c(c1)N1CCC[C@@H]1CN(S2(=O)=O)[C@H](c1ccccc1)C
  • InChi: 1S/C19H21BrN2O2S/c1-14(15-6-3-2-4-7-15)22-13-17-8-5-11-21(17)18-12-16(20)9-10-19(18)25(22,23)24/h2-4,6-7,9-10,12,14,17H,5,8,11,13H2,1H3/t14-,17+/m0/s1
  • InChiKey: HYHZQJJFICKXKO-WMLDXEAASA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 4 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.0183 0.0182
Brugia malayi hypothetical protein 0.0046 0.0084 0.0153
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0013
Loa Loa (eye worm) cytochrome P450 family protein 0.0069 0.0149 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0171 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0171 0.0307
Echinococcus multilocularis regulator of G protein signaling 0.0046 0.0084 0.0082
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0084 0.0129
Echinococcus granulosus lipoxygenase domain containing protein 0.017 0.0435 0.0679
Schistosoma mansoni fkbp-rapamycin associated protein 0.0018 0.0004 0.0005
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0023 0.0016 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0171 0.0307
Giardia lamblia GTOR 0.0097 0.0228 0.0399
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0017 0.0024
Echinococcus granulosus Smad4 0.0043 0.0075 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0084 0.0146
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0101 0.0239 0.0373
Echinococcus granulosus neuropeptide s receptor 0.1022 0.2855 0.4464
Schistosoma mansoni alpha tubulin 0.1401 0.3932 0.6149
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0123 0.0226
Echinococcus granulosus single minded 2 0.0157 0.0398 0.0621
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0235 0.062 0.481
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0033 0.0045 0.0043
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0269 0.0486
Loa Loa (eye worm) tubulin beta-1 chain 0.1936 0.5452 1
Echinococcus multilocularis Niemann Pick C1 protein 0.031 0.0832 0.0831
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0017 0.0024
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0084 0.0191 0.1421
Echinococcus multilocularis CREB binding protein 0.015 0.0377 0.0376
Schistosoma mansoni organic anion transporter 0.009 0.0209 0.0325
Mycobacterium leprae Conserved hypothetical protein 0.0023 0.0016 0.0013
Plasmodium vivax SET domain protein, putative 0.0095 0.0223 0.0407
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0101 0.0239 0.0373
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0101 0.0239 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0171 0.0307
Loa Loa (eye worm) hypothetical protein 0.0045 0.008 0.0144
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0062 0.0128 0.0232
Brugia malayi sodium-independent organic anion transporter family protein 0.009 0.0209 0.0383
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0017 0.0029
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.0695 0.5398
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0069 0.0149 0.1092
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0042 0.0069
Loa Loa (eye worm) hypothetical protein 0.0046 0.0084 0.0151
Echinococcus multilocularis lipoxygenase domain containing protein 0.017 0.0435 0.0434
Echinococcus granulosus Polycystic kidney disease protein 0.017 0.0435 0.0679
Entamoeba histolytica hypothetical protein 0.0046 0.0084 0.0146
Schistosoma mansoni Smad4 0.0019 0.0007 0.0009
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0159 0.029
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0023 0.0016 0.0046
Loa Loa (eye worm) hypothetical protein 0.0041 0.0069 0.0124
Leishmania major epsilon tubulin, putative 0.1069 0.2988 0.5479
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0101 0.0239 0.0437
Entamoeba histolytica tubulin gamma chain 0.1069 0.2989 0.5479
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0023 0.0017 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0084 0.0146
Entamoeba histolytica hypothetical protein 0.0192 0.0497 0.0904
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0011 0.0012
Schistosoma mansoni cpg binding protein 0.0096 0.0226 0.0351
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0023 0.0016 0.0046
Brugia malayi isocitrate dehydrogenase 0.0035 0.0051 0.0093
Echinococcus multilocularis axis inhibition protein axin 0.0046 0.0084 0.0082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0223 0.0347
Trypanosoma brucei alpha tubulin 0.1401 0.3932 0.721
Schistosoma mansoni hypothetical protein 0.0192 0.0497 0.0775
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.0245 0.0244
Loa Loa (eye worm) hypothetical protein 0.0386 0.1048 0.1921
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.0007 0.0009
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0023 0.0016 0.0046
Echinococcus granulosus Tubulin beta 2C chain 0.1936 0.5452 0.8527
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0054 0.0096
Brugia malayi photoreceptor-specific nuclear receptor 0.0101 0.0239 0.0439
Trichomonas vaginalis tubulin epsilon chain, putative 0.0467 0.1278 0.2338
Trichomonas vaginalis tubulin gamma chain, putative 0.1069 0.2988 0.5477
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0042 0.1437
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0045 0.008 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0101 0.0239 0.0439
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0109 0.0192
Brugia malayi hypothetical protein 0.009 0.0209 0.0383
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.0284 0.0283
Brugia malayi hypothetical protein 0.0045 0.008 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0157 0.0281
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0011 0.0012
Trichomonas vaginalis tubulin beta chain, putative 0.1401 0.3932 0.7209
Echinococcus multilocularis tubulin alpha chain 0.1401 0.3932 0.3931
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.0245 0.0447
Schistosoma mansoni nuclear hormone receptor 0.0045 0.008 0.0123
Loa Loa (eye worm) hypothetical protein 0.009 0.0209 0.0381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0157 0.0281
Echinococcus multilocularis tubulin subunit beta 0.1936 0.5452 0.5452
Echinococcus multilocularis beta tubulin 0.1936 0.5452 0.5452
Trypanosoma cruzi tubulin gamma chain 0.1069 0.2989 0.5481
Trypanosoma brucei beta tubulin 0.1936 0.5452 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0101 0.0239 0.0373
Trypanosoma cruzi epsilon tubulin, putative 0.1069 0.2988 0.5479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0137 0.0244
Brugia malayi Regulator of G protein signaling domain containing protein 0.0046 0.0084 0.0153
Toxoplasma gondii exonuclease III APE 0.0021 0.0011 0.0017
Echinococcus multilocularis lamin dm0 0.0088 0.0203 0.0202
Toxoplasma gondii transporter, major facilitator family protein 0.009 0.0209 0.0381
Echinococcus granulosus tubulin alpha chain 0.1401 0.3932 0.6149
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0054 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0228 0.0411
Schistosoma mansoni transcription factor LCR-F1 0.0192 0.0497 0.0775
Echinococcus multilocularis thyroid hormone receptor alpha 0.0101 0.0239 0.0238
Plasmodium falciparum tubulin beta chain 0.1936 0.5452 1
Echinococcus granulosus organic anion transporting polypeptide 30B 0.009 0.0209 0.0325
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0034 0.005 0.0089
Toxoplasma gondii tubulin, putative 0.0029 0.0034 0.006
Loa Loa (eye worm) hypothetical protein 0.0712 0.1974 0.362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0228 0.0411
Brugia malayi Thioredoxin reductase 0.0103 0.0245 0.0449
Brugia malayi hypothetical protein 0.0056 0.0112 0.0205
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0141 0.0219
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0054 0.0082
Schistosoma mansoni follistatin 0.0062 0.0128 0.0198
Loa Loa (eye worm) histone methyltransferase 0.0032 0.0042 0.0075
Loa Loa (eye worm) tubulin alpha 2 0.0361 0.0978 0.1791
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0026 0.0027 0.0047
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0095 0.0223 0.0222
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.0245 0.0381
Echinococcus granulosus GPCR family 2 0.0019 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0024 0.002 0.0035
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0023 0.0016 0.0046
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0097 0.0228 0.0416
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.0112 0.0173
Schistosoma mansoni nuclear receptor 0.0045 0.008 0.0123
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0235 0.062 0.481
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0182 0.0334
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.008 0.0079
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0043 0.0073 0.0113
Schistosoma mansoni tubulin subunit alpha 0.1401 0.3932 0.6149
Mycobacterium leprae cell division protein FtsZ 0.0467 0.1278 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0046 0.0084 0.0129
Echinococcus multilocularis nuclear receptor nhr 48 0.0045 0.008 0.0079
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0023 0.0017 0.0029
Echinococcus granulosus cpg binding protein 0.0096 0.0226 0.0351
Leishmania major alpha tubulin 0.1401 0.3932 0.721
Brugia malayi hypothetical protein 0.0208 0.0542 0.0994
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0284 0.0519
Onchocerca volvulus 0.009 0.0209 0.0982
Brugia malayi Cytochrome P450 family protein 0.0023 0.0016 0.003
Mycobacterium ulcerans cell division protein FtsZ 0.0467 0.1278 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0091 0.0211 0.0385
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0023 0.0016 0.0046
Schistosoma mansoni hypothetical protein 0.009 0.0207 0.0321
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0017 0.0024
Plasmodium vivax glutathione reductase, putative 0.0103 0.0245 0.0447
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0046 0.0084 0.0129
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0017 0.0049
Trypanosoma brucei alpha tubulin 0.1401 0.3932 0.721
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.0571 0.2743
Echinococcus granulosus lamin dm0 0.0088 0.0203 0.0316
Entamoeba histolytica tubulin family protein 0.1936 0.5452 1
Leishmania major beta tubulin 0.1936 0.5452 1
Trichomonas vaginalis helicase, putative 0.0021 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.009 0.0209 0.0381
Loa Loa (eye worm) DR-78 0.0045 0.008 0.0144
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0033 0.0045 0.0079
Echinococcus granulosus beta-adrenergic receptor kinase 0.0047 0.0086 0.0133
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0017 0.0025
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0033 0.0045 0.0079
Leishmania major beta tubulin 0.1936 0.5452 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0054 0.0339
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0051 0.005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0101 0.0239 0.0439
