Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0244 | 0.3846 | 0.3846 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0244 | 0.3846 | 0.3846 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0274 | 0.4505 | 0.4505 |
Schistosoma mansoni | zinc finger protein | 0.0244 | 0.3846 | 0.3846 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.4505 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0274 | 0.4505 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.4505 | 0.1071 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0274 | 0.4505 | 0.4505 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0274 | 0.4505 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.4505 | 0.1071 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0244 | 0.3846 | 0.3846 |
Schistosoma mansoni | nuclear hormone receptor | 0.0244 | 0.3846 | 0.3846 |
Schistosoma mansoni | nuclear receptor | 0.0244 | 0.3846 | 0.3846 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0244 | 0.3846 | 0.3846 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0274 | 0.4505 | 0.4505 |
Schistosoma mansoni | nuclear hormone receptor | 0.0244 | 0.3846 | 0.3846 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0244 | 0.3846 | 0.3846 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0274 | 0.4505 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0274 | 0.4505 | 0.1071 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0244 | 0.3846 | 0.3846 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.4505 | 0.1071 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0274 | 0.4505 | 0.4505 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0244 | 0.3846 | 0.3846 |
Brugia malayi | hypothetical protein | 0.0274 | 0.4505 | 0.1071 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0244 | 0.3846 | 0.3846 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0244 | 0.3846 | 0.3846 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0244 | 0.3846 | 0.3846 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0244 | 0.3846 | 0.3846 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.4505 | 0.1071 |
Brugia malayi | nuclear receptor RXR | 0.0274 | 0.4505 | 0.1071 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0244 | 0.3846 | 0.3846 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0244 | 0.3846 | 0.3846 |
Schistosoma mansoni | nuclear receptor | 0.0244 | 0.3846 | 0.3846 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0244 | 0.3846 | 0.3846 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0244 | 0.3846 | 0.3846 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.