Detailed information for compound 1313858

Basic information

Technical information
  • TDR Targets ID: 1313858
  • Name: N-(1,3-benzodioxol-5-yl)-2-[3-(4-ethylbenzoyl )-6,7-dimethoxy-4-oxoquinolin-1-yl]acetamide
  • MW: 514.526 | Formula: C29H26N2O7
  • H donors: 1 H acceptors: 3 LogP: 4.7 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCc1ccc(cc1)C(=O)c1cn(CC(=O)Nc2ccc3c(c2)OCO3)c2c(c1=O)cc(c(c2)OC)OC
  • InChi: 1S/C29H26N2O7/c1-4-17-5-7-18(8-6-17)28(33)21-14-31(22-13-25(36-3)24(35-2)12-20(22)29(21)34)15-27(32)30-19-9-10-23-26(11-19)38-16-37-23/h5-14H,4,15-16H2,1-3H3,(H,30,32)
  • InChiKey: IVIMJYKGZQNGAI-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(1,3-benzodioxol-5-yl)-2-[3-(4-ethylbenzoyl)-6,7-dimethoxy-4-oxo-1-quinolyl]acetamide
  • N-(1,3-benzodioxol-5-yl)-2-[3-[(4-ethylphenyl)-oxomethyl]-6,7-dimethoxy-4-oxo-1-quinolyl]acetamide
  • N-(1,3-benzodioxol-5-yl)-2-[3-(4-ethylbenzoyl)-4-keto-6,7-dimethoxy-1-quinolyl]acetamide
  • N-(1,3-benzodioxol-5-yl)-2-[3-(4-ethylphenyl)carbonyl-6,7-dimethoxy-4-oxo-quinolin-1-yl]ethanamide
  • C647-0059
  • NCGC00110960-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.003 0.015 0.0352
Entamoeba histolytica type A flavoprotein, putative 0.0102 0.1031 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0306 0.1002
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0307 0.0722
Brugia malayi Cathepsin L-like precursor 0.002 0.0025 0.0081
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.003 0.015 0.0352
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0442 0.1448
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0223 0.0731
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0025 0.0081
Giardia lamblia GTOR 0.0054 0.0442 0.1156
Echinococcus granulosus cathepsin l1 0.002 0.0025 0.0025
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0102 0.1031 0.3374
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0722 0.1698
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0025 0.0081
Loa Loa (eye worm) acetyltransferase 0.0175 0.1924 0.6296
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0406 0.0955
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0442 0.1448
Brugia malayi FAD binding domain containing protein 0.0165 0.1802 0.5895
Loa Loa (eye worm) cysteine protease 0.002 0.0025 0.0081
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0408 0.278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0025 0.0081
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0025 0.0025
Leishmania major NADH-cytochrome b5 reductase, putative 0.003 0.015 0.0352
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1924 0.1924
Echinococcus multilocularis cytochrome b5 reductase 4 0.003 0.015 0.015
Leishmania major cytochrome P450 reductase, putative 0.0237 0.2683 0.6312
Plasmodium vivax ferredoxin--NADP reductase, putative 0.003 0.015 0.0411
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.003 0.015 0.0411
Leishmania major oxidoreductase-like protein 0.003 0.015 0.0352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0025 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0025 0.0081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0025 0.0081
Echinococcus multilocularis cysteine protease 0.002 0.0025 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0722 0.1698
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0136 0.0444
Schistosoma mansoni diflavin oxidoreductase 0.0133 0.1404 0.1404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0175 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0442 0.1448
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0025 0.0025
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0267 0.3056 0.3056
Trypanosoma cruzi oxidoreductase-like protein, putative 0.003 0.015 0.0352
Trypanosoma brucei oxidoreductase-protein, putative 0.003 0.015 0.0352
Brugia malayi Cathepsin L-like precursor 0.002 0.0025 0.0081
Treponema pallidum flavodoxin 0.0102 0.1031 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0442 0.1448
Entamoeba histolytica type A flavoprotein, putative 0.0102 0.1031 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0025 0.0081
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0267 0.3056 0.3056
Leishmania major cysteine peptidase A (CPA) 0.002 0.0025 0.0058
Leishmania major NADH-cytochrome b5 reductase, putative 0.003 0.015 0.0352
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1894 0.4456
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0272 0.089
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0356 0.1091
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0025 0.0081
Leishmania major hypothetical protein, conserved 0.0102 0.1031 0.2425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0136 0.0444
Brugia malayi FAD binding domain containing protein 0.0267 0.3056 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.4251 1
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0267 0.3056 0.7188
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.003 0.015 0.0352
Loa Loa (eye worm) cytochrome b5 reductase 4 0.003 0.015 0.0489
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.1894 0.4456
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.003 0.015 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0272 0.089
Trypanosoma brucei NADH-dependent fumarate reductase 0.003 0.015 0.0352
Trypanosoma brucei NADH-dependent fumarate reductase 0.003 0.015 0.0352
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.003 0.015 0.0352
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.064 0.1505
Loa Loa (eye worm) FAD binding domain-containing protein 0.0267 0.3056 1
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.003 0.015 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0171 0.0558
Loa Loa (eye worm) hypothetical protein 0.0267 0.3056 1
Loa Loa (eye worm) FAD binding domain-containing protein 0.0165 0.1802 0.5895
Leishmania major cathepsin L-like protease 0.002 0.0025 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0025 0.0081
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0025 0.0025
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0025 0.0081
Loa Loa (eye worm) hypothetical protein 0.006 0.0509 0.1667
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0722 0.1698
Loa Loa (eye worm) fibroinase 0.002 0.0025 0.0081
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0102 0.1031 0.332
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1864 0.1864
Toxoplasma gondii flavodoxin domain-containing protein 0.0133 0.1404 1