Brugia malayi jmjC domain containing protein 0.007 0.0151 0.0278
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0051 0.005
Trypanosoma brucei PAB1-binding protein , putative 0.011 0.0264 0.0483
Loa Loa (eye worm) hypothetical protein 0.0047 0.0085 0.0153
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0054 0.0096
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0009
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0017 0.0024
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0032 0.0042 0.004
Trichomonas vaginalis tubulin beta chain, putative 0.1401 0.3932 0.7209
Echinococcus granulosus CREB binding protein 0.0036 0.0054 0.0082
Trichomonas vaginalis tubulin beta chain, putative 0.1936 0.5452 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0637 0.1762 0.323
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0042 0.0069
Echinococcus granulosus mixed lineage leukemia protein mll 0.0026 0.0026 0.0039
Leishmania major beta tubulin 0.1936 0.5452 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.1401 0.3932 0.3931
Echinococcus granulosus tubulin subunit TubB 0.1401 0.3932 0.6149
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0934 0.2605 0.4775
Schistosoma mansoni tubulin subunit delta 0.0467 0.1278 0.1997
Loa Loa (eye worm) RecQ helicase 0.0045 0.0081 0.0146
Schistosoma mansoni coup transcription factor 0.0101 0.0239 0.0373
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0284 0.0519
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0112 0.0269 0.0491
Loa Loa (eye worm) hypothetical protein 0.0045 0.008 0.0144
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0045 0.008 0.0123
Echinococcus multilocularis Polycystic kidney disease protein 0.017 0.0435 0.0434
Brugia malayi Smad1 0.0043 0.0075 0.0138
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0007 0.0011
Plasmodium vivax delta tubulin, putative 0.0467 0.1278 0.2342
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0101 0.0239 0.0238
Trypanosoma cruzi zeta tubulin, putative 0.0769 0.2138 0.392
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0011 0.0015
Echinococcus granulosus smad 0.0043 0.0075 0.0116
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0041 0.0075
Echinococcus multilocularis ATP binding cassette sub family B 0.0023 0.0016 0.0015
Mycobacterium ulcerans hypothetical protein 0.0022 0.0015 0.0033
Trypanosoma brucei beta tubulin 0.1936 0.5452 1
Schistosoma mansoni lipoxygenase 0.0679 0.1882 0.2942
Loa Loa (eye worm) hypothetical protein 0.0093 0.0216 0.0394
Brugia malayi tailless protein 0.0045 0.008 0.0146
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0023 0.0016 0.0046
Loa Loa (eye worm) Smad1 0.0043 0.0075 0.0136
Brugia malayi Regulator of G protein signaling domain containing protein 0.0046 0.0084 0.0153
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0023 0.0017 0.0029
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0828 0.2304 0.4221
Giardia lamblia Alpha-tubulin 0.1401 0.3932 0.7206
Trichomonas vaginalis ABC transporter, putative 0.0023 0.0017 0.0024
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0054 0.0339
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0023 0.0016 0.0046
Leishmania major cytochrome p450-like protein 0.0069 0.0149 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0157 0.0281
Loa Loa (eye worm) sodium-independent organic anion transporter 0.009 0.0209 0.0381
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0046 0.0084 0.0129
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0269 0.0486
Trypanosoma cruzi cytochrome P450, putative 0.0069 0.0149 0.0271
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0051 0.0091
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0018 0.0004 0.0005
Loa Loa (eye worm) tubulin alpha chain 0.1401 0.3932 0.721
Brugia malayi MAP kinase sur-1 0.0112 0.0269 0.0493
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0054 0.0091
Trypanosoma cruzi PAB1-binding protein , putative 0.011 0.0264 0.0483
Trichomonas vaginalis tubulin alpha chain, putative 0.1936 0.5452 1
Brugia malayi jmjC domain containing protein 0.0017 0.0001 0.0002
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.008 0.0079
Brugia malayi nuclear hormone receptor family member nhr-6 0.0045 0.008 0.0146
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0097 0.0228 0.0418
Schistosoma mansoni tubulin subunit beta 0.1936 0.5452 0.8527
Leishmania major alpha tubulin 0.1401 0.3932 0.721
Loa Loa (eye worm) hypothetical protein 0.0218 0.0571 0.1046
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0045 0.008 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0101 0.0239 0.0439
Leishmania major alpha tubulin 0.1401 0.3932 0.721
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0047 0.0086 0.0156
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.0762 0.1391
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0046 0.0082 0.0149
Brugia malayi Cytochrome P450 family protein 0.0023 0.0016 0.003
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0017 0.0049
Plasmodium falciparum ataxin-2 like protein, putative 0.011 0.0264 0.0483
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0191 0.0347
Echinococcus multilocularis musashi 0.0088 0.0203 0.0202
Schistosoma mansoni zinc finger protein 0.0045 0.008 0.0123
Onchocerca volvulus Protein ultraspiracle homolog 0.0101 0.0239 0.113
Loa Loa (eye worm) hypothetical protein 0.011 0.0264 0.0483
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0284 0.0514
Echinococcus multilocularis agrin 0.0062 0.0128 0.0126
Trichomonas vaginalis tubulin epsilon chain, putative 0.1936 0.5452 1
Entamoeba histolytica tubulin alpha-1 chain 0.1401 0.3932 0.7209
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0042 0.0069
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0043 0.0073 0.0132
Brugia malayi PXA domain containing protein 0.0046 0.0084 0.0153
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0141 0.0256
Brugia malayi ecdysteroid receptor 0.0101 0.0239 0.0439
Brugia malayi nuclear receptor NHR-88 0.0045 0.008 0.0146
Loa Loa (eye worm) hypothetical protein 0.0217 0.0568 0.1039
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0055 0.0109 0.0197
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0023 0.0016 0.0046
Echinococcus multilocularis expressed protein 0.0807 0.2243 0.2242
Schistosoma mansoni Smad4 0.0043 0.0075 0.0116
Echinococcus multilocularis axis inhibition protein axin 0.0046 0.0084 0.0082
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0097 0.0228 0.0227
Brugia malayi A-kinase anchor protein 10, precursor 0.0046 0.0084 0.0153
Mycobacterium leprae putative cytochrome p450 0.0023 0.0016 0.0013
Echinococcus multilocularis expressed conserved protein 0.0204 0.053 0.0529
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0035 0.0051 0.0078
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0042 0.0074
Onchocerca volvulus Huntingtin homolog 0.0386 0.1048 0.5062
Brugia malayi steroid hormone receptor 0.0101 0.0239 0.0439
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.0284 0.2159
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0054 0.0052
Echinococcus multilocularis protein dispatched 1 0.0106 0.0254 0.0252
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0068 0.0123
Brugia malayi PAS domain containing protein 0.0212 0.0555 0.1018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.008 0.0123
Schistosoma mansoni cpg binding protein 0.0096 0.0226 0.0351
Trypanosoma brucei zeta tubulin 0.0769 0.2138 0.392
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.0348 0.2659
Trypanosoma brucei beta tubulin 0.104 0.2906 0.5329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0157 0.0281
Echinococcus granulosus intermediate filament protein 0.0088 0.0203 0.0316
Trypanosoma brucei tubulin delta chain 0.0648 0.1792 0.3286
Entamoeba histolytica P-glyco protein 6, putative 0.0023 0.0017 0.0024
Trypanosoma cruzi MFS transporter, putative 0.009 0.0209 0.0381
Loa Loa (eye worm) hypothetical protein 0.0101 0.0239 0.0437
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0112 0.0269 0.0491
Leishmania major beta tubulin 0.1936 0.5452 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0657 0.1818 0.3332
Leishmania major beta tubulin 0.1936 0.5452 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0573 0.158 0.2892
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0141 0.1029
Toxoplasma gondii protease inhibitor PI2 0.0062 0.0128 0.0232
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0035 0.0051 0.0091
Brugia malayi MH2 domain containing protein 0.0019 0.0007 0.0013
Schistosoma mansoni hypothetical protein 0.0049 0.0092 0.0142
Brugia malayi Doublecortin family protein 0.017 0.0435 0.0799
Schistosoma mansoni single-minded 0.0212 0.0555 0.0866
Echinococcus granulosus raf serine:threonine protein kinase 0.0046 0.0084 0.0129
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.0137 0.0135
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0051 0.0091
Brugia malayi ABC transporter family protein 0.0023 0.0017 0.0031
Brugia malayi Cell division protein ftsZ 0.0467 0.1278 0.2344
Loa Loa (eye worm) BEN-1 protein 0.1936 0.5452 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0095 0.0223 0.0222
Echinococcus granulosus axis inhibition protein axin 0.0046 0.0084 0.0129
Trichomonas vaginalis tubulin beta chain, putative 0.1401 0.3932 0.7209
Onchocerca volvulus 0.009 0.0209 0.0982
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0008
Schistosoma mansoni tubulin subunit beta 0.1936 0.5452 0.8527
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0141 0.1029
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.0284 0.0443
Loa Loa (eye worm) hypothetical protein 0.0095 0.0223 0.0407
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0035 0.0051 0.0091
Loa Loa (eye worm) transcription factor SMAD2 0.0637 0.1762 0.323
Schistosoma mansoni hypothetical protein 0.0023 0.0016 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0011 0.0012
Brugia malayi tubulin alpha-2 chain 0.1401 0.3932 0.7211
Echinococcus multilocularis regulator of G protein signaling 7 0.0057 0.0114 0.0113
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0026 0.0039
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.0016 0.0028
Echinococcus multilocularis tubulin alpha chain 0.1401 0.3932 0.3931
Leishmania major beta tubulin 0.1936 0.5452 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0028
Leishmania major beta tubulin 0.1936 0.5452 1
Echinococcus granulosus Niemann Pick C1 protein 0.031 0.0832 0.1299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0117 0.0207
Echinococcus granulosus tubulin alpha 1C chain 0.1401 0.3932 0.6149
Trichomonas vaginalis tubulin, putative 0.0573 0.158 0.2892
Loa Loa (eye worm) doublecortin family protein 0.017 0.0435 0.0797
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0115 0.0204
Brugia malayi regulator of G-protein signaling rgs-7 0.0046 0.0084 0.0153
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0054 0.0096
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0068 0.0105
