Detailed information for compound 1314085

Basic information

Technical information
  • TDR Targets ID: 1314085
  • Name: 1-cyclohexyl-3-(3-methoxy-4-propoxyphenyl)-4- propylpiperazine-2,5-dione
  • MW: 402.527 | Formula: C23H34N2O4
  • H donors: 0 H acceptors: 2 LogP: 4.29 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN1C(=O)CN(C(=O)C1c1ccc(c(c1)OC)OCCC)C1CCCCC1
  • InChi: 1S/C23H34N2O4/c1-4-13-24-21(26)16-25(18-9-7-6-8-10-18)23(27)22(24)17-11-12-19(29-14-5-2)20(15-17)28-3/h11-12,15,18,22H,4-10,13-14,16H2,1-3H3
  • InChiKey: VMICPPJWCXIFRM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-cyclohexyl-3-(3-methoxy-4-propoxy-phenyl)-4-propyl-piperazine-2,5-dione
  • 1-cyclohexyl-3-(3-methoxy-4-propoxy-phenyl)-4-propyl-piperazine-2,5-quinone
  • MLS000046102
  • SMR000031711
  • EU-0096805

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide F-like receptor 0.0098 0.0486 0.0486
Echinococcus granulosus tumor protein p63 0.0331 0.1781 0.1781
Schistosoma mansoni growth hormone secretagogue receptor 0.0098 0.0486 0.0486
Schistosoma mansoni acetylcholinesterase 0.0234 0.1241 0.1241
Onchocerca volvulus 0.0098 0.0486 0.392
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0217 0.1145 0.1145
Mycobacterium ulcerans carboxylesterase, LipT 0.0234 0.1241 0.4019
Echinococcus granulosus g protein coupled receptor 0.0098 0.0486 0.0486
Schistosoma mansoni bromodomain containing protein 0.0015 0.0025 0.0025
Schistosoma mansoni gliotactin 0.0234 0.1241 0.1241
Echinococcus multilocularis neuropeptide s receptor 0.0098 0.0486 0.0486
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0236 0.0236
Schistosoma mansoni myosin xvIII 0.0098 0.0486 0.0486
Echinococcus granulosus hypothetical protein 0.0098 0.0486 0.0486
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0284 1
Echinococcus multilocularis neuropeptides capa receptor 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0024 0.0031
Mycobacterium ulcerans short chain dehydrogenase 0.0552 0.3008 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0501 0.0501
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.0977 0.0977
Schistosoma mansoni smad1 5 8 and 0.0016 0.0032 0.0032
Echinococcus granulosus allatostatin A receptor 0.0098 0.0486 0.0486
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0024 0.0032
Schistosoma mansoni BC026374 protein (S09 family) 0.0234 0.1241 0.1241
Echinococcus multilocularis neuropeptide Y receptor 0.0098 0.0486 0.0486
Schistosoma mansoni amine GPCR 0.0098 0.0486 0.0486
Brugia malayi isocitrate dehydrogenase 0.0035 0.0138 0.0181
Echinococcus multilocularis rhodopsin orphan GPCR 0.0098 0.0486 0.0486
Loa Loa (eye worm) G-protein coupled receptor 0.0098 0.0486 0.0486
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0098 0.0486 0.0486
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0666 0.2074
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Schistosoma mansoni smad1 5 8 and 0.0016 0.0032 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Echinococcus granulosus sex peptide receptor 0.0098 0.0486 0.0486
Echinococcus granulosus rhodopsin orphan GPCR 0.0098 0.0486 0.0486
Schistosoma mansoni Smad4 0.0016 0.0032 0.0032
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0747 0.2347
Loa Loa (eye worm) bromodomain containing protein 0.0054 0.0243 0.0243
Onchocerca volvulus 0.0098 0.0486 0.392
Echinococcus granulosus rhodopsin orphan GPCR 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Schistosoma mansoni hypothetical protein 0.0047 0.0203 0.0203
Plasmodium vivax glutathione reductase, putative 0.0057 0.026 1
Trypanosoma cruzi ISWI complex protein 0.0047 0.0203 0.7249
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0098 0.0486 0.0486
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0098 0.0486 0.0486
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0098 0.0486 0.0486
Brugia malayi Smad1 0.0016 0.0032 0.0041
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0098 0.0486 0.0486
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0283 0.0371
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0098 0.0486 0.0638
Echinococcus granulosus neuropeptide Y receptor 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0053 0.0236 0.0236
