Detailed information for compound 1317394

Basic information

Technical information
  • TDR Targets ID: 1317394
  • Name: 6-methyl-4-(morpholin-4-ylmethyl)chromen-2-on e
  • MW: 259.3 | Formula: C15H17NO3
  • H donors: 0 H acceptors: 1 LogP: 1.29 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)c(CN1CCOCC1)cc(=O)o2
  • InChi: 1S/C15H17NO3/c1-11-2-3-14-13(8-11)12(9-15(17)19-14)10-16-4-6-18-7-5-16/h2-3,8-9H,4-7,10H2,1H3
  • InChiKey: ICJPSOWZOAYPBH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-methyl-4-(morpholinomethyl)chromen-2-one
  • 6-methyl-4-(morpholinomethyl)-2-chromenone
  • 6-methyl-4-(morpholinomethyl)coumarin
  • IDI1_001361
  • 6-Methyl-4-(4-morpholinylmethyl)-2H-chromen-2-one
  • Coumarin, 6-methyl-4-(4-morpholylmethyl)-
  • SR-01000615689-2
  • Maybridge2_000321
  • Oprea1_823363
  • MLS000080609
  • SMR000038124

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.051 0.051
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0302 0.0302
Brugia malayi polk-prov protein 0.0042 0.1106 0.1258
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0382 0.0714
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.051 0.051
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.051 0.051
Mycobacterium ulcerans phosphoglycerate kinase 0.0167 0.5346 0.5984
Leishmania major phosphoglycerate kinase C, glycosomal 0.0167 0.5346 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0078 0.2326 0.2565
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.1481 0.1481
Chlamydia trachomatis phosphoglycerate kinase 0.0167 0.5346 0.5
Leishmania major DNA polymerase kappa, putative 0.0058 0.166 0.2977
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0052 0.1439 0.1439
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0167 0.5346 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0637 0.1029
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 1 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.051 0.051
Echinococcus multilocularis dna polymerase kappa 0.0078 0.2326 0.2326
Plasmodium vivax importin-beta 2, putative 0.0028 0.0637 0.083
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.1871 0.1871
Brugia malayi jmjC domain containing protein 0.0025 0.051 0.058
Plasmodium vivax phosphoglycerate kinase, putative 0.0167 0.5346 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.2289 0.2289
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.2326 0.4247
Echinococcus multilocularis lysine specific demethylase 5A 0.0093 0.282 0.282
Schistosoma mansoni importin beta-1 0.0028 0.0637 0.0637
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.126 0.126
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0642 0.1201
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1549 0.1549
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0454 0.0411
Plasmodium falciparum DNA repair protein REV1, putative 0.0016 0.0219 0.0409
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.1871 0.213
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.1481 0.1685
Brugia malayi Phosphoglycerate kinase 0.0061 0.1753 0.1995
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.051 0.051
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.126 0.126
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0061 0.1753 0.3155
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.051 0.051
Brugia malayi RNA, U transporter 1 0.0081 0.2421 0.2756
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0999 0.1137
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.2326 0.4247
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.1481 0.1481
Echinococcus multilocularis dna polymerase eta 0.0077 0.2289 0.2289
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0219 0.0232
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0382 0.0714
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0219 0.0232
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.3745 0.3745
Brugia malayi glutaminase DH11.1 0.0268 0.8786 1
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.2289 0.2605
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.1753 0.3155
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.2326 0.4247
Brugia malayi MH2 domain containing protein 0.012 0.3745 0.4262
Schistosoma mansoni jumonji domain containing protein 0.0025 0.051 0.051
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.047 0.0429
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.051 0.0953
Trypanosoma brucei unspecified product 0.0036 0.089 0.1511
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0219 0.0232
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0642 0.0642
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.126 0.126
Loa Loa (eye worm) glutaminase 2 0.0268 0.8786 0.8786
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.1871 0.1871
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.111 0.193
Loa Loa (eye worm) hypothetical protein 0.0042 0.1106 0.1106
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0637 0.1029
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0078 0.2326 0.2565
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0382 0.0382
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.126 0.126
Mycobacterium tuberculosis Conserved hypothetical protein 0.0052 0.1439 0.1014
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.6207 0.6207
Schistosoma mansoni jumonji domain containing protein 0.0132 0.4173 0.4173
Echinococcus granulosus jumonji domain containing protein 0.004 0.1023 0.1023
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0642 0.0642
Treponema pallidum phosphoglycerate kinase 0.0167 0.5346 1
Schistosoma mansoni glutaminase 0.0268 0.8786 0.8786
Echinococcus granulosus importin subunit beta 1 0.0028 0.0637 0.0637
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.051 0.0953
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.2326 0.4247
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.1753 0.3155
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.047 0.0429
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0041 0.1068 0.1999
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.2326 0.4247
Brugia malayi jmjC domain containing protein 0.0152 0.4828 0.5495
Leishmania major DNA polymerase kappa, putative 0.0016 0.0219 0.0232
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0999 0.1718
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0219 0.0232
Entamoeba histolytica phosphoglycerate kinase, putative 0.0167 0.5346 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.111 0.193
