Detailed information for compound 1316336

Basic information

Technical information
  • TDR Targets ID: 1316336
  • Name: 7-nitro-9H-[1,2,4]triazolo[5,1-b][1,3]benzoth iazin-9-ol
  • MW: 250.234 | Formula: C9H6N4O3S
  • H donors: 1 H acceptors: 5 LogP: 1.36 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc2c(c1)C(O)n1c(S2)ncn1
  • InChi: 1S/C9H6N4O3S/c14-8-6-3-5(13(15)16)1-2-7(6)17-9-10-4-11-12(8)9/h1-4,8,14H
  • InChiKey: YRPGNKJOKGQCKN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ST062475
  • MLS000856828
  • SMR000278773
  • BAS 06339539
  • 6-Nitro-4H-9-thia-1,3,3a-triaza-cyclopenta[b]naphthalen-4-ol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0139 0.0148
Onchocerca volvulus 0.0134 0.1469 1
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0139 0.0148
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0023 0.0139 0.0148
Brugia malayi Carboxylesterase family protein 0.0134 0.1469 0.1564
Schistosoma mansoni amine GPCR 0.0023 0.0139 0.0148
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0023 0.0139 0.0148
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0134 0.1469 0.1564
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0139 0.0148
Mycobacterium ulcerans carboxylesterase, LipT 0.0134 0.1469 0.0951
Echinococcus granulosus acetylcholinesterase 0.0793 0.939 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0059 0.0572 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0139 0.0148
Schistosoma mansoni opsin-like receptor 0.0023 0.0139 0.0148
Echinococcus granulosus somatostatin receptor 0.0023 0.0139 0.0148
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0059 0.0572 0.061
Echinococcus multilocularis serotonin receptor 0.0023 0.0139 0.0148
Brugia malayi hypothetical protein 0.0023 0.0139 0.0148
Echinococcus granulosus neuropeptide receptor 0.0023 0.0139 0.0148
Brugia malayi putative neuropeptide receptor NPR1 0.0023 0.0139 0.0148
Echinococcus multilocularis neuropeptide s receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Onchocerca volvulus 0.0134 0.1469 1
Brugia malayi Carboxylesterase family protein 0.0134 0.1469 0.1564
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0023 0.0139 0.0148
Echinococcus multilocularis acetylcholinesterase 0.0793 0.939 1
Echinococcus granulosus muscleblind protein 0.018 0.2026 0.2157
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.0139 0.0148
Brugia malayi ORL1-like opioid receptor 0.0023 0.0139 0.0148
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.0139 0.0148
Leishmania major UDP-galactopyranose mutase 0.0059 0.0572 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.0139 0.0148
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0785 0.9286 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0347 0.037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0139 0.0148
Echinococcus multilocularis neuropeptide receptor A26 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0059 0.0572 0.061
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0139 0.0148
Echinococcus multilocularis orexin receptor type 2 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0059 0.0572 0.061
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0059 0.0572 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.0139 0.0148
Brugia malayi Dopamine receptor protein 2 0.0023 0.0139 0.0148
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0139 0.0148
Brugia malayi hypothetical protein 0.0023 0.0139 0.0148
Schistosoma mansoni gliotactin 0.0134 0.1469 0.1564
Brugia malayi larval opioid receptor 0.0023 0.0139 0.0148
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.0139 0.0148
Schistosoma mansoni opsin-like receptor 0.0023 0.0139 0.0148
Echinococcus granulosus neuroligin 0.0134 0.1469 0.1564
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0392 0.0418
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0059 0.0572 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0139 0.0148
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0139 0.0148
Echinococcus granulosus acetylcholinesterase 0.0793 0.939 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0572 0.5
Schistosoma mansoni hypothetical protein 0.0023 0.0139 0.0148
Echinococcus multilocularis 0.0059 0.0572 0.061
Echinococcus multilocularis BC026374 protein (S09 family) 0.0134 0.1469 0.1564
Schistosoma mansoni neuropeptide receptor 0.0023 0.0139 0.0148
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0392 0.0418
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.0139 0.0148
Schistosoma mansoni acetylcholinesterase 0.0134 0.1469 0.1564
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.0139 0.0148
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0134 0.1469 0.1029
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0139 0.0148
Brugia malayi hypothetical protein 0.0023 0.0139 0.0148
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0059 0.0572 0.5
Schistosoma mansoni amine GPCR 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0059 0.0572 0.061
Trypanosoma cruzi UDP-galactopyranose mutase 0.0059 0.0572 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Schistosoma mansoni BC026374 protein (S09 family) 0.0134 0.1469 0.1564
Brugia malayi hypothetical protein 0.0023 0.0139 0.0148
Echinococcus granulosus neuropeptide receptor 0.0023 0.0139 0.0148
Schistosoma mansoni histamine h1 receptor 0.0023 0.0139 0.0148
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0023 0.0139 0.0148
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0139 0.0148
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0134 0.1469 0.1564
Echinococcus granulosus BC026374 protein S09 family 0.0134 0.1469 0.1564
Schistosoma mansoni biogenic amine receptor 0.0023 0.0139 0.0148
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.0139 0.0148
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0059 0.0572 0.5
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0059 0.0572 0.5
Loa Loa (eye worm) hypothetical protein 0.0793 0.939 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0023 0.0139 0.0148