Echinococcus multilocularis rhodopsin orphan GPCR 0.0098 0.0486 0.0486
Schistosoma mansoni hypothetical protein 0.0063 0.0294 0.0294
Schistosoma mansoni cpg binding protein 0.0029 0.0102 0.0102
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0098 0.0486 0.0638
Schistosoma mansoni hypothetical protein 0.0505 0.2746 0.2746
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0032 0.0032
Brugia malayi MH2 domain containing protein 0.0016 0.0032 0.0041
Schistosoma mansoni neuroligin 3 (S09 family) 0.0234 0.1241 0.1241
Echinococcus granulosus fmrfamide receptor 0.0098 0.0486 0.0486
Echinococcus granulosus tm gpcr rhodopsin 0.0098 0.0486 0.0486
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.1239 0.1239
Echinococcus granulosus para nitrobenzyl esterase 0.0234 0.1241 0.1241
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0184 0.0967 0.0967
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Echinococcus multilocularis cpg binding protein 0.0036 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0234 0.1241 0.1241
Plasmodium falciparum thioredoxin reductase 0.0057 0.026 1
Onchocerca volvulus 0.0234 0.1241 1
Echinococcus multilocularis g protein coupled receptor 0.0098 0.0486 0.0486
Brugia malayi Serotonin receptor 0.0098 0.0486 0.0638
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Echinococcus multilocularis G protein coupled receptor 139 0.0098 0.0486 0.0486
Echinococcus multilocularis carboxylesterase 5A 0.1384 0.7622 0.7622
Echinococcus multilocularis BC026374 protein (S09 family) 0.0234 0.1241 0.1241
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0098 0.0486 0.0486
Onchocerca volvulus 0.0234 0.1241 1
Brugia malayi PHD-finger family protein 0.0078 0.0375 0.0493
Echinococcus granulosus g-protein coupled receptor 0.0098 0.0486 0.0486
Schistosoma mansoni methyl-cpg binding protein mbd 0.0052 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Echinococcus granulosus neuropeptide s receptor 0.0098 0.0486 0.0486
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0236 0.0236
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.012 0.012
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0234 0.1241 0.1241
Brugia malayi hypothetical protein 0.0098 0.0486 0.0638
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0053 0.007
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Schistosoma mansoni neuropeptide receptor 0.0098 0.0486 0.0486
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0035 0.0138 0.4118
Echinococcus granulosus neuropeptide receptor A26 0.0098 0.0486 0.0486
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0186 0.0977 0.0977
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.026 1
Loa Loa (eye worm) carboxylesterase 0.1384 0.7622 0.7622
Echinococcus granulosus G protein coupled receptor 139 0.0098 0.0486 0.0486
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0098 0.0486 0.0486
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0098 0.0486 0.0486
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.012 0.012
Echinococcus multilocularis neuropeptides capa receptor 0.0098 0.0486 0.0486
Echinococcus granulosus neuropeptide receptor 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.011 0.0554 0.0554
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0666 0.2074
Echinococcus granulosus smad 0.0016 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Echinococcus granulosus acetylcholinesterase 0.1384 0.7622 0.7622
Brugia malayi CXXC zinc finger family protein 0.0029 0.0102 0.0133
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0024 0.0031
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0035 0.0138 0.4118
Echinococcus granulosus fetal alzheimer antigen falz 0.0071 0.0335 0.0335
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0032 0.0032
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0098 0.0486 0.0486
Brugia malayi MH2 domain containing protein 0.0016 0.0032 0.0041
Echinococcus multilocularis geminin 0.0505 0.2746 0.2746
Schistosoma mansoni biogenic amine receptor 0.0098 0.0486 0.0486
Brugia malayi TAR-binding protein 0.0061 0.0283 0.0371
Echinococcus granulosus carboxylesterase 5A 0.1384 0.7622 0.7622
Echinococcus multilocularis neuropeptide FF receptor 2 0.0098 0.0486 0.0486
