Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0136 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3836 | 0.3652 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.9171 | 0.9171 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.029 | 0.029 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.4723 | 0.4566 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0039 | 0.2589 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.3836 | 0.3652 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.1215 | 0.0953 |
Brugia malayi | Inositol-1 | 0.0039 | 0.2589 | 0.2589 |
Echinococcus granulosus | tar DNA binding protein | 0.0136 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3836 | 0.3652 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0035 | 0.228 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.2589 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.029 | 0.029 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0136 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.1215 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.2589 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0035 | 0.228 | 0.3037 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.2589 | 0.2589 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.1215 | 0.0953 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3836 | 0.3652 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.3836 | 0.3652 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.9171 | 0.9171 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0039 | 0.2589 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.2589 | 0.2368 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0067 | 0.4723 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.2589 | 0.2368 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0009 | 0.029 | 0.029 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.2589 | 0.3917 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0009 | 0.029 | 0.029 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.4723 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.3836 | 0.3652 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.1215 | 0.5 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.2589 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.1215 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.4723 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.2589 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.3836 | 0.3836 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.2589 | 0.3917 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.1215 | 0.0953 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.029 | 0.029 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.9171 | 0.9171 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.3836 | 0.3652 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0039 | 0.2589 | 0.3917 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.1215 | 0.1215 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.1215 | 0.0953 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0039 | 0.2589 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0067 | 0.4723 | 0.4566 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.1215 | 0.1215 |
Brugia malayi | TAR-binding protein | 0.0136 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0136 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.3836 | 0.3836 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0067 | 0.4723 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.029 | 0.029 |
Brugia malayi | Smad1 | 0.0009 | 0.029 | 0.029 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.1215 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.4723 | 0.4566 |
Loa Loa (eye worm) | Smad1 | 0.0009 | 0.029 | 0.029 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.4723 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0067 | 0.4723 | 0.4566 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.2589 | 0.2368 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.2589 | 0.2368 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0067 | 0.4723 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.2589 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0136 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 195 um | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] | ChEMBL. | No reference |
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.