Detailed information for compound 1316371

Basic information

Technical information
  • TDR Targets ID: 1316371
  • Name: 7-chloro-6-methyl-3a,4,5,9b-tetrahydro-3H-cyc lopenta[c]quinoline-4-carboxylic acid
  • MW: 263.719 | Formula: C14H14ClNO2
  • H donors: 2 H acceptors: 2 LogP: 3.47 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C1Nc2c(C3C1CC=C3)ccc(c2C)Cl
  • InChi: 1S/C14H14ClNO2/c1-7-11(15)6-5-10-8-3-2-4-9(8)13(14(17)18)16-12(7)10/h2-3,5-6,8-9,13,16H,4H2,1H3,(H,17,18)
  • InChiKey: XFHJYHWLYWRLBP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 312713-96-5
  • Oprea1_090587
  • Oprea1_810858
  • NSC727708
  • ARONIS014460
  • A2148/0090221
  • BIM-0027201.P001
  • CBMicro_027243

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 4, group A, member 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0 0.5
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0008 0 0.5
Toxoplasma gondii oxidoreductase, putative 0.0008 0 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 1 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0008 0 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0012 1 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0008 0 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 1 1
Plasmodium falciparum steroid dehydrogenase, putative 0.0008 0 0.5
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 1 1
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0008 0 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0008 0 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0008 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0008 0 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0008 0 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0 0.5
Leishmania major oxidoreductase-like protein 0.0008 0 0.5
Mycobacterium leprae Probable oxidoreductase 0.0008 0 0.5
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0008 0 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0008 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 1 1
Trypanosoma brucei oxidoreductase-like protein 0.0008 0 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0008 0 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0008 0 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 1 1
Leishmania major hypothetical protein, conserved 0.0008 0 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 1 1
Schistosoma mansoni nuclear hormone receptor 0.0012 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0 0.5
Mycobacterium ulcerans oxidoreductase 0.0008 0 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0008 0 0.5
Onchocerca volvulus 0.0012 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0 0.5
Trichomonas vaginalis steroid dehydrogenase, putative 0.0008 0 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0008 0 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 1 1
Leishmania major dehydrogenase-like protein 0.0008 0 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0008 0 0.5
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0008 0 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0008 0 0.5
Plasmodium vivax steroid dehydrogenase, putative 0.0008 0 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 1 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0008 0 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0008 0 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0008 0 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0 0.5
Schistosoma mansoni thyroid hormone receptor 0.0012 1 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 1 1
Toxoplasma gondii oxidoreductase, putative 0.0008 0 0.5
Leishmania major short chain dehydrogenase, putative 0.0008 0 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0008 0 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0008 0 0.5
Leishmania major hypothetical protein, conserved 0.0008 0 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0012 1 1
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0008 0 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0008 0 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 1 1
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0008 0 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0008 0 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 1 1
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0008 0 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0 0.5
Leishmania major 3-keto-dihydrosphingosine reductase 0.0008 0 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 1 1
Leishmania major short chain dehydrogenase, putative 0.0008 0 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0008 0 0.5
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0008 0 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0 0.5
Brugia malayi nuclear hormone receptor 0.0012 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0008 0 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0008 0 0.5
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0008 0 0.5
Giardia lamblia Hypothetical protein 0.0008 0 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0 0.5
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0 0.5
Echinococcus granulosus FTZ F1 alpha 0.0012 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0012 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0008 0 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0008 0 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0 0.5
Brugia malayi steroid hormone receptor 0.0012 1 1
Brugia malayi nuclear receptor NHR-88 0.0012 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 1 1
Leishmania major hypothetical protein, conserved 0.0008 0 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 1 1
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0008 0 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 1 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0008 0 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0008 0 0.5
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0008 0 0.5
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0008 0 0.5
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0008 0 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 1 1
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0008 0 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0012 1 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0008 0 0.5
Plasmodium vivax hypothetical protein, conserved 0.0008 0 0.5
Mycobacterium ulcerans short-chain type oxidoreductase 0.0008 0 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0 0.5
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0008 0 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0 0.5
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0008 0 0.5
Leishmania major hypothetical protein, conserved 0.0008 0 0.5
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0008 0 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0008 0 0.5
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0008 0 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0008 0 0.5
Leishmania major hypothetical protein, conserved 0.0008 0 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0 0.5
Mycobacterium ulcerans dehydrogenase/reductase 0.0008 0 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0 0.5
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0008 0 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0008 0 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 1 1
Leishmania major short chain dehydrogenase/reductase, putative 0.0008 0 0.5
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0008 0 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0 0.5
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0008 0 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 1 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0008 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 1 1
Entamoeba histolytica short chain dehydrogenase family protein 0.0008 0 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0008 0 0.5
Mycobacterium ulcerans dehydrogenase 0.0008 0 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0008 0 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 1 1
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0008 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 1 1
Leishmania major short chain dehydrogenase-like protein 0.0008 0 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0008 0 0.5
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0008 0 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 1 1
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0008 0 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0 0.5
Schistosoma mansoni thyroid hormone receptor 0.0012 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0 0.5
Toxoplasma gondii carbonyl reductase 1, putative 0.0008 0 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0008 0 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0012 1 1
Mycobacterium ulcerans oxidoreductase 0.0008 0 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0008 0 0.5
Entamoeba histolytica hypothetical protein 0.0008 0 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0008 0 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Schistosoma mansoni coup transcription factor 0.0012 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0008 0 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0 0.5
Giardia lamblia Short-chain dehydrogenase, putative 0.0008 0 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0 0.5
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0008 0 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 1 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0008 0 0.5
Mycobacterium ulcerans carveol-like dehydrogenase 0.0008 0 0.5
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0008 0 0.5
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0008 0 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 1 1
Mycobacterium ulcerans ketoacyl reductase 0.0008 0 0.5
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0008 0 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 1 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0008 0 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0008 0 0.5
Brugia malayi Steroid receptor seven-up type 2 0.0012 1 1
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0008 0 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0008 0 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0 0.5
Giardia lamblia Reductase, putative 0.0008 0 0.5
Leishmania major pteridine reductase 1 0.0008 0 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0012 1 1
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0008 0 0.5

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 5.21 um PUBCHEM_BIOASSAY: Fluorescence Polarization Dose Response Assay for TR3-Based Bcl-B Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1240, 748, 432 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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