Detailed information for compound 1316029

Basic information

Technical information
  • TDR Targets ID: 1316029
  • Name: N-cyclopentyl-2-(4-morpholin-4-ylsulfonylphen oxy)acetamide
  • MW: 368.448 | Formula: C17H24N2O5S
  • H donors: 1 H acceptors: 3 LogP: 1.28 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1CCCC1)COc1ccc(cc1)S(=O)(=O)N1CCOCC1
  • InChi: 1S/C17H24N2O5S/c20-17(18-14-3-1-2-4-14)13-24-15-5-7-16(8-6-15)25(21,22)19-9-11-23-12-10-19/h5-8,14H,1-4,9-13H2,(H,18,20)
  • InChiKey: DDPAKDVORXSJHU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-cyclopentyl-2-(4-morpholinosulfonylphenoxy)acetamide
  • N-cyclopentyl-2-(4-morpholin-4-ylsulfonylphenoxy)ethanamide
  • MLS000099859
  • N-cyclopentyl-2-[4-(4-morpholinylsulfonyl)phenoxy]acetamide
  • SMR000080875

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi larval opioid receptor 0.0041 1 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0032 0.5209 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.5209 0.5209
Onchocerca volvulus 0.0041 1 1
Loa Loa (eye worm) oxidoreductase 0.0032 0.5209 0.5209
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.5209 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0041 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0041 1 1
Schistosoma mansoni amine GPCR 0.0041 1 1
Brugia malayi Dopamine receptor protein 1 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 1 1
Schistosoma mansoni hypothetical protein 0.0041 1 1
Schistosoma mansoni aldo-keto reductase 0.0032 0.5209 0.5209
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 1 1
Echinococcus granulosus aldo keto reductase 0.0032 0.5209 0.5209
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 1 1
Brugia malayi Serotonin receptor 0.0041 1 1
Schistosoma mansoni hypothetical protein 0.0041 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0041 1 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0032 0.5209 1
Echinococcus multilocularis g protein coupled receptor 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Leishmania major aldo-keto reductase-like protein 0.0032 0.5209 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0032 0.5209 1
Echinococcus multilocularis aldo keto reductase 0.0032 0.5209 0.5209
Brugia malayi hypothetical protein 0.0041 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.5209 0.5209
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.5209 0.5209
Echinococcus granulosus dro:myosuppressin receptor 0.0041 1 1
Leishmania major prostaglandin f synthase, putative 0.0032 0.5209 1
Echinococcus multilocularis neuropeptides capa receptor 0.0041 1 1
Schistosoma mansoni amine GPCR 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Schistosoma mansoni amine GPCR 0.0041 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0041 1 1
Onchocerca volvulus 0.0041 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0041 1 1
Toxoplasma gondii aldose reductase, putative 0.0032 0.5209 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.5209 0.5209
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0041 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0041 1 1
Echinococcus granulosus somatostatin receptor 0.0041 1 1
Echinococcus granulosus hypothetical protein 0.0041 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Echinococcus granulosus neuropeptide receptor 0.0041 1 1
Brugia malayi hypothetical protein 0.0041 1 1
Echinococcus multilocularis fmrfamide receptor 0.0041 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.5209 0.5209
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0041 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Onchocerca volvulus 0.0041 1 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0032 0.5209 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0041 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.5209 0.5209
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0041 1 1
Brugia malayi G-protein coupled receptor 0.0041 1 1
Brugia malayi sulfakinin receptor protein 0.0041 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 1 1
Echinococcus multilocularis aldo keto reductase 0.0032 0.5209 0.5209
Schistosoma mansoni opsin-like receptor 0.0041 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.5209 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Echinococcus multilocularis serotonin receptor 0.0041 1 1
Brugia malayi G protein-coupled receptor 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 1 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0032 0.5209 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0041 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0041 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0041 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0041 1 1
Brugia malayi hypothetical protein 0.0041 1 1
Schistosoma mansoni amine GPCR 0.0041 1 1
Brugia malayi ORL1-like opioid receptor 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Schistosoma mansoni pol-related 0.0032 0.5209 0.5209
Echinococcus multilocularis neuropeptide Y receptor 0.0041 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0041 1 1
Echinococcus multilocularis g protein coupled receptor 0.0041 1 1
Brugia malayi Dopamine receptor protein 2 0.0041 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0041 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0041 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0032 0.5209 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.5209 0.5209
