Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | RAB9A, member RAS oncogene family | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | ras-related protein Rab-5B | RAB9A, member RAS oncogene family | 201 aa | 165 aa | 30.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1659 | 0.1659 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3397 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3397 | 0.3397 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3397 | 0.3397 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3397 | 0.3397 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1659 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3397 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3397 | 0.3397 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3397 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1659 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1659 | 0.1659 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1659 | 0.4884 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1659 | 0.4884 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1659 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3397 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3397 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3397 | 0.3397 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3397 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3397 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1659 | 0.4884 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3397 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1659 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 21.3313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.