Onchocerca volvulus 0.0095 0.0223 0.105
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.104 0.2906 0.5329
Loa Loa (eye worm) BEN-1 protein 0.1936 0.5452 1
Leishmania major p-glycoprotein 0.0023 0.0017 0.0029
Loa Loa (eye worm) tubulin alpha-3 chain 0.0828 0.2304 0.4224
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0112 0.0269 0.0491
Loa Loa (eye worm) hypothetical protein 0.0056 0.0112 0.0203
Schistosoma mansoni DNA helicase recq5 0.0032 0.0042 0.0063
Brugia malayi nuclear receptor RXR 0.0056 0.0112 0.0205
Brugia malayi hypoxia-induced factor 1 0.0657 0.1818 0.3334
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0016
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0159 0.029
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0032 0.0042 0.0063
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0017 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0054 0.0096
Giardia lamblia Alpha-tubulin 0.1401 0.3932 0.7206
Entamoeba histolytica P-glycoprotein-1 0.0023 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0101 0.0239 0.0437
Loa Loa (eye worm) hypothetical protein 0.0046 0.0084 0.0151
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0068 0.0106
Giardia lamblia Delta tubulin 0.0467 0.1278 0.2329
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0023 0.0016 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0101 0.0239 0.0439
Entamoeba histolytica hypothetical protein 0.0046 0.0084 0.0146
Echinococcus granulosus Tubulin beta 2C chain 0.1936 0.5452 0.8527
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0137 0.0212
Brugia malayi CXXC zinc finger family protein 0.0091 0.0211 0.0387
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0101 0.0239 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0101 0.0239 0.0439
Trypanosoma brucei epsilon tubulin 0.1069 0.2988 0.5479
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0056 0.0112 0.0173
Echinococcus granulosus Protein patched homolog 1 0.0093 0.0216 0.0336
Echinococcus multilocularis beta adrenergic receptor kinase 0.0047 0.0086 0.0085
Echinococcus multilocularis tubulin alpha 1C chain 0.1401 0.3932 0.3931
Giardia lamblia Beta tubulin 0.1936 0.5452 1
Echinococcus multilocularis protein patched 0.0093 0.0216 0.0215
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0123 0.0223
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0123 0.0226
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0073 0.0159 0.0247
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0006 0.0005
Echinococcus granulosus Tubulin beta 2C chain 0.1936 0.5452 0.8527
Loa Loa (eye worm) hypothetical protein 0.0056 0.0112 0.0203
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0023 0.0016 0.0046
Echinococcus multilocularis Tubulin beta 2C chain 0.1936 0.5452 0.5452
Echinococcus granulosus expressed protein 0.0807 0.2243 0.3508
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0086 0.0133
Brugia malayi nuclear receptor NHR-67 0.0045 0.008 0.0146
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0265 0.0704 0.1099
Schistosoma mansoni z-protein (S1r protein) 0.0057 0.0114 0.0176
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0141 0.0256
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0648 0.1792 0.3286
Echinococcus multilocularis jun protein 0.0265 0.0704 0.0702
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0004 0.0005
Trypanosoma cruzi target of rapamycin kinase 3 0.0077 0.0172 0.0313
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0065
Brugia malayi Tubulin beta chain 0.0573 0.158 0.2898
Loa Loa (eye worm) hypothetical protein 0.0934 0.2605 0.4778
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0074
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0068 0.0125
Mycobacterium ulcerans epimerase 0.0022 0.0015 0.0033
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0055 0.0109 0.0197
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0068 0.0117
Loa Loa (eye worm) hypothetical protein 0.0046 0.0084 0.0151
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0042 0.0069
Echinococcus granulosus tubulin subunit beta 0.1936 0.5452 0.8527
Leishmania major alpha tubulin 0.1401 0.3932 0.721
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0054 0.0096
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0073 0.0159 0.0292
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0101 0.0239 0.0238
Loa Loa (eye worm) hypothetical protein 0.0041 0.0069 0.0124
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0023 0.0017 0.0024
Leishmania major beta tubulin 0.1936 0.5452 1
Brugia malayi CHE-14 protein 0.0093 0.0216 0.0397
Brugia malayi Tubulin beta chain 0.0467 0.1278 0.2344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0101 0.0177
Mycobacterium tuberculosis Cell division protein FtsZ 0.0467 0.1278 1
Trypanosoma brucei tubulin gamma chain 0.1069 0.2989 0.5481
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0042 0.0069
Loa Loa (eye worm) hypothetical protein 0.0055 0.0109 0.0197
Trypanosoma brucei trypanothione reductase 0.0103 0.0245 0.0447
Echinococcus multilocularis isocitrate dehydrogenase 0.0035 0.0051 0.005
Brugia malayi Isocitrate dehydrogenase 0.0035 0.0051 0.0093
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0017 0.0016
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0023 0.0016 0.0028
Entamoeba histolytica hypothetical protein 0.0192 0.0497 0.0904
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0077 0.0172 0.0313
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0018 0.0004 0.0005
Schistosoma mansoni thyroid hormone receptor 0.0101 0.0239 0.0373
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.0762 0.1381
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0042 0.0073 0.0131
Schistosoma mansoni lamin 0.0088 0.0203 0.0316
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0112 0.0205
Loa Loa (eye worm) nuclear hormone receptor 0.0045 0.008 0.0144
Plasmodium falciparum glutathione reductase 0.0103 0.0245 0.0447
Loa Loa (eye worm) CBP-B 0.0152 0.0383 0.07
Plasmodium falciparum tubulin delta chain, putative 0.0467 0.1278 0.2342
Loa Loa (eye worm) hypothetical protein 0.009 0.0209 0.0381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0157 0.0281
Trichomonas vaginalis tubulin, putative 0.0496 0.1361 0.2491
Leishmania major zeta tubulin, putative 0.0769 0.2138 0.392
Echinococcus granulosus dnaJ subfamily B 0.09 0.251 0.3924
Trichomonas vaginalis tubulin alpha chain, putative 0.0573 0.158 0.2892
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0042 0.0069
Echinococcus multilocularis peroxisome assembly protein 26 0.1401 0.3932 0.3931
Echinococcus multilocularis Tubulin alpha 1 chain 0.1401 0.3932 0.3931
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0097 0.0228 0.0416
Echinococcus granulosus tubulin gamma 1 chain 0.1069 0.2989 0.4674
Schistosoma mansoni hypothetical protein 0.0215 0.0563 0.0878
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0097 0.0228 0.0355
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0054 0.0079
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0011
Onchocerca volvulus 0.0088 0.0203 0.0953
Trichomonas vaginalis set domain proteins, putative 0.0743 0.2064 0.378
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0035 0.0051 0.0317
Loa Loa (eye worm) hypothetical protein 0.009 0.0209 0.0381
Plasmodium falciparum tubulin gamma chain 0.1069 0.2989 0.5481
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0042 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0101 0.0239 0.0437
Trypanosoma cruzi PAB1-binding protein , putative 0.011 0.0264 0.0483
Brugia malayi hypothetical protein 0.009 0.0209 0.0383
Echinococcus granulosus lipoxygenase domain containing protein 0.017 0.0435 0.0679
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0762 0.1391
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0054 0.0096
Echinococcus multilocularis regulator of G protein signaling 3 0.0046 0.0084 0.0082
Loa Loa (eye worm) hypothetical protein 0.0045 0.008 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0074
Entamoeba histolytica recQ family helicase, putative 0.0034 0.005 0.0084
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0023 0.0016 0.0046
Schistosoma mansoni tubulin subunit epsilon 0.1069 0.2988 0.4672
Onchocerca volvulus 0.0062 0.0128 0.0585
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0049 0.0092 0.0091
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.0348 0.2659
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0084 0.0191 0.035
Trichomonas vaginalis tubulin beta chain, putative 0.0573 0.158 0.2892
Loa Loa (eye worm) hypothetical protein 0.0041 0.0069 0.0124
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0017 0.0024
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0051 0.005
Loa Loa (eye worm) agrin synaptic family protein 0.0062 0.0128 0.0232
Echinococcus granulosus tubulin alpha 3 chain 0.1401 0.3932 0.6149
Loa Loa (eye worm) multidrug resistance protein 3 0.0023 0.0017 0.0029
Schistosoma mansoni hypothetical protein 0.009 0.0207 0.0321
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0042 0.0069
Leishmania major alpha tubulin 0.1401 0.3932 0.721
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0023 0.0017 0.0051
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0051 0.0091
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0011 0.0012
Leishmania major beta tubulin 0.1936 0.5452 1
Echinococcus granulosus Niemann Pick C1 protein 0.0217 0.0568 0.0886
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0045 0.008 0.0144
Schistosoma mansoni tubulin subunit beta 0.1936 0.5452 0.8527
Loa Loa (eye worm) pax transcription factor protein 2 0.0266 0.0708 0.1296
Schistosoma mansoni hypothetical protein 0.0276 0.0737 0.115
Echinococcus multilocularis cpg binding protein 0.0096 0.0226 0.0225
Brugia malayi Pax transcription factor protein 2 0.0266 0.0708 0.1298
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.0245 0.0447
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0026 0.0025
Brugia malayi alpha-tubulin 0.1401 0.3932 0.7211
Schistosoma mansoni ap endonuclease 0.0021 0.0011 0.0015
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0018 0.0004 0.0003
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0027 0.0029 0.005
Schistosoma mansoni aryl hydrocarbon receptor 0.0212 0.0555 0.0866
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.008 0.0353
Loa Loa (eye worm) hypothetical protein 0.0056 0.0112 0.0203
Brugia malayi hypothetical protein 0.017 0.0435 0.0799
Plasmodium falciparum thioredoxin reductase 0.0103 0.0245 0.0447
Loa Loa (eye worm) tubulin beta chain 0.0467 0.1278 0.2342
Entamoeba histolytica tubulin family protein 0.1936 0.5452 1
Schistosoma mansoni smdr2 0.0023 0.0017 0.0025
Loa Loa (eye worm) hypothetical protein 0.0088 0.0203 0.037
Brugia malayi 6-phosphofructokinase 0.0117 0.0285 0.0523
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0284 0.0519
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.0007 0.0013
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0069 0.0126