Brugia malayi neuropeptide F receptor 0.0041 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.5209 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.5209 0.5209
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 1 1
Entamoeba histolytica aldose reductase, putative 0.0032 0.5209 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 1 1
Echinococcus granulosus aldo keto reductase 0.0032 0.5209 0.5209
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0041 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 1 1
Schistosoma mansoni neuropeptide receptor 0.0041 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.5209 0.5209
Echinococcus granulosus tm gpcr rhodopsin 0.0041 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0041 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Entamoeba histolytica aldose reductase, putative 0.0032 0.5209 1
Echinococcus multilocularis serotonin receptor 0.0041 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.5209 0.5209
Schistosoma mansoni biogenic amine receptor 0.0041 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0041 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0041 1 1
Onchocerca volvulus 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0041 1 1
Echinococcus granulosus sex peptide receptor 0.0041 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.5209 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0032 0.5209 1
Brugia malayi RE15519p 0.0041 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0041 1 1
Schistosoma mansoni aldo-keto reductase 0.0032 0.5209 0.5209
Brugia malayi Serotonin receptor 0.0041 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0041 1 1
Brugia malayi neuropeptide F receptor 0.0041 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.5209 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.5209 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Onchocerca volvulus 0.0041 1 1
Echinococcus multilocularis neuropeptide receptor 0.0041 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0041 1 1
Onchocerca volvulus 0.0041 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0041 1 1
Loa Loa (eye worm) oxidoreductase 0.0032 0.5209 0.5209
Onchocerca volvulus 0.0041 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0041 1 1
Echinococcus multilocularis aldo keto reductase 0.0032 0.5209 0.5209
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0041 1 1
Echinococcus multilocularis orexin receptor type 2 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Brugia malayi Dopamine receptor 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0041 1 1
Schistosoma mansoni neuropeptide receptor 0.0041 1 1
Trypanosoma brucei prostaglandin f synthase 0.0032 0.5209 1
Echinococcus multilocularis g protein coupled receptor 0.0041 1 1
Brugia malayi G-protein coupled receptor 0.0041 1 1
Echinococcus multilocularis aldehyde reductase 0.0023 0.0095 0.0095
Brugia malayi hypothetical protein 0.0041 1 1
Trypanosoma cruzi aldo-keto reductase 0.0032 0.5209 1
Echinococcus granulosus g protein coupled receptor 0.0041 1 1
Schistosoma mansoni neuropeptide receptor 0.0041 1 1
Schistosoma mansoni neuropeptide receptor 0.0041 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.5209 0.5209
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Brugia malayi putative neuropeptide receptor 0.0041 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 1 1
Schistosoma mansoni hypothetical protein 0.0041 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.0041 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0041 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 1 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0032 0.5209 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Echinococcus granulosus hypothetical protein 0.0032 0.5209 0.5209
Onchocerca volvulus 0.0041 1 1
Echinococcus granulosus G protein coupled receptor 139 0.0041 1 1
Schistosoma mansoni histamine h1 receptor 0.0041 1 1
Echinococcus granulosus fmrfamide receptor 0.0041 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 1 1
Echinococcus granulosus aldo keto reductase 0.0032 0.5209 0.5209
Brugia malayi hypothetical protein 0.0041 1 1
Echinococcus granulosus neuropeptide s receptor 0.0041 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 1 1
Entamoeba histolytica aldose reductase, putative 0.0032 0.5209 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0041 1 1
Echinococcus multilocularis somatostatin receptor 0.0041 1 1
Brugia malayi hypothetical protein 0.0041 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Echinococcus granulosus g protein coupled receptor 0.0041 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.5209 0.5209
Trypanosoma brucei aldo-keto reductase, putative 0.0032 0.5209 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.5209 0.5209
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0041 1 1
Schistosoma mansoni hypothetical protein 0.0041 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0041 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.5209 0.5209
Onchocerca volvulus 0.0041 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.5209 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.5209 0.5209
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.5209 0.5209
Loa Loa (eye worm) neuropeptide F receptor 0.0041 1 1
Onchocerca volvulus 0.0041 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0041 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0041 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0041 1 1