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0035 0.0138 0.0138
Echinococcus multilocularis tumor protein p63 0.0331 0.1781 0.1781
Onchocerca volvulus 0.0098 0.0486 0.392
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0283 0.0283
Onchocerca volvulus 0.0098 0.0486 0.392
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0138 0.0138
Brugia malayi G protein-coupled receptor 0.0098 0.0486 0.0638
Brugia malayi Carboxylesterase family protein 0.0234 0.1241 0.1628
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0098 0.0486 0.0486
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0098 0.0486 0.392
Brugia malayi Isocitrate dehydrogenase 0.0035 0.0138 0.0181
Loa Loa (eye worm) hypothetical protein 0.0132 0.0677 0.0677
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0098 0.0486 0.0486
Echinococcus granulosus neuropeptide receptor 0.0098 0.0486 0.0486
Schistosoma mansoni methyl-cpg binding protein mbd 0.0052 0.0233 0.0233
Echinococcus granulosus biogenic amine 5HT receptor 0.084 0.4604 0.4604
Echinococcus granulosus acetylcholinesterase 0.1384 0.7622 0.7622
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0098 0.0486 0.0486
Echinococcus granulosus GPCR family 2 0.0032 0.012 0.012
Brugia malayi Carboxylesterase family protein 0.0234 0.1241 0.1628
Schistosoma mansoni hypothetical protein 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.026 0.0701
Loa Loa (eye worm) hypothetical protein 0.1384 0.7622 0.7622
Onchocerca volvulus 0.0098 0.0486 0.392
Mycobacterium tuberculosis Probable reductase 0.013 0.0666 0.2074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0098 0.0486 0.0486
Brugia malayi Bromodomain containing protein 0.0117 0.0594 0.0779
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0053 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0098 0.0486 0.0486
Loa Loa (eye worm) glutathione reductase 0.0057 0.026 0.026
Echinococcus granulosus BC026374 protein S09 family 0.0234 0.1241 0.1241
Trypanosoma cruzi ISWI complex protein 0.0047 0.0203 0.7249
Echinococcus granulosus alpha 1A adrenergic receptor 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0117 0.0595 0.0595
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0098 0.0486 0.0486
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0138 0.4118
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.026 0.026
Brugia malayi hypothetical protein 0.0098 0.0486 0.0638
Echinococcus multilocularis fmrfamide receptor 0.0098 0.0486 0.0486
Echinococcus multilocularis g protein coupled receptor 0.0098 0.0486 0.0486
Echinococcus granulosus cpg binding protein 0.0036 0.0143 0.0143
Schistosoma mansoni neuropeptide receptor 0.0098 0.0486 0.0486
Echinococcus granulosus rhodopsin orphan GPCR 0.0098 0.0486 0.0486
Brugia malayi hypothetical protein 0.0098 0.0486 0.0638
Schistosoma mansoni neuropeptide receptor 0.0098 0.0486 0.0486
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0098 0.0486 0.0486
Leishmania major trypanothione reductase 0.0057 0.026 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0098 0.0486 0.0638
Loa Loa (eye worm) G-protein coupled receptor 0.0098 0.0486 0.0486
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0747 0.2347
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0098 0.0486 0.0486
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.012 0.012
Brugia malayi Serotonin receptor 0.0098 0.0486 0.0638
Echinococcus multilocularis GPCR, family 2 0.0032 0.012 0.012
Trichomonas vaginalis spcc417.12 protein, putative 0.0234 0.1241 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0098 0.0486 0.0486
Loa Loa (eye worm) acetylcholinesterase 1 0.1384 0.7622 0.7622
Brugia malayi MH1 domain containing protein 0.0016 0.0032 0.0041
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0098 0.0486 0.0486
Onchocerca volvulus 0.0098 0.0486 0.392
Loa Loa (eye worm) Smad1 0.0016 0.0032 0.0032
Loa Loa (eye worm) isocitrate dehydrogenase 0.0035 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0138 0.4118
Onchocerca volvulus 0.0098 0.0486 0.392
Schistosoma mansoni opsin-like receptor 0.0098 0.0486 0.0486
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0283 0.0283
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1384 0.7622 0.7622
