Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0136 | 1 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0136 | 1 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0136 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0136 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0136 | 1 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0136 | 1 | 1 |
Onchocerca volvulus | 0.0136 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0136 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0136 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0136 | 1 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0136 | 1 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0136 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 1 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0136 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0136 | 1 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0136 | 1 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0136 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0136 | 1 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0136 | 1 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0136 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0136 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0136 | 1 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0136 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0136 | 1 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0136 | 1 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0136 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0136 | 1 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0136 | 1 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0136 | 1 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0105 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0136 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0136 | 1 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0136 | 1 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0136 | 1 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0136 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 1 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0136 | 1 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0136 | 1 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0136 | 1 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0136 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0136 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0136 | 1 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0136 | 1 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0136 | 1 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0136 | 1 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0136 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0136 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0136 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0136 | 1 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0136 | 1 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0136 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0136 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0136 | 1 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0136 | 1 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0136 | 1 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0136 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0136 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0136 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0136 | 1 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0136 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.