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.1871 0.338
Entamoeba histolytica hypothetical protein 0.0023 0.0454 0.068
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.2326 0.4247
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.051 0.0786
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0167 0.5346 1
Echinococcus multilocularis peregrin 0.0029 0.0642 0.0642
Echinococcus granulosus phd:f box containing protein 0.0025 0.051 0.051
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1677 0.1677
Echinococcus granulosus peregrin 0.0029 0.0642 0.0642
Schistosoma mansoni hypothetical protein 0.0029 0.0642 0.0642
Schistosoma mansoni phosphoglycerate kinase 0.0167 0.5346 0.5346
Schistosoma mansoni ran 0.0021 0.0382 0.0382
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0999 0.1868
Leishmania major GTP-binding protein, putative 0.0021 0.0382 0.0542
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0382 0.0542
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0382 0.0714
Schistosoma mansoni protein phosphatase 2C 0.0025 0.051 0.051
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0152 0.4828 0.4828
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0944 0.0944
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.1068 0.185
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.1481 0.1481
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.051 0.0953
Trypanosoma brucei phosphoglycerate kinase 0.0167 0.5346 1
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.051 0.051
Schistosoma mansoni jumonji/arid domain-containing protein 0.0093 0.282 0.282
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1549 0.1549
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1549 0.1549
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1871 0.338
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.2326 0.4247
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.051 0.051
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.1753 0.3155
Echinococcus granulosus bloom syndrome protein 0.0024 0.047 0.047
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0052 0.1439 0.1439
Onchocerca volvulus 0.0047 0.126 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.051 0.051
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.2326 0.4247
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.051 0.051
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0642 0.0642
Brugia malayi mbt repeat family protein 0.0047 0.126 0.1434
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1549 0.1549
Schistosoma mansoni jumonji/arid domain-containing protein 0.0093 0.282 0.282
Brugia malayi jmjC domain containing protein 0.0025 0.051 0.058
Loa Loa (eye worm) hypothetical protein 0.0118 0.37 0.37
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1549 0.1549
Schistosoma mansoni ran 0.0021 0.0382 0.0382
Plasmodium falciparum importin beta, putative 0.0028 0.0637 0.1192
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0999 0.091
Brugia malayi Phosphoglycerate kinase 0.0167 0.5346 0.6084
Trypanosoma brucei chrX additional, unordered contigs 0.0016 0.0219 0.0232
Echinococcus granulosus dna polymerase kappa 0.0078 0.2326 0.2326
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.051 0.051
Brugia malayi PHD-finger family protein 0.0029 0.0642 0.073
Mycobacterium ulcerans glutaminase 0.0268 0.8786 1
Mycobacterium ulcerans DNA polymerase IV 0.0078 0.2326 0.246
Trypanosoma brucei unspecified product 0.0072 0.2106 0.3828
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0454 0.0411
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.1106 0.1921
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0637 0.1192
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.126 0.126
Loa Loa (eye worm) jmjC domain-containing protein 0.0093 0.282 0.282
Giardia lamblia DNA damage repair protein 0.0016 0.0219 0.0409
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0999 0.1718
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0382 0.0434
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.2326 0.4247
Trichomonas vaginalis glutaminase, putative 0.0268 0.8786 1
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0167 0.5346 1
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.051 0.051
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0999 0.1718
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0204 0.0382
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.1871 0.1871
Brugia malayi mbt repeat family protein 0.0047 0.126 0.1434
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.051 0.0786
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.1753 0.3155
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0167 0.5346 1
Trypanosoma brucei unspecified product 0.0036 0.089 0.1511
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.126 0.126
Plasmodium vivax DNA repair protein REV1, putative 0.0016 0.0219 0.0016
Toxoplasma gondii exonuclease III APE 0.0039 0.0999 0.1868
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0373 0.0698
Mycobacterium ulcerans DNA polymerase IV 0.0078 0.2326 0.246
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0999 0.1037
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0999 0.0999
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.126 1
Schistosoma mansoni DNA polymerase eta 0.0077 0.2289 0.2289
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.111 0.193
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.1871 0.338
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.1753 0.3155
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.0439 0.0821
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0637 0.0637
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0454 0.0411
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0152 0.4828 0.4828
Loa Loa (eye worm) hypothetical protein 0.0047 0.126 0.126
Loa Loa (eye worm) hypothetical protein 0.0064 0.1863 0.1863
Leishmania major hypothetical protein, conserved 0.0025 0.051 0.0786
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0167 0.5346 1
Schistosoma mansoni hypothetical protein 0.0292 0.9609 0.9609
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.051 0.0786
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1871 0.338
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.051 0.051
Trypanosoma brucei DNA polymerase IV, putative 0.0072 0.2106 0.3828
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0382 0.0542
Entamoeba histolytica Ran family GTPase 0.0021 0.0382 0.0542
