Detailed information for compound 1314866

Basic information

Technical information
  • TDR Targets ID: 1314866
  • Name: 5-[[2-(4-chloro-3-fluorophenoxy)phenyl]methyl idene]-1,3-dimethyl-1,3-diazinane-2,4,6-trion e
  • MW: 388.777 | Formula: C19H14ClFN2O4
  • H donors: 0 H acceptors: 3 LogP: 3.58 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(C)C(=O)C(=Cc2ccccc2Oc2ccc(c(c2)F)Cl)C(=O)N1C
  • InChi: 1S/C19H14ClFN2O4/c1-22-17(24)13(18(25)23(2)19(22)26)9-11-5-3-4-6-16(11)27-12-7-8-14(20)15(21)10-12/h3-10H,1-2H3
  • InChiKey: JNYSLUXBRAJIRS-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5-[[2-(4-chloro-3-fluoro-phenoxy)phenyl]methylene]-1,3-dimethyl-hexahydropyrimidine-2,4,6-trione
  • 5-[[2-(4-chloro-3-fluorophenoxy)phenyl]methylene]-1,3-dimethylhexahydropyrimidine-2,4,6-trione
  • 5-[2-(4-chloro-3-fluoro-phenoxy)benzylidene]-1,3-dimethyl-barbituric acid
  • 5-[[2-(4-chloro-3-fluoro-phenoxy)phenyl]methylidene]-1,3-dimethyl-1,3-diazinane-2,4,6-trione
  • 5-{[2-(4-chloro-3-fluorophenoxy)phenyl]methylene}-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione
  • MLS000546599
  • SMR000179997
  • 3R-0064

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1021 0.1659
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.1021 0.1294
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0112 0.0328
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0822 0.1336
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0822 1
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.2932 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0301 0.049
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0013 0.0428 0.0542
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0013 0.0428 0.0542
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0147 0.0239
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.7068 0.8958
Trypanosoma brucei polo-like protein kinase 0.0114 0.6153 1
Echinococcus multilocularis dna polymerase eta 0.0054 0.276 0.4486
Mycobacterium leprae putative cytochrome p450 0.0013 0.0428 0.0542
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0013 0.0428 0.0542
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.1026 0.1668
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0822 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0013 0.0428 0.417
Leishmania major DNA polymerase kappa, putative 0.0023 0.1021 0.1659
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0013 0.0428 0.0542
Brugia malayi Cytochrome P450 family protein 0.0023 0.1026 0.1668
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0013 0.0428 0.0542
Loa Loa (eye worm) hypothetical protein 0.0007 0.0112 0.0182
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.2932 0.4765
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0525 0.0853
Mycobacterium tuberculosis Probable reductase 0.013 0.7068 0.8958
Toxoplasma gondii cytochrome p450 superfamily protein 0.0013 0.0428 0.1252
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0612 0.0994
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.1026 0.1668
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.4211 0.6843
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0822 0.2803
Loa Loa (eye worm) CYP4Cod1 0.0023 0.1026 0.1668
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0147 0.0239
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0013 0.0428 0.417
Plasmodium vivax DNA repair protein REV1, putative 0.0007 0.0112 0.0382
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0013 0.0428 0.417
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0822 0.1336
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.019 0.0309
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.1021 0.1659
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.1026 0.1668
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.789 1
Trypanosoma brucei cytochrome P450, putative 0.0023 0.1026 0.1668
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0013 0.0428 0.417
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1021 0.1659
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0612 0.0994
Brugia malayi glutathione reductase 0.0057 0.2932 0.4765
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.1021 0.1021
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.1021 0.1659
Giardia lamblia DNA damage repair protein 0.0007 0.0112 0.0182
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.7068 0.8958
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.6153 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1021 0.1659
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.2896 0.4707
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0013 0.0428 0.417
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.6153 1
Giardia lamblia Kinase, PLK 0.0114 0.6153 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0822 0.8009
Leishmania major cytochrome p450-like protein 0.0013 0.0428 0.0696
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0013 0.0428 0.0542
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0013 0.0428 0.417
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0013 0.0428 0.0542
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0822 0.2803
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0013 0.0428 0.0542
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0822 0.1042
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0013 0.0428 0.417
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.1021 0.1659
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.1021 0.1659
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.1021 0.1659
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.789 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0612 0.0994
Trypanosoma cruzi DNA damage repair protein, putative 0.0007 0.0112 0.0182
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.6153 0.6153
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.4211 0.6843
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.1021 0.1659
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0822 1
Leishmania major DNA polymerase eta, putative 0.0038 0.1851 0.3009
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.789 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0822 0.1336
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0013 0.0428 0.0696
Echinococcus multilocularis 0.0013 0.0428 0.0696
Brugia malayi Cytochrome P450 family protein 0.0013 0.0428 0.0696
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.2932 0.4765
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0112 0.0182
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0822 0.2803
Leishmania major DNA polymerase eta, putative 0.0054 0.276 0.4486
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0013 0.0428 0.417
