Detailed information for compound 1316993

Basic information

Technical information
  • TDR Targets ID: 1316993
  • Name: [1-(furan-2-ylmethylamino)-3-methyl-1-oxobuta n-2-yl] thiophene-2-carboxylate
  • MW: 307.365 | Formula: C15H17NO4S
  • H donors: 1 H acceptors: 2 LogP: 3.09 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C(C(=O)NCc1ccco1)OC(=O)c1cccs1)C
  • InChi: 1S/C15H17NO4S/c1-10(2)13(20-15(18)12-6-4-8-21-12)14(17)16-9-11-5-3-7-19-11/h3-8,10,13H,9H2,1-2H3,(H,16,17)
  • InChiKey: RPPQDHJCVZGLIU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-(2-furylmethylcarbamoyl)-2-methyl-propyl] thiophene-2-carboxylate
  • 2-thiophenecarboxylic acid [1-[(2-furylmethylamino)-oxomethyl]-2-methylpropyl] ester
  • thiophene-2-carboxylic acid [1-(2-furylmethylcarbamoyl)-2-methyl-propyl] ester
  • [1-(furan-2-ylmethylamino)-3-methyl-1-oxo-butan-2-yl] thiophene-2-carboxylate
  • Thiophene-2-carboxylic acid 1-[(furan-2-ylmethyl)-carbamoyl]-2-methyl-propyl ester
  • MLS000074331
  • SMR000006570
  • ASN 06396495

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum glutathione reductase 0.0057 0.2852 1
Schistosoma mansoni hypothetical protein 0.0017 0.0554 0.0554
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0554 0.0578
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0186 0.0194
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0186 0.0108
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0718 0.2517
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0186 0.0194
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.1804 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0412 0.213
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0919 0.3223
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0186 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0919 0.3223
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0186 0.0186
Toxoplasma gondii exonuclease III APE 0.0023 0.0885 0.2647
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0554 0.048
Onchocerca volvulus 0.0101 0.5368 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.1804 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0186 0.0108
Plasmodium falciparum glutathione reductase 0.002 0.0718 0.2517
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.1804 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0919 0.0848
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0718 0.7811
Loa Loa (eye worm) hypothetical protein 0.001 0.0186 0.0194
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.7866 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0186 0.0186
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.2852 1
Leishmania major DNA polymerase kappa, putative 0.0023 0.0919 0.3223
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0919 0.3223
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0186 0.0108
Trypanosoma brucei glucosidase, putative 0.0039 0.1804 0.6327
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0412 0.213
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0505 0.1772
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0175 0.9582 0.9988
Toxoplasma gondii thioredoxin reductase 0.0057 0.2852 0.8528
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0718 0.3857
Schistosoma mansoni hypothetical protein 0.0017 0.0554 0.0554
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.9582 0.9596
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.7866 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.1804 1
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0412 0.1446
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0186 0.0108
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0919 0.3223
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0885 0.3104
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0885 0.3104
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0919 0.3223
Echinococcus multilocularis GPCR, family 2 0.0017 0.0554 0.048
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0186 0.0194
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0186 0.0194
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0186 0.0186
Echinococcus granulosus dna polymerase kappa 0.0023 0.0919 0.0848
Loa Loa (eye worm) hypothetical protein 0.0023 0.0919 0.0958
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.1804 0.6327
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.2852 0.28
Brugia malayi steroid hormone receptor 0.001 0.0186 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0919 0.3223
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0885 0.0814
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0919 0.0958
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0186 0.0194
Schistosoma mansoni serine/threonine protein kinase 0.004 0.1881 0.1881
Brugia malayi nuclear receptor NHR-88 0.001 0.0186 0.0194
Brugia malayi glutathione reductase 0.0057 0.2852 0.2972
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0718 0.0645
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0718 0.2517
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.02 0.0122
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.1677 0.1748
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.7866 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0186 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0505 0.1772
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0919 0.3223
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0718 0.0748
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.1804 0.6327
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.004 0.1881 0.182
Trypanosoma brucei unspecified product 0.0016 0.0505 0.1772
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0919 1
Echinococcus granulosus geminin 0.0182 0.9982 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0412 0.213
Schistosoma mansoni alpha glucosidase 0.0039 0.1804 0.1804
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.1804 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.2852 0.28
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0919 0.3223
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0554 0.048
Schistosoma mansoni alpha-glucosidase 0.015 0.819 0.819
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0885 0.963
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0885 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0186 0.0108
Mycobacterium tuberculosis Probable reductase 0.013 0.7035 0.8837
Loa Loa (eye worm) hypothetical protein 0.0014 0.0412 0.043
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0186 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0186 0.0194
Brugia malayi ecdysteroid receptor 0.001 0.0186 0.0194