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0098 0.0486 0.0486
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0795 0.4355 0.4355
Schistosoma mansoni opsin-like receptor 0.0098 0.0486 0.0486
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.026 0.026
Loa Loa (eye worm) neuropeptide F receptor 0.0098 0.0486 0.0486
Echinococcus multilocularis g protein coupled receptor 0.0098 0.0486 0.0486
Brugia malayi Bromodomain containing protein 0.0231 0.1226 0.1609
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0032 0.0032
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0098 0.0486 0.0486
Echinococcus multilocularis G-protein coupled receptor, putative 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0035 0.0138 0.0138
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Schistosoma mansoni hypothetical protein 0.0069 0.0325 0.0325
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0052 0.0233 0.0233
Brugia malayi RE15519p 0.0098 0.0486 0.0638
Brugia malayi hypothetical protein 0.0098 0.0486 0.0638
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0098 0.0486 0.0486
Echinococcus granulosus orexin receptor type 2 0.0098 0.0486 0.0486
Brugia malayi MH2 domain containing protein 0.0234 0.1239 0.1626
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.026 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0236 0.0236
Loa Loa (eye worm) TYRA-2 protein 0.0098 0.0486 0.0486
Trypanosoma brucei trypanothione reductase 0.0057 0.026 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0098 0.0486 0.0486
Onchocerca volvulus 0.0029 0.0102 0.082
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Mycobacterium tuberculosis Carboxylesterase LipT 0.0234 0.1241 0.4019
Brugia malayi Thioredoxin reductase 0.0057 0.026 0.0341
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0098 0.0486 0.0486
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0234 0.1241 0.1241
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0666 0.2074
Brugia malayi Carboxylesterase family protein 0.1384 0.7622 1
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0138 0.3696
Treponema pallidum NADH oxidase 0.002 0.0053 0.5
Loa Loa (eye worm) hypothetical protein 0.0234 0.1241 0.1241
Schistosoma mansoni biogenic amine (5HT) receptor 0.084 0.4604 0.4604
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Brugia malayi Dopamine receptor protein 1 0.0098 0.0486 0.0638
Brugia malayi hypothetical protein 0.0098 0.0486 0.0638
Loa Loa (eye worm) carboxylesterase 0.0234 0.1241 0.1241
Schistosoma mansoni biogenic amine receptor 0.0098 0.0486 0.0486
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0098 0.0486 0.0486
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0325 0.0426
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0184 0.0967 0.0967
Schistosoma mansoni histamine h1 receptor 0.0098 0.0486 0.0486
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0098 0.0486 0.0486
Loa Loa (eye worm) RNA binding protein 0.0061 0.0283 0.0283
Brugia malayi follicle stimulating hormone receptor 0.0098 0.0486 0.0638
Loa Loa (eye worm) melatonin receptor type 1A 0.0098 0.0486 0.0486
Brugia malayi hypothetical protein 0.0234 0.1241 0.1628
Brugia malayi larval opioid receptor 0.0098 0.0486 0.0638
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0098 0.0486 0.0638
Loa Loa (eye worm) hypothetical protein 0.0234 0.1241 0.1241
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0212 0.0212
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0666 0.2074
Onchocerca volvulus 0.0098 0.0486 0.392
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0098 0.0486 0.0486
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0098 0.0486 0.0638
Schistosoma mansoni neuropeptide receptor 0.0098 0.0486 0.0486
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0035 0.0138 0.4118
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0098 0.0486 0.0486
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0098 0.0486 0.0486
Echinococcus granulosus neuropeptide Y receptor 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.1384 0.7622 0.7622
Echinococcus multilocularis smad 0.0016 0.0032 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0098 0.0486 0.0486