Schistosoma mansoni CREB-binding protein 2 0.0218 0.0572 0.0894
Brugia malayi Intermediate filament tail domain containing protein 0.0088 0.0203 0.0372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0101 0.0239 0.0437
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0017 0.0024
Echinococcus granulosus tubulin beta 1 chain 0.1936 0.5452 0.8527
Loa Loa (eye worm) hypothetical protein 0.0046 0.0084 0.0151
Echinococcus multilocularis Tubulin alpha 1 chain 0.1401 0.3932 0.3931
Trypanosoma brucei cytochrome P450, putative 0.0069 0.0149 0.0271
Brugia malayi nuclear receptor RXR 0.0045 0.008 0.0146
Brugia malayi Tubulin alpha-2 chain 0.1401 0.3932 0.7211
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0054 0.0096
Loa Loa (eye worm) hypothetical protein 0.0215 0.0563 0.1031
Trichomonas vaginalis tubulin gamma chain, putative 0.1936 0.5452 1
Schistosoma mansoni tubulin subunit beta 0.1936 0.5452 0.8527
Schistosoma mansoni smad 0.0019 0.0007 0.0009
Echinococcus granulosus axis inhibition protein axin 0.0046 0.0084 0.0129
Leishmania major cytochrome p450-like protein 0.0023 0.0016 0.0028
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0068 0.0105
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0011 0.0017
Trypanosoma cruzi cytochrome P450, putative 0.0069 0.0149 0.0271
Echinococcus granulosus CREB binding protein 0.0218 0.0572 0.0894
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.0075 0.0074
Echinococcus granulosus thyroid hormone receptor alpha 0.0045 0.008 0.0123
Toxoplasma gondii beta-tubulin, putative 0.1936 0.5452 1
Onchocerca volvulus 0.0208 0.0542 0.2601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0171 0.0307
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0016 0.0023
Mycobacterium ulcerans putative regulatory protein 0.0157 0.0398 0.3058
Brugia malayi glutathione reductase 0.0103 0.0245 0.0449
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0151 0.0276
Giardia lamblia Sgs1 DNA helicase, putative 0.0032 0.0042 0.0057
Entamoeba histolytica hypothetical protein 0.0192 0.0497 0.0904
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0017 0.0024
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0095 0.0223 0.0407
Trypanosoma brucei alpha tubulin 0.1401 0.3932 0.721
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0151 0.0235
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.008 0.0353
Schistosoma mansoni agrin 0.0062 0.0128 0.0198
Brugia malayi Tubulin alpha chain 0.1401 0.3932 0.7211
Loa Loa (eye worm) hypothetical protein 0.0056 0.0112 0.0203
Brugia malayi Pre-SET motif family protein 0.0653 0.1808 0.3316
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0235 0.062 0.481
Brugia malayi hypothetical protein 0.0386 0.1048 0.1923
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0073 0.0159 0.029
Leishmania major beta tubulin 0.1936 0.5452 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.1936 0.5452 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0023 0.0016 0.0046
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0008
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0027 0.0049
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0011 0.0017
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0023 0.0017 0.0011
Brugia malayi sodium-independent organic anion transporter family protein 0.009 0.0209 0.0383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0101 0.0178
Echinococcus multilocularis tubulin alpha 1C chain 0.1401 0.3932 0.3931
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0011 0.0017
Trichomonas vaginalis tubulin beta chain, putative 0.1401 0.3932 0.7209
Onchocerca volvulus 0.0023 0.0017 0.0048
Brugia malayi hypothetical protein 0.0071 0.0154 0.0282
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0054 0.0339
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0023 0.0016 0.0046
Echinococcus multilocularis 0.0023 0.0016 0.0015
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0072 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0101 0.0239 0.0437
Schistosoma mansoni hypothetical protein 0.09 0.251 0.3924
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0062 0.0128 0.0232
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.0284 0.2159
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0023 0.0016 0.0046
Onchocerca volvulus 0.0215 0.0563 0.2703
Brugia malayi Tubulin alpha chain 0.0467 0.1278 0.2344
Echinococcus granulosus histone lysine methyltransferase setb 0.0095 0.0223 0.0347
Echinococcus granulosus aryl hydrocarbon receptor 0.0055 0.0109 0.0168
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0068 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0101 0.0239 0.0437
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0011 0.0012
Trypanosoma cruzi tubulin delta chain 0.0648 0.1792 0.3286
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0042 0.1437
Loa Loa (eye worm) tubulin alpha 2 0.0934 0.2605 0.4778
Brugia malayi nuclear receptor NHR-88 0.0101 0.0239 0.0439
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0023 0.0017 0.0025
Echinococcus multilocularis lamin 0.0088 0.0203 0.0202
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0023 0.0016 0.0046
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0141 0.1029
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0017 0.0029
Trichomonas vaginalis taga, putative 0.0023 0.0017 0.0024
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0015 0.0033
Leishmania major beta tubulin 0.1936 0.5452 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0026 0.0026 0.0025
Trypanosoma cruzi alpha tubulin, putative 0.1401 0.3932 0.721
Leishmania major gamma-tubulin 0.1069 0.2989 0.5481
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0055 0.0109 0.0192
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0011 0.0012
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0269 0.0486
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0084 0.0146
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0284 0.0514
Brugia malayi hypothetical protein 0.0261 0.0694 0.1274
Brugia malayi MH1 domain containing protein 0.0043 0.0075 0.0138
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0223 0.0347
Echinococcus granulosus tubulin alpha chain 0.1401 0.3932 0.6149
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.0762 0.5927
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0062 0.0128 0.0232
Loa Loa (eye worm) tubulin beta-2A chain 0.1936 0.5452 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0114 0.0207
Leishmania major alpha tubulin 0.1401 0.3932 0.721
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0101 0.0239 0.0238
Toxoplasma gondii beta-1 tubulin, putative 0.1936 0.5452 1
Brugia malayi MH2 domain containing protein 0.0043 0.0075 0.0138
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0467 0.1278 0.2338
Schistosoma mansoni ap endonuclease 0.0021 0.0011 0.0015
Trichomonas vaginalis tubulin gamma chain, putative 0.0467 0.1278 0.2338
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0062 0.0128 0.0234
Brugia malayi hypothetical protein 0.0056 0.0112 0.0205
Echinococcus granulosus cytochrome P450 2K1 0.0023 0.0016 0.0024
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0023 0.0016 0.0046
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0023 0.0016 0.0046
Schistosoma mansoni cytochrome P450 0.0023 0.0016 0.0024
Trichomonas vaginalis guanylate cyclase, putative 0.0055 0.0109 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0101 0.0239 0.0439
Loa Loa (eye worm) hypothetical protein 0.009 0.0209 0.0381
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0004 0.0008
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0086 0.0133
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0023 0.0016 0.0046
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0182 0.0283
Brugia malayi cytochrome P450 0.0023 0.0016 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0762 0.1391
Echinococcus granulosus Tubulin alpha 1 chain 0.1401 0.3932 0.6149
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0047 0.0086 0.0159
Chlamydia trachomatis endonuclease IV 0.0084 0.0191 1
Echinococcus granulosus Tubulin alpha 1 chain 0.1401 0.3932 0.6149
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0016 0.0015
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0496 0.136 0.2493
Plasmodium falciparum thioredoxin reductase 0.0036 0.0054 0.0096
Schistosoma mansoni hypothetical protein 0.009 0.0207 0.0321
Brugia malayi regulator of G-protein signaling egl-10 0.0057 0.0114 0.0209
Brugia malayi hypothetical protein 0.0045 0.008 0.0146
Onchocerca volvulus 0.0101 0.0239 0.113
Schistosoma mansoni smad1 5 8 and 0.0043 0.0075 0.0116
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0101 0.0239 0.0439
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0056 0.0112 0.0202
Trypanosoma brucei alpha tubulin, putative 0.0573 0.158 0.2896
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0192 0.0497 0.0496
Brugia malayi prostaglandin transporter 0.009 0.0209 0.0383
Trichomonas vaginalis conserved hypothetical protein 0.0467 0.1278 0.2338
Loa Loa (eye worm) hypothetical protein 0.009 0.0209 0.0381
Brugia malayi ecdysone receptor 0.0045 0.008 0.0146
Trichomonas vaginalis abcb9, putative 0.0023 0.0017 0.0024
Leishmania major alpha tubulin 0.1401 0.3932 0.721
Echinococcus multilocularis tubulin alpha 3 chain 0.1401 0.3932 0.3931
Loa Loa (eye worm) hypothetical protein 0.0261 0.0694 0.1272
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0008
Brugia malayi Nuclear hormone receptor-like 1 0.0101 0.0239 0.0439
Leishmania major beta tubulin 0.1936 0.5452 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0017 0.0024
Schistosoma mansoni nuclear receptor 0.0045 0.008 0.0123
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0025
Echinococcus multilocularis Tubulin beta 2C chain 0.1936 0.5452 0.5452
Brugia malayi 6-phosphofructokinase 0.0117 0.0284 0.0521
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0068 0.0123
Loa Loa (eye worm) tubulin alpha chain 0.1401 0.3932 0.721
Toxoplasma gondii target of rapamycin (TOR), putative 0.0072 0.0157 0.0286
Schistosoma mansoni intermediate filament proteins 0.0088 0.0203 0.0316
Echinococcus granulosus tubulin delta chain 0.0467 0.1278 0.1997
Onchocerca volvulus 0.009 0.0209 0.0982
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0101 0.0239 0.0373
Echinococcus multilocularis mitogen activated protein kinase 0.0112 0.0269 0.0268
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0011 0.0012
Echinococcus multilocularis aryl hydrocarbon receptor 0.0055 0.0109 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0117 0.0207
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0023 0.0017 0.0029
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0032 0.0042 0.0041
Onchocerca volvulus Putative organic anion transporter 0.009 0.0209 0.0982
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0086 0.0133
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0045 0.008 0.0146
Echinococcus granulosus follistatin 0.0062 0.0128 0.0198
Loa Loa (eye worm) hypothetical protein 0.0041 0.0068 0.0123
