Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.8339 | 0.8339 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.2874 | 0.2874 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.8339 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.2874 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.8339 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.2874 | 0.2874 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.8339 | 0.8339 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 1 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.8339 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.2874 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 1 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.8339 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.8339 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0.7204 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.2874 | 0.3447 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.2874 | 0.5 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.8339 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.2874 | 0.2874 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 1 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.8339 | 0.7669 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.2874 | 0.3447 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.2874 | 0.3447 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.8339 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.2874 | 0.3447 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.2874 | 0.3989 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.8339 | 0.8339 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.2874 | 0.2874 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.8339 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.7204 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.8339 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.8339 | 0.8339 |
Brugia malayi | Inositol-1 | 0.0038 | 0.8339 | 0.7669 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.2874 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.8339 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.8339 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.5821 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: Secondary Concentration-Response Assay for Agonists of the Thyroid Stimulating Hormone Receptor: HTRF Activity Detection. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.