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.0139 0.0148
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0139 0.0148
Brugia malayi hypothetical protein 0.0023 0.0139 0.0148
Schistosoma mansoni amine oxidase 0.0059 0.0572 0.061
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0139 0.0148
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0139 0.0148
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.0139 0.0148
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.0139 0.0148
Brugia malayi Serotonin receptor 0.0023 0.0139 0.0148
Echinococcus multilocularis sex peptide receptor 0.0023 0.0139 0.0148
Echinococcus granulosus orexin receptor type 2 0.0023 0.0139 0.0148
Brugia malayi hypothetical protein 0.0023 0.0139 0.0148
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.0139 0.0148
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0793 0.939 1
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0139 0.0148
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0134 0.1469 0.1029
Echinococcus multilocularis allatostatin A receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Brugia malayi Carboxylesterase family protein 0.0793 0.939 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0059 0.0572 0.061
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.0139 0.0148
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0134 0.1469 0.1564
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0139 0.0148
Echinococcus multilocularis carboxylesterase 5A 0.0793 0.939 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0134 0.1469 0.1564
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0139 0.0148
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0059 0.0572 0.061
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.0139 0.0148
Schistosoma mansoni neuropeptide receptor 0.0023 0.0139 0.0148
Brugia malayi neuropeptide F receptor 0.0023 0.0139 0.0148
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.0139 0.0148
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.0139 0.0148
Brugia malayi SWIRM domain containing protein 0.0059 0.0572 0.061
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0347 0.037
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0023 0.0139 0.0148
Brugia malayi RE15519p 0.0023 0.0139 0.0148
Echinococcus granulosus neuropeptide s receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0134 0.1469 0.1564
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.018 0.2026 0.2157
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0844 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0023 0.0139 0.0148
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0139 0.0148
Schistosoma mansoni biogenic amine receptor 0.0023 0.0139 0.0148
Echinococcus granulosus g protein coupled receptor 0.0023 0.0139 0.0148
Echinococcus granulosus hypothetical protein 0.0023 0.0139 0.0148
Echinococcus granulosus sex peptide receptor 0.0023 0.0139 0.0148
Echinococcus granulosus serotonin receptor 0.0023 0.0139 0.0148
Brugia malayi Muscleblind-like protein 0.018 0.2026 0.2157
Brugia malayi Serotonin receptor 0.0023 0.0139 0.0148
Brugia malayi Dopamine receptor 0.0023 0.0139 0.0148
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0139 0.0148
Loa Loa (eye worm) TYRA-2 protein 0.0023 0.0139 0.0148
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0139 0.0148
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0023 0.0139 0.0148
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0139 0.0148
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0134 0.1469 0.1564
Schistosoma mansoni hypothetical protein 0.0023 0.0139 0.0148
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0139 0.0148
Schistosoma mansoni amine GPCR 0.0023 0.0139 0.0148
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0023 0.0139 0.0148
Loa Loa (eye worm) carboxylesterase 0.0134 0.1469 0.1564
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.0139 0.0148
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0572 0.5
Loa Loa (eye worm) hypothetical protein 0.0059 0.0572 0.061
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0139 0.0148
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0139 0.0148
Schistosoma mansoni amine GPCR 0.0023 0.0139 0.0148
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0139 0.0148
Schistosoma mansoni myosin xvIII 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Echinococcus multilocularis somatostatin receptor 0.0023 0.0139 0.0148
Echinococcus granulosus fmrfamide receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0134 0.1469 0.1564
Echinococcus granulosus g protein coupled receptor 0.0023 0.0139 0.0148
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0059 0.0572 0.061
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0134 0.1469 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Brugia malayi G protein-coupled receptor 0.0023 0.0139 0.0148
Brugia malayi hypothetical protein 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Onchocerca volvulus 0.0134 0.1469 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0793 0.939 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0134 0.1469 0.1564
Brugia malayi Carboxylesterase family protein 0.0793 0.939 1
Schistosoma mansoni amine GPCR 0.0023 0.0139 0.0148
Trypanosoma cruzi UDP-galactopyranose mutase 0.0059 0.0572 0.5
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0139 0.0148
Echinococcus multilocularis muscleblind protein 0.018 0.2026 0.2157
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0059 0.0572 0.061
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0139 0.0148
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0059 0.0572 0.061
Mycobacterium tuberculosis Carboxylesterase LipT 0.0134 0.1469 0.1029
Schistosoma mansoni hypothetical protein 0.0023 0.0139 0.0148
Brugia malayi hypothetical protein 0.0023 0.0139 0.0148
Brugia malayi hypothetical protein 0.0059 0.0572 0.061
Brugia malayi Melatonin receptor type 1A 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.0139 0.0148