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0045 0.008 0.0123
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0023 0.0016 0.0046
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0235 0.062 0.4792
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.0075 0.0074
Schistosoma mansoni multidrug resistance protein 0.0023 0.0017 0.0025
Loa Loa (eye worm) RGS-3 protein 0.0046 0.0084 0.0151
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0011 0.0012
Plasmodium vivax tubulin gamma chain, putative 0.1069 0.2989 0.5481
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0023 0.0016 0.0046
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0032 0.0042 0.0074
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.0348 0.2635
Schistosoma mansoni tubulin subunit alpha 0.1401 0.3932 0.6149
Echinococcus multilocularis hypothetical protein 0.1401 0.3932 0.3931
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0074
Brugia malayi cytoplasmic intermediate filament protein 0.0047 0.0086 0.0159
Echinococcus multilocularis CREB binding protein 0.0036 0.0054 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0216 0.0389
Echinococcus multilocularis tubulin alpha 0.104 0.2906 0.2905
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0056 0.0112 0.0173
Brugia malayi Nuclear hormone receptor E75 0.0045 0.008 0.0146
Echinococcus granulosus Tubulin beta 2C chain 0.1936 0.5452 0.8527
Echinococcus multilocularis mitogen activated protein kinase 3 0.0112 0.0269 0.0268
Brugia malayi Pre-SET motif family protein 0.0095 0.0223 0.0409
Brugia malayi jmjC domain containing protein 0.0017 0.0001 0.0002
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0284 0.0514
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0097 0.0228 0.0416
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0006 0.0011
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0112 0.0269 0.0491
Leishmania major trypanothione reductase 0.0103 0.0245 0.0447
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0101 0.0239 0.0437
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0006 0.0009
Echinococcus granulosus lamin 0.0088 0.0203 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0109 0.0192
Toxoplasma gondii thioredoxin reductase 0.0103 0.0245 0.0447
Toxoplasma gondii alpha-tubulin I, putative 0.1401 0.3932 0.721
Schistosoma mansoni tubulin subunit alpha 0.0467 0.1278 0.1997
Echinococcus granulosus mitogen activated protein kinase 0.0112 0.0269 0.0419
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0284 0.0514
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0054 0.0339
Echinococcus multilocularis raf serine:threonine protein kinase 0.0046 0.0084 0.0083
Trypanosoma cruzi epsilon tubulin, putative 0.1069 0.2988 0.5479
Brugia malayi nuclear hormone receptor 0.0101 0.0239 0.0439
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0762 0.1391
Echinococcus granulosus regulator of G protein signaling 3 0.0046 0.0084 0.0129
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0151 0.0235
Echinococcus granulosus tumor protein p63 0.147 0.4127 0.6454
Leishmania major beta tubulin 0.1936 0.5452 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0051 0.0091
Onchocerca volvulus Putative organic anion transporter 0.009 0.0209 0.0982
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0033 0.0045 0.0079
Brugia malayi multidrug resistance protein 3 0.0023 0.0017 0.0031
Loa Loa (eye worm) hypothetical protein 0.0257 0.0683 0.1251
Brugia malayi jmjC domain containing protein 0.0017 0.0001 0.0002
Echinococcus multilocularis bloom syndrome protein 0.0045 0.0081 0.0079
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0023 0.0016 0.0046
Echinococcus granulosus bloom syndrome protein 0.0045 0.0081 0.0124
Brugia malayi jmjC domain containing protein 0.0017 0.0001 0.0002
Brugia malayi orphan nuclear receptor NR2E1 0.0045 0.008 0.0146
Echinococcus multilocularis GPCR, family 2 0.0019 0.0006 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0023 0.0016 0.0046
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0054 0.0096
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0004 0.0008
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.0007 0.0009
Loa Loa (eye worm) alpha-tubulin 0.1401 0.3932 0.721
Echinococcus multilocularis Tubulin beta 2C chain 0.1936 0.5452 0.5452
Plasmodium falciparum tubulin epsilon chain, putative 0.1069 0.2988 0.5479
Echinococcus granulosus tubulin beta 4A class IVa 0.1936 0.5452 0.8527
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0017 0.0025
Toxoplasma gondii alpha tubulin TUBA1 0.1401 0.3932 0.721
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0017 0.0024
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0017 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0068 0.0117
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0055 0.0109 0.0192
Echinococcus granulosus serine protein kinase ATM 0.0018 0.0004 0.0005
Mycobacterium ulcerans endonuclease IV 0.0084 0.0191 0.1421
Brugia malayi bHLH-PAS transcription factor 0.0157 0.0398 0.073
Leishmania major beta tubulin 0.1936 0.5452 1
Trichomonas vaginalis conserved hypothetical protein 0.0467 0.1278 0.2338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0117 0.0207
Loa Loa (eye worm) tubulin alpha-2 chain 0.1401 0.3932 0.721
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0101 0.0239 0.0439
Mycobacterium tuberculosis Probable reductase 0.0235 0.062 0.481
Schistosoma mansoni tubulin subunit beta 0.1936 0.5452 0.8527
Echinococcus multilocularis tubulin delta chain 0.0467 0.1278 0.1277
Echinococcus granulosus Solute carrier organic anion transporter family 0.009 0.0209 0.0325
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0101 0.0239 0.0238
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0284 0.0514
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0101 0.0239 0.0439
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0057 0.0114 0.0207
Schistosoma mansoni organic anion transporter 0.009 0.0209 0.0325
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0284 0.0514
Brugia malayi intermediate filament protein 0.0088 0.0203 0.0372
Echinococcus multilocularis follistatin 0.0062 0.0128 0.0126
Entamoeba histolytica tubulin alpha chain, putative 0.1401 0.3932 0.7209
Echinococcus granulosus Tubulin beta 2C chain 0.1936 0.5452 0.8527
Entamoeba histolytica P-glycoprotein-5 0.0023 0.0017 0.0024
Onchocerca volvulus Huntingtin homolog 0.0386 0.1048 0.5062
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0033 0.0045 0.0082
Echinococcus multilocularis RUN 0.017 0.0435 0.0434
Trypanosoma brucei protein kinase, putative 0.0112 0.0269 0.0491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0026 0.004
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0068 0.0117
Schistosoma mansoni axis inhibition protein axin 0.0046 0.0084 0.0129
Onchocerca volvulus 0.0573 0.158 0.7645
Trypanosoma brucei alpha tubulin 0.1401 0.3932 0.721
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0033 0.0045 0.0079
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0112 0.0205
Echinococcus multilocularis ecdysone induced protein 78C 0.0101 0.0239 0.0238
Trypanosoma cruzi zeta tubulin, putative 0.0769 0.2138 0.392
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.0695 0.5398
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0141 0.0219
Giardia lamblia Beta tubulin 0.1936 0.5452 1
Leishmania major alpha tubulin 0.1401 0.3932 0.721
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0023 0.0017 0.0029
Schistosoma mansoni RAR-like nuclear receptor 0.0101 0.0239 0.0373
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0062 0.0128 0.0234
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.009 0.0208 0.0323
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0011 0.0017
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0269 0.0486
Brugia malayi PXA domain containing protein 0.0046 0.0084 0.0153
Plasmodium falciparum ataxin-2 like protein, putative 0.011 0.0264 0.0483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0115 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0084 0.0146
Schistosoma mansoni blooms syndrome DNA helicase 0.0029 0.0035 0.0053
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0008
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0032 0.0042 0.004
Trichomonas vaginalis tubulin gamma chain, putative 0.1069 0.2989 0.5479
Toxoplasma gondii non-specific serine/threonine protein kinase 0.002 0.001 0.0016
Onchocerca volvulus 0.0088 0.0203 0.0953
Entamoeba histolytica P-glycoprotein-2, putative 0.0023 0.0017 0.0024
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0265 0.0704 0.0702
Brugia malayi Steroid receptor seven-up type 2 0.0101 0.0239 0.0439
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0054 0.0096
Echinococcus granulosus Tubulin alpha 1 chain 0.1401 0.3932 0.6149
Echinococcus granulosus regulator of G protein signaling 3 0.0046 0.0084 0.0129
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0023 0.0017 0.0025
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0049 0.0092 0.0142
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0112 0.0269 0.0491
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0762 0.1391
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0017 0.0016
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0006 0.0011
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0192 0.0497 0.0775
Loa Loa (eye worm) tubulin beta-4 chain 0.1936 0.5452 1
Trichomonas vaginalis guanylate cyclase, putative 0.0055 0.0109 0.0192
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0051 0.0091
Trichomonas vaginalis abcb9, putative 0.0023 0.0017 0.0024
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0068 0.0117
Leishmania major beta tubulin 0.1936 0.5452 1
Trichomonas vaginalis tubulin, putative 0.1936 0.5452 1
Echinococcus multilocularis tubulin beta 1 chain 0.1936 0.5452 0.5452
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0223 0.0347
Echinococcus multilocularis tubulin alpha chain 0.1401 0.3932 0.3931
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0023 0.0016 0.0046
Schistosoma mansoni polycystin 1-related 0.017 0.0435 0.0679
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0011 0.0017
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0112 0.0269 0.0491
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0011 0.0017
Plasmodium falciparum LCCL domain-containing protein 0.017 0.0435 0.0797
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0023 0.0016 0.0046
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0653 0.1808 0.3315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0074
Loa Loa (eye worm) hypothetical protein 0.0828 0.2304 0.4224
Brugia malayi jmjC domain containing protein 0.0065 0.0137 0.0251
Loa Loa (eye worm) cytochrome P450 family protein 0.0069 0.0149 0.0271
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0018 0.0004 0.0005
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0034 0.005 0.0089
Echinococcus multilocularis Regulator of G protein signaling 20 0.0046 0.0084 0.0082