Trypanosoma brucei phosphoglycerate kinase 0.0061 0.1753 0.3155
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.2326 0.4247
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.3745 0.3745
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0382 0.0382
Trypanosoma brucei phosphoglycerate kinase 0.0167 0.5346 1
Loa Loa (eye worm) MBCTL1 0.0053 0.1481 0.1481
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0016 0.0219 0.0409
Brugia malayi jmjC domain containing protein 0.0093 0.282 0.321
Schistosoma mansoni DNA polymerase IV / kappa 0.0016 0.0219 0.0219
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.1481 0.1481
Leishmania major DNA polymerase eta, putative 0.0077 0.2289 0.4176
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0382 0.0542
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.2289 0.4176
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.2326 0.4247
Echinococcus granulosus phosphoglycerate kinase 1 0.0167 0.5346 0.5346
Loa Loa (eye worm) hypothetical protein 0.0053 0.1481 0.1481
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0052 0.1439 0.1439
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.1481 0.1481
Schistosoma mansoni phosphoglycerate kinase 0.0167 0.5346 0.5346
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0167 0.5346 1
Schistosoma mansoni phd/f-box containing protein 0.0025 0.051 0.051
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0058 0.166 0.2977
Brugia malayi jmjC domain containing protein 0.0025 0.051 0.058
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.2289 0.4176
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0219 0.0232
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1871 0.338
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0999 0.1718
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0999 0.1718
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.2326 0.4247
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0999 0.1868
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0052 0.1439 0.1439
Schistosoma mansoni hypothetical protein 0.0304 1 1
Plasmodium falciparum phd finger protein, putative 0.0029 0.0642 0.1201
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0219 0.0232
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0999 0.0999
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0999 0.1037
Schistosoma mansoni ap endonuclease 0.0039 0.0999 0.0999
Echinococcus multilocularis phosphoglycerate kinase 1 0.0167 0.5346 0.5346
Loa Loa (eye worm) hypothetical protein 0.0029 0.0642 0.0642
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.126 0.126
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0642 0.0642
Loa Loa (eye worm) glutaminase 0.0268 0.8786 0.8786
Loa Loa (eye worm) hypothetical protein 0.0025 0.051 0.051
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.2326 0.4247
Brugia malayi Importin beta-1 subunit 0.0028 0.0637 0.0725
Echinococcus granulosus lysine specific demethylase 5A 0.0093 0.282 0.282
Leishmania major DNA polymerase eta, putative 0.0041 0.1068 0.185
Plasmodium vivax JmjC domain containing protein 0.0025 0.051 0.0582
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0167 0.5346 0.604
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0642 0.0839
Echinococcus granulosus dna polymerase eta 0.0077 0.2289 0.2289
Echinococcus multilocularis jumonji domain containing protein 0.004 0.1023 0.1023
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.6207 0.6207
Leishmania major phosphoglycerate kinase B, cytosolic 0.0167 0.5346 1
Trichomonas vaginalis ran, putative 0.0021 0.0382 0.0327
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0999 0.0999
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.1106 0.1921
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.1871 0.1871
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1549 0.1763
Trypanosoma brucei phosphoglycerate kinase, putative 0.0061 0.1753 0.3155
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0219 0.0232
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.051 0.051
Brugia malayi jmjC domain containing protein 0.0025 0.051 0.058
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0219 0.0232
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0058 0.166 0.152
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1549 0.1549
Plasmodium falciparum phosphoglycerate kinase 0.0167 0.5346 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0052 0.1439 0.1439
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0642 0.1201
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0167 0.5346 0.604
Leishmania major importin beta-1 subunit, putative 0.0023 0.0454 0.068
Loa Loa (eye worm) hypothetical protein 0.0028 0.0637 0.0637
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1549 0.1549
Echinococcus multilocularis snurportin 1 0.0304 1 1
Loa Loa (eye worm) RecQ helicase 0.0024 0.047 0.047
Giardia lamblia Phosphoglycerate kinase 0.0167 0.5346 1
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.047 0.0535
Giardia lamblia PHD finger protein 15 0.0029 0.0642 0.1201
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.166 0.2977
Brugia malayi ImpB/MucB/SamB family protein 0.0052 0.1439 0.1638
Leishmania major DNA damage repair protein, putative 0.0016 0.0219 0.0232
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.126 0.126
Echinococcus multilocularis bloom syndrome protein 0.0024 0.047 0.047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1549 0.1549
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0999 0.1534
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0167 0.5346 0.5
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0382 0.0333
Echinococcus multilocularis phd:f box containing protein 0.0025 0.051 0.051
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0944 0.0944
Loa Loa (eye worm) hypothetical protein 0.0167 0.5346 0.5346
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0382 0.0382
Brugia malayi Bromodomain containing protein 0.0029 0.0642 0.073
Entamoeba histolytica deoxycytidyl transferase, putative 0.0052 0.1439 0.2557
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.2326 0.4247
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.2326 0.4247
Giardia lamblia DINP protein human, muc B family 0.0058 0.166 0.3104
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0454 0.068
Schistosoma mansoni ap endonuclease 0.0039 0.0999 0.0999

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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