Echinococcus multilocularis dro:myosuppressin receptor 0.0098 0.0486 0.0486
Echinococcus granulosus peptide allatostatin:somatostatin 0.0098 0.0486 0.0486
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0098 0.0486 0.0486
Onchocerca volvulus 0.0098 0.0486 0.392
Brugia malayi Latrophilin receptor protein 2 0.0032 0.012 0.0157
Echinococcus multilocularis biogenic amine (5HT) receptor 0.084 0.4604 0.4604
Echinococcus granulosus zinc finger protein 0.0062 0.0285 0.0285
Brugia malayi MH1 domain containing protein 0.0016 0.0032 0.0041
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0234 0.1241 0.1241
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0098 0.0486 0.0486
Plasmodium falciparum glutathione reductase 0.0057 0.026 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.012 0.012
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Brugia malayi neuropeptide F receptor 0.0098 0.0486 0.0638
Brugia malayi putative neuropeptide receptor NPR1 0.0098 0.0486 0.0638
Echinococcus multilocularis g-protein coupled receptor 0.0098 0.0486 0.0486
Leishmania major hypothetical protein, conserved 0.0047 0.0203 0.7249
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0501 0.0658
Schistosoma mansoni amine GPCR 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0048 0.0212 0.0212
Onchocerca volvulus 0.0234 0.1241 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.011 0.0554 0.0554
Echinococcus multilocularis allatostatin A receptor 0.0098 0.0486 0.0486
Echinococcus granulosus tm gpcr rhodopsin 0.0098 0.0486 0.0486
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0283 0.0283
Echinococcus multilocularis neuropeptide receptor A26 0.0098 0.0486 0.0486
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0283 0.0283
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0186 0.0977 0.1282
Onchocerca volvulus 0.0234 0.1241 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Schistosoma mansoni biogenic amine receptor 0.0098 0.0486 0.0486
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0234 0.1241 0.1241
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0053 0.5
Brugia malayi neuropeptide F receptor 0.0098 0.0486 0.0638
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0666 0.2074
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0053 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0098 0.0486 0.0486
Loa Loa (eye worm) carboxylesterase 0.0234 0.1241 0.1241
Echinococcus granulosus methyl CpG binding domain protein 2 0.0052 0.0233 0.0233
Brugia malayi G protein-coupled receptor F59B2.13 0.0098 0.0486 0.0638
Echinococcus granulosus tar DNA binding protein 0.0061 0.0283 0.0283
Brugia malayi GnHR receptor homolog 0.0098 0.0486 0.0638
Brugia malayi putative neuropeptide receptor 0.0098 0.0486 0.0638
Onchocerca volvulus 0.0048 0.0212 0.1711
Echinococcus multilocularis neuropeptide receptor 0.0098 0.0486 0.0486
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0234 0.1241 0.1241
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0098 0.0486 0.0486
Schistosoma mansoni zinc finger protein 0.0047 0.0203 0.0203
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0098 0.0486 0.0486
Schistosoma mansoni bromodomain containing protein 0.0195 0.1027 0.1027
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0071 0.0335 0.0335
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0053 0.0053
Echinococcus granulosus rhodopsin orphan GPCR 0.0098 0.0486 0.0486
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0035 0.0138 0.0288
Echinococcus granulosus rhodopsin orphan GPCR 0.0098 0.0486 0.0486
Schistosoma mansoni hypothetical protein 0.0505 0.2746 0.2746
Loa Loa (eye worm) hypothetical protein 0.0234 0.1241 0.1241
Echinococcus multilocularis fmrfamide receptor 0.0098 0.0486 0.0486
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.0977 0.0977
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.0977 0.0977
Loa Loa (eye worm) hypothetical protein 0.0032 0.012 0.012
Onchocerca volvulus 0.0098 0.0486 0.392
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0032 0.0032
Schistosoma mansoni opsin-like receptor 0.0098 0.0486 0.0486
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0279 0.0279
Echinococcus multilocularis acetylcholinesterase 0.1384 0.7622 0.7622