Entamoeba histolytica type A flavoprotein, putative 0.0102 0.1031 1
Trypanosoma cruzi p450 reductase, putative 0.003 0.015 0.0352
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0408 0.278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0722 0.1698
Leishmania major cathepsin L-like protease 0.002 0.0025 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0722 0.1698
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0442 0.4151
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0025 0.0025
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0307 0.0722
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0442 0.1041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0136 0.0446
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0406 0.0955
Trypanosoma cruzi nitrate reductase, putative 0.003 0.015 0.0352
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0442 0.1041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0722 0.1698
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0025 0.0081
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0267 0.3056 0.7188
Echinococcus granulosus methionine synthase reductase 0.0165 0.1802 0.1802
Brugia malayi flavodoxin family protein 0.0102 0.1031 0.3374
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.003 0.015 0.0904
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.003 0.015 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0272 0.089
Leishmania major cathepsin L-like protease 0.0077 0.0722 0.1698
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.003 0.015 0.015
Echinococcus granulosus tumor protein p63 0.0408 0.4783 0.4783
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0102 0.1031 0.2425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0136 0.0444
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1924 0.1924
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0102 0.1031 0.332
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0267 0.3056 0.7188
Trypanosoma cruzi oxidoreductase-protein, putative 0.003 0.015 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0306 0.1002
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0267 0.3056 0.7188
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0408 0.0408
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0442 0.1041
Echinococcus granulosus cytochrome b5 reductase 4 0.003 0.015 0.015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0025 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0175 0.0571
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0025 0.0081
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0081
Leishmania major cathepsin L-like protease 0.002 0.0025 0.0058
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0267 0.3056 0.7188
Entamoeba histolytica type A flavoprotein, putative 0.0102 0.1031 1
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0102 0.1031 0.3374
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0306 0.1002
Leishmania major NADH-cytochrome b5 reductase, putative 0.003 0.015 0.0352
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0442 0.0442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0025 0.0081
Giardia lamblia Nitric oxide synthase, inducible 0.0237 0.2683 1
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.003 0.015 0.0904
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0442 0.0442
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.003 0.015 0.0352
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.003 0.015 0.015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0025 0.0081
Leishmania major p450 reductase, putative 0.0267 0.3056 0.7188
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0053 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0025 0.0081
Brugia malayi flavodoxin family protein 0.0267 0.3056 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0025 0.0081
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0025 0.0025
Echinococcus multilocularis tumor protein p63 0.0408 0.4783 0.4783
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0025 0.0081
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.003 0.015 0.0352
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0442 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0272 0.089
Echinococcus multilocularis cysteine protease 0.002 0.0025 0.0025
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0442 0.1041
Schistosoma mansoni NADH-cytochrome B5 reductase 0.003 0.015 0.015
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0307 0.0722
Brugia malayi Cathepsin L-like precursor 0.002 0.0025 0.0081
Echinococcus granulosus cytochrome b5 reductase 4 0.003 0.015 0.015
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.003 0.015 0.0352
Trichomonas vaginalis sulfite reductase, putative 0.0267 0.3056 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0408 0.1336
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0442 0.4151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0306 0.1002
Giardia lamblia Hypothetical protein 0.0237 0.2683 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0175 0.0571
Leishmania major nitrate reductase, putative 0.003 0.015 0.0352
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0025 0.0081
Onchocerca volvulus 0.006 0.0509 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0442 0.1041
Leishmania major cathepsin L-like protease 0.0077 0.0722 0.1698
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.4251 1
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0102 0.1031 0.3374
Loa Loa (eye worm) ctsf protein 0.002 0.0025 0.0081
Brugia malayi diaphorase 0.003 0.015 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0272 0.089
Schistosoma mansoni NADPH flavin oxidoreductase 0.0135 0.1429 0.1429
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.003 0.015 0.0352
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0267 0.3056 0.3056
Plasmodium falciparum ferredoxin--NADP reductase 0.003 0.015 0.0411
Leishmania major cytochrome-b5 reductase, putative 0.003 0.015 0.0352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0722 0.1698
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.003 0.015 0.0352
Trypanosoma cruzi p450 reductase, putative 0.0267 0.3056 0.7188
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0267 0.3056 0.3056
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0267 0.3056 1
Leishmania major NADH-dependent fumarate reductase-like protein 0.003 0.015 0.0352
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0025 0.0025
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.003 0.015 0.0352