Brugia malayi hypothetical protein 0.0041 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0041 1 1
Brugia malayi GnHR receptor homolog 0.0041 1 1
Schistosoma mansoni opsin-like receptor 0.0041 1 1
Echinococcus granulosus orexin receptor type 2 0.0041 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0041 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0041 1 1
Onchocerca volvulus 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Brugia malayi Melatonin receptor type 1A 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0041 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0041 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0041 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.5209 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.5209 0.5209
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0041 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 1 1
Echinococcus granulosus allatostatin A receptor 0.0041 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0041 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 1 1
Loa Loa (eye worm) oxidoreductase 0.0032 0.5209 0.5209
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.5209 0.5209
Giardia lamblia Aldose reductase 0.0032 0.5209 1
Echinococcus granulosus neuropeptide receptor 0.0041 1 1
Mycobacterium ulcerans oxidoreductase 0.0032 0.5209 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0041 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.5209 0.5209
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.5209 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0041 1 1
Echinococcus multilocularis aldo keto reductase 0.0032 0.5209 0.5209
Brugia malayi hypothetical protein 0.0041 1 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0032 0.5209 1
Echinococcus multilocularis neuropeptide receptor 0.0041 1 1
Loa Loa (eye worm) oxidoreductase 0.0032 0.5209 0.5209
Echinococcus multilocularis fmrfamide receptor 0.0041 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0041 1 1
Onchocerca volvulus 0.0041 1 1
Onchocerca volvulus 0.0041 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.5209 1
Brugia malayi follicle stimulating hormone receptor 0.0041 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 1 1
Echinococcus granulosus serotonin receptor 0.0041 1 1
Echinococcus granulosus g-protein coupled receptor 0.0041 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0041 1 1
Giardia lamblia Aldose reductase 0.0032 0.5209 1
Schistosoma mansoni opsin-like receptor 0.0041 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0041 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0041 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 1 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.5209 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0041 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.5209 0.5209
Brugia malayi AKH receptor 0.0041 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0041 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0041 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0041 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0032 0.5209 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0041 1 1
Loa Loa (eye worm) oxidoreductase 0.0032 0.5209 0.5209
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.5209 0.5209
Brugia malayi putative neuropeptide receptor NPR1 0.0041 1 1
Echinococcus granulosus g protein coupled receptor 0.0041 1 1
Brugia malayi hypothetical protein 0.0041 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.5209 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.5209 0.5209
Echinococcus granulosus tm gpcr rhodopsin 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Schistosoma mansoni biogenic amine receptor 0.0041 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0041 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.5209 0.5209
Schistosoma mansoni biogenic amine receptor 0.0041 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0041 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0041 1 1
Schistosoma mansoni amine GPCR 0.0041 1 1
Onchocerca volvulus 0.0041 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0041 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0041 1 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0041 1 1
Onchocerca volvulus 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0041 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0041 1 1
Echinococcus multilocularis sex peptide receptor 0.0041 1 1
Onchocerca volvulus 0.0041 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0041 1 1
Echinococcus granulosus aldehyde reductase 0.0023 0.0095 0.0095
Echinococcus granulosus 7TM GPCR rhodopsin 0.0041 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.5209 0.5209
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 1 1
Schistosoma mansoni adenoreceptor 0.0041 1 1
Onchocerca volvulus 0.0041 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0041 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0032 0.5209 1
Loa Loa (eye worm) hypothetical protein 0.0041 1 1
Echinococcus multilocularis allatostatin A receptor 0.0041 1 1
Schistosoma mansoni myosin xvIII 0.0041 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.5209 0.5209

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0141 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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