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0098 0.0486 0.0486
Echinococcus granulosus geminin 0.0505 0.2746 0.2746
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0138 0.0138
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0501 0.0658
Schistosoma mansoni adenoreceptor 0.0098 0.0486 0.0486
Echinococcus multilocularis Smad4 0.0016 0.0032 0.0032
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Echinococcus multilocularis orexin receptor type 2 0.0098 0.0486 0.0486
Echinococcus multilocularis rhodopsin orphan GPCR 0.0098 0.0486 0.0486
Trypanosoma brucei ISWI complex protein 0.0047 0.0203 0.7249
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0234 0.1241 0.4019
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0035 0.0138 0.0138
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0098 0.0486 0.0486
Schistosoma mansoni amine GPCR 0.0098 0.0486 0.0486
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0747 0.2347
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0035 0.0138 0.4118
Echinococcus granulosus rhodopsin orphan GPCR 0.0098 0.0486 0.0486
Echinococcus multilocularis rhodopsin orphan GPCR 0.0098 0.0486 0.0486
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0234 0.1241 0.1241
Echinococcus granulosus rhodopsin orphan GPCR 0.0098 0.0486 0.0486
Brugia malayi hypothetical protein 0.0098 0.0486 0.0638
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Onchocerca volvulus 0.0098 0.0486 0.392
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0102 0.0102
Echinococcus multilocularis para nitrobenzyl esterase 0.0234 0.1241 0.1241
Echinococcus granulosus 7TM GPCR rhodopsin 0.0098 0.0486 0.0486
Brugia malayi glutathione reductase 0.0057 0.026 0.0341
Brugia malayi ORL1-like opioid receptor 0.0098 0.0486 0.0638
Schistosoma mansoni hypothetical protein 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Echinococcus multilocularis neuropeptide Y receptor 0.0098 0.0486 0.0486
Onchocerca volvulus 0.0098 0.0486 0.392
Loa Loa (eye worm) hypothetical protein 0.0234 0.1241 0.1241
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0138 0.4118
Echinococcus granulosus g protein coupled receptor 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0098 0.0486 0.0486
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0098 0.0486 0.0486
Onchocerca volvulus 0.0098 0.0486 0.392
Schistosoma mansoni hypothetical protein 0.0098 0.0486 0.0486
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0098 0.0486 0.0638
Onchocerca volvulus 0.0098 0.0486 0.392
Schistosoma mansoni hypothetical protein 0.0032 0.012 0.012
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0053 0.5
Schistosoma mansoni cpg binding protein 0.0036 0.0143 0.0143
Echinococcus granulosus tm gpcr rhodopsin 0.0098 0.0486 0.0486
Echinococcus multilocularis isocitrate dehydrogenase 0.0035 0.0138 0.0138
Echinococcus granulosus g protein coupled receptor 0.0098 0.0486 0.0486
Mycobacterium tuberculosis Probable oxidoreductase 0.0552 0.3008 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0032 0.0032
Schistosoma mansoni smad 0.0016 0.0032 0.0032
Echinococcus multilocularis neuroligin 0.0234 0.1241 0.1241
Brugia malayi hypothetical protein 0.0098 0.0486 0.0638
Brugia malayi hypothetical protein 0.0098 0.0486 0.0638
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Echinococcus multilocularis rhodopsin orphan GPCR 0.0098 0.0486 0.0486
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0283 0.0283
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0747 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0098 0.0486 0.392
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.012 0.0157
Echinococcus multilocularis neuropeptide receptor 0.0098 0.0486 0.0486
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0032 0.0032
Brugia malayi Melatonin receptor type 1A 0.0098 0.0486 0.0638
Echinococcus granulosus neuropeptides capa receptor 0.0098 0.0486 0.0486
Echinococcus granulosus somatostatin receptor 0.0098 0.0486 0.0486
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0234 0.1241 0.1241
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0138 0.0138
Echinococcus granulosus serotonin receptor 0.0098 0.0486 0.0486