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0718 0.2517
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.7035 0.8837
Schistosoma mansoni nuclear hormone receptor 0.001 0.0186 0.0186
Schistosoma mansoni hypothetical protein 0.0017 0.0554 0.0554
Loa Loa (eye worm) hypothetical protein 0.001 0.0186 0.0194
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0885 0.3104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0186 0.0194
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0718 0.2517
Trypanosoma brucei unspecified product 0.0016 0.0505 0.1772
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0718 0.2517
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0718 0.7811
Brugia malayi Glycosyl hydrolases family 31 protein 0.0175 0.9582 0.9988
Schistosoma mansoni DNA polymerase eta 0.0023 0.0919 0.0919
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.2645 0.2757
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.9594 0.9594
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0186 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0186 0.0194
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0186 0.0108
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0186 0.0186
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.1804 0.9477
Loa Loa (eye worm) hypothetical protein 0.0053 0.2645 0.2757
Loa Loa (eye worm) histone methyltransferase 0.0011 0.02 0.0208
Schistosoma mansoni hypothetical protein 0.0037 0.1677 0.1677
Schistosoma mansoni ap endonuclease 0.0023 0.0885 0.0885
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0718 0.2517
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.1804 0.1881
Entamoeba histolytica protein kinase, putative 0.004 0.1881 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.1677 0.1748
Loa Loa (eye worm) hypothetical protein 0.001 0.0186 0.0194
Leishmania major DNA polymerase eta, putative 0.0023 0.0919 0.3223
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0919 0.0919
Schistosoma mansoni coup transcription factor 0.001 0.0186 0.0186
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0186 0.0186
Schistosoma mansoni ap endonuclease 0.0023 0.0885 0.0885
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0412 0.213
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0885 0.0923
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0919 0.3223
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0885 1
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0412 0.1446
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0919 0.3223
Echinococcus granulosus FTZ F1 alpha 0.001 0.0186 0.0108
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0885 0.3104
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0718 0.2517
Brugia malayi nuclear hormone receptor 0.001 0.0186 0.0194
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0885 0.4803
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0919 0.0848
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0919 0.0919
Echinococcus granulosus GPCR family 2 0.0017 0.0554 0.048
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.004 0.188 0.1819
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0919 0.0281
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0554 0.048
Echinococcus granulosus lysosomal alpha glucosidase 0.0175 0.9582 0.9596
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.1804 0.5396
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.02 0.0122
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0554 0.048
Schistosoma mansoni alpha-glucosidase 0.015 0.819 0.819
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0175 0.9594 1
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.2852 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0554 0.0578
Echinococcus granulosus cpg binding protein 0.0037 0.1683 0.1619
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0718 0.5
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0192 0.02
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0718 0.2517
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.7035 0.8837
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0718 0.2517
Schistosoma mansoni hypothetical protein 0.0182 0.9982 0.9982
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0919 0.3223
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0718 0.7811
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.1804 0.6327
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0718 0.2517
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0919 0.0848
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0718 0.2517
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0718 0.2517
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0718 0.2517
Loa Loa (eye worm) hypothetical protein 0.001 0.0186 0.0194
Schistosoma mansoni hypothetical protein 0.0017 0.0554 0.0554
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0919 0.3223
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0919 0.3223
Plasmodium falciparum thioredoxin reductase 0.0057 0.2852 1
Onchocerca volvulus 0.0035 0.157 0.267
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.1804 0.1742
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0186 0.0194
Echinococcus multilocularis cpg binding protein 0.0037 0.1683 0.1619
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0885 0.3104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0186 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0186 0.0194
Schistosoma mansoni cpg binding protein 0.0037 0.1683 0.1683
Loa Loa (eye worm) hypothetical protein 0.001 0.0186 0.0194
Echinococcus granulosus dna polymerase eta 0.0023 0.0919 0.0848
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0412 0.1446
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0919 0.0958
Loa Loa (eye worm) glutathione reductase 0.0057 0.2852 0.2972
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.2852 0.2985
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.1804 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.1804 0.9477
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0186 0.0194
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0885 0.3104
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0718 0.2517
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0186 0.0194
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0919 0.4995
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0718 0.2517
Leishmania major trypanothione reductase 0.0057 0.2852 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0919 0.4995
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.3344 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0186 0.0194
