Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0102 | 0.6501 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0311 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0311 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0044 | 0.1846 | 0.1846 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1834 | 0.1834 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.172 | 0.2596 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.1846 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0347 | 0.0534 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1834 | 0.2461 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.172 | 0.2596 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0102 | 0.6501 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3593 | 0.5422 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0311 | 0.0478 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0311 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.3593 | 0.5528 |
Brugia malayi | RNA binding protein | 0.0065 | 0.3593 | 0.5303 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0311 | 0.0478 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.4133 | 0.4133 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0102 | 0.6501 | 0.6501 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.248 | 0.3815 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.5201 | 0.8001 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0044 | 0.1846 | 0.1846 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0532 | 0.0532 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1834 | 0.2461 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1834 | 0.2767 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0059 | 0.0091 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.3593 | 0.5303 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.0762 | 0.0728 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.183 | 0.183 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0044 | 0.1846 | 0.1846 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0311 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0532 | 0.0532 |
Echinococcus multilocularis | protein dispatched 1 | 0.005 | 0.2341 | 0.2341 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0245 | 0.0245 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3593 | 0.5422 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0311 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0311 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1834 | 0.2461 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0311 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3593 | 0.5422 |
Brugia malayi | CHE-14 protein | 0.0044 | 0.1846 | 0.2481 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2634 | 0.4051 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0532 | 0.0803 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.183 | 0.183 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1834 | 0.1834 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0245 | 0.0369 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1846 | 0.284 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.4133 | 0.4133 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2066 | 0.3178 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.3593 | 0.3593 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1834 | 0.2461 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0311 | 0.5 |
Echinococcus multilocularis | protein patched | 0.0044 | 0.1846 | 0.1846 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3593 | 0.5422 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.5616 | 0.857 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0102 | 0.6501 | 0.6501 |
Echinococcus multilocularis | expressed conserved protein | 0.0095 | 0.6007 | 0.6007 |
Echinococcus granulosus | expressed conserved protein | 0.0095 | 0.6007 | 0.6007 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.6501 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.172 | 0.2596 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.2059 | 0.2824 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0311 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0311 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0311 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.172 | 0.2596 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0347 | 0.0524 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.448 | 0.676 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1834 | 0.2461 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.3593 | 0.5528 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.3593 | 0.5528 |
Onchocerca volvulus | 0.0024 | 0.0311 | 0.5 | |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0311 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3593 | 0.5422 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0311 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0103 | 0.6627 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0311 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0311 | 0.0478 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0044 | 0.1846 | 0.284 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1834 | 0.2767 |
Schistosoma mansoni | patched 1 | 0.0044 | 0.1846 | 0.2786 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.3593 | 0.3593 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0245 | 0.0245 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.3593 | 0.5303 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2295 | 0.3531 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0311 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.5131 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.