Plasmodium vivax hypothetical protein, conserved 0.0102 0.1031 0.332
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.003 0.015 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0345 0.1129
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.4251 1
Loa Loa (eye worm) diaphorase 0.003 0.015 0.0489
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0543 0.1278
Leishmania major cytochrome-b5 reductase, putative 0.003 0.015 0.0352
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.003 0.015 0.0352
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.003 0.015 0.0352
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.003 0.015 0.0411
Schistosoma mansoni cytochrome P450 reductase 0.0267 0.3056 0.3056
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0356 0.3287
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0408 0.1265
Leishmania major cathepsin L-like protease 0.002 0.0025 0.0058
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0356 0.0813
Entamoeba histolytica type A flavoprotein, putative 0.0102 0.1031 1
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0722 0.1698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0025 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0722 0.1698
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0722 0.1698
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0025 0.0081
Mycobacterium ulcerans hypothetical protein 0.0192 0.2133 0.6826
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0237 0.2683 0.878
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0406 0.0955
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0136 0.0446
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0442 0.1041
Brugia malayi Cathepsin L-like precursor 0.002 0.0025 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0025 0.0081
Echinococcus multilocularis methionine synthase reductase 0.0165 0.1802 0.1802
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0406 0.0955
Plasmodium vivax flavodoxin domain containing protein 0.0237 0.2683 0.877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0136 0.0446
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.4251 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0025 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0722 0.1698
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0509 0.0509
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0025 0.0081
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1894 0.4456
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0102 0.1031 0.2425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0025 0.0081
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0722 0.1698
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.003 0.015 0.0352
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0025 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0171 0.0558
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0722 0.1698
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0442 0.1448
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.052 0.1222
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.2133 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0092 0.0215
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1924 0.6296
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0272 0.089
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0025 0.0025
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0102 0.1031 0.2425
Onchocerca volvulus 0.003 0.015 0.2573
Leishmania major reductase, putative 0.003 0.015 0.0352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0025 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0272 0.089
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0722 0.1698
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.003 0.015 0.0489
Leishmania major cathepsin L-like protease 0.0077 0.0722 0.1698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0025 0.0081
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.003 0.015 0.0352
Trypanosoma brucei nitrate reductase, putative 0.003 0.015 0.0352
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0267 0.3056 0.7188
Toxoplasma gondii hypothetical protein 0.0059 0.0498 0.3434
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.003 0.015 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0306 0.1002
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0272 0.1792
Brugia malayi Cathepsin L-like precursor 0.002 0.0025 0.0081
Chlamydia trachomatis sulfite reductase 0.0165 0.1802 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0209 0.0684
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.003 0.015 0.0352
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.003 0.015 0.0352
Plasmodium falciparum nitric oxide synthase, putative 0.0267 0.3056 1
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0267 0.3056 0.7188
Leishmania major cathepsin L-like protease 0.002 0.0025 0.0058
Loa Loa (eye worm) flavodoxin family protein 0.0102 0.1031 0.3374
Schistosoma mansoni cytochrome B5 0.003 0.015 0.015
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0102 0.1031 0.3374
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0267 0.3056 1
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0102 0.1031 0.2425
Trypanosoma cruzi reductase, putative 0.003 0.015 0.0352
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.003 0.015 0.0352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0722 0.1698
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0025 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0025 0.0081
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0408 0.1336
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0165 0.1802 0.1802
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.003 0.015 0.0352
Toxoplasma gondii flavodoxin domain-containing protein 0.0133 0.1404 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0136 0.0446
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0267 0.3056 0.7188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0025 0.0081
Leishmania major NADH-dependent fumarate reductase, putative 0.003 0.015 0.0352

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.3281 uM PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] ChEMBL. No reference
Potency (binding) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 11.6681 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) 42.2841 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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