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0718 0.0718
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0718 0.7811
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0186 0.0194
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0412 0.213
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0186 0.0186
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.7035 0.8837
Echinococcus multilocularis geminin 0.0182 0.9982 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0919 0.3223
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0505 0.1772
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0186 0.0108
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0186 0.0108
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0186 0.0108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0186 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0919 0.3223
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0919 0.0958
Loa Loa (eye worm) hypothetical protein 0.001 0.0186 0.0194
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0718 0.2147
Giardia lamblia DINP protein human, muc B family 0.0023 0.0919 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0186 0.0186
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0412 0.213
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0186 0.0108
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.7035 0.8837
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0554 0.0578
Loa Loa (eye worm) hypothetical protein 0.001 0.0186 0.0194
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0919 0.3223
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.2852 0.2972
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0885 0.4803
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0885 0.3218
Loa Loa (eye worm) hypothetical protein 0.001 0.0186 0.0194
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0919 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0718 0.0645
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0412 0.1446
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0919 0.3223
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0718 0.2147
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.7866 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0919 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0186 0.0194
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0885 0.0923
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0186 0.0108
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0718 0.2517
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0919 0.3223
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.004 0.188 0.1819
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0418 0.0435
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.9582 0.9596
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.7035 0.8837
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.1804 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0186 0.0108
Brugia malayi Protein kinase domain containing protein 0.0175 0.9594 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.1804 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0718 0.2517
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0412 0.043
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.1804 0.1742
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0718 0.2517
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0186 0.0108
Schistosoma mansoni cpg binding protein 0.0035 0.157 0.157
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0418 0.0435
Trypanosoma brucei unspecified product 0.0023 0.0919 0.3223
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.2645 0.2757
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0186 0.0108
Entamoeba histolytica protein kinase, putative 0.004 0.1881 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0412 0.213
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0186 0.0194
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.3793 0.3793
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0718 0.2517
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0186 0.0108
Echinococcus granulosus serine:threonine protein kinase Chk2 0.004 0.1881 0.182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0186 0.0194
Plasmodium vivax glutathione reductase, putative 0.0057 0.2852 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0919 0.3223
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0885 0.963
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0186 0.0186
Schistosoma mansoni hypothetical protein 0.0182 0.9982 0.9982
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0412 0.213
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.1804 0.1881
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.2645 0.2757
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0186 0.0194
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0885 0.0814
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.157 0.1636
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0186 0.0108
Schistosoma mansoni thyroid hormone receptor 0.001 0.0186 0.0186
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0554 0.0578
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0919 0.3449
Brugia malayi CXXC zinc finger family protein 0.0035 0.157 0.1636
Plasmodium falciparum thioredoxin reductase 0.002 0.0718 0.2517
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0412 0.0437
Brugia malayi Thioredoxin reductase 0.0057 0.2852 0.2972
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0079 0.0079
Echinococcus multilocularis dna polymerase eta 0.0023 0.0919 0.0848
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0885 0.0234
Trypanosoma brucei trypanothione reductase 0.0057 0.2852 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0186 0.0194
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0718 0.2517
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.1804 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0186 0.0194
Schistosoma mansoni thyroid hormone receptor 0.001 0.0186 0.0186
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0718 0.3857
Schistosoma mansoni cpg binding protein 0.0037 0.1683 0.1683
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0919 0.3223
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0718 0.2517

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 um PUBCHEM_BIOASSAY: HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target. Inhibition of phosphatase activity by colorimetric assay of released free phosphate (BioMol green). Secondary Screen (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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