Echinococcus multilocularis tubulin gamma 1 chain 0.1069 0.2989 0.2988
Schistosoma mansoni rab6-interacting 0.017 0.0435 0.0679
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0017 0.0016
Echinococcus granulosus RUN 0.017 0.0435 0.0679
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.0075 0.0116
Loa Loa (eye worm) hypothetical protein 0.0062 0.0128 0.0232
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0011 0.0012
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0055 0.0109 0.0192
Loa Loa (eye worm) hypothetical protein 0.0045 0.008 0.0144
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0073 0.0159 0.0158
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0055 0.0109 0.0192
Brugia malayi nuclear hormone receptor 0.0045 0.008 0.0146
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0218 0.0572 0.0894
Schistosoma mansoni cellular tumor antigen P53 0.0215 0.0563 0.0879
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.008 0.0079
Echinococcus granulosus tubulin epsilon chain 0.1069 0.2988 0.4672
Loa Loa (eye worm) phosphofructokinase 0.0117 0.0284 0.0519
Schistosoma mansoni nuclear hormone receptor 0.0101 0.0239 0.0373
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0056 0.0112 0.0203
Schistosoma mansoni tubulin subunit beta 0.0467 0.1278 0.1997
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0023 0.0016 0.0046
Schistosoma mansoni steroid hormone receptor ad4bp 0.0101 0.0239 0.0373
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.0245 0.0447
Schistosoma mansoni regulator of G protein signaling 0.0046 0.0084 0.0129
Plasmodium falciparum alpha tubulin 2 0.1401 0.3932 0.721
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0011 0.0009
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0042 0.0074
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0035 0.0051 0.005
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0073 0.0159 0.0247
Plasmodium vivax tubulin beta chain, putative 0.1936 0.5452 1
Echinococcus granulosus jun protein 0.0265 0.0704 0.1099
Loa Loa (eye worm) alpha-tubulin 0.1401 0.3932 0.721
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0762 0.1391
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0045 0.008 0.0123
Trichomonas vaginalis ABC transporter, putative 0.0023 0.0017 0.0024
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0055 0.0109 0.0107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0762 0.1391
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0026 0.0039
Onchocerca volvulus 0.0055 0.0109 0.0494
Plasmodium vivax multidomain scavenger receptor, putative 0.017 0.0435 0.0797
Schistosoma mansoni jun-related protein 0.0215 0.0563 0.0878
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0068 0.0105
Brugia malayi hypothetical protein 0.0192 0.0497 0.0911
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0073 0.0159 0.0285
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0035 0.0051 0.0091
Echinococcus granulosus sterol regulatory element binding protein 0.0093 0.0216 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0101 0.0239 0.0439
Brugia malayi secreted modular calcium-binding protein 1 0.0062 0.0128 0.0234
Loa Loa (eye worm) hypothetical protein 0.0062 0.0128 0.0232
Echinococcus granulosus ecdysone induced protein 78C 0.0101 0.0239 0.0373
Brugia malayi SPARC precursor 0.0062 0.0128 0.0234
Brugia malayi MH2 domain containing protein 0.0043 0.0075 0.0138
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0023 0.0016 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0101 0.0239 0.0439
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0259 0.0687 0.1258
Brugia malayi nuclear hormone receptor family member odr-7 0.0045 0.008 0.0146
Echinococcus multilocularis multidrug resistance protein 1 0.0023 0.0017 0.0016
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0141 0.0219
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0097 0.0228 0.0416
Schistosoma mansoni hypothetical protein 0.0053 0.0103 0.016
Echinococcus multilocularis serine protein kinase ATM 0.0018 0.0004 0.0003
Loa Loa (eye worm) nuclear factor I 0.0024 0.002 0.0035
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0023 0.0016 0.0046
Echinococcus multilocularis tubulin epsilon chain 0.1069 0.2988 0.2987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0074
Brugia malayi hypothetical protein 0.011 0.0264 0.0485
Trypanosoma brucei beta tubulin 0.1936 0.5452 1
Plasmodium falciparum multidrug resistance protein 1 0.0023 0.0017 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0101 0.0178
Echinococcus multilocularis regulator of G protein signaling 3 0.0046 0.0084 0.0082
Loa Loa (eye worm) glutathione reductase 0.0103 0.0245 0.0447
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0023 0.0016 0.0046
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0017 0.0024
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0235 0.062 0.481
Trichomonas vaginalis tubulin epsilon chain, putative 0.1401 0.3932 0.7209
Echinococcus granulosus nuclear receptor nhr 48 0.0045 0.008 0.0123
Schistosoma mansoni regulator of G protein signaling 0.0057 0.0114 0.0176
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0054 0.0096
Giardia lamblia Beta tubulin 0.1936 0.5452 1
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0055 0.0109 0.0168
Loa Loa (eye worm) hypothetical protein 0.0101 0.0239 0.0437
Echinococcus granulosus alpha tubulin 0.1401 0.3932 0.6149
Loa Loa (eye worm) hypothetical protein 0.009 0.0209 0.0381
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0042 0.0246
Onchocerca volvulus 0.0091 0.0211 0.0992
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0284 0.0514
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0054 0.0096
Echinococcus multilocularis beta tubulin 0.1936 0.5452 0.5452
Loa Loa (eye worm) tubulin beta chain 0.1936 0.5452 1
Trypanosoma cruzi tubulin delta chain 0.0648 0.1792 0.3286
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0103 0.0243 0.0444
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0101 0.0239 0.0373
Loa Loa (eye worm) hypothetical protein 0.0114 0.0276 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0101 0.0177
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0017 0.0024
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0054 0.0098
Echinococcus multilocularis geminin 0.0903 0.2518 0.2517
Trichomonas vaginalis ABC transporter, putative 0.0023 0.0017 0.0024
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0033 0.0045 0.0068
Schistosoma mansoni regulator of G protein signaling 0.0047 0.0087 0.0134
Leishmania major phosphatidylinositol 3-kinase, putative 0.0033 0.0045 0.0079
Brugia malayi Tubulin beta-1 chain 0.1936 0.5452 1
Schistosoma mansoni regulator of G protein signaling 0.0046 0.0084 0.0129
Giardia lamblia Kinase, CMGC MAPK 0.0112 0.0269 0.0475
Schistosoma mansoni survival motor neuron protein 0.0053 0.0103 0.016
Schistosoma mansoni smad1 5 8 and 0.0043 0.0075 0.0116
Loa Loa (eye worm) CYP4Cod1 0.0069 0.0149 0.0271
Brugia malayi beta-tubulin, identical 0.1936 0.5452 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0097 0.0228 0.0416
Onchocerca volvulus 0.0045 0.008 0.0353
Echinococcus multilocularis FTZ F1 alpha 0.0101 0.0239 0.0238
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0017 0.0016
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0017 0.0024
Brugia malayi sodium-independent organic anion transporter family protein 0.009 0.0209 0.0383
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.0075 0.0136
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0467 0.1278 1
Schistosoma mansoni hypothetical protein 0.017 0.0435 0.0679
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0023 0.0016 0.0046
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0054 0.0096
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0101 0.0239 0.0373
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.0183 0.0285
Schistosoma mansoni loxhd1 0.017 0.0435 0.0679
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0159 0.029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0095 0.0223 0.0347
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0017 0.0016
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.004 0.0067 0.012
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0042 0.0074
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0023 0.0016 0.0046
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0035 0.0051 0.0091
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.0075 0.0116
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0042 0.0076
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0035 0.0051 0.0078
Entamoeba histolytica P-glycoprotein 5, putative 0.0023 0.0017 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0762 0.1391
Schistosoma mansoni nuclear hormone receptor 0.0045 0.008 0.0123
Onchocerca volvulus 0.0081 0.0182 0.0852
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0054 0.0096
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0097 0.0228 0.0355
Echinococcus multilocularis tubulin alpha chain 0.1401 0.3932 0.3931
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0097 0.0228 0.0416
Loa Loa (eye worm) hypothetical protein 0.0056 0.0112 0.0203
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0068 0.0067
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0068 0.0067
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0068 0.0123
Trichomonas vaginalis abcb9, putative 0.0023 0.0017 0.0024
Onchocerca volvulus 0.0744 0.2064 1
Brugia malayi N-terminal motif family protein 0.0218 0.0571 0.1048
Schistosoma mansoni cpg binding protein 0.0091 0.0211 0.0328
Brugia malayi MH1 domain containing protein 0.0024 0.002 0.0037
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0068 0.0123
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0101 0.0239 0.0373
Echinococcus multilocularis lipoxygenase domain containing protein 0.017 0.0435 0.0434
Trichomonas vaginalis tubulin, putative 0.0573 0.158 0.2892
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0097 0.0228 0.0411
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0284 0.0519
Loa Loa (eye worm) hypothetical protein 0.0045 0.008 0.0144
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0015 0.0027
Brugia malayi MH1 domain containing protein 0.0043 0.0075 0.0138
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.008 0.0123
Echinococcus multilocularis Tubulin beta 2C chain 0.1936 0.5452 0.5452
Schistosoma mansoni tubulin subunit alpha 0.1401 0.3932 0.6149
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0141 0.1029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0063 0.0131 0.0233
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0046 0.0084 0.0129
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0101 0.0239 0.113
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0023 0.0016 0.0024
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0056 0.0112 0.0202
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0101 0.0239 0.0437
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0042 0.0074