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0013 0.0428 0.417
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0822 0.1336
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.7068 0.8958
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.4211 0.6843
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0822 0.1336
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.276 0.4486
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0822 0.1336
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.6153 1
Loa Loa (eye worm) glutathione reductase 0.0057 0.2932 0.4765
Plasmodium falciparum thioredoxin reductase 0.0057 0.2932 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.3863 0.3863
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.1664 0.2704
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1021 0.1659
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1021 0.1659
Trypanosoma brucei unspecified product 0.0023 0.1021 0.1659
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0147 0.0239
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0147 0.0239
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0112 0.0182
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0013 0.0428 0.417
Plasmodium falciparum thioredoxin reductase 0.002 0.0822 0.2803
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0112 0.0182
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.1021 0.9947
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0013 0.0428 0.0542
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0013 0.0428 0.0542
Brugia malayi Cytochrome P450 family protein 0.0059 0.3034 0.493
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.019 0.0309
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0822 0.8009
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0013 0.0428 0.417
Echinococcus granulosus cytochrome P450 2K1 0.0013 0.0428 0.0696
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0013 0.0428 0.0542
Giardia lamblia DINP protein human, muc B family 0.0023 0.1021 0.1659
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.1021 0.1659
Leishmania major cytochrome p450-like protein 0.0023 0.1026 0.1668
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0822 0.1336
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0013 0.0428 0.417
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0822 0.1336
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0147 0.0239
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0822 0.2404
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1021 0.1659
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1021 0.1659
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.6153 1
Echinococcus multilocularis cpg binding protein 0.0037 0.1776 0.2886
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0822 0.1336
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0147 0.0239
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.6153 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0147 0.0239
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.6153 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1021 0.1659
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0822 0.1336
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.2312 0.3758
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0822 0.8009
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.4211 0.6843
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.2932 0.4765
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0112 0.0112
Schistosoma mansoni cpg binding protein 0.0037 0.1776 0.1776
Schistosoma mansoni cpg binding protein 0.0035 0.1664 0.1664
Treponema pallidum NADH oxidase 0.002 0.0822 1
Loa Loa (eye worm) cytochrome P450 0.0013 0.0428 0.0696
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.6153 1
Echinococcus granulosus cpg binding protein 0.0037 0.1776 0.2886
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0013 0.0428 0.417
Leishmania major DNA polymerase kappa, putative 0.0007 0.0112 0.0182
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0147 0.0239
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.276 0.4486
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.1021 0.1659
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.4211 0.6843
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.2932 0.4765
Loa Loa (eye worm) hypothetical protein 0.0054 0.276 0.4486
Leishmania major trypanothione reductase 0.0057 0.2932 0.4765
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.6153 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.1021 0.1659
Schistosoma mansoni hypothetical protein 0.0013 0.0428 0.0428
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.1026 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.019 0.0309
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0147 0.0239
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0013 0.0428 0.0542
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0013 0.0428 0.0696
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0013 0.0428 0.0542
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0822 0.1336
Schistosoma mansoni cpg binding protein 0.0037 0.1776 0.1776
Plasmodium falciparum glutathione reductase 0.002 0.0822 0.2803
Brugia malayi Thioredoxin reductase 0.0057 0.2932 0.4765
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.4211 0.6843
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0013 0.0428 0.0542
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0822 0.1336
Toxoplasma gondii thioredoxin reductase 0.0057 0.2932 0.8577
Trichomonas vaginalis helicase, putative 0.0008 0.0147 0.0239
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.031 0.0503
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.1026 0.1668
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.789 1
Leishmania major DNA damage repair protein, putative 0.0007 0.0112 0.0182
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0428 0.0696
Echinococcus multilocularis dna polymerase kappa 0.0023 0.1021 0.1659
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0013 0.0428 0.417
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0822 0.1336
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.019 0.0309
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.6153 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.4211 0.6843
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0112 0.0182
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0013 0.0428 0.0542
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0013 0.0428 0.417
Echinococcus granulosus dna polymerase kappa 0.0023 0.1021 0.1659
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0822 0.1336
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0013 0.0428 0.417
