Detailed information for compound 1313989

Basic information

Technical information
  • TDR Targets ID: 1313989
  • Name: 2-[[2-[(4-fluorophenyl)sulfonylamino]acetyl]- (phenylmethyl)amino]-N-(furan-2-ylmethyl)acet amide
  • MW: 459.491 | Formula: C22H22FN3O5S
  • H donors: 2 H acceptors: 4 LogP: 1.95 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(C(=O)CNS(=O)(=O)c1ccc(cc1)F)Cc1ccccc1)NCc1ccco1
  • InChi: 1S/C22H22FN3O5S/c23-18-8-10-20(11-9-18)32(29,30)25-14-22(28)26(15-17-5-2-1-3-6-17)16-21(27)24-13-19-7-4-12-31-19/h1-12,25H,13-16H2,(H,24,27)
  • InChiKey: SNFZMKAUBSERTN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[2-[(4-fluorophenyl)sulfonylamino]acetyl]-(phenylmethyl)amino]-N-(2-furylmethyl)acetamide
  • 2-[[2-[(4-fluorophenyl)sulfonylamino]-1-oxoethyl]-(phenylmethyl)amino]-N-(2-furylmethyl)acetamide
  • 2-[benzyl-[2-[(4-fluorophenyl)sulfonylamino]acetyl]amino]-N-(2-furylmethyl)acetamide
  • 2-[2-[(4-fluorophenyl)sulfonylamino]ethanoyl-(phenylmethyl)amino]-N-(furan-2-ylmethyl)ethanamide
  • ASN 05455856

