Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0474 | 0.1806 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.2628 | 0.5 |
Loa Loa (eye worm) | histone methyltransferase | 0.0011 | 0.0891 | 0.2042 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0056 | 0.0056 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0584 | 0.0584 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.2628 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0584 | 0.1037 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5634 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5634 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0474 | 0.1806 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.2628 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.5634 | 0.5634 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0474 | 0.1806 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0474 | 0.1806 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.2628 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.2628 | 0.4664 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.2628 | 0.4664 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0474 | 0.1806 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.2628 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0891 | 0.1581 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0009 | 0.0584 | 0.1037 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.2628 | 0.4664 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0474 | 0.1806 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0474 | 0.1806 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.2628 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8861 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.465 | 0.465 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.2628 | 0.6023 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5634 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.2628 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.2628 | 0.4664 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0474 | 0.1806 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.2628 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0474 | 0.1806 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0474 | 0.1806 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.5634 | 0.5634 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0474 | 0.1806 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0474 | 0.1806 |
Brugia malayi | hypothetical protein | 0.0043 | 0.5634 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.465 | 0.8253 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4363 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0474 | 0.1806 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0009 | 0.0584 | 0.1037 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.2628 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4363 | 0.4363 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.2628 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.2628 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.2628 | 0.2628 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0891 | 0.1581 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.465 | 0.8253 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.2628 | 0.2628 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4363 | 0.7745 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5634 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.2628 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0584 | 0.1037 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0474 | 0.1806 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0474 | 0.1806 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0474 | 0.1806 |
Onchocerca volvulus | 0.0035 | 0.4363 | 1 | |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.465 | 0.465 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0011 | 0.0871 | 0.1546 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.2628 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.5634 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.5634 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0474 | 0.1806 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0474 | 0.1806 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.2628 | 0.2966 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.2589 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.8048 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.