Schistosoma mansoni thyroid hormone receptor 0.0101 0.0239 0.0373
Schistosoma mansoni nuclear receptor nhr-48 0.0045 0.008 0.0123
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0016 0.0028
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0101 0.0239 0.0373
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0023 0.0016 0.0046
Loa Loa (eye worm) nuclear receptor NHR-67 0.0045 0.008 0.0144
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0008
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0017 0.0024
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0679 0.1882 0.2942
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0101 0.0239 0.0439
Trichomonas vaginalis tubulin epsilon chain, putative 0.1401 0.3932 0.7209
Echinococcus granulosus tubulin alpha chain 0.1401 0.3932 0.6149
Echinococcus granulosus tubulin alpha 0.104 0.2906 0.4544
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0062 0.0128 0.0234
Schistosoma mansoni tubulin subunit beta 0.1936 0.5452 0.8527
Trypanosoma brucei epsilon tubulin 0.1069 0.2988 0.5479
Leishmania major alpha tubulin 0.1401 0.3932 0.721
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0029
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0054 0.0096
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0269 0.0419
Echinococcus multilocularis Tubulin beta 2C chain 0.1936 0.5452 0.5452
Entamoeba histolytica P-glycoprotein-2 0.0023 0.0017 0.0024
Plasmodium falciparum glutathione reductase 0.0036 0.0054 0.0096
Schistosoma mansoni lamin 0.0088 0.0203 0.0316
Echinococcus multilocularis Smad4 0.0043 0.0075 0.0074
Echinococcus granulosus expressed conserved protein 0.0204 0.053 0.0828
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0011 0.0012
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0018 0.0004 0.0005
Schistosoma mansoni Smad4 0.0019 0.0007 0.0009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0101 0.0239 0.0373
Echinococcus granulosus beta tubulin 0.1936 0.5452 0.8527
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.0016 0.0028
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0042 0.0074
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0011 0.0019
Loa Loa (eye worm) hypothetical protein 0.006 0.0123 0.0223
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0046 0.0084 0.0146
Brugia malayi tubulin alpha chain - mouse 0.1401 0.3932 0.7211
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0284 0.0443
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0011 0.0012
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0017 0.0029
Echinococcus multilocularis tubulin alpha 3 chain 0.1401 0.3932 0.3931
Brugia malayi bZIP transcription factor family protein 0.0265 0.0704 0.129
Schistosoma mansoni niemann-pick C1 (NPC1) 0.022 0.0577 0.0901
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0023 0.0016 0.0046
Echinococcus multilocularis tubulin alpha chain 0.1401 0.3932 0.3931
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0015 0.0033
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.0695 0.5398
Plasmodium vivax tubulin alpha chain, putative 0.1401 0.3932 0.721
Loa Loa (eye worm) hypothetical protein 0.0101 0.0239 0.0437
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0054 0.2112
Leishmania major beta tubulin 0.1936 0.5452 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0017 0.0029
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1401 0.3932 0.7209
Brugia malayi MH2 domain containing protein 0.0637 0.1762 0.3232
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0054 0.0096
Trichomonas vaginalis tubulin alpha chain, putative 0.104 0.2906 0.5326
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0197 0.0511 0.0798
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0042 0.0074
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0023 0.0017 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0109 0.0192
Leishmania major alpha tubulin 0.1401 0.3932 0.721
Loa Loa (eye worm) hypothetical protein 0.0081 0.0182 0.0332
Entamoeba histolytica hypothetical protein 0.0046 0.0084 0.0146
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0054 0.0096
Echinococcus granulosus survival motor neuron protein 1 0.0261 0.0694 0.1084
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0112 0.0269 0.0491
Echinococcus granulosus tubulin alpha 1C chain 0.1401 0.3932 0.6149
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0068 0.0067
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.0007 0.0006
Onchocerca volvulus Bile acid receptor homolog 0.0101 0.0239 0.113
Loa Loa (eye worm) intermediate filament protein 0.0088 0.0203 0.037
Brugia malayi TAZ zinc finger family protein 0.0218 0.0572 0.105
Echinococcus granulosus peroxisome assembly protein 26 0.1401 0.3932 0.6149
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0054 0.0096
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.0137 0.0212
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0023 0.0016 0.0046
Mycobacterium tuberculosis Probable dehydrogenase 0.0235 0.062 0.481
Loa Loa (eye worm) hypothetical protein 0.017 0.0435 0.0797
Echinococcus granulosus regulator of G protein signaling 7 0.0057 0.0114 0.0176
Loa Loa (eye worm) hypothetical protein 0.1401 0.3932 0.721
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0054 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0011 0.0012
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0068 0.0105
Schistosoma mansoni axis inhibition protein axin 0.0046 0.0084 0.0129
Brugia malayi Raf kinase 0.0046 0.0084 0.0154
Trichomonas vaginalis tubulin alpha chain, putative 0.0573 0.158 0.2892
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0191 0.0347
Echinococcus multilocularis CREB binding protein 0.0036 0.0054 0.0052
Brugia malayi Tubulin gamma chain 0.1069 0.2989 0.5482
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.0284 0.2133
Echinococcus multilocularis Niemann Pick C1 protein 0.0217 0.0568 0.0566
Schistosoma mansoni retinoic acid receptor RXR 0.0101 0.0239 0.0373
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0054 0.0096
Echinococcus multilocularis Solute carrier organic anion transporter family 0.009 0.0209 0.0208
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0084 0.0191 0.1392
Trichomonas vaginalis tubulin beta chain, putative 0.1401 0.3932 0.7209
Brugia malayi hypothetical protein 0.0046 0.0084 0.0153
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0042 0.0074
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0077 0.0172 0.0313
Leishmania major cytochrome p450-like protein 0.0023 0.0016 0.0028
Loa Loa (eye worm) hypothetical protein 0.0045 0.008 0.0144
Loa Loa (eye worm) tubulin alpha 2 0.0934 0.2605 0.4778
Onchocerca volvulus 0.009 0.0209 0.0982
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0015 0.0037
Plasmodium vivax tubulin epsilon chain, putative 0.1069 0.2988 0.5479
Trypanosoma cruzi beta tubulin, putative 0.1936 0.5452 1
Echinococcus multilocularis dnaJ subfamily B 0.09 0.251 0.2509
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0046 0.0084 0.0082
Mycobacterium leprae Possible regulatory protein 0.0055 0.0109 0.0743
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0112 0.0269 0.0491
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0056 0.0112 0.011
Leishmania major beta tubulin 0.1936 0.5452 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0054 0.0339
Trichomonas vaginalis DNA helicase recq, putative 0.0034 0.005 0.0084
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0032 0.0042 0.0074
Brugia malayi Tubulin alpha-2 chain 0.1401 0.3932 0.7211
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0679 0.1882 0.1881
Plasmodium vivax tubulin alpha chain, putative 0.1401 0.3932 0.721
Trichomonas vaginalis ABC transporter, putative 0.0023 0.0017 0.0024
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0284 0.0443
Loa Loa (eye worm) tubulin gamma chain 0.1069 0.2989 0.5481
Schistosoma mansoni microtubule-associated protein tau 0.2268 0.6393 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0182 0.0181
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.009 0.0209 0.0208
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0062 0.0128 0.0232
Echinococcus multilocularis survival motor neuron protein 1 0.0261 0.0694 0.0693
Loa Loa (eye worm) hypothetical protein 0.0084 0.0191 0.0347
Loa Loa (eye worm) hypothetical protein 0.0045 0.008 0.0144
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0054 0.0096
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0011 0.0012
Brugia malayi follicle stimulating hormone receptor 0.0259 0.0687 0.126
Brugia malayi Cytochrome P450 family protein 0.0069 0.0149 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0101 0.0178
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0062 0.0128 0.0232
Brugia malayi MH1 domain containing protein 0.0024 0.002 0.0037
Entamoeba histolytica hypothetical protein 0.0192 0.0497 0.0904
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0023 0.0016 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0045 0.008 0.0144
Schistosoma mansoni alpha tubulin 0.1401 0.3932 0.6149
Brugia malayi phosphofructokinase 0.0117 0.0284 0.0521
Loa Loa (eye worm) hypothetical protein 0.0062 0.0128 0.0232
Brugia malayi Bloom's syndrome protein homolog 0.0045 0.0081 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0084 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0157 0.0281
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0097 0.0228 0.0416
Loa Loa (eye worm) cytochrome P450 0.0023 0.0016 0.0028
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0034 0.005 0.0089
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0023 0.0016 0.0046
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0011 0.0012
Giardia lamblia Epsilon tubulin 0.0496 0.136 0.248
Schistosoma mansoni alpha tubulin 0.1401 0.3932 0.6149
Trichomonas vaginalis tubulin alpha chain, putative 0.0573 0.158 0.2892
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0055 0.0109 0.0197
Trichomonas vaginalis adenylate cyclase, putative 0.0055 0.0109 0.0192
Treponema pallidum cell division protein FtsZ 0.0467 0.1278 1
Schistosoma mansoni hypothetical protein 0.0903 0.2518 0.3937
Toxoplasma gondii FATC domain-containing protein 0.0018 0.0004 0.0005
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0103 0.019
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0054 0.0082
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.0137 0.0135
Trypanosoma brucei beta tubulin 0.1936 0.5452 1
Echinococcus granulosus beta tubulin 0.1936 0.5452 0.8527
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0011 0.0012
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0056 0.0112 0.0202
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0023 0.0017 0.0016
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0055 0.0109 0.0197
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.0151 0.0235
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0101 0.0239 0.0373
Toxoplasma gondii cytochrome p450 superfamily protein 0.0023 0.0016 0.0028