Brugia malayi sulfakinin receptor protein 0.0023 0.0139 0.0148
Schistosoma mansoni hypothetical protein 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0035 0.0283 0.0301
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.0139 0.0148
Brugia malayi hypothetical protein 0.0023 0.0139 0.0148
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0139 0.0148
Brugia malayi hypothetical protein 0.0134 0.1469 0.1564
Onchocerca volvulus 0.0134 0.1469 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Echinococcus granulosus lysine specific histone demethylase 1A 0.0059 0.0572 0.061
Brugia malayi hypothetical protein 0.0023 0.0139 0.0148
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0139 0.0148
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0139 0.0148
Echinococcus multilocularis neuroligin 0.0134 0.1469 0.1564
Loa Loa (eye worm) acetylcholinesterase 1 0.0793 0.939 1
Schistosoma mansoni adenoreceptor 0.0023 0.0139 0.0148
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0134 0.1469 0.1564
Schistosoma mansoni amine oxidase 0.0059 0.0572 0.061
Echinococcus multilocularis protoporphyrinogen oxidase 0.0059 0.0572 0.061
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0347 0.037
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0139 0.0148
Schistosoma mansoni neuropeptide receptor 0.0023 0.0139 0.0148
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.0139 0.0148
Brugia malayi G-protein coupled receptor 0.0023 0.0139 0.0148
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Echinococcus granulosus g protein coupled receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0139 0.0148
Echinococcus granulosus carboxylesterase 5A 0.0793 0.939 1
Plasmodium falciparum protoporphyrinogen oxidase 0.0059 0.0572 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0139 0.0148
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.0139 0.0148
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0134 0.1469 0.1564
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.0139 0.0148
Brugia malayi putative neuropeptide receptor 0.0023 0.0139 0.0148
Brugia malayi Carboxylesterase family protein 0.0134 0.1469 0.1564
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) carboxylesterase 0.0793 0.939 1
Echinococcus multilocularis acetylcholinesterase 0.0793 0.939 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.2026 0.2157
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) melatonin receptor type 1A 0.0023 0.0139 0.0148
Brugia malayi Carboxylesterase family protein 0.0134 0.1469 0.1564
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Onchocerca volvulus 0.0059 0.0572 0.3259
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.0139 0.0148
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0139 0.0148
Loa Loa (eye worm) carboxylesterase 0.0134 0.1469 0.1564
Brugia malayi Dopamine receptor protein 1 0.0023 0.0139 0.0148
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.018 0.2026 0.2157
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0023 0.0139 0.0148
Brugia malayi AKH receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Echinococcus multilocularis para nitrobenzyl esterase 0.0134 0.1469 0.1564
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0139 0.0148
Brugia malayi amine oxidase, flavin-containing family protein 0.0059 0.0572 0.061
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.0139 0.0148
Brugia malayi neuropeptide F receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0134 0.1469 0.1564
Echinococcus granulosus neuropeptide receptor A26 0.0023 0.0139 0.0148
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Echinococcus multilocularis serotonin receptor 0.0023 0.0139 0.0148
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.0139 0.0148
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0134 0.1469 0.1564
Schistosoma mansoni biogenic amine receptor 0.0023 0.0139 0.0148
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0139 0.0148
Schistosoma mansoni neuropeptide receptor 0.0023 0.0139 0.0148
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0139 0.0148
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0139 0.0148
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.0139 0.0148
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0139 0.0148
Trichomonas vaginalis spcc417.12 protein, putative 0.0134 0.1469 1
Brugia malayi G-protein coupled receptor 0.0023 0.0139 0.0148
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0139 0.0148
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0139 0.0148
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Echinococcus granulosus para nitrobenzyl esterase 0.0134 0.1469 0.1564
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Echinococcus granulosus g-protein coupled receptor 0.0023 0.0139 0.0148
Onchocerca volvulus 0.0134 0.1469 1
Brugia malayi follicle stimulating hormone receptor 0.0023 0.0139 0.0148
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0139 0.0148
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0059 0.0572 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.0139 0.0148
Toxoplasma gondii histone lysine-specific demethylase 0.0059 0.0572 0.5
Echinococcus granulosus allatostatin A receptor 0.0023 0.0139 0.0148
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0139 0.0148
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0139 0.0148
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0347 0.037
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.0139 0.0148
Brugia malayi GnHR receptor homolog 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0134 0.1469 0.1564
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0139 0.0148
Schistosoma mansoni opsin-like receptor 0.0023 0.0139 0.0148
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0148
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0139 0.0148

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) 6.3096 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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