Brugia malayi Dopamine receptor protein 2 0.0098 0.0486 0.0638
Schistosoma mansoni neuropeptide f receptor 76f 0.0098 0.0486 0.0486
Schistosoma mansoni hypothetical protein 0.0032 0.012 0.012
Brugia malayi Dopamine receptor 0.0098 0.0486 0.0638
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Brugia malayi Carboxylesterase family protein 0.1384 0.7622 1
Schistosoma mansoni neuropeptide F-like receptor 0.0098 0.0486 0.0486
Brugia malayi G-protein coupled receptor 0.0098 0.0486 0.0638
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0236 0.0236
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0098 0.0486 0.0486
Echinococcus multilocularis zinc finger protein 0.0062 0.0285 0.0285
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0138 0.3696
Toxoplasma gondii thioredoxin reductase 0.0057 0.026 0.8976
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0098 0.0486 0.0486
Brugia malayi AKH receptor 0.0098 0.0486 0.0638
Echinococcus multilocularis somatostatin receptor 0.0098 0.0486 0.0486
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.0977 0.0977
Echinococcus granulosus neuropeptide FF receptor 2 0.0098 0.0486 0.0486
Brugia malayi RNA binding protein 0.0061 0.0283 0.0371
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0234 0.1241 0.4019
Brugia malayi sulfakinin receptor protein 0.0098 0.0486 0.0638
Echinococcus granulosus neuroligin 0.0234 0.1241 0.1241
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.1239 0.1239
Echinococcus multilocularis acetylcholinesterase 0.1384 0.7622 0.7622
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0032 0.0032
Echinococcus granulosus dro:myosuppressin receptor 0.0098 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0069 0.0325 0.0325
Onchocerca volvulus 0.0098 0.0486 0.392
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0098 0.0486 0.0486
Loa Loa (eye worm) neuropeptide F receptor 0.0098 0.0486 0.0486
Schistosoma mansoni hypothetical protein 0.0032 0.012 0.012
Brugia malayi hypothetical protein 0.0098 0.0486 0.0638
Onchocerca volvulus 0.0098 0.0486 0.392
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0098 0.0486 0.0486
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0098 0.0486 0.0486
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0283 0.0283
Onchocerca volvulus 0.0098 0.0486 0.392
Echinococcus granulosus Smad4 0.0016 0.0032 0.0032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0098 0.0486 0.0486
Echinococcus granulosus tachykinin peptides receptor 99D 0.0098 0.0486 0.0486
Schistosoma mansoni hypothetical protein 0.0098 0.0486 0.0486
Brugia malayi hypothetical protein 0.0098 0.0486 0.0638
Brugia malayi Carboxylesterase family protein 0.0234 0.1241 0.1628
Loa Loa (eye worm) PHD-finger family protein 0.0063 0.0294 0.0294
Loa Loa (eye worm) hypothetical protein 0.0125 0.0635 0.0635
Schistosoma mansoni zinc finger protein 0.0062 0.0285 0.0285
Brugia malayi Carboxylesterase family protein 0.0234 0.1241 0.1628
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0234 0.1241 1
Schistosoma mansoni hypothetical protein 0.0032 0.012 0.012
Onchocerca volvulus 0.0234 0.1241 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0071 0.0335 0.0335
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.0977 0.0977
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0098 0.0486 0.0486
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0053 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.0977 0.0977
Schistosoma mansoni cpg binding protein 0.0036 0.0143 0.0143
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0053 0.0053
Echinococcus granulosus neuropeptides capa receptor 0.0098 0.0486 0.0486
Schistosoma mansoni amine GPCR 0.0098 0.0486 0.0486
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.026 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0098 0.0486 0.0486
Schistosoma mansoni amine GPCR 0.0586 0.3194 0.3194
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.0977 0.0977
Echinococcus multilocularis sex peptide receptor 0.0098 0.0486 0.0486
Brugia malayi G-protein coupled receptor 0.0098 0.0486 0.0638

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0033 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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