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.3418 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0822 0.1336
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1021 0.1659
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0013 0.0428 0.0696
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.6153 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0013 0.0428 0.0542
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0822 0.1336
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0013 0.0428 0.0542
Trypanosoma brucei trypanothione reductase 0.0057 0.2932 0.4765
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.6153 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1021 0.1659
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0013 0.0428 0.417
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0302 0.0491
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0822 0.2803
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0013 0.0428 0.417
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.2896 0.4707
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0147 0.0239
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0112 0.0182
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0822 0.1336
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.1021 0.1294
Brugia malayi cytochrome P450 0.0013 0.0428 0.0696
Echinococcus granulosus transcription factor Dp 1 0.0046 0.2312 0.3758
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.6153 1
Trypanosoma brucei unspecified product 0.0016 0.0612 0.0994
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.4211 0.4211
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.1851 0.3009
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.1851 0.5416
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0822 0.1336
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.7068 0.8958
Mycobacterium leprae Conserved hypothetical protein 0.0013 0.0428 0.0542
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.019 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0112 0.0182
Schistosoma mansoni kinase 0.0058 0.2981 0.2981
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0112 0.0182
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0822 0.2404
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1021 0.1659
Plasmodium vivax glutathione reductase, putative 0.0057 0.2932 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0013 0.0428 0.0542
Brugia malayi polk-prov protein 0.0007 0.0112 0.0182
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0013 0.0428 0.417
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0147 0.0239
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.1021 0.1021
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.276 0.4486
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.1021 0.1659
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0428 0.0696
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0822 0.1336
Schistosoma mansoni cytochrome P450 0.0013 0.0428 0.0428
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0822 0.1336
Schistosoma mansoni DNA polymerase eta 0.0054 0.276 0.276
Trypanosoma brucei chrX additional, unordered contigs 0.0007 0.0112 0.0182
Onchocerca volvulus 0.0035 0.1664 0.2704
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.6153 1
Brugia malayi Cytochrome P450 family protein 0.0023 0.1026 0.1668
Mycobacterium ulcerans hypothetical protein 0.0007 0.0112 0.1092
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.6153 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0822 0.1336
Plasmodium falciparum glutathione reductase 0.0057 0.2932 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0147 0.0239
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1021 0.1659
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0112 0.0182
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0013 0.0428 0.0542
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0147 0.0239
Plasmodium falciparum DNA repair protein REV1, putative 0.0007 0.0112 0.0382
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0147 0.0239
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0822 0.1336
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.7068 0.8958
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0147 0.0239
Leishmania major cytochrome p450-like protein 0.0013 0.0428 0.0696
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0822 0.1336
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0147 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1021 0.1659
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.4211 0.6843
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0013 0.0428 0.417
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.3034 0.493
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.1021 0.1659
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0822 0.0822
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.4211 0.6843
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.6153 1
Loa Loa (eye worm) histone methyltransferase 0.0011 0.031 0.0503
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0147 0.0239
Trypanosoma cruzi DNA damage repair protein, putative 0.0007 0.0112 0.0182
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0525 0.0853
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.2932 0.3716
Trypanosoma brucei unspecified product 0.0016 0.0612 0.0994
Brugia malayi CXXC zinc finger family protein 0.0035 0.1664 0.2704
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0007 0.0112 0.0328
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.1021 0.9947
Echinococcus granulosus dna polymerase eta 0.0054 0.276 0.4486
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0013 0.0428 0.0542
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.6153 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.031 0.0503
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.7068 0.8958
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1021 0.1659

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.548133892 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 6.309573445 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 14.12537545 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 22.38721139 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
IC50 (functional) 51.85 uM PUBCHEM_BIOASSAY: Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588708, AID588742] ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 4.2284 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.8115 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds that Act as Potentiators of the Vanilloid Receptor 1: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 33.8078 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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