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus snurportin 1 0.0372 0.525 0.5202
Plasmodium falciparum phd finger protein, putative 0.0035 0.0107 1
Loa Loa (eye worm) hypothetical protein 0.0361 0.5079 0.5029
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0107 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0322 0.4489 0.443
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.525 0.5202
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0317 0.0219
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0317 0.0219
Brugia malayi tailless protein 0.0322 0.4489 0.4433
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0107 0.0006
Brugia malayi jmjC domain containing protein 0.0043 0.022 0.012
Brugia malayi hypothetical protein 0.0361 0.5079 0.5029
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0361 0.5079 0.5029
Loa Loa (eye worm) hypothetical protein 0.0322 0.4489 0.4433
Echinococcus granulosus Nuclear hormone receptor HR96 0.0322 0.4489 0.4433
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.022 0.012
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.022 0.012
Loa Loa (eye worm) nuclear receptor NHR-67 0.0322 0.4489 0.4433
Schistosoma mansoni hypothetical protein 0.0035 0.0107 0.0006
Brugia malayi nuclear hormone receptor family member odr-7 0.0322 0.4489 0.4433
Loa Loa (eye worm) DR-78 0.0322 0.4489 0.4433
Loa Loa (eye worm) hypothetical protein 0.0322 0.4489 0.4433
Brugia malayi RNA, U transporter 1 0.0099 0.1082 0.0991
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.1331 0.1243
Brugia malayi conserved hypotetical protein 0.0322 0.4489 0.4433
Brugia malayi nuclear receptor NHR-67 0.0322 0.4489 0.4433
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0361 0.5079 0.5029
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0107 0.0006
Loa Loa (eye worm) hypothetical protein 0.0361 0.5079 0.5029
Loa Loa (eye worm) hypothetical protein 0.0322 0.4489 0.4433
Loa Loa (eye worm) hypothetical protein 0.0322 0.4489 0.4433
Loa Loa (eye worm) hypothetical protein 0.0322 0.4489 0.4433
Echinococcus multilocularis peregrin 0.0035 0.0107 0.0006
Loa Loa (eye worm) hypothetical protein 0.0361 0.5079 0.5029
Loa Loa (eye worm) hypothetical protein 0.0322 0.4489 0.4433
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.022 0.012
Loa Loa (eye worm) hypothetical protein 0.0361 0.5079 0.5029
Echinococcus granulosus thyroid hormone receptor alpha 0.0322 0.4489 0.4433
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0322 0.4489 0.4433
Brugia malayi nuclear hormone receptor family member nhr-6 0.0322 0.4489 0.4433
Loa Loa (eye worm) hypothetical protein 0.006 0.0491 0.0394
Schistosoma mansoni zinc finger protein 0.0322 0.4489 0.4433
Echinococcus granulosus peregrin 0.0035 0.0107 0.0006
Loa Loa (eye worm) hypothetical protein 0.0322 0.4489 0.4433
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.022 0.012
Schistosoma mansoni hypothetical protein 0.0372 0.525 0.5202
Brugia malayi hypothetical protein 0.0322 0.4489 0.4433
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0322 0.4489 0.4433
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0107 0.0006
Brugia malayi Bromodomain containing protein 0.0035 0.0107 0.0006
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0322 0.4489 0.4433
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0101 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0322 0.4489 0.4433
Echinococcus granulosus nuclear receptor nhr 48 0.0322 0.4489 0.4433
Brugia malayi Nuclear hormone receptor-like 1 0.0361 0.5079 0.5029
Echinococcus multilocularis snurportin 1 0.0372 0.525 0.5202
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0361 0.5079 0.5029
Onchocerca volvulus 0.0182 0.2357 0.2275
Brugia malayi Nuclear hormone receptor E75 0.0322 0.4489 0.4433
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0322 0.4489 0.443
Brugia malayi hypothetical protein 0.0322 0.4489 0.4433
Onchocerca volvulus 0.0322 0.4489 0.443
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0322 0.4489 0.4433
Brugia malayi jmjC domain containing protein 0.0115 0.1331 0.1243
Loa Loa (eye worm) hypothetical protein 0.0322 0.4489 0.4433
Loa Loa (eye worm) hypothetical protein 0.0322 0.4489 0.4433
Loa Loa (eye worm) hypothetical protein 0.0182 0.2357 0.228
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0107 0.0006
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0322 0.4489 0.4433
Brugia malayi orphan nuclear receptor NR2E1 0.0322 0.4489 0.4433
Schistosoma mansoni nuclear receptor 0.0322 0.4489 0.4433
Brugia malayi nuclear receptor NHR-88 0.0322 0.4489 0.4433
Schistosoma mansoni nuclear receptor 0.0322 0.4489 0.4433
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0107 1
Loa Loa (eye worm) hypothetical protein 0.0322 0.4489 0.4433
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0322 0.4489 0.4433
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0361 0.5079 0.5029
Loa Loa (eye worm) hypothetical protein 0.0035 0.0107 0.0006
Loa Loa (eye worm) hypothetical protein 0.0322 0.4489 0.4433
Schistosoma mansoni nuclear receptor nhr-48 0.0322 0.4489 0.4433
Schistosoma mansoni nuclear hormone receptor 0.0322 0.4489 0.4433
Brugia malayi Nuclear hormone receptor-like 1 0.0361 0.5079 0.5029
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0322 0.4489 0.4433
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0361 0.5079 0.5029
Brugia malayi Nuclear hormone receptor E75 0.0322 0.4489 0.4433
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.022 0.012
Brugia malayi ecdysone receptor 0.0322 0.4489 0.4433
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.1331 0.1243
Giardia lamblia PHD finger protein 15 0.0035 0.0107 0.5
Echinococcus multilocularis nuclear receptor nhr 48 0.0322 0.4489 0.4433
Loa Loa (eye worm) hypothetical protein 0.0322 0.4489 0.4433
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0969 0.0877
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0322 0.4489 0.4433
Loa Loa (eye worm) hypothetical protein 0.0361 0.5079 0.5029
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0101 0.5
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0322 0.4489 0.4433
Schistosoma mansoni nuclear hormone receptor 0.0322 0.4489 0.4433
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0322 0.4489 0.4433
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0107 1
Brugia malayi nuclear receptor RXR 0.0322 0.4489 0.4433
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.068 0.0585
Brugia malayi nuclear receptor RXR 0.0361 0.5079 0.5029
Loa Loa (eye worm) nuclear hormone receptor 0.0322 0.4489 0.4433
Onchocerca volvulus 0.0322 0.4489 0.443
Loa Loa (eye worm) hypothetical protein 0.0322 0.4489 0.4433
Brugia malayi hypothetical protein 0.0182 0.2357 0.228
Brugia malayi nuclear hormone receptor 0.0322 0.4489 0.4433
Brugia malayi hypothetical protein 0.0361 0.5079 0.5029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0322 0.4489 0.4433
Brugia malayi PHD-finger family protein 0.0035 0.0107 0.0006

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 2.5929 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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