Echinococcus multilocularis expressed protein 0.0062 0.0128 0.0126
Onchocerca volvulus Putative organic anion transporter 0.009 0.0209 0.0982
Brugia malayi Cytochrome P450 family protein 0.0069 0.0149 0.0273
Echinococcus granulosus CREB binding protein 0.0036 0.0054 0.0082
Echinococcus multilocularis sterol regulatory element binding protein 0.0093 0.0216 0.0215
Toxoplasma gondii beta tubulin 0.1936 0.5452 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0023 0.0017 0.0024
Trichomonas vaginalis DNA helicase recq1, putative 0.0045 0.0081 0.014
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0017 0.0024
Onchocerca volvulus 0.0045 0.008 0.0353
Leishmania major alpha tubulin 0.1401 0.3932 0.721
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0112 0.0269 0.0491
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0081 0.014
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0097 0.0228 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0011 0.0012
Plasmodium vivax ataxin-2 like protein, putative 0.011 0.0264 0.0483
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0023 0.0016 0.0046
Schistosoma mansoni smad1 5 8 and 0.0043 0.0075 0.0116
Echinococcus multilocularis tumor protein p63 0.147 0.4127 0.4126
Schistosoma mansoni hypothetical protein 0.0041 0.0069 0.0106
Echinococcus granulosus CREB binding protein 0.0135 0.0335 0.0522
Loa Loa (eye worm) hypothetical protein 0.0062 0.0128 0.0232
Echinococcus multilocularis smad 0.0043 0.0075 0.0074
Onchocerca volvulus 0.017 0.0435 0.2082
Loa Loa (eye worm) PXA domain-containing protein 0.0046 0.0084 0.0151
Brugia malayi Nuclear hormone receptor E75 0.0045 0.008 0.0146
Schistosoma mansoni lipoxygenase 0.0373 0.1011 0.158
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0055 0.0109 0.0192
Leishmania major hypothetical protein, conserved 0.011 0.0264 0.0483
Entamoeba histolytica hypothetical protein 0.0023 0.0017 0.0023
Schistosoma mansoni hypothetical protein 0.0903 0.2518 0.3937
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0101 0.0239 0.0238
Schistosoma mansoni multidrug resistance protein 0.0023 0.0017 0.0025
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.0762 0.1391
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0006 0.0005
Schistosoma mansoni multidrug resistance protein 0.0023 0.0017 0.0025
Echinococcus granulosus FTZ F1 alpha 0.0101 0.0239 0.0373
Echinococcus granulosus tubulin alpha chain 0.1401 0.3932 0.6149
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.0075 0.0116
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0054 0.0096
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0073 0.0159 0.029
Leishmania major delta tubulin, putative 0.0648 0.1792 0.3286
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0023 0.0016 0.0046
Onchocerca volvulus 0.017 0.0435 0.2082
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.0284 0.2159
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0017 0.0024
Loa Loa (eye worm) steroid hormone receptor 0.0101 0.0239 0.0437
Loa Loa (eye worm) hypothetical protein 0.0045 0.008 0.0144
Loa Loa (eye worm) hypothetical protein 0.0101 0.0239 0.0437
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0072 0.0111
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0934 0.2605 0.4778
Echinococcus multilocularis tubulin subunit TubB 0.1401 0.3932 0.3931
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0042 0.0057
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0141 0.014
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0017 0.0025
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0047 0.0086 0.0156
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0017 0.0049
Echinococcus granulosus regulator of G protein signaling 7 0.0057 0.0114 0.0176
Loa Loa (eye worm) hypothetical protein 0.0046 0.0084 0.0151
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0033 0.0045 0.0079
Toxoplasma gondii LsmAD domain-containing protein 0.011 0.0264 0.0483
Echinococcus multilocularis microtubule associated protein 2 0.2268 0.6393 0.6393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0228 0.0411
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0762 0.1391
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.0284 0.0519
Loa Loa (eye worm) phosphatidylinositol 3 0.0033 0.0045 0.0079
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0017 0.0049
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0093 0.0216 0.0394
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0017 0.0049
Loa Loa (eye worm) hypothetical protein 0.017 0.0435 0.0797
Schistosoma mansoni patched 1 0.0093 0.0216 0.0336
Echinococcus multilocularis transfer RNA-Lys 0.0157 0.0398 0.0397
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0217 0.0568 0.1034
Echinococcus granulosus tubulin alpha 3 chain 0.1401 0.3932 0.6149
Schistosoma mansoni DNA helicase recq1 0.0032 0.0042 0.0063
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0023 0.0016 0.0028
Trichomonas vaginalis tubulin beta chain, putative 0.1401 0.3932 0.7209
Trypanosoma brucei epsilon tubulin 0.104 0.2906 0.5329
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0062 0.0128 0.0234
Echinococcus granulosus Regulator of G protein signaling 20 0.0046 0.0084 0.0129
Echinococcus multilocularis neuropeptide receptor A26 0.1022 0.2855 0.2854
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0055 0.0109 0.5285
Loa Loa (eye worm) hypothetical protein 0.0101 0.0239 0.0437
Echinococcus granulosus tubulin alpha chain 0.1401 0.3932 0.6149
Echinococcus multilocularis multidrug resistance protein 1 0.0023 0.0017 0.0016
Onchocerca volvulus 0.0266 0.0708 0.3405
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.0695 0.5383
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0042 0.0074
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0042 0.0069
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0042 0.0076
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0006 0.0008
Leishmania major alpha tubulin 0.1401 0.3932 0.721
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0084 0.0146
Trypanosoma brucei zeta tubulin, putative 0.0769 0.2138 0.392
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0045 0.008 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0101 0.0178
Loa Loa (eye worm) hypothetical protein 0.0045 0.008 0.0144
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.0075 0.0136
Echinococcus granulosus microtubule associated protein 2 0.2268 0.6393 1
Onchocerca volvulus 0.0053 0.0103 0.0468
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0054 0.0096
Onchocerca volvulus 0.0157 0.0398 0.1901
Echinococcus granulosus mitogen activated protein kinase 3 0.0112 0.0269 0.0419
Entamoeba histolytica P-glycoprotein-2 0.0023 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0045 0.008 0.0144
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0043 0.0073 0.0072
Loa Loa (eye worm) hypothetical protein 0.0101 0.0239 0.0437
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0101 0.0239 0.0373
Echinococcus granulosus neuropeptide receptor A26 0.1022 0.2855 0.4464
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0007 0.0011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0011 0.0017
Schistosoma mansoni regulator of G protein signaling 0.0046 0.0084 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0083 0.0188 0.0337
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1936 0.5452 0.5452
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0054 0.0096
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0032 0.0042 0.0064
Echinococcus multilocularis neuropeptide s receptor 0.1022 0.2855 0.2854
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.0245 0.1849
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0101 0.0239 0.0238
Loa Loa (eye worm) hypothetical protein 0.0386 0.1048 0.1921
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0088 0.0203 0.037
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0033 0.0045 0.0068
Plasmodium vivax multidrug resistance protein 1, putative 0.0023 0.0017 0.0029
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0017 0.0029
Loa Loa (eye worm) raf kinase 0.0046 0.0084 0.0152
Echinococcus multilocularis regulator of G protein signaling 7 0.0057 0.0114 0.0113
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0023 0.0016 0.0046
Toxoplasma gondii endonuclease IV APN 0.0084 0.0191 0.0347
Loa Loa (eye worm) hypothetical protein 0.0045 0.008 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0101 0.0177
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0023 0.0017 0.0024
Schistosoma mansoni smad 0.0043 0.0075 0.0116
Echinococcus granulosus geminin 0.0903 0.2518 0.3937
Loa Loa (eye worm) beta-tubulin 0.1936 0.5452 1
Schistosoma mansoni rab6-interacting 0.017 0.0435 0.0679
Loa Loa (eye worm) isocitrate dehydrogenase 0.0035 0.0051 0.0091
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0023 0.0016 0.0046
Echinococcus granulosus agrin 0.0062 0.0128 0.0198
Brugia malayi hypothetical protein 0.0712 0.1974 0.3621
Schistosoma mansoni hypothetical protein 0.009 0.0207 0.0321
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0056 0.0112 0.0202
Treponema pallidum NADH oxidase 0.0036 0.0054 0.0339
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0006 0.0008
Plasmodium falciparum alpha tubulin 1 0.1401 0.3932 0.721
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0101 0.0239 0.0373
Echinococcus multilocularis CREB binding protein 0.0036 0.0054 0.0052
Schistosoma mansoni tubulin subunit gamma 0.1069 0.2989 0.4674
Leishmania major beta tubulin 0.1936 0.5452 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0182 0.0283
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.008 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0101 0.0239 0.0439
Brugia malayi hypothetical protein 0.017 0.0435 0.0799
Giardia lamblia Gamma tubulin 0.1069 0.2989 0.5474
Loa Loa (eye worm) hypothetical protein 0.0032 0.0042 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0011 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0011 0.0012
Onchocerca volvulus 0.009 0.0209 0.0982
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0011
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0032 0.0042 0.0063
Brugia malayi conserved hypotetical protein 0.0045 0.008 0.0146
Toxoplasma gondii histone lysine methyltransferase SET1 0.018 0.0464 0.0848
Leishmania major protein kinase, putative 0.0061 0.0125 0.0227
Brugia malayi Niemann-Pick C1 protein precursor 0.0217 0.0568 0.1041
Leishmania major protein kinase, putative 0.0056 0.0112 0.0202
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0087 0.0198 0.0362
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0054 0.0339
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0023 0.0016 0.0046
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0047 0.0086 0.0156
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0027 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0157 0.0281

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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